Clinical trials: Reproductive Effects
Polycystic Ovary Syndrome (PCOS), Overweight
The Effect of GLP-1 Agonists Versus OCs on Reproductive Disorders and Cardiovascular Risks in Overweight PCOS
Polycystic ovary syndrome (PCOS) is a health problem that affects one in 10 women of childbearing age, which is usually characterized by hormonal imbalance and metabolism problems such as hyperandrogenism and obesity.
- Conditions
- Polycystic Ovary Syndrome (PCOS), Overweight, Obesity
- Trial name
- NCT03151005
- Testing
- Metformin-GLP-1 Receptor Agonist, Metformin-Oral Contraceptive(OC)
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Xinqiao Hospital of Chongqing
Assisted Reproduction
Effect of Trophectoderm Biopsy for Sex Selection on the Pregnancy and Miscarriage Rates of Women Undergoing IVF/ICSI
Records of women who had trophectoderm biopsy for sex selection over the last 3 years will be reviewed and its outcome will be compared to other records of women who had IVF/ICSI without embryo biopsy.
- Trial name
- NCT02412605
- Testing
- Trophectoderm embryo biopsy
- Where
- Egypt
- Volunteers
- 5,000 people
- Sponsor
- Cairo University
IVF
A Cohort Study of Environmental Endocrine Disrupting Chemicals and Female Reproductive Health
Infertility is a disease that seriously affects the physical and mental health of women of childbearing age. The incidence of infertility has been increasing in recent years.
- Trial name
- PKU-ERC (NCT05373290)
- Testing
- there is no intervention in the study
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Peking University People's Hospital
Sterility, Infertility
Myo-Inositol- Based Co-treatment in Women With PCOS Undergoing Assisted Reproductive Technology
This is a prospective comparative randomized controlled study investigating the effect of Myo-Inositol-based co-treatment on oocyte quality measures in women with PCOS.
- Trial name
- NCT03177122
- Testing
- Myo-inositol
- Where
- Lebanon
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Hypogonadism, Hypergonadism
Observation of Environment and Reproductive-Endocrine Effects
Background: Endocrine disorders occur when the glands that make hormones do not work properly. Hormones levels that are too high or too low can cause problems such as late or early puberty, irregular periods, and infertility.
- Conditions
- Hypogonadism, Hypergonadism, Precocious Puberty, Late Puberty
- Trial name
- NCT06280807
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Reproductive Issues, Cesarean Section; Dehiscence
Hysteroscopic Isthmocele Repair on IVF Outcome
Hysteroscopic Isthmocele repair on IVF outcome It aims to assesse the efficacy of Hysteroscopic CS scar defect repair on the clinical pregnancy rate after embryo transfer.
- Conditions
- Reproductive Issues, Cesarean Section; Dehiscence, Intrauterine Disorder
- Trial name
- NCT05590104
- Testing
- Hysteroscopic CS scar defect repair
- Where
- 2 sites in United Arab Emirates
- Volunteers
- 50 people
- Sponsor
- HealthPlus Fertility Center
COVID-19 Infection
Novel Coronavirus Infection and Reproductive Function
This study aims to observe the impact of COVID-19 infection on the reproductive function and assisted pregnancy outcome of infertile couples undergoing assisted reproductive technology and to determine which factors are related…
- Trial name
- NCT05685992
- Testing
- no intervention
- Where
- 3 sites in China
- Volunteers
- 400 people
- Sponsor
- Jinling Hospital, China
Polycystic Ovary Syndrome (PCOS), Obesity
Effects of GLP-1RAs on Fertility Outcomes in Obese Women With PCOS
The goal of this clinical trial is to examine whether GLP1-RA and healthy lifestyle education in women with PCOS and obesity prior to fertility treatment improves live birth rate and other reproductive, maternal and perinatal…
- Conditions
- Polycystic Ovary Syndrome (PCOS), Obesity, Infertility, Female
- Trial name
- NCT07687667
- Testing
- GLP-1 receptor agonist, Metformin
- Where
- China
- Volunteers
- 406 people
- Sponsor
- Peking University Third Hospital
Infertility
Comparison of IVF and ICSI in Human IVF
In this prospective randomized clinical trial we plan to compare two fertilization method which are widely used during in vitro fertilization (IVF) treatment.
- Trial name
- NCT03513913
- Testing
- ICSI
- Where
- Hungary
- Volunteers
- 600 people
- Sponsor
- Semmelweis University
Chatbot, Large Language Model
Effects of a Large Language Model-Driven Chatbot on Reproductive Concerns After Cancer
Reproductive health has emerged as a critical yet overlooked concern among Adolescent and Young Adult (AYA) cancer survivors, given their compromised potential for biological parenthood in prime childbearing years.
- Conditions
- Chatbot, Large Language Model, Adolescent and Young Adult Cancer Survivors, Reproductive Health
- Trial name
- NCT07741266
- Testing
- Chatbot, Electronic brochure
- Where
- 2 sites in China, Hong Kong
- Volunteers
- 60 people
- Sponsor
- The Hong Kong Polytechnic University
Iron Deficiency Anemia
Effects of Oral Iron Supplementation on Vaccine Response in Iron Deficient Kenyan Women
Iron deficiency (ID) anemia (IDA) is a global public health problem, with the highest prevalence in Africa. Vaccines often underperform in low- and middle- income countries (LMIC), and undernutrition, including ID, likely plays a…
- Trial name
- NCT05919472
- Testing
- Oral iron supplementation (pre-treatment), COVID-19 vaccine, MenACWY vaccine
- Where
- Kenya
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Nicole Stoffel
Thyroiditis, Autoimmune
The Effect of Thyroid Antibodies on Female Reproductive Function and Pregnancy Outcomes
Some women at reproductive age have positive antithyroid antibodies (ATAs). Thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb) are the most common ATAs.
- Trial name
- NCT04952012
- Testing
- LT4
- Where
- China
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Birth, Spontaneous Abortion
The Effects of Aspirin in Gestation and Reproduction
The primary objective of the study is to help elucidate the effects of low-dose aspirin in combination with folic acid on the incidence of live births and spontaneous abortions among a group of women who become pregnant compared…
- Trial name
- EAGeR (NCT00467363)
- Testing
- acetylsalicylic-acid (aspirin), Folic acid
- Where
- 4 sites in United States
- Volunteers
- 1,228 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
The Effect of Iodine and BPA on AITD in Reproduction Women
The Relationship Between Urine Iodine, Urine Bisphenol A and Autoimmune Thyroid Disease in Reproductive Women
Autoimmune thyroid disease (AITD) is the main cause of hypothyroidism in reproduction women, iodine and bisphenol A are the environmental factors for AITD.
- Trial name
- NCT03932487
- Testing
- urinary iodine and urine BPA
- Where
- China
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Xiaomei Zhang
Male Reproductive Problem
Effect of Formal Letter of Invitation on Male Partner Involvement at Antenatal Care Clinic
Prevention of mother to child transmission (PMTCT) of human immune deficiency virus (HIV) program requires great male participation in achieving a sustained reduction of mother-to-child transmission of HIV.
- Trial name
- NCT06171503
- Testing
- letter of invitation on MI in PMTCT service
- Where
- Ethiopia
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Jimma University
Health Knowledge, Attitudes, Practice, Vaccine-Preventable Diseases
Culturally Tailored HPV Psychoeducational Multimedia Intervention
Community members ages 18 - 45 years old from the El Paso, Texas, U.S.-Mexico Border Region will be recruited to compare psychoeducational multimedia interventions focused on the human papillomavirus (HPV).
- Conditions
- Health Knowledge, Attitudes, Practice, Vaccine-Preventable Diseases, Intention, Adherence, Patient
- Trial name
- NCT06098690
- Testing
- Culturally Tailored Multimedia Psychoeducational HPV Intervention, General HPV Multimedia Psychoeducational Control Group
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Texas, El Paso
Female Infertility, Obesity
Effect of the Glycemic Index of Diet on Metabolic and Reproductive Parameters in Overweight and Obese Infertile Women
Infertility has been currently recognized as a disorder related to obesity. Among several metabolic changes associated with obesity, insulin resistance appears to be linked to hormonal disorders that affect reproductive system.
- Trial name
- NCT02416960
- Testing
- Low Glycemic Index Diet Group, Conventional Diet Group
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Abnormal Vaginal Microbiota, Infertility
The Microbiome of Infertile Couples and Its Effect on Their Reproductive Outcomes
A prospective cohort study in IVF patients at 5 IVF centres in Denmark. The primary aim is to include patients positive for abnormal vaginal microbiota to an RCT (EUDRACT 2016-002385-31).
- Trial name
- NCT03420859
- Testing
- qPCR for abnormal vaginal microbiota
- Where
- Denmark
- Volunteers
- 1,850 people
- Sponsor
- Peter Humaidan
Oocyte Retrieval, Pain
Oocyte Retrieval and Virtual Reality (REVPO)
The aim of the study is to ass wether or not the use of virtual reality during oocyte retrieval provides a better pain relief for patients, compared to a standard analgesic procedure.
- Conditions
- Oocyte Retrieval, Pain, Fertilization in Vitro
- Trial name
- REVPO (NCT04935658)
- Testing
- Hypnotic relaxation induced by virtual reality (device), local anesthesia
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Clermont-Ferrand
Male Infertility, Heart Valve Disease
Warfarin Effects on Male Fertility After Cardiac Surgery
Young male patients undergoing cardiac surgery may require oral anticoagulation with warfarin either lifelong, such as after mechanical valve replacement, or for a limited postoperative period, for example following valve repair…
- Trial name
- NCT07330869
- Testing
- Semen analysis, sperm DNA fragmentation and hormonal evaluation
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Città di Lecce Hospital, GVM Care & Research