Clinical trials: Reproductive Sterility
Female Infertility
Multiple Dose FSH-GEX(TM) in Healthy Volunteers
The aim of the current study is the pharmacokinetic and pharmacodynamic characterization of a multiple dose administration of FSH-GEX™ in healthy pituitary-suppressed female volunteers, in comparison with two marketed comparator…
- Trial name
- NCT01477073
- Testing
- FSH-GEX™, recombinant FSH, urinary FSH
- Where
- Netherlands
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Glycotope GmbH
Infertility Female
Glucose Pattern in Infertile Women Receiving Assisted Reproduction Using Continuous Glucose Monitoring
No studies have been seen on glucose variation during medication for assisted reproduction. The aim of this study is to continuously observe glucose variation during assisted reproduction treatment using continuous glucose…
- Trial name
- NCT06863337
- Testing
- CGM
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai 6th People's Hospital
Infertility
Subcutaneous Progesterone Versus Vaginal Progesterone for Endometrial Preparation in Fresh Donated Oocytes Recipients
Randomised, prospective, investigator-blinded, controlled, single-centre study to assess the impact on the ongoing pregnancy rate with the use of two progesterones with different administration routes, in recipients of fresh…
- Trial name
- NCT02363127
- Testing
- subcutaneous progesterone, vaginal progesterone
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Instituto Bernabeu
POSEIDON Category 4, Low Prognosis in Assisted Reproductive Technology
Impact of Day 2 Versus Day 3 Fresh Embryo Transfer on Live Birth Rate in Poor-Prognosis Patients
This study aimed to compare the efficacy (live birth rate) of fresh embryo transfer on Day 2 versus Day 3 in POSEIDON Group 4 patients, and to determine the optimal timing of embryo transfer for this population.
- Conditions
- POSEIDON Category 4, Low Prognosis in Assisted Reproductive Technology, Female Infertility Due to Diminished Ovarian Reserve
- Trial name
- NCT07533695
- Testing
- Day 2 Fresh Embryo Transfer
- Volunteers
- 470 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Uterine Fibroid, Pregnancy Complications
Pregnancy Outcomes Following Myomectomy
The most prevalent genital pathology, uterine fibroids have a detrimental impact on the health of women. Fibroid symptoms are typically more impactful on females and frequently require uterine excision.
- Conditions
- Uterine Fibroid, Pregnancy Complications, Reproductive Issues, Reproductive Sterility
- Trial name
- NCT06474065
- Testing
- Myomectomy
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centro di Ricerca Clinica Salentino
Reproductive Techniques, Assisted
Study to Evaluate if the Addition of r-hLH (Luveris®) to FSH From Day 8 of Ovarian Stimulation is Able to Decrease Total FSH Dose and to Improve Cycle Outcome in Infertile Women Undergoing ART, Who Required High FSH Dose in a Previous Cycle
The present study was designed to investigate, in hyporesponder subjects, that required in a previous assisted reproductive technologies (ART) cycle follicle stimulating hormone (FSH) >3500 International Unit (IU), the…
- Trial name
- Luveris in ART (NCT01071200)
- Testing
- Recombinant human Follicle Stimulating Hormone (r-hFSH) and Recombinant human Luteinizing Hormone (r-hLH), r-hFSH
- Where
- Italy
- Volunteers
- 133 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Reproductive Disorder
Recall by Genotype: Neuropeptide Stimulation
The objective of this protocol is to assess response to kisspeptin and gonadotropin-releasing hormone (GnRH) stimulation testing as well as the baseline patterns of luteinizing hormone (LH) secretion in individuals who carry…
- Trial name
- NCT05901467
- Testing
- kisspeptin 112-121, GnRH
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Stephanie B. Seminara, MD
Infertility/Sterility
Positive Adjustment Coping Intervention
Involuntary childlessness is experienced as emotionally stressful, however psychosocial counseling is not always available on the spot.
- Trial name
- PACI (NCT03118219)
- Testing
- Positive adjustment coping intervention, Brainteaser
- Where
- Germany
- Volunteers
- 401 people
- Sponsor
- University Hospital Heidelberg
Infertility
Clinical Performance and Safety Investigation of ENDOmetrial Washing MEdical DEvice Forielle
This is a multicenter, prospective randomized controlled, interventional investigation to assess the safety and clinical performance of Forielle, a medical device for endometrial washing, in restoring favorable endometrial…
- Trial name
- ENDOMEDE (NCT03387059)
- Testing
- Forielle
- Where
- 7 sites in Italy
- Volunteers
- 9 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Rokitansky Kuster Hauser Syndrome, Sterility, Female
Uterus Transplantation Procedure From a Live Donor
Absolut uterine factor, meaning the absence of uterus, represents a cause for sterility without the possibility of a present treatment.
- Trial name
- NCT04314869
- Testing
- Uterus transplantation
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Hospital Clinic of Barcelona
Infertility
3D Ultrasound Measurement of Junctional Zone Thickness and Its Relation to Implantation Success
100 patients aged 21-40 years old, diagnosed as primary or secondary infertility . These patients are then assigned to receive fertility treatment (ovulation induction, ICSI, intrauterine insemination and IVF).
- Trial name
- NCT02362061
- Testing
- 3D ultrasound
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Fertility Issues
Assisted Reproductive Techniques (ART) With Sperm Donation : an Inclusive Model of ART for All Women
This is a monocentric, retrospective, non-interventional study. The main objective is to describe the populations requesting assisted reproductive techniques (ART) with sperm donation ; and compare them between groups depending…
- Trial name
- PMAPT (NCT06163079)
- Testing
- No intervention
- Where
- France
- Volunteers
- 675 people
- Sponsor
- Central Hospital, Nancy, France
Infertility, Obesity
Physical Activity and ARTs
Obese women experience increased infertility rate and longer time to conception showing lower pregnancy and live-birth rates both in natural and assisted conceptions.
- Conditions
- Infertility, Obesity, Stable BMI
- Trial name
- SETART (NCT01892111)
- Testing
- Structured exercise program.
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- University of Modena and Reggio Emilia
Infertility
Evaluation of IMSI to Treat Male Infertility
Intracytoplasmic Morphologically Selected Sperm (IMSI) is a modification of IntraCytoplasmic Sperm Injection (ICSI) with a choice of the spermatozoon to be injected done at a 6000x magnification instead of 400x commonly used in…
- Trial name
- PHRC-IMSI (NCT01780649)
- Testing
- IMSI, ICSI
- Where
- 9 sites in France
- Volunteers
- 255 people
- Sponsor
- University Hospital, Toulouse
Infertility, Female
Effects of Pentoxifylline and Vitamin E on Pregnancy Rate in Infertile Women Treated by ICSI:
Our findings will provide preliminary clinical evidence to suggest the new experimental treatment approaches, toward female factor infertility treatment with pentoxyfylline.
- Trial name
- NCT03476564
- Testing
- pentoxifylline, Vit E
- Where
- Egypt
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Benha University
Infertility
Association of the Mediterranean Diet With Fertility Outcomes
Infertility affects one of every six couples and one out of ten couples may seek fertility treatment such as ovulation induction and assisted reproductive technologies. With respect to diet, several dietary factors, i.e.
- Trial name
- MedDietIVF (NCT03050944)
- Testing
- Lifestyle behaviour and dietary habits assessment
- Where
- Greece
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Reproductive Issues, Male Infertility
Efficacy and Safety of a New Sperm Capacitation Method
Prospective, multicenter research study with a split-sample design on semen samples, without intervention, to evaluate the efficacy and safety of HyperSperm, a new sperm capacitation method, in 300 semen samples with various…
- Conditions
- Reproductive Issues, Male Infertility, Asthenozoospermia, Oligozoospermia
- Trial name
- HyperSperm01 (NCT06742437)
- Testing
- Standard sperm preparation, HyperSperm
- Where
- 4 sites in Spain
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Fecundis Lab SL
Infertility, Female, Reproductive Disorder
A Comparison of Clinical Outcomes of Warmed Embryo Vitrified at 2PN Stage and Fresh Embryo Transfers
The aim of this study was to compare the clinical outcomes between fresh embryo and frozen embryo transfer in in vitro fertilization (IVF).
- Trial name
- NCT03317548
- Testing
- progesterone, day 3 embryo
- Where
- Taiwan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Chung Shan Medical University
Infertility, Female, Reproductive Sterility
Evaluation of Salivary ELISA for Hormone Monitoring in Donors
In donors or patients undergoing assisted reproduction treatments (ART) it is necessary to closely control ovarian stimulation to monitor the number and size of developing follicles.
- Trial name
- MINT-II (NCT05780489)
- Testing
- Determination of progesterone and oestradiol
- Where
- 2 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Adenomyosis, Infertility
Adenomyosis and Pregnancy Outcomes in Women Undergoing Assisted Reproductive Technology Treatment
Rationale: A rising number of adenomyosis cases are being diagnosed in women in the age group of 30 to 40 years. This is due to a combination of better diagnostic imaging techniques and a higher number of women delaying the…
- Conditions
- Adenomyosis, Infertility, ART, Pregnancy Loss
- Trial name
- AdAPT-ART (NCT05418140)
- Testing
- Ultrasound diagnosis of adenomyosis
- Where
- 9 sites in United Kingdom
- Volunteers
- 828 people
- Sponsor
- CARE Fertility UK