Clinical trials: Reproductive Tract Infections
Bacterial Vaginoses
The Temporo-spatial Dynamics of Genital Tract Microbiota - an Observational Study in Oocyte Donors
The investigators aim to examine the endometrium with state of the art sequencing techniques to investigate the endometrial microbiota.
- Trial name
- NCT04393857
- Where
- Spain
- Volunteers
- 26 people
- Sponsor
- Peter Humaidan
HIV Infection, Vaginal Atrophy
Accelerated Genital Tract Aging in HIV: Estradiol Clinical Trial
During menopause, there is a decrease in a hormone estrogen, which leads to aging of the vagina. Vaginal aging includes changes in the type and amount of healthy bacteria in the vagina, inflammation and a breakdown of natural…
- Conditions
- HIV Infection, Vaginal Atrophy, Menopause, Menopause Related Conditions
- Trial name
- NCT04079218
- Testing
- Estradiol Vaginal Insert
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kerry Murphy
HIV Infections
Antiviral Therapy and HIV in the Female Genital Tract
HIV is found in both the blood and the genital tract. This study will compare the levels and types of HIV found in the blood with the levels and types of HIV found in the female genital tract.
- Trial name
- NCT00067106
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Comparing Raltegravir Genital Tract Distribution in HIV-infected Men and Women
The purpose of this research study is to determine how much raltegravir gets into the male and female genital tract.
- Trial name
- NCT00745368
- Testing
- Raltegravir
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Rochester
Early Pregnancy
Chlamydia Tracomatis and Other Lower Genital Tract Infections Among Women With Unexplained Early Miscarriage
Although one fourth of pregnant women experience at least 1 abortion, yet only 50% of causes are identified. Pregnancy loss can result from viral, bacterial, and other infections.
- Trial name
- NCT04152278
- Testing
- cervicovaginal culture and qPCR for chlamydial trachomatis and wadallia chondrophila
- Where
- Egypt
- Volunteers
- 600 people
- Sponsor
- Fayoum University Hospital
HIV/AIDS, Contraception
Modifiers of Tenofovir in the Female Genital Tract
Two-armed, single visit, pharmacokinetic study to compare tenofovir diphosphate concentrations in cervical tissues of women on Depo-Provera contraception vs non-hormonal contraception.
- Trial name
- NCT03377608
- Testing
- Tenofovir Disoproxil Fumarate, Depo-Provera
- Where
- Uganda
- Volunteers
- 50 people
- Sponsor
- University of Minnesota
First Trimester Abortion
Unexplained Early Miscarriage : Role and Prevalence of Lower Genital Tract Infections
The study group included 910 women who attended Fayoum university hospital gynecology outpatient clinic for postabortive evaluation.
- Trial name
- NCT03413774
- Testing
- vaginal swab
- Where
- Egypt
- Volunteers
- 1,850 people, healthy volunteers welcome
- Sponsor
- Cairo University
Long Covid-19
LOng COvid COmorbidities: Andrological, Reproductive, Sexual Dysfunctions in Patients Recovered From COVID-19
Considering the compelling amount of studies focused on patients in the active phase of COVID-19 disease and the scarcity of studies focused on patient cured from disease aimed at evaluating the sequelae of Severe Acute…
- Trial name
- NCT05379556
- Testing
- Assessment of andrological profile of LO-COCO-ANDRO male patients, Assessment of reproductive function of LO-COCO-ANDRO male patients, Assessment of sexual function of LO-COCO-ANDRO male patients
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Federico II University
Streptococcus Suis Infection
Human Suis and Pig Diseases in Northern Vietnam
This study aim to test the hypothesis that human S.suis infections are associated in time and space with outbreaks of Porcine Reproductive and Respiratory Syndrome (PRRS) virus or other diseases in pigs.
- Trial name
- NCT01434719
- Where
- Vietnam
- Volunteers
- 273 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Reproductive Disorder, Neurodegeneration
Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease
The objective of this protocol is to use a case-control paradigm to compare the response to an intravenous administration of kisspeptin in individuals with and without post-covid-19 syndrome.
- Conditions
- Reproductive Disorder, Neurodegeneration, SARS-CoV 2, Long COVID
- Trial name
- NCT07224490
- Testing
- Kisspeptin 112-121
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Stephanie B. Seminara, MD
COVID-19 Infection
Novel Coronavirus Infection and Reproductive Function
This study aims to observe the impact of COVID-19 infection on the reproductive function and assisted pregnancy outcome of infertile couples undergoing assisted reproductive technology and to determine which factors are related…
- Trial name
- NCT05685992
- Testing
- no intervention
- Where
- 3 sites in China
- Volunteers
- 400 people
- Sponsor
- Jinling Hospital, China
HIV Infections
A Randomized, Controlled, Cross-Over Trial of Safety of Vaginal Use of Carraguard by HIV-Infected Women
Randomized, controlled, double-blinded, cross-over trial of 60 HIV-infected women recruited from general medical clinics, family planning clinics, groups/organizations working with persons living with AIDS to assess product…
- Trial name
- NCT00213044
- Testing
- Carraguard (PC-515)
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Population Council
COVID-19 Pandemic
Effect of Covid-19 Vaccination on Male
we will assess the effect ofcovid19 vaccination on the reproductive and sexual function of the Male Egyptian
- Trial name
- NCT05299307
- Testing
- semen analysis and hormonal proflie
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Assiut University
Human Immunodeficiency Virus, Virus Shedding
The Compartmental Biology of HIV in the Male Genital Tract
Male participants taking tenofovir-emtricitabine (TDF/FTC) will provide semen and blood samples which will be analyzed to better understand the pharmacology of antiretroviral therapy in the male genital tract.
- Trial name
- NCT02638493
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Malaria
Optimal Chemopreventive Regimens to Prevent Malaria and Improve Birth Outcomes in Uganda
This trial tests the hypothesis that intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) + dihydroartemisin-piperaquine (DP) will significantly reduce the risk of adverse birth outcomes…
- Trial name
- NCT04336189
- Testing
- Sulfadoxine-pyrimethamine (SP), Dihydroartemisinin-piperaquine (DP)
- Where
- Uganda
- Volunteers
- 2,757 people, healthy volunteers welcome
- Sponsor
- Grant Dorsey, M.D, Ph.D.
Streptococcal Infections
Long Term Follow-up of Patients With Group A Streptococcal Infection Originating From the Genital Tract
Group A streptococcus (GAS) causes a variety of human infections. It is also an uncommon but serious cause of postpartum infections.
- Trial name
- NCT00299663
- Where
- Israel
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Bacterial Vaginosis
Optimization of Bacterial Vaginosis Treatment in Women of Reproductive Age
The purpose of this clinical trial is to study the efficacy of bovgialuronidase azoximere in the treatment and duration of recurrence-free course of bacterial vaginosis in women of reproductive age.
- Trial name
- NCT06458543
- Testing
- Longidaza, Metronidazole 500 mg
- Where
- 2 sites in Russia
- Volunteers
- 100 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Herpes Simplex Virus
Identification of Herpes Simplex Virus (HSV) Shedding in the Female Genital Tract of Pregnant and Nonpregnant Women by GeneXpert PCR, Routine PCR, and Culture
PCR detection of HSV DNA shedding in the female genital tract using the GeneXpert system (Cepheid, Sunnyvale CA) will be compared with traditional (routine) PCR (pregnant and nonpregnant women) and with HSV culture (nonpregnant…
- Trial name
- NCT01878383
- Testing
- Genexpert assay
- Where
- 15 sites in United States
- Volunteers
- 12,550 people
- Sponsor
- University of Alabama at Birmingham
Covid-19, SARS-CoV Infection
Analysing the French COVID-19 Epidemic Using a National SARS-CoV-2 RT-PCR Database
Analysing ths spread of COVID-19 epidemics in a timely manner is key to implementing public health control strategies. The investigators propose to analyse a large set of laboratory SARS-CoV-2 RT-PCR data to explore potential…
- Trial name
- CovPCR (NCT04738331)
- Where
- France
- Volunteers
- 10,000,000 people
- Sponsor
- University Hospital, Montpellier
Hormonal Contraception
Contraceptive Hormones, Immunity, and Microbiome Evaluation
The study is a prospective cohort study to explore the mechanisms underlying the HIV risk associated with pharmacologic doses of exogenous sex hormones via hormonal contraceptives specially progestin-containing hormonal…
- Trial name
- CHIME (NCT03660046)
- Testing
- Depot medroxyprogesterone acetate (DMPA), Etonogestrel implant (Eng-Implant), Levonorgestrel IUD (Lng-IUD)
- Where
- 3 sites in United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Emory University