Clinical trials: Research Subjects
Alcohol Use Disorder
Cannabidiol Effects on Blood Alcohol Level and Intoxication
The main objectives of this study were to test if 2 different doses of Cannabidiol (compared to placebo) alter 1) breath alcohol concentration, 2) craving and subjective responses to alcohol or 3) cognitive performance following…
- Trial name
- NCT06105138
- Testing
- 200mg Cannabidiol oral solution, 30mg Cannabidiol oral solution
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Human Health, Polyphenols
Scavenging of Reactive Carbonyl Species by Apple Polyphenols in Human
This is an interventional study to investigate formation and pharmacokinetics of reactive carbonyl species adducts of apple polyphenols in human after a single dose of apple consumption.
- Conditions
- Human Health, Polyphenols, Pharmacokinetics
- Trial name
- NCT03911050
- Testing
- Apple consumption, Control group
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- North Carolina Agriculture & Technical State University
Diabetes Mellitus, Type 2
A Research Study to Compare Two Types of Insulin, a New Insulin, Insulin Icodec and an Available Insulin, Insulin Degludec, in People With Type 2 Diabetes Who Have Not Used Insulin Before (ONWARDS 3)
This study compares insulin icodec (a new insulin taken once a week) to insulin degludec (an insulin taken once daily which is already available on the market) in people with type 2 diabetes.
- Trial name
- ONWARDS 3 (NCT04795531)
- Testing
- Insulin icodec, Insulin degludec
- Where
- 190 sites in United States, Argentina and 10 more
- Volunteers
- 588 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 2
A Research Study to Compare Insulin 287 Once a Week to Insulin Glargine (100 Units/mL) Once a Day in People With Type 2 Diabetes.
The study compares 2 medicines for people with type 2 diabetes: insulin 287 (a new medicine) and insulin glargine (a medicine doctors can already prescribe).
- Trial name
- NCT03751657
- Testing
- Insulin icodec, Metformin, Dipeptidyl peptidase-4 inhibitors
- Where
- 49 sites in United States, Canada and 5 more
- Volunteers
- 247 people
- Sponsor
- Novo Nordisk A/S
Alcohol Use Disorder
Does Oxytocin Alter Tolerance to or Motivation for Alcohol
This pilot study is intended to demonstrate feasibility and acquire preliminary data. If successful, this data could support a future project studying the effect of oxytocin on tolerance and alcohol seeking in humans.
- Trial name
- NCT05312008
- Testing
- Intranasal oxytocin
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Indiana University
Alcoholism
Managing Alcoholism in People Who Do Not Respond to Naltrexone
This is a study involving treatment for alcohol dependence (alcoholism). The study will combine motivational enhancement therapy and cognitive behavioral therapy (combined behavioral intervention, or CBI) and tests the benefits…
- Trial name
- EXTEND (NCT00115037)
- Testing
- Naltrexone, Medication Management (MM), Combined Behavioral Intervention (CBI)
- Where
- United States
- Volunteers
- 302 people
- Sponsor
- University of Pennsylvania
Overweight, Obesity
Two-year Research Study Investigating How Well Semaglutide Works in People Suffering From Overweight or Obesity
This study will look at the change in body weight from the start to the end of the study. Researchers will compare the weight loss in people taking semaglutide (a new medicine) to people taking "dummy" medicine.
- Trial name
- STEP 5 (NCT03693430)
- Testing
- Semaglutide
- Where
- 41 sites in United States, Canada and 3 more
- Volunteers
- 304 people
- Sponsor
- Novo Nordisk A/S
Cardiovascular Risk Factors
Study of Raisins Versus Alternative Snacks on Cardiovascular Risk Factors In Generally Healthy Subjects
This trial compared the effects of raisin intake on cardiovascular risk factors compared to common, commercially available, alternative snacks.
- Trial name
- NCT01260272
- Testing
- Alternative Snack Comparator, Raisins
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Louisville Metabolic and Atherosclerosis Research Center
Pain
To Measure Pain Perception With Electronic Pressure Algometer of Different Size Probes : a Healthy Subjects Research
This study was conducted to explore the influencing factors, subjects and testers' evaluation about pain measurement with hand-held pressure algometer with different size probes.
- Trial name
- NCT01618942
- Testing
- pressure algometer
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Xianwei Zhang
Diabetes, Diabetes Mellitus, Type 2
Research Study Comparing a New Medicine Semaglutide to Liraglutide in People With Type 2 Diabetes
This study is conducted in Europe. The aim of the study is to compare the effect of semaglutide subcutaneous (s.c., under the skin) 1.0 mg once-weekly to liraglutide s.c.1.2 mg once-daily on blood sugar levels after 30 weeks of…
- Trial name
- SUSTAIN 10 (NCT03191396)
- Testing
- Semaglutide, Liraglutide
- Where
- 92 sites in Bulgaria, Czechia and 10 more
- Volunteers
- 577 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 2
Research Study to Look at How Well Cagrilintide Together With Semaglutide Works in People With Type 2 Diabetes
This study looks at how well a new medicine called cagrilintide works together with semaglutide on blood sugar levels in people with type 2 diabetes compared to cagrilintide alone or semaglutide alone.
- Trial name
- NCT04982575
- Testing
- Semaglutide 2.4 mg, Cagrilintide 2.4 mg
- Where
- 23 sites in United States
- Volunteers
- 92 people
- Sponsor
- Novo Nordisk A/S
Lumbosacral Radicular Pain
A Research Study to Characterize the Pharmacodynamics and Safety of Repeat Dose SP-102
This is an open-label, single-arm, repeat dose study to characterize the pharmacodynamics and safety/tolerability of SP-102 administered by epidural injection.
- Trial name
- NCT03613662
- Testing
- SP-102
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Semnur Pharmaceuticals, Inc.
Diabetes Complications, Hypoglycemia
Testing Glial Pathways to HAAF in Human Subjects Using Carbon 13 Magnetic Resonance Spectroscopy
Hypoglycemia-associated autonomic failure (HAAF), a condition commonly developed in diabetic patients, which causes them to have severely low blood sugar levels.
- Trial name
- GLIMpSE (NCT02690168)
- Testing
- Fasting
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Overuse Injury
Throwing Device Tracker for Youth Injury Prevention
The primary objective of this study is to collect motion-capture data on movements common to baseball play in order to develop an algorithm for a wearable device for the prevention and rehabilitation of sports-related overuse…
- Trial name
- NCT04098107
- Testing
- Throwing Device
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Erythema, Edema
Safety and Feasibility of Prima-Temp Thermometer Patch
The purpose of this study is to test the safety and feasibility of the Prima-Temp Thermometer Patch in determining baseline temperatures of research subjects in a hospital intensive care unit (ICU).
- Conditions
- Erythema, Edema, Papules White, Eruption
- Trial name
- Prima-Temp (NCT01587014)
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Poudre Valley Health System
Dyslipidemia
Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk Open-label Extension
The primary clinical hypothesis is that long-term exposure of evolocumab will be safe and well tolerated in subjects with clinically evident atherosclerotic cardiovascular disease (CVD).
- Trial name
- FOURIER OLE (NCT02867813)
- Testing
- Evolocumab
- Where
- 198 sites in United States, Czechia and 5 more
- Volunteers
- 5,035 people
- Sponsor
- Amgen
Obesity
Research Study Looking at How Well Semaglutide Works in People Suffering From Obesity and Knee Osteoarthritis
This study will look at participants body weight from the start to the end of the study. It will also look at how much pain participants have in participants knee from the start to the end of the study and how this affects…
- Trial name
- NCT05064735
- Testing
- semaglutide 2.4 mg
- Where
- 122 sites in United States, Canada and 9 more
- Volunteers
- 407 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Healthy
A Two-week Crossover Evaluation of Two Hand Antiseptic Products on Skin Condition in Healthy Human Subjects
Evaluate the effect of two hand antiseptic products on hand skin conditions of healthy volunteers.
- Trial name
- NCT00731042
- Testing
- Avagard, Purell Surgical Scrub
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Solventum US LLC
Deep Mycosis
Diflucan Research For Infant Evaluation Of Antifungal Treatment And Prophylaxis Medication
To collect the efficacy and safety information of fluconazole on infant subjects related to their appropriate use in daily practice.
- Trial name
- DREAM (NCT01680458)
- Testing
- Fluconazole
- Volunteers
- 30 people
- Sponsor
- Pfizer
Post Traumatic Stress Disorder
Transcranial Direct Current Stimulation (tDCS) in Human Subjects With PTSD Receiving an Exposure-based, Behavioral Therapy
The primary objective of this study is to evaluate the safety, feasibility, and psychological and physiological treatment benefits of transcranial direct current stimulation (tDCS), a noninvasive brain stimulation technique, when…
- Trial name
- NCT05419999
- Testing
- Soterix 1x1 tDCS mini CT, Written Exposure Therapy (WET)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- The University of Texas Health Science Center at San Antonio