Clinical trials: Resection
Post-Hepatectomy Liver Failure, Liver Failure
CT Volumetry and Hepatic Vascular Deformation Mapping to Predict Post-Hepatectomy Liver Failure
Removing a large part of the liver (major hepatectomy) can cure primary and secondary liver cancers, but it carries the risk of post-hepatectomy liver failure (PHLF), a serious complication in which the liver left behind - the…
- Conditions
- Post-Hepatectomy Liver Failure, Liver Failure, Liver Neoplasms, Carcinoma, Hepatocellular
- Trial name
- BEYOND-SIZE (NCT07727759)
- Testing
- Preoperative CT volumetry with hepatic vascular deformation mapping (VDM)
- Where
- 3 sites in Egypt
- Volunteers
- 1,070 people
- Sponsor
- Minia University
Segmentectomy
Segmentectomy After Induction Therapy (SAINT)
The primary objective will be to determine the feasibility of performing a high-quality sublobar anatomic resection (segmentectomy) with R0 margin status on final pathology for patients who received induction therapy for NSCLC…
- Trial name
- SAINT (NCT06496659)
- Testing
- Segmentectomy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Northwestern University
Pain During Caries Excavation
Comparison of Intraoperative Pain Perception During Caries Excavation Using Smart Burs and Carisolv to Conventional Diamond Burs
The goal of this randomized controlled trial is to compare the amount of pain experienced during removal of dental caries using Smart burs, Carisolv, and conventional diamond burs in adults aged 18-45 years with active caries in…
- Trial name
- NCT07869407
- Testing
- polymer burs, Carisolv, Conventional Diamond Burs
- Where
- Pakistan
- Volunteers
- 66 people
- Sponsor
- Rehman Medical Institute - RMI
Malignant Glioma
Study of NPC-07 for Fluorescence-guided Resection of Malignant Gliomas
The aim of the present Phase III study is to assess the positive predictive value of NPC-07 (5-aminolevulinic acid hydrochloride) induced tissue fluorescence, safety and pharmacokinetics following a single dose of NPC-07 orally…
- Trial name
- NCT01167322
- Testing
- NPC-07 for oral administration
- Where
- 3 sites in Japan
- Volunteers
- 45 people
- Sponsor
- Nobelpharma
Colorectal Liver Metastasis (CRLM)
Ablation With Systemic Therapy vs Liver Resection With Systemic Therapy for Colorectal Liver Metastasis
For patients with colorectal liver metastases (CRLM) ≤5 cm, Clinical guidelines recommend surgery, but a growing number of studies have shown that thermal ablation is as effective as surgery.
- Trial name
- ASRS-CRLM (NCT07559851)
- Testing
- ablation combined with systemic therapy, liver resection combined with systemic therapy
- Where
- China
- Volunteers
- 151 people
- Sponsor
- The First Hospital of Jilin University
Dental Pain
Study of Diclofenac Capsules to Treat Dental Pain
The purpose of this study is to determine whether Diclofenac Test Formulation Capsules are safe and effective for the treatment of dental pain.
- Trial name
- NCT00985439
- Testing
- Diclofenac Test (lower dose), Diclofenac Test (upper dose), Celecoxib 400 mg
- Where
- United States
- Volunteers
- 202 people
- Sponsor
- Iroko Pharmaceuticals, LLC
Laparoscopic Liver Resection, Open Liver Resection
Short and Long Outcomes Between Laparoscopic and Open Hepatectomy
LLR was applied for tumors located at the lower edge and lateral segments of the liver that could be resected more easily than posterosuperior segments.
- Trial name
- NCT03672357
- Testing
- Laparoscopic liver resection, Open liver resection
- Where
- China
- Volunteers
- 80 people
- Sponsor
- hui hou
Laparoscopic Liver Resection, Vascular Occlusion
Bulldog vs. Cotton Tourniquet in Laparoscopic Hepatectomy for Patients
LLR was applied for tumors located at the lower edge and lateral segments of the liver that could be resected more easily than posterosuperior segments.
- Conditions
- Laparoscopic Liver Resection, Vascular Occlusion, Tourniquet
- Trial name
- NCT04277065
- Testing
- BULLDOG ,A Useful Vascular Occlusion Tourniquet In Laparoscopic Liver Resection, cotton tourniquet
- Where
- China
- Volunteers
- 88 people
- Sponsor
- hui hou
Hepatic Metastases, Colon Cancer
Hepatic Arterial Infusion With Floxuridine and Dexamethasone Combination With Chemotherapy With/Without Bevacizumab for Hepatic Metastases From Colorectal Cancer
The purpose of this study is to determine whether the addition of bevacizumab, to hepatic arterial therapy with floxuridine (FUDR) and dexamethasone (Dex) (regional chemotherapy), and either oxaliplatin or CPT-11, plus…
- Conditions
- Hepatic Metastases, Colon Cancer, Rectal Cancer
- Trial name
- NCT00200200
- Testing
- Bevacizumab HAI plus systemic chemotherapy, HAI plus systemic chemotherapy
- Where
- 5 sites in United States
- Volunteers
- 73 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Large Intrauterine Polyps, Smaller Type 0 and 1 Myomas
The Hysteroscopic Morcellator (HM).
Rationale: The hysteroscopic morcellator (HM) is a novel technique for removal of intrauterine polyps, myomas and placental tissue. It withholds some technical advantages over resectoscopy.
- Conditions
- Large Intrauterine Polyps, Smaller Type 0 and 1 Myomas, Residual Placental Tissue
- Trial name
- HM (NCT01537822)
- Testing
- Hysteroscopic morcellator, Resectoscope
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 253 people
- Sponsor
- University Hospital, Ghent
Esophageal Cancer, Gastric Cancer
Surveillance After Resection of Oesophageal aNd Gastric Cancer (SARONG-II) Trial
Cancer of the food pipe (oesophagus) and stomach are increasingly common. Currently, most patients with cancer of the oesophagus and stomach are treated with surgery with or without additional chemotherapy or radiotherapy.
- Trial name
- SARONG-II (NCT06115629)
- Testing
- Surveillance protocol
- Where
- 13 sites in Germany, Ireland and 3 more
- Volunteers
- 952 people
- Sponsor
- University of Dublin, Trinity College
Melanoma
Effectiveness and Safety of Dabrafenib in Combination With Trametinib as Adjuvant Treatment for Chinese Patients With Stage III BRAF V600 Mutation-positive Melanoma After Complete Resection
This is a prospective, open label, single-arm, multicenter, non-interventional study of dabrafenib in combination with trametinib as adjuvant treatment for Chinese patients with stage III BRAF V600 mutation positive melanoma…
- Trial name
- NCT04666272
- Testing
- dabrafenib, trametinib
- Where
- 8 sites in China
- Volunteers
- 78 people
- Sponsor
- Novartis Pharmaceuticals
Pancreaticoduodenectomy, Distal Pancreatectomy
Randomized Controlled Trial Comparing Closed-suction Drain Versus Passive Gravity Drain Following Pancreatic Resection
Pancreatic resection is the only potentially curative modality of treatment for pancreatic neoplasm. The mortality associated with this procedure decreased rapidly in the past decades.
- Trial name
- DRAPA (NCT01988519)
- Testing
- Closed gravity drain, closed suction drain
- Where
- 2 sites in Czechia
- Volunteers
- 223 people
- Sponsor
- University Hospital Hradec Kralove
Hair Remval
Clinical Evaluation of Splendor X for Hair Removal
At least 40 healthy male or female subjects that wish to remove their hair will be enrolled to this study. Each subject will receive five treatments at 6-8 weeks intervals.
- Trial name
- NCT04152707
- Testing
- Splendor X
- Where
- 2 sites in United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Lumenis Be Ltd.
Pediatric Cancer, Neuroblastoma
Biomarkers of Resiliency In Childhood Cancer Surgery
This observational study is to better understand how children and their families recover after the stress of major surgery for cancer so that investigators can create ways to improve resilience during recovery.
- Conditions
- Pediatric Cancer, Neuroblastoma, Sarcoma, Wilms Tumor and Other Childhood Kidney Tumors
- Trial name
- BRICCS (NCT06674811)
- Testing
- Wearing Smartwatch, Patient Report Outcomes, Blood Draw
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Endometriosis, Post Operative Pain
The Using Postoperative Ketamine and Exploring the Effect on Endometriosis Pain (UPKEEEP) Study
This is a randomized, single blinded, placebo-controlled trial to study the effectiveness of a subanesthetic dose (0.6 mg/kg) of ketamine versus placebo (saline) on postoperative pain and pain on adult female chronic pelvic pain…
- Trial name
- NCT05229653
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- NYU Langone Health
Colonic Neoplasms, Ileostomy - Stoma
Early Closure Versus Conventional Closure in Postoperative Patients With Low Anteriresection for Rectal Cancer
Colorectal cancer worldwide is the third most common in men and the second in female, although mortality is not as high as its incidence, there is less survival in developing countries.
- Conditions
- Colonic Neoplasms, Ileostomy - Stoma, Colorectal Surgery
- Trial name
- NCT03746353
- Testing
- early ileostomy closure
- Where
- 3 sites in Colombia
- Volunteers
- 52 people
- Sponsor
- Instituto Nacional de Cancerologia, Columbia
Liver Tumours, Liver Cancer (Primary and Metastatic)
Italian Group of Regenerative and Occlusive Worldwide-used Techniques of Hepatic Hypertrophy
The goal of this national mutlticenter observational study is to learn and describe trends over time in the use of techniques for inducing hepatic hypertrophy in Italy.
- Conditions
- Liver Tumours, Liver Cancer (Primary and Metastatic), Liver Resection, Liver Hypertrophy
- Trial name
- I-GROWtoh (NCT07445412)
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Esophageal Neoplasms, Endoscopic Mucosal Resection
Comparison of 0.4% Hyaluronic Acid Solution Versus Hydroxyethylamide Solution in Submucosal Endoscopic Resections
This is a randomized, single-center clinical trial that will compare the efficacy of two substances used in the submucosal cushion formation stage of endoscopic submucosal resections of early esophageal malignant neoplasms.
- Conditions
- Esophageal Neoplasms, Endoscopic Mucosal Resection, Hyaluronic Acid
- Trial name
- NCT06077981
- Testing
- Submucous Endoscopic Dissection with hydroxyethylamide, Submucous Endoscopic Dissection with Hyaluronic acid (TS-905 Blue Eye)
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Colon Cancer
A Prospective Study of Pharmacogenetic Factors and Gene Expression Profile
This study is a parallel translational study of a Randomized Phase III trial Investigating the Role of Oxaliplatin duration (6 Cycles Versus 12 Cycles) in modified FOLFOX-6 Regimen as Adjuvant Therapy for Patients with Stage…
- Trial name
- NCT01472601
- Where
- South Korea
- Volunteers
- 2,660 people
- Sponsor
- Samsung Medical Center