Clinical trials: Resection Margin
Blepharitis
Lipids of the Human Tear Film and Their Effect on Tear Stability
This prospective, randomized, comparative clinical trial evaluates the effect of either oral doxycycline, oral essential fatty acid, or topical azithromycin to modify the secretions of the meibomian gland in subjects with…
- Trial name
- NCT00803452
- Testing
- doxycycline, azithromycin
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Benign Skin Tumor, Basal Cell Carcinoma
Study to Examine Lesions of the Skin Using Confocal Laser Microscopy
Using ex-vivo confocal laser scanning microscopy, a reliable statement can be made about the extent, histological structure and possible significance of a skin change without having to send tissue samples for demanding and…
- Conditions
- Benign Skin Tumor, Basal Cell Carcinoma, Melanoma, Squamous Cell Cancer
- Trial name
- NCT06598137
- Testing
- Ex vivo confocal laser microscopy
- Where
- Germany
- Volunteers
- 645 people, healthy volunteers welcome
- Sponsor
- LMU Klinikum
Soft Tissue Sarcoma of the Limb, AJCC Stage II and III
Preoperative Radiotherapy for Sarcomas of the Extremities With Intensity-Modulation, Image-Guidance and Small Safety-margins
RATIONALE: Modern radiotherapy techniques in a neoadjuvant setting have the potential to minimize morbidity and maximize efficacy.
- Trial name
- PREMISS (NCT01552239)
- Testing
- IMRT/IGRT, Tumor resection, Brachytherapy
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Technical University of Munich
Oral Cancer, Osteosarcoma
Quantitative Margin Assessment Using High-resolution Positron Emission Tomography - Computed Tomograhy
The primary endpoint is the assessment of the clinical value of a novel high-resolution mobile PET-CT scanner for intraoperative margin assessment in oral squamous cell carcinoma, soft tissue sarcoma and osteosarcoma surgery.
- Conditions
- Oral Cancer, Osteosarcoma, Soft Tissue Sarcoma, Oral Squamous Cell Carcinoma (OSCC)
- Trial name
- qMAP (NCT06726512)
- Testing
- XEOS AURA 10
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- University Medical Center Groningen
Gingivitis
Influence of the Restorative Cervical Margin Placement on the Supracrestal Tissue Attachment
The aim of the present study is to understand the influence that marginal/subgingival restorations exert on the surrounding periodontal tissues.
- Trial name
- NCT04299347
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Siena
Breast Cancer, Head and Neck Cancers
Surgical Margin Assessment Using Intra-operative High-resolution PET/CT in Patients With Cancers Referred to Surgical Resection, an Exploratory Pilot Study
Reoperation is often required in surgical oncology because of positive resection margins and is associated with substantial physical, psychological, and economic consequences.
- Conditions
- Breast Cancer, Head and Neck Cancers, Lung Cancer, Sarcoma
- Trial name
- SMART-PET (NCT07884487)
- Testing
- FDG radiotracer
- Where
- Belgium
- Volunteers
- 250 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Hepatocellular Carcinoma
The Influence of Resection Margin on the Recurrence of Early-stage Hepatocellular Carcinoma
Before the surgery, the investigators predict the risk of microvascular invasion (MVI) presence for the early-stage hepatocellular carcinoma according to the nomogram the investigators have created.
- Trial name
- NCT02525965
- Testing
- Wide resection margin >1cm, Narrow resection margin <1cm
- Where
- China
- Volunteers
- 194 people
- Sponsor
- Eastern Hepatobiliary Surgery Hospital
Breast Cancer
Evaluation of Breast Cancer Surgical Margins Using Optical Spectroscopy
This study will apply optical spectroscopy to intraoperative margin assessment during surgery for breast cancer. We hypothesize that a combination of fluorescence spectroscopy and diffuse reflectance spectroscopy will reliably…
- Trial name
- NCT00214292
- Testing
- fluorescence spectroscopy and diffuse spectroscopy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Wisconsin, Madison
Breast Cancer Female
Intraoperative Use of an Optical Coherence Tomography (OCT) Imaging System to Guide Additional Margin Cavity Shaves in Breast Conserving Surgery (BCS)
Female patients undergoing a breast conserving procedure will be consented for the excised breast tissue to be imaged on an investigational OCT-based device.
- Trial name
- NCT04314700
- Testing
- OCT- based investigational imaging device
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Perimeter Medical Imaging
Oral Tumors
Oral Margin Spectroscopy Detection Using Optical Spectroscopy
The goal of this clinical research study is to evaluate an imaging technology that may help clinicians see how far an area of pre-cancerous or cancerous tissue extends in the mouth.
- Trial name
- NCT00439205
- Testing
- FastEEM4 System, Multispectral Digital Microscope
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- M.D. Anderson Cancer Center
Squamous Cell Carcinoma (SCC), Basal Cell Carcinoma (BCC)
Intraoperative Margin Assessment During Mohs Surgery
The research team will develop an intraoperative handheld device for assessing surgical margins during Mohs surgery. The device technology is based on multimodal optical spectroscopy (MMS), combining three optical spectroscopy…
- Trial name
- NCT02750033
- Testing
- Multimodal Spectroscopy (MMS)
- Sponsor
- Seton Healthcare Family
Early Gastric Cancer
Usefulness of Probe-based Confocal Laser Endo-microscopy in Delineation of Margin of Early Gastric Cancer for Endoscopic Submucosal Dissection
The aim of this study is to evaluate the usefulness of pCLE (probe-based confocal laser endomicroscopy) compared with conventional chromoendoscopy (CE) for delineating the margin of early gastric cancer (EGC) with endoscopic…
- Trial name
- NCT02189226
- Testing
- Endoscopic submucosal dissection (ESD) with or without probe-based confocal laser endomicroscopy (pCLE)
- Where
- South Korea
- Volunteers
- 101 people
- Sponsor
- Yonsei University
Breast Cancer
Excision Followed by Radiofrequency Ablation for Breast Cancer
The purpose of this study will be to evaluate, in a multi-center setting, the ability of radiofrequency ablation (RFA) of breast cancer lumpectomy sites to extend the "final" negative margin and consequently decrease the rates of…
- Trial name
- ABLATE (NCT01153035)
- Testing
- Radiofrequency Ablation
- Where
- 6 sites in United States
- Volunteers
- 104 people
- Sponsor
- University of Arkansas
Hepatic Insufficiency, Liver Insufficiency
Liver Transplantation and Reticuloendothelial Clearance Capacity
Study summary: "Liver transplantation and the reticuloendothelial clearance capacity." The purpose of this study is to evaluate the effect of liver transplantation on the immune system.
- Trial name
- NCT00929032
- Testing
- Nanocoll®
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Edinburgh
Breast Cancer
The Impact of Surgeon-Interpreted Intraoperative Margin Assessment During Breast Conserving Surgery on Postoperative Treatment
To learn if Pegulicianine Fluorescence-Guided Surgery (pFGS), which is part of the Lumicell Direct Visualization System, and Digital Breast Tomosynthesis (DBT) can improve the identification of tumor margins during a partial…
- Trial name
- NCT07140965
- Testing
- Pegulicianine Fluorescence-Guided Surgery, Digital Breast Tomosynthesis, Breast Conserving Therapy
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- M.D. Anderson Cancer Center
Low or Intermediate Risk Prostate Cancer
Advanced Imaging for Radiotherapy Treatment Planning and Guidance for Low-Intermediate Risk Prostate Cancer (Margin)
The integration of magnetic resonance imaging (MRI) in the treatment planning process for prostate cancer will reduce uncertainties in delineation of the prostate gland, and will enable delineation of the urethra, penile bulb…
- Trial name
- NCT00890006
- Testing
- Advanced imaging for radiotherapy planning and guidance
- Where
- Canada
- Volunteers
- 99 people
- Sponsor
- University Health Network, Toronto
Dental Restoration Failure of Marginal Integrity
Clinical Evaluation of Subgingival Open Sandwich Restorations
This study was designed to evaluate and compare the 3-year periodontal responses and clinical performance of proximal subgingival open sandwich restorations using three different glass ionomer-based restorative materials and…
- Trial name
- NCT05125900
- Testing
- Proximal box elevation using one of the tested materials
- Where
- Egypt
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Deep Marginal Elevation
The Effect of Material Choice on Clinical Outcomes in Deep Margin Elevation
In dentistry, particularly in posterior teeth with extensive caries or old restorations, the extension of restoration margins below the gingival level presents a significant clinical challenge.
- Trial name
- NCT07234266
- Testing
- 3d printed resin restoration with deep margin elevation
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Mersin University
Gummy Smile
Clinical Evaluation of Conventional Versus Microsurgical Techniques of Esthetic Crown Lengthening
the study compare gingival margin stability following conventional approach versus microsurgical approach of esthetic crown lengthening in management of patients with short clinical crowns in the upper anterior region.In…
- Trial name
- NCT03804281
- Testing
- Test group, Control group
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Breast Neoplasm Female, Breast Cancer
Fluorescence Imaging of Carcinoma During Breast Conserving Surgery
Breast conserving surgery (BCS) is performed on patients with breast cancer to resect and completely remove the cancer while conserving as much of the surrounding healthy tissue as possible.
- Trial name
- NCT04815083
- Testing
- Aminolevulinic Acid Hydrochloride, Eagle V1.2 Imaging System
- Where
- 7 sites in United States
- Volunteers
- 57 people
- Sponsor
- SBI ALApharma Canada, Inc.