Clinical trials: Residual
Glioma
Residual IDH1-Mutant Tumor Cell Quantification Study
This is a single-site, single-arm, prospective, interventional cohort study using intraoperative ultra-rapid droplet digital polymerase chain reaction (UR- ddPCR) to assess residual IDH1-mutant tumor at the end of surgical…
- Trial name
- NCT07219199
- Testing
- UR-ddPCR
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- NYU Langone Health
Galactose Single Point (GSP), Residual Liver Function
Clinical Study for Development of Oral Galactose Single Point (OGSP) Solution (G.S.P. Oral Solution®)
The primary objective is to determine the oral galactose single point (OGSP) cutoff values to discriminate subjects with different hepatic function.
- Trial name
- NCT03457311
- Testing
- G.S.P. Oral Solution 400 mg/ml
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Richever Enterprise Co., Ltd.
Breast Cancer
A Study of Dato-DXd With or Without Durvalumab Versus Investigator's Choice of Therapy in Patients With Stage I-III Triple-negative Breast Cancer Without Pathological Complete Response Following Neoadjuvant Therapy (TROPION-Breast03)
This is a Phase III, randomized, open-label, 3-arm, multicenter, international study assessing the efficacy and safety of Dato-DXd with or without durvalumab compared with ICT in participants with stage I to III TNBC with…
- Trial name
- NCT05629585
- Testing
- Dato-DXd, Durvalumab, Capecitabine
- Where
- 276 sites in United States, Belgium and 15 more
- Volunteers
- 1,174 people
- Sponsor
- AstraZeneca
Critically Ill, Extubation
Does Tracheal Suction During Extubation in Intensive Care Unit Decrease Functional Residual Capacity
Little is known about the procedure of extubation of patients admitted in Intensive Care Units (ICU). In particular, effects of tracheal suction during extubation have never been evaluated.
- Conditions
- Critically Ill, Extubation, Intensive Care Unit
- Trial name
- NCT03681626
- Testing
- no tracheal suction, tracheal suction
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Residual Neuromuscular Blockade
Electromyographic and Acceleromyographic Monitoring in Restricted Arm Movement Surgical Setting
Researchers are comparing the ease of use and repeatability of the force vs electrical activity produced by a muscle after it has undergone nerve stimulation during a surgical procedure in which the patients' arm movement is…
- Trial name
- NCT04352140
- Testing
- Tetragraph, ToFscan
- Where
- 3 sites in United States, France and 1 more
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Breast Cancer
Feasibility Study of Intraoperative Imaging in Breast Cancer
For most breast cancer patients, surgery is the primary treatment. When patients undergo a lumpectomy, it is difficult for the surgeon to determine the extent of the tumor which results in incomplete tumor removal as determined…
- Trial name
- NCT02438358
- Testing
- LUM015, LUM 2.6 Imaging Device
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Lumicell, Inc.
Breast Cancer, Fatigue
Studying Biological Markers of Fatigue in Women With Residual Invasive Breast Cancer Enrolled on Clinical Trial NSABP-B-45
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to fatigue.
- Trial name
- NCT00914043
- Testing
- gene expression analysis, microarray analysis, polymerase chain reaction
- Sponsor
- NSABP Foundation Inc
Insomnia
Effects of Ramelteon on Driving Ability
The primary purpose of this study is to investigate the effects of bedtime administration of a single dose of ramelteon (8 mg), zopiclone (7.5 mg), and placebo on next-morning on-road driving performance.
- Trial name
- NCT00319215
- Testing
- Ramelteon 8 mg, Zopiclone 7.5 mg
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Utrecht Institute for Pharmaceutical Sciences
Untreated Philadelphia Positive Acute Lymphoblastic Leukemia, De Novo
MRD/Risk-oriented Therapy of Adult Ph- ALL Including Pegylated Asparaginase and Lineage-targeted Methotrexate
This study will be conducted in different centres and will study adult patients with Philadelphia chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL).
- Conditions
- Untreated Philadelphia Positive Acute Lymphoblastic Leukemia, De Novo, Secondary, Low-dose Corticosteroids Pretreatment
- Trial name
- LAL1913 (NCT02067143)
- Testing
- Prephase PDN + CY, Cycle 1 Induction, Cycle 2 Induction / Early consolidation
- Where
- 61 sites in Italy
- Volunteers
- 204 people
- Sponsor
- Gruppo Italiano Malattie EMatologiche dell'Adulto
Newly Diagnosed MGMT Unmethylated Glioblastoma
D2C7-IT and 2141-V11 in Newly Diagnosed GBM Patients
The purpose of this research study is to determine the safety and efficacy of administering a single intracerebral (within the brain) dose of investigational compounds called D2C7-immunotoxin (IT) and 2141-V11 in residual disease…
- Trial name
- NCT05734560
- Testing
- D2C7-IT, 2141-V11
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Darell Bigner
Paroxysmal Nocturnal Hemoglobinuria (PNH)
Study of Efficacy and Safety of Twice Daily Oral LNP023 in Adult PNH Patients With Residual Anemia Despite Anti-C5 Antibody Treatment
This study was a multi-center, randomized, open-label, active comparator-controlled, parallel group study. The purpose of this Phase 3 study in PNH patients presenting with residual anemia despite treatment with anti-C5 antibody…
- Trial name
- APPLY-PNH (NCT04558918)
- Testing
- LNP023, Eculizumab, Ravulizumab
- Where
- 39 sites in United States, Brazil and 10 more
- Volunteers
- 97 people
- Sponsor
- Novartis Pharmaceuticals
Postoperative Residual Curarization
Comparison of Train of Four, Tetanus 50 and 100 Hz Recovery After Rocuronium Block Reversed by Neostigmine
Despite neuromuscular transmission monitoring and pharmacological reversal allowing a train of four ratio recovery higher than 0.9, patients receiving neuromuscular blocking agent during general anesthesia have a high risk of…
- Trial name
- DECURATOF 2 (NCT05224648)
- Testing
- TOF scan train of four ratio monitoring, ITF device tetanus stimulation monitoring
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Poitiers University Hospital
Primary Breast Cancer
Zoledronic Acid in the Treatment of Breast Cancer With Minimal Residual Disease in the Bone Marrow
Metastatic bone disease is an important prognostic factor for survival which will in median be close to two years after first diagnosis of osseous metastases.
- Trial name
- MRD-1 (NCT00172068)
- Testing
- Zoledronic acid + Calcium/Vitamin D
- Where
- 4 sites in Germany
- Volunteers
- 96 people
- Sponsor
- Novartis Pharmaceuticals
Kidney Calculi
Assessment of Flexible Ureteroscopy Residual Fragments
Residual fragments of urinary calculi after flexible ureteroscopy (URF) can cause symptoms and additional surgeries. The assessment of residual fragments by imaging is not standardized.
- Trial name
- NCT02434068
- Testing
- CT
- Where
- Brazil
- Volunteers
- 115 people
- Sponsor
- University of Sao Paulo General Hospital
Speech Sound Disorder
Delineation of Sensorimotor Subtypes Underlying Residual Speech Errors
Children with speech sound disorder show diminished accuracy and intelligibility in spoken communication and may thus be perceived as less capable or intelligent than peers, with negative consequences for both socioemotional and…
- Trial name
- C-RESULTS (NCT03736213)
- Testing
- Visual-acoustic biofeedback, Ultrasound biofeedback
- Where
- 3 sites in United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- New York University
Residual Limb Pain, Amputation Neuroma
Surgical Treatments for Postamputation Pain
This is a double-blind randomised controlled trial (RCT) which compares the effectiveness of three surgical techniques for alleviating residual limb pain (RLP), neuroma pain and phantom limb pain (PLP).
- Conditions
- Residual Limb Pain, Amputation Neuroma, Phantom Limb Pain, Pain, Neuropathic
- Trial name
- NCT05009394
- Testing
- Targeted Muscle Reinnervation (TMR), Regenerative Peripheral Nerve Interface (RPNI), Standard neuroma treatment, neuroma excision, and muscle burying
- Where
- 9 sites in United States, Australia and 5 more
- Volunteers
- 110 people
- Sponsor
- Prometei Pain Rehabilitation Center
Breast Cancer
A Study of Trastuzumab Emtansine Versus Trastuzumab as Adjuvant Therapy in Patients With HER2-Positive Breast Cancer Who Have Residual Tumor in the Breast or Axillary Lymph Nodes Following Preoperative Therapy (KATHERINE)
This 2-arm, randomized, open-label study will evaluate the efficacy and safety of trastuzumab emtansine versus trastuzumab as adjuvant therapy in patients with HER2-positive breast cancer who have residual tumor present in the…
- Trial name
- NCT01772472
- Testing
- trastuzumab, trastuzumab emtansine
- Where
- 268 sites in United States, Argentina and 26 more
- Volunteers
- 1,486 people
- Sponsor
- Hoffmann-La Roche
Coronary Artery Disease, Heart Valve Diseases
Centrifugation vs. Multiple-pass Hemofiltration of the Residual Cardiopulmonary Bypass Volume
Traditional cardiac surgery requires patient connection to the Cardiopulmonary Bypass (CPB) apparatus which takes over the function of the heart and lungs while the surgeon performs the necessary surgery.
- Trial name
- NCT01416792
- Testing
- Centrifugation, Multiple-pass hemofiltration
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- University of Saskatchewan
Depression, Major Depressive Disorder
A Six Week, Randomized, Double-Blind Placebo-Controlled, Suvorexant Augmentation Study of Antidepressant Treatment of Major Depressive Disorder With Residual Insomnia
Depression with ongoing insomnia is a common clinical presentation with patients. Clinical data suggests that patients with insomnia that receive concomitant treatment with a sleep aid experience a more robust antidepressant…
- Conditions
- Depression, Major Depressive Disorder, MDD, Insomnia
- Trial name
- NCT02669030
- Testing
- suvorexant
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Institute for Advanced Medical Research, Alpharetta, GA
Astigmatism
Visual Performance With Clareon® Vivity® Intraocular Lenses (IOLs)
The purpose of this study is to generate clinical data to quantify the impact of residual astigmatism on the overall visual performance during distance, intermediate, and near viewing in patients implanted with Clareon Vivity…
- Trial name
- NCT06784063
- Testing
- Clareon Vivity Extended Vision IOL
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Alcon Research
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.