Clinical trials: Residual
Malignant Melanoma
Modified Vaccine for High Risk or Low Residual Melanoma Patients
This study is designed for patients who had malignant melanoma and, following tumor removal, are now free of disease, or have only very minor residual disease, and are at a very high risk of disease recurrence.
- Trial name
- NCT01898039
- Testing
- A2/4-1BBL melanoma vaccine, DNP sensititzation, Cyclophosphamide
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Hadassah Medical Organization
Breast Cancer
The OPBC-07/microNAC Study
The aim of this multicenter retrospective cohort study is to determine the safety of omission of axillary lymph node dissection in patients with residual micrometastases after neoadjuvant chemotherapy.
- Trial name
- NCT06529302
- Where
- 84 sites in United States, Argentina and 28 more
- Volunteers
- 2,000 people
- Sponsor
- University Hospital, Basel, Switzerland
Gastroscopy
Evaluation of Gastric Volume and pH Changes in Gastroscopy Patients
Pulmonary aspiration is a rare but serious complication that can result in 57% mortality and 14% permanent damage. Fasting rules (solid foods 6-8 hours, clear liquids 2 hours) determined by anesthesia associations are applied to…
- Trial name
- NCT06842602
- Testing
- gum, candy, strict fasting rules
- Where
- Turkey (Türkiye)
- Volunteers
- 405 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Type 2 Diabetes
Does the Hematopoietic Stem Cell Govern Residual Inflammatory Cardiovascular Risk in Type 2 Diabetes
To study the effect of type 2 diabetes (T2D) on vascular wall inflammation and hematopoietic stem cell composition in vivo, and whether these changes can be reversed with glucagon like peptide 1 receptor (GLP1R)-agonism.
- Trial name
- DOTAFLAME (NCT05597202)
- Testing
- Semaglutide, 2.0 mg/mL
- Where
- Netherlands
- Volunteers
- 22 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Chronic Hepatitis B
Residual Histological Disease Across Treatment Pathways in Chronic Hepatitis B
This retrospective, two-center observational study evaluates contemporary non-biopsy treatment pathways in treatment-naïve adults with chronic hepatitis B who underwent liver biopsy in routine clinical practice.
- Trial name
- CHB-PATH (NCT07843446)
- Where
- Turkey (Türkiye)
- Volunteers
- 1,201 people
- Sponsor
- Istanbul Medeniyet University
Breast Cancer
DNA-guided Second Line Adjuvant Therapy for High Residual Risk, Estrogen Receptor Positive, HER-2 Negative Breast Cancer (DARE)
A randomized, Phase II trial of circulating tumor DNA-guided second line Adjuvant therapy for high Residual risk, Estrogen Receptor positive, HER-2 negative breast cancer (DARE)
- Trial name
- DARE (NCT04567420)
- Testing
- Palbociclib, Fulvestrant, Adjuvant Therapy
- Where
- 19 sites in United States
- Volunteers
- 70 people
- Sponsor
- Criterium, Inc.
Hyperhidrosis, Residual Limbs
Topical Aluminium Chloride vs OnabotulinumtoxinA Intradermal Injections in Residual Limb Hyperhidrosis (Lower Limbs)
The aim of this study is to demonstrate onabotulinumtoxinA superiority to aluminium chloride for the treatment of residual limb hyperhidrosis.
- Trial name
- SALUTOX (NCT03433859)
- Testing
- OnabotulinumtoxinA, Topical Aluminium Chloride (cosmetic product)
- Where
- 9 sites in France
- Volunteers
- 54 people
- Sponsor
- Direction Centrale du Service de Santé des Armées
Pulmonary Aspiration During Anaesthetic Induction
Effects of Beginning a GLP1-Agonist Therapy on Residual Gastric Content and Gastric Emptying
This project explores the elevated risk of pulmonary aspiration during anesthesia in patients undergoing GLP-1 agonist therapy, which prolongs gastric emptying.
- Trial name
- GLP-1 (NCT06659159)
- Testing
- Gastric ultrasound
- Volunteers
- 50 people
- Sponsor
- Sascha Battig
Leukemia, Myeloid, Acute, Minimal Residual Disease
Development and Application of a Novel Digital Array PCR for Acute Myeloid Leukemia (AML)
Purpose: The purpose of this trial is to investigate whether a digital array assay can detect trace amounts of residual leukemia and predict relapse in acute myeloid leukemia (AML) patients in remission who have undergone…
- Trial name
- NCT04920188
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Gastrointestinal Stromal Tumors, Minimal Residual Disease
Prediction of Postoperative Treatment Efficacy and Recurrence Risk of High-risk GIST Based on Liquid Biopsy MRD
So far, MRD assessment by liquid biopsy (ctDNA) has not been used to predict postoperative treatment efficacy and recurrence risk of GIST patients because of special disease characteristics and technological limitations.
- Trial name
- NCT05408897
- Testing
- liquid biopsy
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Peking University People's Hospital
End Stage Renal Disease, Anuria
Randomized Controlled Trial Comparing Residual Kidney Function in Patients Undergoing Three or Four Exchanges CAPD
The purpose of this study was to explore the impacts of different continuous ambulatory peritoneal dialysis (CAPD) dosage (three 2-Liter exchanges CAPD vs.
- Conditions
- End Stage Renal Disease, Anuria, Peritonitis
- Trial name
- NCT01637792
- Testing
- Three 2-liter exchanges daily CAPD, Four 2-liter exchanges daily CAPD
- Where
- China
- Volunteers
- 139 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Limb Pain, Phantom
A Study of Contralateral Limb Block
This research is being done to determine if an anesthetic like Lidocaine, may be effective when injected around the sciatic nerve of the intact limb in patients with limb loss pain on the contralateral side.
- Trial name
- NCT06045936
- Testing
- Lidocaine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
HIV-1-infection, Methamphetamine-dependence
Effect of Methamphetamine on Residual Latent HIV Disease Study
The most commonly used illicit stimulant in HIV-infected individuals is methamphetamine (MA). Prior studies demonstrate strong evidence that MA promotes increased HIV transcription as well as immune dysregulation.
- Trial name
- EMRLHD (NCT03825536)
- Testing
- Oral Methamphetamine
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of California, San Francisco
Deep Vein Thrombosis
Resolution Enhancement by a Supplemental Obstruction Lessening Venoactive Drug for Eight Weeks in Deep Vein Thrombosis
The RESOLVE-DVT study is a randomized single-center pilot study to determine the effects of hydroxyethylrutoside (Venoruton) on aspects of deep vein thrombosis (DVT) resolution associated with post-thrombotic syndrome (PTS).
- Trial name
- Resolve-DVT (NCT04670432)
- Testing
- Hydroxyethylrutoside
- Where
- Netherlands
- Volunteers
- 44 people
- Sponsor
- Maastricht University Medical Center
Edentulism in Lower Jaw
Association Between Salivary Soluble RANKL, OPG Concentration and Mandibular Resorption to Clinically Predict Severe Residual Ridge Resorption Risk
Background. Affecting all individuals, residual ridge resorption (RRR) is a prevalent, progressive condition developing post tooth loss, often remaining silent until denture instability occurs.
- Trial name
- NCT06807944
- Where
- Vietnam
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Nguyen Thu Thuy
Acute Myeloid Leukemia, Pediatric AML
UPDATE AML: UPdated Disease Monitoring And Treatment for Enhanced Outcomes for Pediatric AML
This research study investigates the tolerability of substituting two cycles of chemotherapy into the standard pediatric acute myeloid leukemia (AML) chemotherapy treatment regimen for patients with newly diagnosed AML at…
- Trial name
- NCT07059975
- Testing
- Idarubicin Hydrochloride, Fludarabine, Cytarabine (Ara-C)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Baylor College of Medicine
Residual Curarization
Residual Curarization and Its Incidence at Tracheal Extubation in China
This study will assess the residual neuromuscular blockade (NMB) Train-Of-Four (TOF) ratios at tracheal extubation when anesthesiologists have determined that full recovery of neuromuscular function has occurred using standard…
- Trial name
- RECITE-China (NCT01871064)
- Testing
- TOF-Watch SX® Monitoring of NMB
- Where
- 32 sites in China
- Volunteers
- 1,571 people
- Sponsor
- Xinmin Wu
Chronic Kidney Disease (CKD) Stage 5, Kidney Dysfunction Requiring Dialysis (KDRD)
Incremental Hemodialysis for Veterans in the First Year of Dialysis (IncHVets)
In this pragmatic clinical trial, which will dovetail with Veterans' routine outpatient dialysis clinic visits in six VA medical centers, the investigators will study 252 Veterans with kidney disease who need to start dialysis…
- Conditions
- Chronic Kidney Disease (CKD) Stage 5, Kidney Dysfunction Requiring Dialysis (KDRD), Dialysis Dependency
- Trial name
- INCHVETS (NCT05465044)
- Testing
- Twice-weekly hemodialysis with incremental crossover to thrice-weekly schedule, Thrice-Weekly Hemodialysis
- Where
- 8 sites in United States
- Volunteers
- 252 people
- Sponsor
- VA Office of Research and Development
Breast Cancer
Combination of Talimogene Laherparepvec With Atezolizumab in Early Breast Cancer
PROMETEO is a window opportunity, single arm, exploratory study to evaluate the effect of T- VEC combined with Atezolizumab in women with operable early breast cancer who present residual disease after Neoadjuvant Chemotherapy…
- Trial name
- PROMETEO (NCT03802604)
- Testing
- Talimogene laherparepvec, Atezolizumab
- Where
- 4 sites in Spain
- Volunteers
- 28 people
- Sponsor
- SOLTI Breast Cancer Research Group
Multiple Myeloma
Study With Elranatamab Versus Lenalidomide in Patients With Newly Diagnosed Multiple Myeloma After Transplant
The purpose of this study is to evaluate whether elranatamab monotherapy can provide clinical benefit compared to lenalidomide monotherapy (control) in participants with newly diagnosed multiple myeloma after undergoing…
- Trial name
- MagnetisMM-7 (NCT05317416)
- Testing
- Elranatamab, Lenalidomide
- Where
- 209 sites in United States, Australia and 25 more
- Volunteers
- 854 people
- Sponsor
- Pfizer
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