Clinical trials: Residual
Cystic Fibrosis
Study Evaluating the Long-term Safety and Efficacy of VX-445 Combination Therapy
This study evaluated the long-term safety, efficacy, and pharmacodynamics of elexacaftor (ELX, VX-445) in triple combination (TC) with tezacaftor (TEZ) and ivacaftor (IVA) in subjects with cystic fibrosis (CF) who are…
- Trial name
- NCT04058366
- Testing
- ELX/TEZ/IVA, IVA
- Where
- 84 sites in United States, Australia and 10 more
- Volunteers
- 251 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Residual Paralysis
Residual Paralysis in the Post Anesthesia Care Unit: the Association Beetween Residual Neuromuscular Block Risk Prediction Score and the Train-of-Four Ratio. a Prospective Single-Center Open-Label Cohort Study
The reported incidence of rNMB varies between 16% to more than 70 depending on the used definition (train-of-four [TOF] ratio 0.7 or 0.9), type of NMBA, type of reversal agent, and timing of measurements The degree of residual…
- Trial name
- NCT06796777
- Volunteers
- 91 people
- Sponsor
- Assiut University
Urolithiasis, Calyx; Calculus
Citrate Salts for Stone-free Result After Flexible Ureterorenoscopy for Inferior Calyx Calculi
The prevalence of urolithiasis is around 10 % in the French population. It is thus a major public health issue. When the stone is not spontaneously removed, interventions such as extracorporeal lithotripsy or flexible…
- Trial name
- CiRUS (NCT04021381)
- Testing
- Potassium and magnesium citrate
- Where
- France
- Volunteers
- 262 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Incidence of Postoperative Residual Curarization
Combined Use of Low-dose Sugammadex Plus Neostigmine Administered for Reversal of Rocuronium
Reversal of rocuronium-induced neuromuscular block by the combination of low-doses of neostigmine plus sugammadex decreases the cost of anesthetic medications, while maintaining efficacy of reversal in obese patients.
- Trial name
- NCT03328312
- Testing
- Sugammadex, neostigmine+atropine, neostigmine+atropine+sugammadex
- Volunteers
- 90 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Fasting, Gastric Emptying
Comparison of Residual Gastric Volume Between Children Who Drink Different Clear Oral Fluid Volume
According to the American Society of Anesthesiologists (ASA) fasting guideline for patients undergoing elective surgery, the 2-hour fasting period is suggested for clear oral fluid (including water, pulp-free juice and tea or…
- Trial name
- NCT03741777
- Testing
- Clear oral fluid
- Where
- United States
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Philadelphia Chromosome Positive Acute Lymphocytic Leukemia, Stem Cell Transplantation
TKI Therapy Based on Molecular Monitoring in Allogeneic-HSCT Recipients With Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia
The purpose of this study is to evaluate the efficacy of tyrosine kinase inhibitor(TKI) therapy based on molecular monitoring of BCR/ABL levels in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL)undergoing…
- Conditions
- Philadelphia Chromosome Positive Acute Lymphocytic Leukemia, Stem Cell Transplantation, Minimal Residual Disease
- Trial name
- NCT01883219
- Testing
- TKIs
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Brain Cancer, Breast Cancer
cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease
This is an observational case-control study to train and validate a genome-wide methylome enrichment platform to detect multiple cancer types and to differentiate amongst cancer types.
- Conditions
- Brain Cancer, Breast Cancer, Bladder Cancer, Cervical Cancer
- Trial name
- CAMPERR (NCT05366881)
- Where
- 17 sites in United States
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- Adela, Inc
HIV Infection
Residual Risk Assessment Of HIV Transmission
The main objective of this one year multidisciplinary research is to estimate the frequency of seropositive men having sex with men (MSM) under antiretroviral therapy (ART) having an undetectable blood viral load (VL) and a…
- Trial name
- EP 49 EVARIST (NCT01413152)
- Testing
- blood and semen sampling, specific biological exams and biobank and self administered questionnaires
- Where
- France
- Volunteers
- 167 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
Esophagogastroduodenoscopy, Colonoscopy
Residual Gastric Volume in Same Day Versus Split Dose and Evening Before Bowel Preparation
The purpose of this study is to determine residual gastric volume and residual gastric pH in patients undergoing combined EGD and colonoscopy comparing the standard single dose prep with the split dose bowel preparation and same…
- Trial name
- NCT02264249
- Testing
- Esophagogastroduodenoscopy and colonoscopy split dose prep, Esophagogastroduodenoscopy and colonoscopy Evening before colonoscopy prep, Esophagogastroduodenoscopy and colonoscopy Same day prep colonoscopy preparation
- Where
- United States
- Volunteers
- 449 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Non-Metastatic Ewings Sarcoma
Prognostic Value of a Positive RT-PCR Test in Patients With Ewing Sarcoma
This study will determine whether the results of a test called reverse transcriptase-polymerase chain reaction (RT-PCR) correlate with clinical outcomes in patients with Ewing sarcoma, and if they can be used to help identify…
- Trial name
- NCT00339898
- Where
- United States
- Volunteers
- 414 people
- Sponsor
- National Cancer Institute (NCI)
Chronic Renal Failure
PD-Improved Dialysis Efficiency With Adapted APD
The aim of this study is to observe the effect of adapted APD (aAPD) on maintenance and/or improvement of the hydration status of more than 250 PD patients, and to observe the tolerability of the therapy over a long period.
- Trial name
- PD-IDEA (NCT02470598)
- Testing
- Treatment with Adapted Automated Peritoneal Dialysis (aAPD)
- Where
- 50 sites in Czechia, Denmark and 4 more
- Volunteers
- 182 people
- Sponsor
- Fresenius Medical Care Deutschland GmbH
Breast Neoplasms
Study Of Capecitabine Combined With Camrelizumab For Non-pCR TNBC With TLS After Neoadjuvant Chemoterapy
This study aims to evaluate the efficacy and safety of camrelizumab in combination with capecitabine compared to placebo in combination with capecitabine as adjuvant therapy for patients with triple-negative breast cancer (TNBC)…
- Trial name
- NCT06313463
- Testing
- Carrellizumab + Capecitabine
- Where
- China
- Volunteers
- 375 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Opioid Use Disorder
Dronabinol and Epidiolex to Manage Uncontrolled Residual Symptoms of Buprenorphine Initiation Trial
The goal of this pilot study is to test novel, adjunctive pharmacotherapy for patients with opioid use disorder (POUD) who may be at risk for overdose and other poor opioid use disorder (OUD) outcomes even after initiating…
- Trial name
- DEMURE (NCT07148206)
- Testing
- Dronabinol Capsules, Epidiolex 100 mg/mL Oral Solution
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Montefiore Medical Center
Type 1 Diabetes
Early High-Dose Vitamin D and Residual β-Cell Function in Pediatric Type 1 Diabetes
The project aims to study the effect of early high-dose vitamin D supplementation on type 1 diabetes in children and adolescents receiving intensive insulin therapy.
- Trial name
- NCT05270343
- Testing
- Cholecalciferol (Vit D3) 400Unit Cap
- Where
- China
- Volunteers
- 198 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
B-cell Non-Hodgkin Lymphoma, Aggressive
DNA Sequencing-Based Monitoring of Minimal Residual Disease to Predict Clinical Relapse in Aggressive B-cell Non-Hodgkin Lymphomas
The purpose of this study is to determine whether a blood test can accurately detect whether if the participant's lymphoma has come back after completion of initial chemotherapy treatment for their aggressive B-cell Non-Hodgkin…
- Trial name
- NCT02633111
- Testing
- collected at pre-treatment tumor biopsy, Peripheral blood tests, PET/CT
- Where
- 12 sites in United States
- Volunteers
- 501 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Amblyopia
Pilot Study to Evaluate Levodopa as Treatment for Residual Amblyopia
This pilot study is being conducted as a prelude to a randomized trial to compare levodopa/carbidopa plus patching versus patching alone.
- Trial name
- ATS14 (NCT00789672)
- Testing
- levodopa/carbidopa, patching
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Jaeb Center for Health Research
Neoplasm Metastasis, Neoplastic Processes
Fractionated Radiosurgery for Painful Spinal Metastases
It is the study hypothesis that hypo-fractionated image-guided radiosurgery significantly improves pain relief compared to historic data of conventionally fractionated radiotherapy.
- Conditions
- Neoplasm Metastasis, Neoplastic Processes, Neoplasm Recurrence, Local, Neoplasm, Residual
- Trial name
- DOSIS (NCT01594892)
- Testing
- Radiosurgery
- Where
- 5 sites in Germany, Netherlands and 2 more
- Volunteers
- 60 people
- Sponsor
- Wuerzburg University Hospital
Neuromuscular Blockade
Frequency of Residual Neuromuscular Blockade in the Pediatric Population
This study is designed to investigate the frequency of Residual Neuromuscular Blockade (RNMB) in the pediatric population.
- Trial name
- NCT01786863
- Testing
- Neuromuscular blockade
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Nationwide Children's Hospital
Mantle Cell Lymphoma
Acalabrutinib-Lenalidomide-Rituximab in Patients With Untreated MCL
This is a multi-arm phase 2 study to evaluate the preliminary evidence of efficacy and safety of the combination of acalabrutinib, lenalidomide and rituximab (ALR) and acalabrutinib, lenalidomide and obinutuzumab (ALO) in…
- Trial name
- NCT03863184
- Testing
- Acalabrutinib, Lenalidomide, Rituximab
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Weill Medical College of Cornell University
Breast Cancer, Lung Cancer
Study of High-Precision Evaluation of Molecular ResiduaL Disease Through a PlatfOrm for Cancer TracKing and Interception (SHERLOCK)
This study will collect, annotate, and sequence biospecimens (blood, tissue, urine, saliva and surgery drainage) from patients across different cancer types to detect molecular residual disease (MRD).
- Conditions
- Breast Cancer, Lung Cancer, Melanoma, Gynecologic Cancer
- Trial name
- SHERLOCK (NCT07524114)
- Where
- Canada
- Volunteers
- 7,000 people
- Sponsor
- University Health Network, Toronto
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