Clinical trials: Residual Disease
Minimal Residual Disease,Acute Leukemia, Hypomethylating Agents, Donor Lymphocyte Infusion, Allogeneic Hematopoietic Cell Transplantation
HMA+DLI vs DLI Preemptive Therapy Based on MRD for AL Undergoing Allo-HSCT
Allogeneic hematopoietic cell transplantation (Allo-HSCT) is an effective therapy for acute leukemia, but relapse is the most common problem affecting long-term survivors of allo-HSCT.
- Trial name
- NCT03662087
- Testing
- HMA+DLI, DLI
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Infant, Premature, Diseases, Nutrition, Enteral
Evaluation of Gastric Residuals and Feedings Progression
This study evaluates the utility of measuring gastric residuals in premature infants born between 26+0 and 33+6 weeks and to determine if its routine use is related with a delay in feedings advancement in this babies compared…
- Trial name
- REGAP (NCT04064398)
- Testing
- Aspiration of gastric residuals
- Where
- Chile
- Volunteers
- 203 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Left Atrial Appendage Thrombosis, Stroke, Ischemic
RF Applications for Residual LAA Leaks
Although the clinical impact of residual left atrial appendage (LAA) leaks still requires confirmation, its patency resulting from incomplete LAA closure may promote blood stagnation and thrombus formation, and increase the risk…
- Conditions
- Left Atrial Appendage Thrombosis, Stroke, Ischemic, Atrial Fibrillation
- Trial name
- REACT (NCT04726943)
- Testing
- Radiofrequency Energy Applications
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Texas Cardiac Arrhythmia Research Foundation
Ovarian Cancer
Assessment of the Minimal Residual Disease in Ovarian Cancer From Circulating Tumor DNA and Immune Repertoire
To analyze the proportion of hereditary tumors in ovarian cancer patients in China, as well as the spectrum of variations; the ctDNA characteristics in patients with ovarian cancer; the correlation between the clonal status of…
- Trial name
- NCT03614689
- Where
- 6 sites in China
- Volunteers
- 104 people
- Sponsor
- Geneplus-Beijing Co. Ltd.
Renal Function Disorder
Renal Protective Effects of Restricted Protein Dietary With α-keto Acid in CAPD Patients
The prospective, double blind randomized, parallel control, and multi-center clinical trial will evaluate the safety and efficacy of α-keto acid with restricted protein diet on protecting residual renal function in continuous…
- Trial name
- NCT01255020
- Testing
- α-Keto Acid with restricted protein diet
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Sun Yat-sen University
Metastatic Colorectal Cancer
Early Detection of Relapses in Stage IV Colorectal Cancer Patients
This study is a prospective, multicenter, observational study on metastatic, operable colorectal cancer to evaluate the proof of concept of the cfDNA analysis for the early detection of recurrences
- Trial name
- REDCLOUD (NCT04232891)
- Testing
- liquid biopsy
- Where
- 2 sites in Italy
- Volunteers
- 141 people
- Sponsor
- Fondazione del Piemonte per l'Oncologia
Consciousness Disorder, Cognitive Impairment
Neurophysiological Evaluation of Residual Cognitive Functions in Patients With Severe Alterations of Consciousness
Identify potential markers of recovery through event-related potentials (ERPs) in the evolution of altered consciousness with potential ability to discriminate between different conditions of altered state of consciousness.
- Trial name
- NCT05802524
- Testing
- Neurowave Group
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Prostate Cancer
Imaging of Residual Tumor During Prostatectomy
Prostate Cancer is the most common cancer in men, affecting about as many men as women diagnosed with breast cancer, and killing about as many men per year as breast cancer kills women.
- Trial name
- NCT01173146
- Where
- United States
- Sponsor
- Spectros Corporation
Basal Cell Carcinoma
Optical Coherence Tomography Guided C&D
The purpose of the study is to identify the presence of residual superficial and nodular basal cell carcinoma (BCC) status-post curettage and desiccation (C\&D) by using optical coherence tomography (OCT).
- Trial name
- NCT04510727
- Testing
- Optical Coherence Tomography (OCT), Curettage & Desiccation (C&D) Procedure
- Where
- United States
- Sponsor
- University of Miami
Anesthesia, Neuromuscular Blockade
International Focus Group Discussion on Neuromuscular Monitoring.
Focus-Group based discussion designed to gain more in-depth information on factors that could lead to an increase in the adoption of neuromuscular monitoring taking into account different country-specific contexts.
- Conditions
- Anesthesia, Neuromuscular Blockade, Neuromuscular Block, Residual, Perioperative/Postoperative Complications
- Trial name
- NCT06945341
- Testing
- Focus-Group discussion
- Where
- Belgium
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Leukemia
Alemtuzumab in Treating Patients With B-Cell Chronic Lymphocytic Leukemia in Partial Remission or Complete Remission
RATIONALE: Monoclonal antibodies, such as alemtuzumab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread.
- Trial name
- NCT00458523
- Testing
- alemtuzumab, fluorescence in situ hybridization, mutation analysis
- Where
- 2 sites in United Kingdom
- Volunteers
- 54 people
- Sponsor
- Leeds Cancer Centre at St. James's University Hospital
Acute Myeloid Leukemia (AML)
Molecular Subtype Combined with Early Minimal Residual Disease to Optimize the Treatment of Newly Diagnosed Acute Myeloid Leukemia
This study aims to investigate the safety and efficacy of drug "X" in combination with intensive chemotherapy in subjects with newly diagnosed AML (excluding APL and CBF-AML).
- Trial name
- NCT06652685
- Testing
- D5-PBCR(-) IA arm, D5-PBCR(+) IA+Venetoclax arm
- Where
- China
- Volunteers
- 218 people
- Sponsor
- Ruijin Hospital
Ischemic Heart Disease, Angina Pectoris
Physiology and Residual Ischemia After Percutaneous Coronary Intervention
Despite optimal angiographic result after stent implantation, a number of patients will undergo repeat angiography within 1 year of index procedure.
- Conditions
- Ischemic Heart Disease, Angina Pectoris, Chest Pain, Coronary Artery Disease
- Trial name
- EASY-PRIPCI (NCT04494750)
- Where
- Canada
- Volunteers
- 260 people
- Sponsor
- Laval University
Acute Lymphoid Leukemia, Minimal Residual Disease
Adult Acute Lymphoblastic Leukemia Treated With Pediatric Regimen in Brazil
In this project, the investigators intend to start a prospective registry for patients with newly diagnosed Philadelphia-negative ALL from 16 years old and above in participating centers, provided that all patients will be…
- Conditions
- Acute Lymphoid Leukemia, Minimal Residual Disease, Gene Abnormality, Chemotherapeutic Toxicity
- Trial name
- BRALLA (NCT05959720)
- Testing
- Prednisone, Vincristin, Daunorubicin
- Where
- Brazil
- Volunteers
- 180 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Neuroblastoma
Serial ctDNA and Molecular Residual Disease Monitoring in Neuroblastoma
This prospective observational study evaluates serial circulating tumor DNA (ctDNA) and molecular residual disease (MRD) monitoring in patients with neuroblastoma.
- Trial name
- NCT07516678
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Sun Yat-sen University
Type 2 Diabetes Mellitus, Elective Abdominal Surgery
Preoperative Carbohydrate Loading in Diabetic Patients Undergoing Elective Abdominal Surgery
This study evaluates the effect of preoperative carbohydrate loading on early postoperative recovery in patients with type 2 diabetes mellitus undergoing elective abdominal surgery.
- Conditions
- Type 2 Diabetes Mellitus, Elective Abdominal Surgery, Gastric Emptying, Postoperative Recovery
- Trial name
- CARB-DM (NCT07451015)
- Testing
- Standard Preoperative Fasting With Water, Preoperative Oral Carbohydrate Loading
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Tanta University
Colorectal Cancer, Lymph Node Metastases
Use of Plasma ctDNA Methylation Haplotypes in Detecting Local Residual or Lymph Node Metastasis
This is a prospective, clinical study. This study is to evaluate the sensitivity of plasma ctDNA methylation haplotypes in detecting local residual or lymph node metastasis.
- Trial name
- NCT03868215
- Testing
- Next-generation sequencing (NGS)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fudan University
Renal Function Disorder
Effect of Diuretics on Fluid Status Control and Residual Renal Function in Peritoneal Dialysis Patients
A prospective, randomized, open-label, stratified, controlled clinical trial to evaluate whether long term furosemide therapy (1 year) would preserve urine volume and/or residual renal function (RRF) and improve fluid state in…
- Trial name
- NCT00936923
- Testing
- furosemide
- Where
- China
- Sponsor
- Sun Yat-sen University
Acute Lymphoblastic Leukemia
A Study of Obecabtagene Autoleucel in People With B-cell Acute Lymphoblastic Leukemia
The researchers are doing this study to find out whether obecabtagene autoleucel (obe-cel) is an effective treatment for people with B-cell acute lymphoblastic leukemia (ALL) that is in complete remission (CR, meaning all signs…
- Trial name
- NCT07400029
- Testing
- Obecabtagene Autoleucel
- Where
- 9 sites in United States
- Volunteers
- 40 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Hematologic Malignancies
Phase I Study to Assess the Tolerability and Efficacy of Nivolumab in Patients With Hematologic Malignancies
This is an open-label, dose escalation Phase I study to evaluate the tolerability and efficacy of single agent of Nivolumab as maintenance treatment to prevent relapse in patients with hematologic malignancies after allogeneic…
- Trial name
- NCT02985554
- Testing
- Nivolumab
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Chicago
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