Clinical trials: Residual Disease
Speech Sound Disorder
Intensive Speech Motor Chaining Treatment for Residual Speech Sound Disorders
The goal of this randomized-controlled trial is to compare distributed treatment schedules and intensive treatment schedules in 84 school-age children with residual speech sound disorders.
- Trial name
- iChain (NCT05929859)
- Testing
- Speech Motor Chaining
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Syracuse University
Asthma
Novel Method for Removal of Orally Deposited Inhaled Fluticasone Propionate
This study is to find out if an Extra Virgin Olive-Oil-based Water (EVOOW) mix, removes more Fluticasone Propionate (FP) from the mouth than Water alone.
- Trial name
- EVOOW (NCT07664527)
- Testing
- Fluticasone Propionate, Water Mouthwash, EVOOW Mouthwash
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Neuromuscular Block, Residual, Pain Management
Methylprednisolone vs Dexamethasone Interaction With Sugammadex in Pediatric Patients
This randomized controlled trial aims to compare the interaction of methylprednisolone and dexamethasone with sugammadex in pediatric patients undergoing adenoidectomy and/or tonsillectomy.
- Conditions
- Neuromuscular Block, Residual, Pain Management, Postoperative Nausea
- Trial name
- NCT07175623
- Testing
- Methyl Prednisolone (MP), Dexamethasone (0.2 mg/kg), Saline (0.9% NaCl)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Konya City Hospital
Acute Myeloid Leukaemia (AML), Leukemia
A Multi-Site Break Through Cancer Trial: Targeting Measurable Residual Disease in Patients With Acute Myeloid Leukemia: A Phase 1/2 Study of Tagraxofusp, Azacitidine, and Venetoclax
The purpose of this research study is to test the safety and efficacy of a new drug combination with three agents, azacitidine, venetoclax and tagraxofusp.
- Conditions
- Acute Myeloid Leukaemia (AML), Leukemia, Blood Cancer, Blood Cancers
- Trial name
- NCT07148180
- Testing
- Tagraxofusp, Azacitidine (AZA), Venetoclax
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- Jacqueline Garcia, MD
Amyloidosis
Assessment of Minimal Residual Disease (MRD) After Antineoplastic Treatment in Patients With AL Amyloidosis
In this study, the investigators seek to evaluate bone marrow and blood samples and treatment responses to see if Minimal Residual Disease (MRD) can be used as a predictive method of response to treatment in amyloidosis.
- Trial name
- MRD (NCT02716103)
- Testing
- blood collection, bone marrow collection
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Boston Medical Center
Chronic Kidney Disease, Peritoneal Dialysis
Effect of Protein-Restricted Diet on Nitrogen Balance and Residual Renal Function in Peritoneal Dialysis (PD) Patients
Current therapy recommendations suggest a low protein diet to preserve residual renal function (RRF) before the start of dialysis, but a higher protein intake during dialysis to prevent protein-energy wasting (PEW).
- Trial name
- NCT00633646
- Testing
- diets contained different levels of protein
- Volunteers
- 94 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
End Stage Renal Disease on Dialysis
Diuretic Use in Hemodialysis Patients With Residual Renal Function
This pilot trial will evaluate the use of diuretic medications (furosemide and chlorthalidone) in participants on dialysis to see if these medications work to preserve existing kidney function, increase urine output, and reduce…
- Trial name
- DIURESED (NCT05915286)
- Testing
- Furosemide, Chlorthalidone
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- University of Alberta
Breast Cancer
Feasibility Study of Intraoperative Imaging in Breast Cancer
For most breast cancer patients, surgery is the primary treatment. When patients undergo a lumpectomy, it is difficult for the surgeon to determine the extent of the tumor which results in incomplete tumor removal as determined…
- Trial name
- NCT02438358
- Testing
- LUM015, LUM 2.6 Imaging Device
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Lumicell, Inc.
Myeloma Multiple
Descartes-08 Consolidation Treatment in Patients With High-Risk Multiple Myeloma High-Risk Multiple Myeloma Who Have Residual Disease After Induction Therapy
To assess Minimal Residual Disease (MRD)-negative Complete Response (sCR) rate after consolidation treatment with Descartes-08 in patients with high-risk myeloma who have residual disease following induction therapy.
- Trial name
- NCT04816526
- Testing
- Descartes 08
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- Cartesian Therapeutics
High-grade Squamous Intraepithelial Lesions (HSIL), Cervical Conization
Predicting Treatment Failure in HSIL Patients with Positive Margins After Conization Via Detection of PAX1 Methylation
The goal of this multicenter, observational study is to evaluate whether methylation testing of paired box gene 1 (PAX1) can better predict and diagnose recurrence or persistent disease in patients with positive margins after…
- Trial name
- NCT06713655
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Speech Sound Disorder
AI-Assisted Treatment for Residual Speech Sound Disorders
The goal of this randomized-controlled trial is to determine how artificial intelligence-assisted home practice may enhance speech learning of the "r" sound in school-age children with residual speech sound disorders.
- Trial name
- NCT05988515
- Testing
- Speech-Language Pathologist-led Speech Motor Chaining, Artificial Intelligence-led Speech Motor Chaining (CHAINING-AI)
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Syracuse University
Type 1 Diabetes
Early High-Dose Vitamin D and Residual β-Cell Function in Pediatric Type 1 Diabetes
The project aims to study the effect of early high-dose vitamin D supplementation on type 1 diabetes in children and adolescents receiving intensive insulin therapy.
- Trial name
- NCT05270343
- Testing
- Cholecalciferol (Vit D3) 400Unit Cap
- Where
- China
- Volunteers
- 198 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Type 1 Diabetes
Encapsulated Faecal Microbiota Transplantation to Preserve Residual Beta Cell Function in Type 1 Diabetes Mellitus
In this single arm pilot study it will be investigated whether encapsulated autologous fecal microbiota transplantation may be used to halt the decline in residual beta cell function in individuals with recent onset Type 1…
- Trial name
- ENCAPSULATE (NCT05323162)
- Testing
- encapsulated autologous fecal microbiota transplantation
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Nordin Hanssen
Esophageal Cancer
Pre-Surgery If Needed for Oesophageal Cancer
A prospective, multi-centre, diagnostic cohort study investigating the accuracy of positron emission tomography with computed tomography (PET-CT), endoscopic bite-on-bite biopsies and endoscopic ultrasonography (EUS) with…
- Trial name
- preSINO (NCT03937362)
- Testing
- First clinical response evaluation (CRE-1), Second clinical response evaluation (CRE-2)
- Where
- 4 sites in China, Hong Kong and 2 more
- Volunteers
- 200 people
- Sponsor
- Shanghai Chest Hospital
Multiple Myeloma
Telo Genomics Technology to Detect & Profile Multiple Myeloma MRD
The purpose : Detect and profile Multiple myeloma Measurable Residual Disease(MRD) prognostics for monitoring post-transplant Multiple Myeloma (MM) Patients receiving maintenance therapy.
- Trial name
- TELO - DMRD (NCT05530096)
- Testing
- Standard of care
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Minimal Residual Disease, Immunoscore
Neoadjuvant CAPEOX Versus Upfront Surgery for Locally Advanced Colon Cancer With Elevated CEA: A Single-Center, Open-Label, Randomized Controlled Trial
The goal of this interventional clinical trial is to compare the efficacy of neoadjuvant chemotherapy versus upfront surgery in adults aged 18-70 years with stage II (high-risk)-III, non-MSI-H colon adenocarcinoma and elevated…
- Conditions
- Minimal Residual Disease, Immunoscore, Neoadjuvant Chemotherapy, Colon Cancer (Stage II &Amp; III)
- Trial name
- NCT07413146
- Testing
- ctDNA-Based Molecular Residual Disease (MRD) Monitoring and Immunoscore Assessment, Neoadjuvant Chemotherapy, Adjuvant chemotherapy
- Volunteers
- 100 people
- Sponsor
- Sun Yat-sen University
Cervical Intraepithelial Neoplasia
Factors Associated With Residual Disease In The Central Cone
Cervical conization using the loop electrosurgical excision procedure (LEEP) is the standard treatment for patients with high-grade cervical intraepithelial neoplasia.
- Trial name
- FARDCC (NCT03788850)
- Volunteers
- 397 people
- Sponsor
- National Institute of Cancerología
Aedes-borne Diseases, Dengue
Quantifying the Epidemiological Impact of Targeted Indoor Residual Spraying on Aedes-borne Diseases
The objective of this trial is evaluate the efficacy of Targeted Indoor Residual Spraying (TIRS) in preventing symptomatic disease caused by Aedes-borne diseases (ABDs) in children 2 to 15 years of age in the city of Merida…
- Conditions
- Aedes-borne Diseases, Dengue, Chikungunya, Zika
- Trial name
- NCT04343521
- Testing
- Targeted Indoor Residual Spraying (TIRS)
- Where
- Mexico
- Volunteers
- 4,461 people
- Sponsor
- Emory University
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
Imlunestrant and Abemaciclib for the Treatment of Estrogen Receptor Positive Breast Cancer in Patients With Minimal Residual Disease, MIRI Trial
This phase II trial studies how well imlunestrant and abemaciclib work in treating patients with estrogen receptor positive (ER+) breast cancer who have tumor remaining in the blood following treatment (minimal residual disease).
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, Invasive Breast Carcinoma
- Trial name
- NCT07191717
- Testing
- Abemaciclib, Biospecimen Collection, Imlunestrant
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Type I Hypersensitivity
Assessment of Residual Allergenicity of Grass/Rye Pollen Allergoid Using Skin Prick Testing
The purpose of this study is to evaluate the residual allergenicity of Grass MATA (modified pollen allergen tyrosine adsorbate) by skin prick testing.
- Trial name
- NCT00104390
- Testing
- Grass MATA MPL
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Allergy Therapeutics
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