Clinical trials: Resistance, Disease
Corticosteroid-resistant or Relapsed ITP
Combination of Danazole With Berberine in the Treatment of ITP
A prospective, multicenter, open-label, Phase II, single arm, trial performed in 6 departments of hematology in China
- Trial name
- NCT03909763
- Testing
- Berberine plus danazol
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Peking University People's Hospital
Bone Metastases, Castrate-resistant Prostate Cancer
Magnetic Resonance Imaging in Measuring the Effect of Cabozantinib in Patients With Castrate Resistant Prostate Cancer
This study is being done to help researchers understand more about prostate cancer that has spread to the bones by using the newest magnetic resonance imaging (MRI) techniques and to better understand the effect of an…
- Conditions
- Bone Metastases, Castrate-resistant Prostate Cancer, Recurrent Prostate Cancer, Stage IV Prostate Cancer
- Trial name
- NCT01599793
- Testing
- cabozantinib, laboratory biomarker analysis, magnetic resonance imaging
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Chicago
Endometrial Cancer, Obesity
Tirzepatide in Obesity-Driven Endometrial Cancer
LCCC2415 examines the antiproliferative effect of tirzepatide on the endometrium of endometrial cancer (EC). This is a pre-operative window clinical study.
- Trial name
- NCT07065552
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Ovarian Neoplasms
Phase 3 Randomized Study of Telcyta + Doxorubicin Versus Doxorubicin in Platinum Refractory or Resistant Ovarian Cancer
The purpose of this research study is to determine if Telcyta® given in combination with liposomal doxorubicin is more effective than liposomal doxorubicin alone in treating women who have recurrent ovarian epithelial cancer…
- Trial name
- ASSIST-5 (NCT00350948)
- Testing
- Telcyta, Liposomal Doxorubicin
- Where
- 71 sites in United States, Belgium and 2 more
- Volunteers
- 244 people
- Sponsor
- Telik
Lipid-induced Insulin Resistance
Fat and Transcapillary Insulin Transport
There is a current debate whether impaired insulin-mediated microvascular perfusion limits the delivery of hormones and nutrients to muscle and whether short term FFA elevation affects transcapillary transport of insulin and…
- Trial name
- FATRAIN (NCT01482455)
- Testing
- Elevation of FFA during OGTT, Elevation of FFA during Clamp
- Where
- Austria
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- German Diabetes Center
Vitamin D Deficiency, Obesity
Vitamin D Deficiency and Low Bone Mineral Content in Children
The Vitamin D study is designed to investigate the effect of body fat mass on vitamin D levels in children. Earlier studies have shown that individuals with increased fat mass may have low vitamin D levels.
- Trial name
- VDS (NCT00756899)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Metabolic Syndrome
Pomegranate Consumption by Poly-medicated Metabolic Syndrome Patients
The objective is to evaluate whether the medication in polymedicated metabolic syndrome patients could determine the effects of a pomegranate extract on i) metabolic markers, ii) inflammatory markers, and iii) the modulation of…
- Trial name
- NCT04075032
- Testing
- Pomegranate extract
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- National Research Council, Spain
Hypertension
Efficacy and Safety of Lorundrostat in Subjects With Uncontrolled and Resistant Hypertension
This is a Phase 3 trial to evaluate the BP-lowering effect of lorundrostat (an aldosterone synthase inhibitor) in subjects with uncontrolled and resistant hypertension taking between 2 and 5 anti-hypertensive (AHT) medications.
- Trial name
- NCT06153693
- Testing
- lorundrostat Dose 1, lorundrostat Dose 2
- Where
- 184 sites in United States, Australia and 11 more
- Volunteers
- 1,083 people
- Sponsor
- Mineralys Therapeutics Inc.
Metastatic Castration-resistant Prostate Cancer
Phase 3 Study of Xaluritamig vs Cabazitaxel or Second Androgen Receptor-Directed Therapy in Participants With Progressive Metastatic Castration-Resistant Prostate Cancer (XALute)
The main objective of the study is to compare overall survival in participants receiving xaluritamig versus investigator's choice (cabazitaxel or second androgen receptor-directed therapy [ARDT]).
- Trial name
- NCT06691984
- Testing
- Xaluritamig, Abiraterone, Enzalutamide
- Where
- 164 sites in United States, Australia and 20 more
- Volunteers
- 707 people
- Sponsor
- Amgen
Cardiometabolic Syndrome, Type 2 Diabetes
Circadian Intervention to Improve Cardiometabolic Health
The overall goal is to examine the efficacy of a circadian intervention in people with overweight and obesity and habitual short sleep duration (HSSD).
- Conditions
- Cardiometabolic Syndrome, Type 2 Diabetes, Sleep, Time Restricted Feeding
- Trial name
- TOCS (NCT05943626)
- Testing
- Circadian Intervention
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Utah
Prostate Cancer, Prostate Carcinoma
The Study of Olaparib in Newly Diagnosed mCRPC Patients With HRR Gene Mutation
This is a multi-center, single-arm, prospective study to assess the efficacy and safety of Olaparib in men with newly diagnosed metastatic castration-resistant prostate cancer (mCRPC) who carried homologous recombination repair…
- Conditions
- Prostate Cancer, Prostate Carcinoma, Metastatic Castration-resistant Prostate Cancer
- Trial name
- PROspect (NCT05262608)
- Testing
- Olaparib
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
HIV Infections
Sequential HIV Therapy in Treatment Resistant HIV-1 Infected Patients
This is an open label, crossover pilot study to explore the safety and efficacy of a rapid cycling regimen of antiretroviral combination therapy in HIV-1 infected patients with virus harboring genotypic resistance to at least…
- Trial name
- NCT00128908
- Testing
- Standard Continuous Highly Active Antiretroviral Therapy (HAART), Rapidly Cycled HAART
- Where
- Netherlands
- Volunteers
- 3 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Ovarian Neoplasm
[18F]Fluciclatide-PET, Pazopanib and Paclitaxel in Ovarian Cancer
The purpose of this study is to assess [18F] -fluciclatide as a biomarker of response to pazopanib and to evaluate the efficacy and safety of the combination of pazopanib and paclitaxel in platinum-resistant ovarian cancer…
- Trial name
- PAZPET-1 (NCT01608009)
- Testing
- Pazopanib and paclitaxel
- Where
- 2 sites in United Kingdom
- Volunteers
- 16 people
- Sponsor
- Imperial College London
Major Depressive Disorders
N-Acetyl Cysteine Supplementation in Therapy Refractory Major Depressive Disorders
The aim of this study is to evaluate the efficacy of N-acetylcysteine (NAC) add-on to antidepressant medication in treating patients who do not relieve during standard antidepressant treatment for 6 weeks at least.
- Trial name
- NCT02972398
- Testing
- N-acetylcysteine
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Tianjin Anding Hospital
Malaria, Parasitic Diseases
Malaria Elimination Pilot Study in Military Forces in Cambodia
Antimalarial drug resistance has reached critical levels on the Thai-Cambodian border. Many have begun advocating for concerted malaria elimination efforts in Cambodia.
- Trial name
- NCT02653898
- Testing
- DHA-PIP, Primaquine, Artesunate + Mefloquine
- Where
- Cambodia
- Volunteers
- 1,050 people, healthy volunteers welcome
- Sponsor
- Armed Forces Research Institute of Medical Sciences, Thailand
Metabolic Disease, Insulin Resistance
Walking Before or After Breakfast - Which is Better to Improve Health in Overweight Individuals?
The aim of this study is to investigate the effectiveness of a home-based walking-based exercise intervention undertaken in the fed or fasted state to improve glycaemic control in overweight and obese individuals.
- Trial name
- NCT06240663
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 34 people
- Sponsor
- Liverpool John Moores University
Gestational Diabetes Mellitus in Pregnancy, Hyperprolactinemia Pregnancy
Prolactin and FGF21 in Gestational Diabetes Mellitus
Prolactin (PRL) and PRL receptor (PRLR) signaling has been validated to play an important role in the modulation of glucolipid metabolism.
- Trial name
- NCT05528393
- Testing
- Blood sampling
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shen Qu
Hypertension, Oxidative Stress
Effect of Antioxidant Supplementation on the Autonomic Balance
Recent evidence suggests that there is a directly proportional relationship between diets with a high concentration of antioxidants and the reduction of blood pressure and the risk of cardiovascular events.
- Conditions
- Hypertension, Oxidative Stress, Autonomic Imbalance, Insulin Resistance
- Trial name
- NCT03510221
- Testing
- Antioxidants capsules
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Vernal Keratoconjunctivitis
Evaluation of the Efficacy and Safety of Tacrolimus Drops in Children With Vernal Keratoconjunctivitis
Non-interventional single-center cohort study (Rothschild Foundation Hospital) of patients aged 0 to 18 years followed up in ophthalmology for KCV, treated with tacrolimus 0.1% eye drops previously treated with ciclosporin 2%…
- Trial name
- KERAVER (NCT05076084)
- Testing
- QUICK questionnaire and 6 additional questions, Retrospective collection of clinical data from the patients' medical records
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Type 2 Diabetes
Health Benefits of Aerobic and Resistance Training in Individuals With Type 2 Diabetes
The goal of the proposed study, Health Benefits of Aerobic and Resistance Training in individuals with type 2 diabetes (HART-D), is to compare the effect of resistance training alone (RT), resistance in combination with aerobic…
- Trial name
- HART-D (NCT00458133)
- Testing
- exercise
- Where
- United States
- Volunteers
- 262 people
- Sponsor
- Pennington Biomedical Research Center