Clinical trials: Resistance, Disease
Coronary Disease, Heart Diseases
VA HDL Intervention Trial (VA-HIT) Ancillary Study Data Analysis
To evaluate additional cardiovascular risk factors using data from the VA HDL Intervention Trial (VA-HIT).
- Conditions
- Coronary Disease, Heart Diseases, Cardiovascular Diseases, Carotid Artery Diseases
- Trial name
- NCT00035711
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Schizophrenia
Safety and Efficacy of Aripiprazole and Ziprasidone Among Schizophrenic Patients With Metabolic Syndrome
Introduction: Schizophrenia is a serious mental illness. For majority of patients it is a lifetime condition,characterized by intermittent episodes of hospitalization due to relapse or acute symptom exacerbation.
- Trial name
- NCT01714011
- Testing
- Ziprasidone, Aripiprazole
- Where
- Malaysia
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Breast Cancer, Stage III Breast Cancer
TeleHealth Resistance Exercise Intervention to Preserve Dose Intensity and Vitality in Elder Breast Cancer Patients
This research is being done to assess whether an exercise intervention with protein intake support vs a health education and support program will make it easier for women age 65 or older who are receiving chemotherapy for breast…
- Conditions
- Breast Cancer, Stage III Breast Cancer, Breast Cancer Female, Stage I Breast Cancer
- Trial name
- THRIVE-65 (NCT05535192)
- Testing
- THRIVE, Health Education Support Program
- Where
- 4 sites in United States
- Volunteers
- 270 people
- Sponsor
- Dana-Farber Cancer Institute
Frailty, Sarcopenia
Development of Frailty Prevention Clinic in Geriatric Comprehensive Clinic RSCM:
There is an increasing number of elderly population, not only in Indonesia, but also in the world. With increasing of age, there is also an increasing number of elderly with sarcopenia and frailty.
- Conditions
- Frailty, Sarcopenia, Resistance Training
- Trial name
- NCT05511311
- Testing
- Resistance Training, Standard Therapy
- Where
- Indonesia
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Dietary Intervention, Gut Microbiota
Phenolic Dependent And Independent Effects Of Whole Grain Sorghum On Immunometabolism
Sorghum is a nutrient-dense ancient grain that, when eaten as a whole grain, provides health-beneficial dietary fiber, protein, and phenolics.
- Conditions
- Dietary Intervention, Gut Microbiota, Insulin Sensitivity/Resistance, Obesity & Overweight
- Trial name
- NCT07832071
- Testing
- Whole grain sumac sorghum, Whole grain white sorghum, White rice
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nebraska Lincoln
Chronic Kidney Disease Stage 3A, Chronic Kidney Disease Stage 3B
Combined Versus Multicomponent Training in People With Chronic Kidney Disease Stages 3a and 3b
This randomized controlled trial will compare the effects of 12 weeks of combined training (aerobic plus resistance exercise) and multicomponent training (aerobic plus resistance plus balance exercise) with a control group…
- Conditions
- Chronic Kidney Disease Stage 3A, Chronic Kidney Disease Stage 3B, Chronic Kidney Disease, Non-dialysis
- Trial name
- NCT07901621
- Testing
- Combined Training, Multicomponent Training
- Where
- Brazil
- Volunteers
- 57 people
- Sponsor
- University of Brasilia
Stroke, Dysphagia
Improving Dysphagia in Stroke Patients With Chin Tuck Against Resistance Exercise
According to a 2014 report from the Ministry of Health and Welfare, cerebrovascular disease is one of the leading causes of death, with a mortality rate of 51.6 per 100,000 population, ranking fourth among the top ten causes of…
- Trial name
- NCT07630116
- Testing
- Chin Tuck Against Resistance (CTAR), Routine Rehabilitation
- Where
- Taiwan
- Volunteers
- 112 people
- Sponsor
- Taichung Veterans General Hospital
Diabetes, Insulin Resistance
Changes in Inflammatory State in Asian Americans Changing From Traditional Asian Diets to American Diet - a Pilot Study
We hypothesize that Asian Americans compared to Caucasians, will be at higher risk of developing a pro-inflammatory state that may contribute to the development of heart disease and diabetes when they change from a traditional…
- Conditions
- Diabetes, Insulin Resistance, Inflammation, Cardiovascular Disease
- Trial name
- NCT00379548
- Testing
- 2 groups of population responding to 2 types of diets
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
Obesity, Insulin Resistance
Intervention Study With Omega-3 Fatty Acids for Weight Loss and Insulin Resistance in Adolescents
The purpose of this study is to evaluate if a supplement containing omega-3 long chain polyunsaturated fatty acids for three months reduce obesity and insulin resistance to obese adolescents if administered together with a…
- Trial name
- O3WLIRADOL (NCT01456221)
- Testing
- Omega3 and an hypocaloric diet., Sunflower oil with an hypocaloric diet.
- Where
- Mexico
- Volunteers
- 366 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Overweight or Obesity
Precision Nutrition Strategies for Improving the Quality of Life of Pre-senior and Senior Populations
The number and proportion of people aged 60 years old and over is increasing worldwide. Ageing is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death.
- Trial name
- NCT04786925
- Testing
- Control diet, Nutriprecision diet
- Where
- Spain
- Volunteers
- 126 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Glucose Metabolism Disorders
Relative Contribution of Brain Insulin Action for Postprandial Metabolism
The goal of this clinical trial is to clarify (i) the contribution of brain insulin action on regulation of systemic metabolism, (ii) sex-specific differences in the central regulation and (iii) the influence of the menstrual…
- Trial name
- BrainInsPPM (NCT06295640)
- Testing
- Oral glucose tolerance test with double-tracer dilution and intranasal insulin spray
- Where
- Germany
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Ulm
NASH Related Cirrhosis
Effect of Metformin on Disease Progression in Patients With Cryptogenic Cirrhosis (NASH-related Cirrhosis) With Diabetes or Impaired Glucose Tolerance or Insulin Resistance
In this study, consecutive patients with cryptogenic cirrhosis (NASH-related cirrhosis), coming to ILBS (Institute of Liver \& Biliary Sciences) OPD (Out patient Department) or getting admitted in the ward will be enrolled on…
- Trial name
- NCT02234440
- Testing
- Metformin, Insulin
- Where
- India
- Volunteers
- 86 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Metabolic Syndrome
Effects of Genistein in Postmenopausal Women With Metabolic Syndrome
The 15-25% of the population of developed countries suffers for metabolic syndrome. It is associated with a 2-4 fold increase in cardiovascular morbility and mortality and with a 5- 9 fold increase in developing type II diabetes.
- Trial name
- NCT01664650
- Testing
- Genistein
- Where
- 3 sites in Italy
- Volunteers
- 120 people
- Sponsor
- University of Messina
Insulin Resistance, Chronic Heart Failure
Cardioprotective and Metabolic Effects of Metformin in Patients With Heart Failure and Diabetes
The aim of the study is to evaluate the effect of metformin on myocardial function, insulin resistance and selected metabolic markers in patients with type 2 diabetes and heart failure (HF+DM+) in a cross-over, randomized…
- Trial name
- CARMET (NCT01690091)
- Testing
- Metformini hydrochloridum (Siofor 1000 tbl, Berlin)
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- Institute for Clinical and Experimental Medicine
End-stage Renal Disease
Nutrition, Inflammation and Insulin Resistance in End-Stage Renal Disease
By 2030 an estimated 2 million people in the US will need dialysis or transplantation. Insulin resistance and chronic inflammation are common in dialysis patients and have been linked to protein-energy wasting, the most important…
- Trial name
- SummerMRI (NCT04067752)
- Testing
- high dialysate sodium concentration (138 mEq/L), Low dialysate sodium concentration
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- VA Office of Research and Development
Coronary Artery Disease, Acute Coronary Syndrome
PAR Regulation of Platelet Function in Diabetic Patients
Thrombin is the most potent activator of platelets, and platelet activation is a hallmark of thrombosis. Coronary artery disease (CAD) is the major cause of mortality and morbidity in the United States and other industrialized…
- Conditions
- Coronary Artery Disease, Acute Coronary Syndrome, Diabetes, Metabolic Syndrome
- Trial name
- NCT00855374
- Where
- United States
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
HIV Infections, Human Immunodeficiency Virus
SP01A: The Study of an Oral Entry Inhibitor in Treatment-Experienced HIV Patients
This is a 28-day, multi-center, placebo-controlled study designed to look at the dose response, efficacy, and safety of SP01A, given as a pill to be swallowed, in the treatment of HIV-infected subjects.
- Trial name
- NCT00299897
- Testing
- SP01A
- Where
- 5 sites in United States
- Volunteers
- 60 people
- Sponsor
- Samaritan Pharmaceuticals, Inc
Adenocarcinoma of the Prostate, Hormone-resistant Prostate Cancer
Docetaxel, Prednisone, and Pasireotide in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer
This phase I/II trial studies the side effects and best dose of pasireotide and to see how well it works when given together with docetaxel and prednisone in treating patients with metastatic hormone-resistant prostate cancer.
- Conditions
- Adenocarcinoma of the Prostate, Hormone-resistant Prostate Cancer, Recurrent Prostate Cancer, Stage IV Prostate Cancer
- Trial name
- NCT01468532
- Testing
- docetaxel, pasireotide, prednisone
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Ovarian Cancer
NUC-1031 in Patients With Platinum-Resistant Ovarian Cancer
This study was designed to evaluate the effect of two dose levels of NUC-1031 (500 mg/m2 and 750mg/m2) in patients with ovarian cancer.
- Trial name
- NCT03146663
- Testing
- NUC-1031 500 mg, NUC-1031 750mg
- Where
- 17 sites in United States, United Kingdom
- Volunteers
- 53 people
- Sponsor
- NuCana plc
Ectopic Lipids, Insulin Sensitivity
The Effect of Dietary Fat Load and Physical Exercise on the Flexibility and Partitioning of Ectopic Lipids.
This study aims at assessing the effect of standardized dietary fat load and short-term aerobic exercise on systemic lipolysis, flexibility and partitioning of ectopic fat stores (intramyocellular = IMCL, intrahepatocellular =…
- Conditions
- Ectopic Lipids, Insulin Sensitivity, Aerobic Exercise, Fat Load
- Trial name
- NCT01467193
- Testing
- Fat diet, 2h standardized aerobic exercise
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern