Clinical trials: Resistant Depression, Treatment
Bipolar Depression
Neurobiological Effects of Psilocybin in Treatment Resistant Bipolar Depression
This study is an open-label, single-arm, proof-of-concept study, wherein treatment resistant bipolar depression (TRBD) participants will receive one 25 mg dose of oral psilocybin accompanied by preparatory, monitoring, and…
- Trial name
- Psilo-BD (NCT06506019)
- Testing
- Psilocybin, Functional MRI
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
HIV, Depression in Adults
The Effects of Cognitive Behavioral Therapy on Insulin Resistance in People With HIV
The goal of this clinical trial is to learn if depression treatment improves insulin resistance, or how the body uses insulin to lower blood sugar, in people with HIV on HIV treatment.
- Conditions
- HIV, Depression in Adults, Insulin Resistance, Cognitive Behavior Therapy
- Trial name
- NCT07226128
- Testing
- Internet cognitive behavioral therapy (iCBT-D), Active Control (AC)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Indiana University
Major Depressive Disorder, Suicide
i-CBT and IV Ketamine for Suicidality in Treatment-Resistant Depression: A Randomized, Midazolam-Controlled Clinical Trial
Approximately four thousand Canadians die by suicide every year, and suicide is the second leading cause of death in youth and young adults (15-34 years).
- Conditions
- Major Depressive Disorder, Suicide, Treatment Resistant Depression
- Trial name
- Ket-CBT (NCT06480500)
- Testing
- Ketamine hydrochloride, i-CBT (Internet-based Cognitive Behavioural Therapy), Midazolam Hydrochloride
- Where
- Canada
- Volunteers
- 76 people
- Sponsor
- University Health Network, Toronto
Treatment Resistant Depression
Dorsomedial Prefrontal Cortex and the Antidepressant Efficacy of Theta Burst Stimulation in Depressed Patients
This study evaluates an association between different dosage and the antidepressant efficacy of theta burst stimulation in patients with treatment-resistant depression.
- Trial name
- NCT04037592
- Testing
- Active standardized iTBS-DMPFC, Active high-dosage iTBS-DMPFC
- Where
- Taiwan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Treatment Resistant Depression
SAINT for Treatment of Preoperative Depression to Reduce Opioid Use Following Arthroplasty
This study evaluates an accelerated schedule of theta-burst stimulation using a transcranial magnetic stimulation device for treatment-resistant depression.
- Trial name
- NCT04195308
- Testing
- Active TBS-DLPFC, Open label TBS-DLPFC
- Where
- United States
- Sponsor
- Stanford University
Depression
Efficacy and Tolerability of Riluzole in Treatment Resistant Depression
This study aims to examine the antidepressant efficacy of riluzole, employing a randomized, double-blind, placebo-controlled, adjunctive trial in treatment-resistant major depressive disorder (TRD).
- Trial name
- NCT01204918
- Testing
- Riluzole
- Where
- 3 sites in United States
- Volunteers
- 104 people
- Sponsor
- Yale University
Major Depression
Antidepressant Effects of NR2B in Major Depression
Purpose : This study will determine whether MK-0657, a selective NR2B Antagonist, can quickly improve symptoms of depressed mood, psychomotor retardation, poor motivation and reduced enjoyment of things in patients with major…
- Trial name
- NCT00472576
- Testing
- MK-0657
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depressive Disorder
Intramuscular Ketamine Versus Aripiprazole and Escitalopram in the Treatment of Resistant Depression
The treatment of resistant depression should be optimized aiming at complete remission of symptoms, a complex condition due to several factors.
- Trial name
- KETProject (NCT04234776)
- Testing
- Ketamine, Cognition, Suicide risk
- Where
- Brazil
- Volunteers
- 88 people
- Sponsor
- University of Sao Paulo
Treatment Resistant Depression
Effects of TBS on 5-HT1A Receptor Binding
Background: Theta-burst stimulation (TBS), a form of repetitive transcranial magnetic stimulation (rTMS) holds promise as an effective treatment for treatment resistant depression (TRD).
- Trial name
- NCT02810717
- Testing
- theta-burst stimulation using a MagPro X1000
- Where
- Austria
- Volunteers
- 80 people
- Sponsor
- Rupert Lanzenberger
Depressive Disorder
Psilocybe Cubensis Mushrooms With or Without Fluoxetine for Refractory Depression
This Phase 2a pilot, exploratory, randomized, double-blind, placebo-controlled, parallel-group trial will estimate whether concurrent fluoxetine alters the antidepressant effect, acute psychedelic experience, or safety of a…
- Trial name
- COGUNILA (NCT06898606)
- Testing
- Psilocybin and Psilocyn, Psychotherapy-assisted session, Fluoxetine
- Where
- Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Federal University of Latin American Integration
Treatment Resistant Depression, Chronic Depression
Schema Therapy for Patients With Chronic Treatment Resistant Depression
The goal of this clinical study is to test a particular form of psychotherapy, called schema therapy, for people with difficult-to-treat depression (when depression is very lengthy or difficult to cure with antidepressive…
- Trial name
- DEPRE-ST (NCT05833087)
- Testing
- Schema therapy, Other psychotherapy, Standard care package content
- Where
- 6 sites in Denmark
- Volunteers
- 129 people
- Sponsor
- Region of Southern Denmark
Major Depressive Disorder (MDD), Treatment Resistant Depression (TRD)
Electroconvulsive Therapy Augmented With Transcranial Magnetic Stimulation for Treatment Resistant Depression
The RTMSECT2 study was design to compare the application of electroconvulsive therapy augmented by transcranial magnetic stimulation.
- Trial name
- RMTSECT2 (NCT07324070)
- Testing
- Electroconvulsive therapy, Transcranial Magnetic Stimulation
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- Charles University, Czech Republic
Major Depressive Disorder (MDD), Treatment-resistant Depression (TRD)
Comparison of Efficacy of Minocyclin and Celecoxib as Adjunctive Treatment in Treatment Resistant Cases of Major Depressive Disorder
This randomized controlled study was conducted to compare the effectiveness of minocycline and celecoxib as add-on treatments in patients with treatment-resistant major depressive disorder.
- Trial name
- NCT07804979
- Testing
- Minocycline, Celecoxib
- Where
- Pakistan
- Volunteers
- 78 people
- Sponsor
- Lahore General Hospital
Treatment Resistant Depression
Neuroimaging in Patients Undergoing TMS for Depression
The goal of this project is to guide rTMS using functional magnetic resonance imaging (fMRI) in individuals with depression who did not respond to standard TMS treatment to evaluate whether targeted TMS using individualized…
- Trial name
- NIPUTFD (NCT02974296)
- Testing
- transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- New York State Psychiatric Institute
Major Depressive Disorder (MDD), Treatment Resistant Depression (TRD)
Accelerated iTBS for Major Depression
Major depressive disorder (MDD) is a common and disabling psychiatric condition, and many patients do not achieve adequate response to standard antidepressant treatments.
- Trial name
- AIM-D (NCT07603804)
- Testing
- Accelerated Intermittent Theta Burst Stimulation (iTBS)
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Istanbul University - Cerrahpasa
Multiple Sclerosis, Major Depressive Disorder
Acceptability and Feasibility of Transcranial Magnetic Stimulation (TMS) for Depression in Multiple Sclerosis
The goal of this single-arm, observational pilot study is to learn about the safety, feasibility, preliminary efficacy of TMS for the treatment of depression in people with MS.
- Conditions
- Multiple Sclerosis, Major Depressive Disorder, Treatment Resistant Depression
- Trial name
- NCT06329414
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Utah
Treatment-Resistant Major Depressive Disorder
Understanding Music and Mindfulness Preferences in Psilocybin-Assisted Psychotherapy
The goal of this pilot clinical trial is to learn whether it is feasible to individually tailor psilocybin-assisted psychotherapy (PAP) for people with treatment-resistant depression (TRD) based on their personal preferences.
- Trial name
- PPP (NCT07373535)
- Testing
- Psilocybin 25mg, Music-centered psilocybin-assisted therapy, Mindfulness-centered psilocybin-assisted therapy
- Where
- 2 sites in Canada
- Volunteers
- 16 people
- Sponsor
- Kyle Greenway
Major Depression Disorder
Molecular Signatures of TMS Response in Treatment-Resistant Depression
Transcranial Magnetic Stimulation (TMS) therapy is an approved and effective treatment option for treatment-resistant depression (TRD).
- Trial name
- PROMET_TMS (NCT07039370)
- Testing
- TMS
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Gulhane Training and Research Hospital
Treatment Resistant Depression, Chronic Pain
Treatment With Psilocybin for Chronic Neuropathic Pain and Depression (TRANSCEND)
Psilocybin, the chemical component of "magic mushrooms", has been administered with psychotherapy in several randomized clinical trials (RCTs) showing large and sustained antidepressant effects.
- Trial name
- TRANSCEND (NCT06518720)
- Testing
- Psilocybin 25 mg
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Centre for Addiction and Mental Health
Depression
Effectiveness of Pramipexole for Treatment-Resistant Depression
This study will evaluate the effectiveness of pramipexole (Mirapex) in managing treatment-resistant depression.
- Trial name
- NCT00231959
- Testing
- Pramipexole (Mirapex)
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Massachusetts General Hospital