Clinical trials: Resistant Hypertension, open to volunteers
Adolescent Obesity, Hypertension,Essential
Treatment and Handling Severe Obesity-Related Comorbidities in Adolescents Through Exercise
The main objective of this project is to analyze the effect of a tailor-made, one-to-one, exercise program (aiming to treat and handle obesity-related comorbidities in adolescents with severe obesity at high risk of…
- Conditions
- Adolescent Obesity, Hypertension,Essential, Non-Alcoholic Fatty Liver Disease, Dyslipidemias
- Trial name
- THOR-X (NCT06520800)
- Testing
- Treatment and handling obesity-related comorbidities in adolescents through exercise
- Volunteers
- 24 people
- Sponsor
- University of Lisbon
MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease, Cirrhosis
MASLD in Type 2 Diabetes in Primary Care - a Follow-up Study
The goal of this observational study is to understand how metabolic dysfunction-associated steatotic liver disease (MASLD) changes over time in individuals with type 2 diabetes who previously participated in the EPSONIP study.
- Conditions
- MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease, Cirrhosis, Advanced Fibrosis, Sarcopenia
- Trial name
- EPSOMIP2 (NCT07312136)
- Where
- Sweden
- Volunteers
- 317 people
- Sponsor
- Linkoeping University
Pulmonary Artery Hypertension
Endothelial Cell Activation and Total Pulmonary Resistance in PAH
To determine whether changes in endothelial cell dysfunction are associated with changes in total pulmonary resistance in patients with pulmonary arterial hypertension
- Trial name
- NCT06035861
- Testing
- XBD173
- Volunteers
- 6 people
- Sponsor
- Imperial College London
Morbid Obesity, Type2diabetes
Comorbidities Resolution After MGB Surgery and Change in Body Composition
This observational study aims to learn about the correlation between the improving comorbidities associated with obesity after MGB (Mini-Gastric Bypass) surgery and changes in body composition in morbidly obese patients.
- Conditions
- Morbid Obesity, Type2diabetes, Sleep Apnea, Hypothyroidism
- Trial name
- MOGAMBO (NCT06015620)
- Testing
- Mini gastric bypass surgery
- Where
- India
- Volunteers
- 35 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Cardiometabolic Syndrome, Physical Inactivity
Black Impact: The Mechanisms Underlying Psychosocial Stress Reduction in a Cardiovascular Health Intervention
Lower attainment of cardiovascular health (CVH), indicated by the American Heart Association's Life's Simple 7 (LS7; physical activity, diet, cholesterol, blood pressure, body mass index, smoking, glycemia) and Life's Essential 8…
- Conditions
- Cardiometabolic Syndrome, Physical Inactivity, Hypertension, Type 2 Diabetes
- Trial name
- NCT06055036
- Testing
- Black Impact Intervention
- Where
- United States
- Volunteers
- 340 people
- Sponsor
- Ohio State University
Metabolic Syndrome, Diabetes
Evaluation of a Novel Self-Sampling Earwax Tool for Chronic Disease Biomarkers [TREARS STUDIES II]
Trears Biomarkers: A New Way to Manage Chronic Diseases Trears Biomarkers are changing how we care for chronic diseases by focusing on patients' needs.
- Conditions
- Metabolic Syndrome, Diabetes, Hypertension, Obesity and Obesity-related Medical Conditions
- Trial name
- Trears-II (NCT06932601)
- Volunteers
- 258 people
- Sponsor
- Trears
High Altitude, Healthy
Assessment of Total Pulmonary Resistance sPAP/CO Between Sea Level LA vs. High Altitude HA After Re-ascent in Healthy Individuals
To study the effect of a re-ascent after a one-week stay at sea level (after prior descent from 2850m) to high altitude (Quito Ecuador: 2850m) on pulmonary resistance (sPAP/CO) and other hemodynamic outcomes in healthy…
- Conditions
- High Altitude, Healthy, Healthy Adult, High Altitude Effects
- Trial name
- NCT07804589
- Testing
- Re-Ascent from sea level to 2850m
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Silvia Ulrich Somaini
Hypertension, Resistant to Conventional Therapy
Antihypertensive Mechanisms of Minocycline in Resistant Hypertension
The goal of this clinical trial is to learn about the mechanisms by which minocycline effect blood pressure in individuals with treatment-resistant hypertension.
- Trial name
- NCT06246396
- Testing
- Minocycline Hydrochloride
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Florida
MASH, MASLD
Global Research Initiative for Patients Screening on MASH
GRIPonMASH will assist (primary) health care providers clinicians to implement the latest patient care pathway, as described by the European Association for the Study of the Liver (EASL), to identify patients at risk of severe…
- Conditions
- MASH, MASLD, MASH With Fibrosis, Fibrosis, Liver
- Trial name
- GRIPonMASH (NCT05651724)
- Where
- 13 sites in Belgium, Czechia and 8 more
- Volunteers
- 10,000 people
- Sponsor
- Julius Clinical
Hypertension, Hypertension (HTN)
Common Carotid Artery-Renal Artery-Femoral Artery Survey for Hypertension
To evaluate both sides of the common carotid artery, renal artery, and femoral artery in Hypertension patient that cause of systemic arterial hypertension and/or the effects of target organ damage, both structural and functional…
- Conditions
- Hypertension, Hypertension (HTN), Artery Disease, Target Organ Damage
- Trial name
- CRF Survey (NCT07760623)
- Testing
- Diameter measurement, Velocity
- Where
- Thailand
- Volunteers
- 100 people
- Sponsor
- DejthidaNathaphong
Blood Pressure Management, Blood Pressure Monitoring, Ambulatory
Impact of Resistance Training Intensity on Blood Pressure
The goal of the clinical trial is to understand the effect of two resistance training protocols employing different loading intensities (% of 1 repetition maximum; 1-RM), but with standardized effort intensity (2 repetitions in…
- Conditions
- Blood Pressure Management, Blood Pressure Monitoring, Ambulatory, Blood Pressure, High, Blood Pressure
- Trial name
- HEART (NCT06845514)
- Testing
- Condition LL-RE, Control, Condition HL-RE
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Resistant Hypertension
A Study Evaluating Aprocitentan Tablets(SYH9108) for the Treatment of Resistant Hypertension
Aprocitentan tablets are currently the only endothelin dual receptor antagonist approved internationally for the treatment of resistant hypertension.This is a multicenter, randomized, double-blind, placebo-controlled Phase 3…
- Trial name
- NCT07635914
- Testing
- Aprocitentan tablets(SYH9108)
- Volunteers
- 382 people
- Sponsor
- CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd.
Obesity, Insulin Resistance
Metabolic Effects of Angiotensin-(1-7)
The overall purpose of this study is to learn more about the metabolic effects of angiotensin-(1-7) in the insulin resistant state associated with obesity.
- Conditions
- Obesity, Insulin Resistance, Hypertension, Metabolic Cardiovascular Syndrome
- Trial name
- NCT02646475
- Testing
- Angiotensin-(1-7), Saline
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Vanderbilt University
Morbid Obesity, Metabolic Syndrome
Impact GLP-1 Agonists Following Bariatric
Glucagon-like peptide 1 (GLP-1) is a hormone that helps regulate blood glucose levels through improved insulin sensitivity and release of insulin from the pancreas, control hunger, induce satiety and plays a role in the metabolic…
- Conditions
- Morbid Obesity, Metabolic Syndrome, Diabetes Mellitus, Hypertension
- Trial name
- NCT06132477
- Testing
- GLP-1 receptor agonist
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Missouri-Columbia
Resistant Hypertension, Secondary Hypertension
Comparison of Catecholamine Concentrations in Venous Blood During Selective Adrenal Artery Embolization
To explore the relationship between perioperative blood pressure and catecholamine concentrations in adrenal venous blood and peripheral venous blood in hypertensive patients with primary aldosteronism (PA) who underwent…
- Conditions
- Resistant Hypertension, Secondary Hypertension, Secondary Hypertension to Endocrine Disorders, Primary Aldosteronism
- Trial name
- NCT06228677
- Testing
- Selective adrenal artery embolization
- Where
- China
- Volunteers
- 196 people
- Sponsor
- First Affiliated Hospital of Chengdu Medical College
Treatment Resistant Hypertension, Chronic Hemodialysis
Effect of Renal Denervation on Bood Pressure in Patients on Hemodialysis
The RDN-HD Study is a prospective, single-center feasibility study. All patients included will undergo endovascular ultrasound-based RDN (no sham group, no blinding).
- Trial name
- RDN-HD (NCT06556407)
- Testing
- renal denervation
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Hypertension, Insulin Resistance Syndrome
Cf-PWV and TyG Index Study
This study aims to investigate how metabolic health is related to arterial stiffness and daily blood pressure patterns. High blood pressure is one of the leading causes of heart disease worldwide, but cardiovascular risk is not…
- Conditions
- Hypertension, Insulin Resistance Syndrome, Arterial Stiffness, Cardiovascular Risk
- Trial name
- RIGID-TyG (NCT07589374)
- Where
- Brazil
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Hospital de Base
Hypertension, Cardiovascular Diseases
Sympathetic-vascular Dysfunction in Obesity and Insulin Resistance (Vitamin C Study)
The main purpose of research is to examine and understanding the development of hypertension in obese adults with insulin resistance.
- Trial name
- NCT04715022
- Testing
- Ascorbic acid solution (American Regent Laboratories Inc.), Saline
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Kansas Medical Center
Hypertension
Effects of Combined High Intensity Interval Training and Resistance Training
Background: Hypertension has long been considered as a major risk factor for cardiovascular disease representing a high public health concern.
- Trial name
- Hypertension (NCT06845436)
- Testing
- Exercise, routine physical activity
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- Prince Sattam Bin Abdulaziz University
Multivessel Coronary Artery Disease, Hypertension Resistant to Conventional Therapy
Expand Management of Blood Pressure With Renal Denervation in Patients Undergoing Staged PCI for Advanced Coronary Artery diseasE
EMBRACE is a randomized, controlled, multicenter clinical study evaluating the effect of renal denervation on clinical adverse events in hypertensive patients undergoing staged percutaneous coronary intervention (PCI) for…
- Trial name
- EMBRACE (NCT07602790)
- Testing
- Renal denervation
- Volunteers
- 1,000 people
- Sponsor
- Ceric Sàrl