Clinical trials: Resistant Infection
Linezolid Resistance, Staphylococcus Aureus
Risk Factors for Linezolid Resistance in Staphylococcus Aureus
This is a retrospective chart review study. The proposed study aims to document the risk factors for quinolone resistance in bloodstream isolates of Klebsiella species.
- Trial name
- NCT00519025
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- University of Pittsburgh
Resistant Infection, Antibiotic Resistant Infection
Impact of Number of Rank of B-lactam Antibiotics on Emergence on Multidrug Resistant Bacteria
This study evaluates the impact of rank of Beta lactam antibiotics on emergence of mutlidrug resistant bacteria colonization in intensive care It's retrospective case controle study.
- Conditions
- Resistant Infection, Antibiotic Resistant Infection, Beta Lactam Resistant Bacterial Infection, Bacterial Resistance
- Trial name
- INOR Blact (NCT03752476)
- Testing
- number of Beta lactam class prescription for the same infection
- Volunteers
- 1,300 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Severe Acute Respiratory Syndrome Coronavirus 2, Metabolic Syndrome
Metformin Glycinate in Patients With MS or DM2 , Hospitalized With COVID-19 and SARS Secondary to SARS-CoV-2
The purpose of this study is to evaluate the efficacy and safety of metformin glycinate at dose of 620 mg twice per day plus standard treatment comparing to standard treatment alone (we will use placebo) of patients who have…
- Conditions
- Severe Acute Respiratory Syndrome Coronavirus 2, Metabolic Syndrome, Type 2 Diabetes
- Trial name
- DMMETCOV19 (NCT04626089)
- Testing
- metformin glycinate
- Where
- Mexico
- Sponsor
- Laboratorios Silanes S.A. de C.V.
Urinary Tract Infections, Prostatitis
Rapid Molecular Organism Identification and Mixed Flora Antibiotic Resistance Profiling (MixAR) Prospective Study
In this protocol, investigators are examining the ability for a novel multiplex PCR assay with mixed floral antibiotic resistance profiling is safe and increases effective treatment for urinary tract infections in a urology…
- Conditions
- Urinary Tract Infections, Prostatitis, Interstitial Cystitis
- Trial name
- RapIDMixAR (NCT03931538)
- Testing
- Guidance 4.0 PCR test, Urine Culture
- Where
- United States
- Volunteers
- 2,511 people
- Sponsor
- Pathnostics
Uncomplicated Urinary Tract Infection, Antibiotic Resistant Infection
Establish the Relationship Between Shift in Prescribing Pattern and Associated Shift in Sensitivity Pattern of Causative Microbes in UTI Patients in a Closed Community
To establish a relationship between changed prescribing pattern and associated shift in sensitivity trend of causative microbes in patients of uncomplicated urinary tract infection in a closed community
- Trial name
- UTI (NCT03716804)
- Testing
- Tablet Nitrofurantoin, Tablet Ciprofloxacin/ Tablet Cefixime/ Tablet Cefuroxime
- Where
- Bangladesh
- Volunteers
- 62 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Clinical Response, Radiological Response
Colistin Versus Colistin Combined With Cefoperazone-sulbactam for Multiresistant Acinetobactor Baumannii Ventilator-associated Pneumonia Treatment
This study aims to evaluate clinical outcomes of colistin versus colistin in combination with cefoperazone-sulbactam for patients with MDR-AB VAP treatment.
- Trial name
- CRAB (NCT07671755)
- Testing
- colistin plus cefoperazone-sulbactam combination group, Colistin
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Shaheed Mohtarma Benazir Bhutto Institue of Trauma
HIV Infections
Safety and Efficacy of ADAPTAVIR's Ability to Eliminate Treatment-Resistant Infectious Virus in Peripheral Blood Mononuclear Cells (PBMCs)
This is a 24 week placebo controlled, double-blind, 2-arm study of ADAPTAVIR, Monomeric Dala1-peptide T-amide (mDAPTA) compared to placebo, in HIV infected individuals with suppressed plasma viral loads < 200 copies/ml by highly…
- Trial name
- NCT00951743
- Testing
- Adaptavir (monomeric DAPTA)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Rapid Laboratories Inc.
Blood Stream Infections, MRSA Infections
Testing Spread and Implementation of Novel Methicillin Resistant Staphylococcal Aureus (MRSA)-Reducing Practices
The purpose of this study is to implement strategies for improved efficiency and waste reduction ("Toyota Lean") and positive deviance, a social behavioral change process, utilizing frontline healthcare personnel to reduce…
- Trial name
- NCT01255943
- Testing
- healthcare staff processes for infection prevention
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- MaineHealth
Sexually Transmitted Diseases, Bacterial, Antibiotic Resistant Infection
The Antibiotic Guardian Study- Clinical Evaluation of a Novel, Rapid Diagnostic for Gonorrhoea and Mycoplasma Infections.
Primary research question: Are novel molecular tests for rapid detection of Mycoplasma and Gonorrhoea infections and antimicrobial resistance sensitive and specific in symptomatic patients attending a sexual health clinic?…
- Trial name
- Guardian (NCT05391035)
- Where
- 2 sites in United Kingdom
- Volunteers
- 160 people
- Sponsor
- Cwm Taf University Health Board (NHS)
Tuberculosis, Drug-resistant Tuberculosis
Rewards for Tuberculosis Contact Screening
This pilot project is an evaluation of the feasibility, acceptability, and cost of offering an economic reward, in the form of a shopping voucher, to the household contacts of index patients (outpatient drug-susceptible and…
- Trial name
- RECON (NCT02234908)
- Testing
- Contacts, Index
- Where
- 2 sites in South Africa
- Volunteers
- 301 people
- Sponsor
- Boston University
Enterobacteriaceae Infections, Community-Acquired Infections
Community-associated Highly-Resistant Enterobacterales
This is a prospective multi-center study. Bacterial isolates from hospitalized patients with CA-HRE will be compared to those from hospitalized patients with healthcare-associated HRE (HA-HRE).
- Conditions
- Enterobacteriaceae Infections, Community-Acquired Infections, Healthcare Associated Infection, Carbapenem-Resistant Enterobacteriaceae Infection
- Trial name
- COCARE (NCT03924934)
- Where
- United States
- Volunteers
- 2,172 people
- Sponsor
- University of North Carolina, Chapel Hill
Infection Wound, Antibiotic Resistant Infection
The Role of Postoperative Antibiotics in Laparoscopic Cholecystectomy
Comparison between postoperative parenteral prophylactic antibiotics, and oral antibiotics regarding the incidence of post laparoscopic cholecystectomy infection.
- Trial name
- NCT06607887
- Testing
- IV antibiotic, Oral antibiotic
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Minia University Hospital
Antibiotic Resistant Infection, Nosocomial Infection
Inulin for Infections in the Intensive Care Unit
Normal gut bacteria prevent colonization and subsequent infection with MDR organisms (MDROs) through competition for resources and other mechanisms.
- Conditions
- Antibiotic Resistant Infection, Nosocomial Infection, Pathogen Transmission, Nutrition Disorders
- Trial name
- NCT03865706
- Testing
- Inulin Oral Suspension, Broad-spectrum antibiotics
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Columbia University
Invasive Aspergillosis
Olorofim Aspergillus Infection Study
The purpose of this study is to compare treatment with olorofim versus treatment with AmBisome® followed by standard of care (SOC) in patients with IFD caused by proven IA or probable lower respiratory tract disease Aspergillus…
- Trial name
- OASIS (NCT05101187)
- Testing
- Olorofim, AmBisome®
- Where
- 143 sites in United States, Australia and 19 more
- Volunteers
- 225 people
- Sponsor
- F2G Ltd
Bacteremia
Vancomycin Versus Daptomycin for the Treatment of Methicillin-resistant Staphylococcus Aureus Bacteremia Due to Isolates With High Vancomycin Minimum Inhibitory Concentrations (MICs)
There is an increased failure rate for the treatment of Staphylococcus Aureus Bacteremia (SAB) with traditional doses of vancomycin, the standard of care for patients with MRSA bacteremia over the last 40 years.
- Trial name
- NCT01287832
- Testing
- Vancomycin, Daptomycin
- Volunteers
- 11 people
- Sponsor
- St. John Health System, Michigan
Hematologic Neoplasms, Gram-Negative Bacterial Infections
Ceftazidime-Avibactam PK/PD and Resistance in Hematology Patients
This is a prospective, single-arm, observational, exploratory clinical study to evaluate whether the standard fixed dose of ceftazidime-avibactam (CAZ-AVI) achieves sufficient drug exposure (pharmacokinetic/pharmacodynamic, or…
- Conditions
- Hematologic Neoplasms, Gram-Negative Bacterial Infections, Pseudomonas Aeruginosa Infection, Klebsiella Pneumoniae Infections
- Trial name
- CZA-TDM (NCT07703644)
- Testing
- Ceftazidime-avibactam, Therapeutic Drug Monitoring (TDM) and Microbiological Surveillance
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Sizhou Feng
Antibiotic Resistant Infection
Effectiveness of Chlorhexidine Wipe for Prevention of Multidrug-resistant Organisms in Intensive Care Unit Patients
The purpose of this study is to determine 2% chlorhexidine wipes are effective in preventing of colonization of multi-drug resistant bacteria in intensive care unit patients.
- Trial name
- NCT01989416
- Testing
- 2% chlorhexidine wipe, Soap
- Where
- Thailand
- Volunteers
- 481 people
- Sponsor
- Mahidol University
Resistance Bacterial, Enterobacteriaceae Infections
Understanding and Modeling Reservoirs, Vehicles and Transmission of ESBL-producing Enterobacteriaceae in the Community and Long Term Care Facilities
The continuing spread of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) is among the most important problems in antimicrobial resistance.
- Trial name
- MODERN (NCT03477084)
- Testing
- ESBL-producing enterobacteriaceae carriage
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
HIV Infections, HIV-1-infection
HIV Drug Resistance Pattern Due to Migration in Poland
According to the Polish governmental statistics migration of people from Ukraine to Poland is growing and only in year 2020 have come to Poland about a quarter of a million of Ukrainian migrants.
- Conditions
- HIV Infections, HIV-1-infection, Resistant Infection
- Trial name
- NCT04636736
- Testing
- HIV drug resistance testing
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Warsaw
Acute Otitis Media
Reduced Clavulanate Formulation of Amoxicillin-Clavulanate in Children 6-23 Months With Acute Otitis Media
To evaluate the safety profile of amoxicillin-clavulanate potassium containing a reduced concentration of clavulanate potassium, 600 mg/21.5 mg/5 mL (a ratio of 28:1), administered at 90/3.2 mg/kg/day (formulation 1) or at…
- Trial name
- NCT02630992
- Testing
- Amoxicillin-Clavulanate potassium
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Nader Shaikh
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