Clinical trials: Resistant Infection
Helicobacter Pylori Infection
Genotypic Resistance-guided Versus Empirical Therapy for H. Pylori Eradication.
This study aims to investigate the efficacy of a 7-day genotypic resistance-guided triple therapy, compared with empirical concomitant therapy, for first-line eradication of H. pylori.
- Trial name
- NCT04090021
- Testing
- Esomeprazole 40mg, Clarithromycin 500mg, Metronidazole 500 mg
- Where
- Greece
- Volunteers
- 304 people
- Sponsor
- Konstantopoulio-Patission General Hospital of Nea Ionia
Pulmonary Tuberculoses, Aspergillosis
Pulmonary Aspergillosis in Tuberculosis Patients
Pulmonary tuberculosis (PTB) is the most common cause of lung destruction, contributing to coinfections development, and Aspergillosis spp. is one of the most important.
- Conditions
- Pulmonary Tuberculoses, Aspergillosis, Old Tuberculosis, Active Tuberculosis
- Trial name
- NCT05045391
- Testing
- Aspergillus IgG detection
- Where
- Uzbekistan
- Volunteers
- 200 people
- Sponsor
- Research Institute of Epidemiology, Microbiology and Infectious Diseases, Uzbekistan
Inflammatory Bowel Disease, Hepatobiliary Disease
Risk of Methicillin-resistant S.Aureus (MRSA) Infections in MRSA Carrier Under Introduction of Rapid MRSA Screening
This study was designed to evaluate the effect of a targeted preoperative Methicillin-resistant Staphylococcus aureus (MRSA) detection by polymerase chain reaction (PCR) on either endogenous or exogenous postoperative MRSA…
- Conditions
- Inflammatory Bowel Disease, Hepatobiliary Disease, Pancreas Disease
- Trial name
- NCT01918813
- Testing
- vancomycin, mupirocin ointment
- Where
- Japan
- Volunteers
- 662 people
- Sponsor
- Chikara Tashiro
Solid Tumors and Hematologic Malignancy
An Open-Label, Dose-Escalation Study of INCB054329 in Patients With Advanced Malignancies
This was a study of INCB054329 given to patients with advanced malignancies that were conducted in three treatment groups. Each treatment group had a dose escalation (Part 1) and a dose expansion (Part 3), two of the treatment…
- Trial name
- NCT02431260
- Testing
- INCB054329 Monotherapy
- Where
- 12 sites in United States
- Volunteers
- 69 people
- Sponsor
- Incyte Corporation
Healthy Subjects
Safety, Tolerability, Pharmacokinetics and Food Effects Study of PBTZ169
Open-label prospective non-comparative ascending dose randomized cohort study of single and multiple oral administration of PBTZ169 (capsules 80 mg) in healthy volunteers
- Trial name
- NCT04150224
- Testing
- PBTZ169 640 mg OD, PBTZ169 640 mg BiD, PBTZ169 960 mg SD
- Where
- Russia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nearmedic Plus LLC
Escherichia Coli; Infection, Intestinal
Study of the Ecological and Evolutionary Dynamics of Escherichia Coli in the Digestive Commensal Flora
Escherichia coli (E. coli) poses a major public health problem. E. coli is not only a commensal of the digestive tract but also a major opportunistic pathogen, first cause of urinary tract infections, first cause of bacteremia.
- Trial name
- EVE (NCT05153824)
- Where
- 2 sites in France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Common Cold
Experimental Human Rhinovirus Infection
Our primary objective is to set up the Human Rhinovirus (HRV)-model in our centre. In addition, to facilitate future clinical trials, we want to determine optimal read-out parameters and read-out time points for experimental HRV…
- Trial name
- EHRVI (NCT01823640)
- Testing
- Human Rhinovirus strain 16 (HRV-16)
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Staphylococcus Aureus Bacteremia, Staphylococcus Aureus Endocarditis
Direct Lysis of Staph Aureus Resistant Pathogen Trial of Exebacase
The purpose of this superiority study is to evaluate the efficacy and safety of exebacase in addition to standard of care antibiotics (SoCA) compared with SoCA alone for the treatment of patients with Staphylococcus aureus (S.
- Trial name
- DISRUPT (NCT04160468)
- Testing
- Exebacase
- Where
- 55 sites in United States
- Volunteers
- 259 people
- Sponsor
- ContraFect
Bacterial Infections
A Single Dose Study of Debio 1450 in Healthy Subjects
The sponsor is trying to develop a medicine for infections that are not cured by regular antibiotics. They have an experimental drug called Debio 1450 that may work. They need about 48 healthy adults to volunteer for this study.
- Trial name
- NCT02162199
- Testing
- Debio 1450
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Debiopharm International SA
Infections, Bacterial
In Vitro Activity of Tigecycline Among Key Bacterial Pathogens Exhibiting Multidrug Resistance
Observational: studies in human beings in which biomedical and/or health outcomes are assessed in pre-defined groups of individuals.
- Trial name
- NCT01132417
- Testing
- In Vitro activity of Tigecycline among key bacterial pathogens exhibiting multidrug resistance
- Where
- Saudi Arabia
- Volunteers
- 500 people
- Sponsor
- King Faisal University
Carbapenem-Resistant Acinetobacter Baumannii Infection
Targeted Antimicrobial Comparison for Treatment Individualization in Critically Ill Patients With CRAB Infection
The goal of this prospective, multicenter observational study is to learn which antibiotic treatment strategies are associated with better outcomes in critically ill adults with severe infections caused by carbapenem-resistant…
- Trial name
- TACTIC-CRAB (NCT07905235)
- Testing
- Antibiotic Therapy for CRAB Infection
- Volunteers
- 1,000 people
- Sponsor
- Central South University
HIV Infections, Tuberculosis
A Prospective Study of Multidrug Resistance and a Pilot Study of the Safety of and Clinical and Microbiologic Response to Levofloxacin in Combination With Other Antimycobacterial Drugs for Treatment of Multidrug-Resistant Pulmonary Tuberculosis (MDRTB) in HIV-Infected Patients.
To determine the demographic, behavioral, clinical, and geographic risk factors associated with the occurrence of multidrug-resistant pulmonary tuberculosis (MDRTB).
- Trial name
- NCT00000796
- Testing
- Cycloserine, Ethionamide, Capreomycin sulfate
- Where
- 21 sites in United States
- Volunteers
- 525 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Chronic Hepatitis c, Metabolic Syndrome
Statins in Chronic Hepatitis C Patients Receiving Sofosbuvir/Daclatasvir Combination
The purpose of the study is to determine if statin can affect the clinical outcome of chronic hepatitis C patients receiving Sofosbuvir/Daclatasvir/Ribavirin combination
- Trial name
- NCT03490097
- Testing
- Simvastatin 10mg, sofosbuvir plus daclatasvir
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Candidiasis, HIV Infections
Incidence of Oral Candidiasis, Prevalence of C. Dubliniensis in HIV Patients and In-vitro Azole Susceptibility
C. dubliniensis has been identified as pathogen in Oropharyngeal Candidiasis(OPC)particularly among HIV patients. Azole therapy is a cornerstone in OPC, but resistance within C.
- Trial name
- ICONIC (NCT00692783)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Florida
Aspergillus Fumigatus Infection
AspergillusOne-Health: Deciphering Azole Resistance in Aspergillus Fungi Using a One Health Approach
During a two year prospective study onpatients from department's hospitals and centralized by the pneumology department Nantes CH,all respiratory clinical samples will be cultivated for Aspergillus isolation…
- Trial name
- AspergillusOH (NCT06532227)
- Testing
- No intervention
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Nantes University Hospital
AIDS, HIV Infection
The Adult Antiretroviral Treatment and Resistance Study (Tshepo)
The "Adult Antiretroviral Treatment and Resistance Study," hereafter referred to as "The Tshepo Study," is the first large-scale research study of antiretroviral therapy to treat AIDS and HIV infection in Botswana.
- Trial name
- NCT00197613
- Testing
- (A) zidovudine, lamivudine and nevirapine, (B) zidovudine, lamivudine and efavirenz, (C) zidovudine, didanosine, and nevirapine
- Where
- Botswana
- Volunteers
- 650 people
- Sponsor
- Harvard School of Public Health (HSPH)
Pneumonia, Staphylococcal, Methicillin-Resistant Staphylococcus Aureus
Aerosolized Vancomycin in Methicillin-Resistant Staphylococcus Aureus Pneumonia Under Mechanical Ventilation
The purpose of this study is to determine whether aerosolized vancomycin is effective in the treatment of methicillin-resistant staphylococcus aureus pneumonia under mechanical ventilation.
- Trial name
- NCT01925066
- Testing
- Vancomycin
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Seoul National University Hospital
Antibiotic Resistance, Respiratory Tract Infections
CRP for Respiratory Diagnosis in Kyrgyz Pediatric Practice
Rationale: Overuse of antibiotics globally is leading to increasing rates of antibiotic resistance and may lead to a 'post-antibiotic' era.
- Conditions
- Antibiotic Resistance, Respiratory Tract Infections, Pediatric Infectious Disease, CRP
- Trial name
- COORDINATE (NCT05195866)
- Testing
- CRP POCT (C-reactive protein point of care test)
- Where
- Kyrgyzstan
- Volunteers
- 1,204 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Helicobacter Pylori Infection
Simplified Dual Regimen Guided by Fecal Clarithromycin Resistance Gene Detection for First-line H. Pylori Eradication
To investigate the efficacy, safety, and compliance of a simplified strategy using vonoprazan plus clarithromycin for first-line treatment in patients with Helicobacter pylori infection, among those infected with strains without…
- Trial name
- NCT07439445
- Testing
- Vonoprazan 20 mg twice daily + clarithromycin 500 mg twice daily for 14 days
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Peking University First Hospital
Carbapenem-Resistant Enterobacteriaceae Infection
Fecal Microbiota Transplantation for Carbapenem-resistant Enterobacteriaceae
2:1, open-label, single center, randomized controlled trial comparing FMT vs. no intervention for CRE carriers,
- Trial name
- NCT04146337
- Testing
- FMT
- Where
- Israel
- Volunteers
- 3 people
- Sponsor
- Rambam Health Care Campus
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