Clinical trials: Resistant Infection
HIV-1-infection, Metabolic Syndrome
Assessing Virologic Success and Metabolic Changes in Patients Switching From a TDF to TAF Containing Antiretroviral Therapy Regimen
Switching patients with HIV infection from tenofovir disoproxil fumarate (TDF) to a tenofovir alafenamide (TAF) based drug regimen can provide many safety benefits including preserving bone mineral density and kidney function.
- Conditions
- HIV-1-infection, Metabolic Syndrome, Cardiovascular Diseases, Weight Gain
- Trial name
- NCT03646370
- Testing
- Tenofovir Alafenamide
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Thomas Jefferson University
Sepsis
Procalcitonin Monitoring May Decrease Antibiotic Use in the Intensive Care Unit
Sepsis is common and is associated with significant mortality, morbidity and health-care costs. Unfortunately, its diagnosis is not straightforward because its signs and symptoms are neither specific nor sensitive; in addition…
- Trial name
- NCT01085994
- Testing
- Literature search
- Where
- Greece
- Sponsor
- University of Athens
HIV
Ibalizumab Plus Optimized Background Regimen in Treatment-Experienced Patients With Multi-Drug Resistant HIV-1
Ibalizumab is a monoclonal antibody that works by blocking HIV entry into the immune system cells (CD4+ or T-cells) the virus typically infects.
- Trial name
- NCT02707861
- Testing
- ibalizumab, Optimized Background Regimen
- Where
- 32 sites in United States, Puerto Rico
- Volunteers
- 79 people
- Sponsor
- TaiMed Biologics Inc.
Malaria, Vivax
Artesunate Plus Sulfadoxine-Pyrimethamine Versus Chloroquine for Vivax Malaria
The purpose of this study was to determine whether the proposed first line treatment for falciparum malaria in this region (sulfadoxine-pyrimethamine + artesunate) would be no worse a treatment for vivax malaria that the standard…
- Trial name
- NCT00486694
- Testing
- Sulfadoxine-pyrimethamine + artesunate, Chloroquine
- Volunteers
- 190 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Tick-borne Diseases, Tick Resistance
Human Immune Response to Ixodes Scapularis Tick Bites
Background: Each year, the number of cases of tick-borne diseases increases. The deer tick (Ixodes scapularis) is the vector of at least 7 pathogens that cause human diseases, including Lyme disease.
- Conditions
- Tick-borne Diseases, Tick Resistance, Lyme Disease
- Trial name
- NCT05036707
- Testing
- Xenodiagnosis Ticks, skin biopsy, blood draw
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Colistin Adverse Reaction
Colistin Dosage Prsonalization Approach
A few studies have evaluated higher doses or the administration or a loading dose, which is routine in adults, in pediatric patients, and reported improved colistin exposure without an increased risk of nephrotoxicity The main…
- Trial name
- NCT06472271
- Testing
- Polymyxin e
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mahmoud I Mostafa
Staphylococcus Haemolyticus, Staphylococcal Infections
Staphylococcus Haemolyticus in the Neonatal Intensive Care Unit of CHSD in 2023: Analysis and Trends
This study looks at cases of Staphylococcus haemolyticus infections in newborns hospitalized in the Neonatal Intensive Care Unit (NICU) at the Saint-Denis Hospital in 2023.
- Conditions
- Staphylococcus Haemolyticus, Staphylococcal Infections, Sepsis, Catheter-Related Infections
- Trial name
- NCT07013864
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Centre Hospitalier de Saint-Denis
Community-Acquired Infections, Methicillin-resistant Staphylococcus Aureus
CA-MRSA Infection in China: Epidemiology, Molecular Characteristics, Treatment, and Outcome
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA), strains of MRSA that are able to infect otherwise healthy people outside of hospital settings, emerged in the late 1990s and have recently arisen in many…
- Trial name
- NCT03064464
- Testing
- None Intervention
- Where
- China
- Volunteers
- 5,400 people
- Sponsor
- Sir Run Run Shaw Hospital
HIV Infection
Prevalence of Drug-resistant Hiv-1 Strains in Patients Experiencing Virologic Failure. (MULTIVIR2025)
In this cross-sectional, national and multicenter study, the main objective is to determine the prevalence of multi-drug resistant viruses (i.e., viruses that are resistant or possibly resistant to at least one antiretroviral…
- Trial name
- MULTIVIR2025 (NCT06842706)
- Volunteers
- 800 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Clostridioides Difficile Infection
Lyophilized Fecal Microbiome Transfer vs. Vancomycin Monotherapy for Primary Clostridioides Difficile Infection
The goal of this clinical trial is to test whether lyophilized fecal microbime transfer - a dried extract of bacteria from the stool of healthy donors - is better than antibiotic therapy only for treating primary clostridioides…
- Trial name
- DONATE (NCT05709184)
- Testing
- Lyophilized fecal microbiome transfer, Vancomycin
- Where
- 6 sites in Canada, Hungary and 4 more
- Volunteers
- 196 people
- Sponsor
- Rambam Health Care Campus
Malaria
Impact of Insecticide-treated Curtains on Antimalarial Drug Resistance
Attempts to understand the relationship malaria transmission intensity and antimalarial drug resistance had rested mainly on mathematical models.
- Trial name
- NCT00169078
- Testing
- Chloroquine
- Where
- Burkina Faso
- Volunteers
- 1,035 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Ascariasis
Follow-up Assessment of Change in Soil-transmitted Helminths Infection Intensity in Uganda
The goal of this prospective follow-up study nested within an open-label randomized controlled trial is to investigate the unexpectedly high prevalence of Ascaris lumbricoides infection observed 3-4 months after school-based mass…
- Trial name
- FACEIT-FU (NCT07873398)
- Testing
- Albendazole 400mg, Ivermectin 3 mg
- Where
- Uganda
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Jennifer Keiser
Chronic Hepatitis C, Insulin Resistance
Pegylated-Interferon and Ribavirin Plus Metformin in the Treatment of Chronic HCV Infection and Insulin Resistance
Chronic hepatitis C virus (HCV) infection is associated with an increased risk for the development of type 2 diabetes and HCV infection itself may promote insulin resistance, irrespective of the severity of liver disease.
- Trial name
- NCT00370617
- Testing
- metformin
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Turin, Italy
Antibiotic Resistant Infection
Modified Surface of PLGA Nanoparticles in Smart Hydrogel
Nanoparticles containing antibiotic were prepared and incorporated in in situ gel to treat recurrent endodontic infections
- Trial name
- NCT05442736
- Testing
- Ciprofloxacin
- Where
- Egypt
- Volunteers
- 55 people
- Sponsor
- British University In Egypt
Chronic Hepatitis C, Insulin Resistance
Pioglitazone vs. Placebo in Association With Pegylated Interferon and Ribavirin in HCV Patients With Insulin Resistance
The purpose of this study is to test whether the correction of insulin resistance with pioglitazone, will improve the response to antiviral treatment.
- Trial name
- PEGLIST C (NCT00927290)
- Testing
- Pioglitazone
- Where
- France
- Volunteers
- 40 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
Methicillin-resistant Staphylococcus Aureus
Cluster Randomized Trial of Hospitals to Assess Impact of Targeted Versus Universal Strategies to Reduce Methicillin-resistant Staphylococcus Aureus (MRSA) in Intensive Care Units (ICUs)
The Randomized Evaluation of Decolonization versus Universal Clearance to Eliminate MRSA (REDUCE MRSA) Trial is a cluster randomized trial of the comparative effectiveness of three strategies to prevent methicillin-resistant…
- Trial name
- REDUCE-MRSA (NCT00980980)
- Testing
- Chlorhexidine bath and nasal mupirocin
- Where
- 42 sites in United States
- Volunteers
- 74,256 people
- Sponsor
- Harvard Pilgrim Health Care
Pulmonary Infection, Pneumonia, Bacterial
Eravacycline Combination Therapy for MRAB
The goal of this observational study is to learn about the eravacycline combination therapy in multidrug-resistant acinetobacter gaumannii pneumonia. The main question is to evaluate the the effectiveness and safety.
- Conditions
- Pulmonary Infection, Pneumonia, Bacterial, Acinetobacter Baumannii
- Trial name
- NCT06282835
- Testing
- Eravacycline Injection
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Fujian Medical University Union Hospital
Hospital-acquired Pneumonia, Antibiotic Resistant Infection
Chinese Hospital Acquired Pneumonia Collaboration Network: Epidemiology, Diagnosis and Treatment
The goal of this prospective and observatory study is to learn about the pathogen, clinical manifestations, prognosis, treatment and antibiotic resistance of bacteria in hospital-acquired pneumonia patients in China.
- Trial name
- CHAPTER (NCT06028217)
- Testing
- prognosis status
- Volunteers
- 4,000 people
- Sponsor
- Ruijin Hospital
COVID-19, Bacterial Infections
Incidence of Colonization by Multidrug-resistant Organisms in Mechanically Ventilated Patients With Severe COVID-19
Retrospective single-center cohort study to evaluate the incidence of colonization by multidrug-resistant organisms (MDRO) in mechanically ventilated patients admitted to a large intensive care unit (ICU) for severe acute…
- Conditions
- COVID-19, Bacterial Infections, Colonization, Asymptomatic
- Trial name
- MDR_in_Fiera (NCT05293418)
- Testing
- data collection
- Where
- Italy
- Volunteers
- 435 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
HIV Infection
Screening Protocol To Determine Eligibility For Studies Of The Chemokine Coreceptor 5 (CCR5) Antagonist GW873140
The purpose of this study is to determine eligibility for one of three treatment studies of the CCR5 antagonist GW873140 or an observational study without GW873140.
- Trial name
- NCT00123890
- Testing
- GW873140
- Where
- 42 sites in United States, Belgium and 3 more
- Sponsor
- GlaxoSmithKline
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