Clinical trials: Resistant Infection
Bacterial Infections, Antibiotic Resistant Infection
Antibiotic Profile of Pathogenic Bacteria Isolated in Public Hospitals in Northern Jordan
The main aim of the study was to identify the various pathogens associated with surgical site infections and their antibiotic susceptibility in a governmental hospital in northern Jordan.
- Conditions
- Bacterial Infections, Antibiotic Resistant Infection, Surgical Site Infection
- Trial name
- NCT05106803
- Testing
- ciprofloxacin
- Where
- Jordan
- Volunteers
- 24 people
- Sponsor
- Yarmouk University
HIV Infection, Hepatitis C
Improving Fibrosis Outcomes With Metformin
This study will evaluate the role of Metformin on liver fibrosis in HCV-HIV co-infected and HCV mono-infected patients with insulin resistance receiving DAA HCV treatment.
- Trial name
- NCT02306070
- Testing
- Metformin, No metformin treatment
- Where
- Canada
- Sponsor
- Ottawa Hospital Research Institute
HIV Infections, Hepatitis B
Treatment of Hepatitis in Patients Who Are Triple-Infected With HIV, Hepatitis B Virus (HBV), and Hepatitis C Virus (HCV)
This study will investigate the safety and effectiveness of using adefovir dipivoxil (ADV), pegylated interferon (PEG-INF), and ribavirin (RBV) in patients triple-infected with hepatitis B virus (HBV), hepatitis C virus (HCV)…
- Conditions
- HIV Infections, Hepatitis B, Hepatitis C
- Trial name
- NCT00051077
- Testing
- Adefovir dipivoxil, Peginterferon-alfa-2A, Ribavirin
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Enteric Fever
Meropenem vs Azithromycin Efficacy in Case XDR Enteric Fever
1. Primary Objective: o To evaluate the efficacy of intravenous azithromycin compared with meropenem in the treatment of extensively drug-resistant (XDR) enteric fever. 2.
- Trial name
- NCT07314281
- Testing
- Azithromycin, Meropenem Injection
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Indus Hospital and Health Network
Acute Otitis Media
Efficacy of Short-Course Antimicrobial Treatment for Children With Acute Otitis Media and Impact on Resistance
The investigators will study whether, in young children with acute otitis media (AOM), shortening length of antibiotic treatment as a strategy for reducing antimicrobial resistance provides satisfactory clinical outcome.
- Trial name
- NCT01511107
- Testing
- Amoxicillin-Clavulanate, 10 days, Amoxicillin-Clavulanate, 5 days
- Where
- 2 sites in United States
- Volunteers
- 520 people
- Sponsor
- Alejandro Hoberman
Methicillin Resistance in Staphylococcus Aureus (MRSA)
Farm-originated Antimicrobial Resistance Modeling: Exploring Humans-to-Animal Dissemination
Antimicrobial resistance is a major public health issue. Methicillin resistance in Staphylococcus aureus (MRSA) is one of the indicators that is monitored particularly closely.
- Trial name
- FARMHAND (NCT07898930)
- Testing
- Sample collection
- Where
- 2 sites in France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier de Saint-Brieuc
Community-acquired Pneumonia
Study of Ingaron's Effect on Efficacy and Resistance to Antibiotics in Community-acquired Pneumonia
The primary purpose of this study is to effect of Ingaron®, a lyophilisate for the preparation of a solution for intramuscular and subcutaneous administration of 100,000 IU (LLC NPP Farmaklon, Russia) on the effectiveness of…
- Trial name
- NCT05395702
- Testing
- Interferon-Gamma
- Where
- Russia
- Volunteers
- 114 people
- Sponsor
- SPP Pharmaclon Ltd.
HIV Infections, Syphilis
Estimating the Incidence of HIV Infection Among Men Who Have Sex With Men in Peru and Ecuador
The purpose of this observational study is to estimate the number of new HIV infections and the number and variability of antiretroviral-resistant HIV strains among men who have sex with men (MSM).
- Conditions
- HIV Infections, Syphilis, Sexually Transmitted Diseases
- Trial name
- NCT00279331
- Where
- 6 sites in Ecuador, Peru
- Volunteers
- 2,608 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tuberculosis, Multidrug-Resistant
Treatment Shortening of MDR-TB Using Existing and New Drugs
The purpose of this study is to compare the efficacy of a 'new treatment regimen including delamanid, linezolid, levofloxacin, and pyrazinamide for nine or twelve months (investigational arm)' and 'the standard treatment regimen…
- Trial name
- MDR-END (NCT02619994)
- Testing
- Linezolid, Delamanid, Levofloxacin
- Where
- South Korea
- Volunteers
- 214 people
- Sponsor
- Seoul National University Hospital
Antimicrobial Resistance (AMR)
NCCR AntiResist:: New Approaches to Combat Antibiotic-resistant Bacteria
This is an explorative, mono-center study including prospectively collected patient samples from the University Hospital of Basel.
- Trial name
- AntiResist (NCT05017766)
- Testing
- analysis of antimicrobial resistance
- Where
- Switzerland
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Nonneoplastic Condition
Vaccine Therapy, Incomplete Freund's Adjuvant, and GM-CSF in Treating Patients With HIV
RATIONALE: Vaccines made from peptides may help the body build an effective immune response. Incomplete Freund's adjuvant may stimulate the immune system in different ways and may help the vaccine work better.
- Trial name
- NCT00381875
- Testing
- E1M184V peptide vaccine, incomplete Freund's adjuvant, sargramostim
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Linezolid, Tuberculosis Multi Drug Resistant Active
Linezolid Tolerance During the BPaL Regimen With Dosage Personalization Based on Therapeutic Drug Monitoring (TDM) During Multidrug-Resistant Tuberculosis Treatment
Multidrug-resistant tuberculosis (MDR-TB) poses a significant challenge to global public health. Globally, the World Health Organization (WHO) estimates the number at 400,000 patients with MDR-TB for 2023.
- Conditions
- Linezolid, Tuberculosis Multi Drug Resistant Active, Therapeutic Drug Monitoring (TDM)
- Trial name
- PLOT-TB (NCT07477119)
- Testing
- Linezolid dose personalization based on TDM
- Where
- Guinea
- Volunteers
- 150 people
- Sponsor
- Marco Schiuma
Chronic Hepatitis B - Antiviral Drug Resistance - Hepatitis B Virus (HBV) Infection
Prevalence and Risk Factors of Antiviral Resistance in Egyptian HBV Patients
This study aims to determine the prevalence of antiviral drug resistance among Egyptian patients with chronic hepatitis B virus (HBV) infection and to identify the associated demographic, clinical, and virological risk factors.
- Trial name
- PRARE-CHB (NCT07274345)
- Volunteers
- 2,000 people
- Sponsor
- Amira Mohamed Zidan
Drug Resistance, Carbapenem-Resistant Enterobacteriaceae Infection
Optimizing Antibiotic Dosing Regimens for the Treatment of Infection Caused by Carbapenem Resistant Enterobacteriaceae
The purpose of this study is to evaluate the treatment outcomes in patients with CRE infections.
- Conditions
- Drug Resistance, Carbapenem-Resistant Enterobacteriaceae Infection, Sepsis, Septic Shock
- Trial name
- NCT04516395
- Testing
- Combined antibiotic regimens, Standard antibiotic regimens
- Where
- Thailand
- Volunteers
- 102 people
- Sponsor
- Phramongkutklao College of Medicine and Hospital
Cytomegalovirus Infections
Letermovir Treatment for Refractory or Resistant Cytomegalovirus Infection
The trial will evaluate the safety and efficacy of letermovir antiviral treatment of active cytomegalovirus infection or cytomegalovirus disease in patients with infections that are refractory or resistant to available treatments…
- Trial name
- NCT03728426
- Testing
- Letermovir
- Where
- 4 sites in United States
- Volunteers
- 10 people
- Sponsor
- Amy C. Sherman, MD
Survival
Metabolic Syndrome and Long-term Survival Following Liver Resection
Although hepatitis C virus (HCV) infection remains one of the main causes of hepatocellular carcinoma (HCC) worldwide, metabolic syndrome, with its increase in prevalence, has become an important and significant risk factor for…
- Trial name
- NCT05568576
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Assiut University
Antibiotic Resistant Infection, Carbapenem-Resistant Enterobacteriaceae Infection
Interventions to Decrease CRE Colonization and Transmission Between Hospitals, Households, Communities and Domesticated Animals
Carbapenem resistant Enterobacteriaceae (CRE) colonization of patients discharged from hospitals is a source of transmission to the community.
- Trial name
- I-CRECT (NCT05871476)
- Testing
- Hospital Cohort Care Intervention at the hospital, , Household Education Communication Hygiene Intervention, Livestock Antibiotic Intervention
- Where
- Vietnam
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Hanoi University of Public Health
Isolation of Enterococci From Samples, Demonstration of Enterococci Antibiotic Susceptibility
Phenotypic and Genotypic Variations of Enterococcus Spp
Enterococci are Gram-positive facultative anaerobic cocci arranged in short and medium chains. Enterococci reside in the gastrointestinal tract and usually function commensally with humans.
- Conditions
- Isolation of Enterococci From Samples, Demonstration of Enterococci Antibiotic Susceptibility, Detection of Strains Enterococci Produce Biofilm, Studying Effect of Nanoparticles on Enterococci Antimicrobial Resistance
- Trial name
- NCT05751317
- Testing
- Culture, Staining:, Biochemical reactions:
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Plasmodium Falciparum
Plasmodium Falciparum Artemisinin Resistance Vietnam
Resistance of Plasmodium falciparum toward Artemisinins, the most important drug for the successful treatment of malaria, has been confirmed in Cambodia.
- Trial name
- NCT01775592
- Testing
- Arterakin (DHA-PPQ)
- Where
- Vietnam
- Volunteers
- 95 people
- Sponsor
- National Institute of Malariology, Parasitology and Entomology, Vietnam
Sepsis
Non-invasive Measurement of CO in Patients With Uncomplicated Sepsis
Little is known about the optimal fluid therapy of patients with uncomplicated sepsis. Most recommendations are extrapolated from studies performed in patients with septic shock.
- Trial name
- NCT03728998
- Testing
- Passive leg raise (PLR), Clearsight non-invasive hemodynamic monitoring system
- Where
- Netherlands
- Volunteers
- 31 people
- Sponsor
- Frisius Medisch Centrum
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.