Clinical trials: Resistant Major Depression
Depressive Disorder, Major
Peripheral Immunomarker Validation in Treatment-resistant Depression
This is a study to characterise the role of inflammatory processes in depression. There is compelling evidence that inflammation is often associated with, and can cause, depression.
- Trial name
- BIODEP (NCT02752178)
- Testing
- MA, DEP
- Where
- 5 sites in United Kingdom
- Volunteers
- 393 people, healthy volunteers welcome
- Sponsor
- University of Cambridge
Depressive Disorder, Major, Depressive Disorder, Treatment-Resistant
Safety, Tolerability, PK Profile, and Symptom Response of a 7-Day Dosing With 25 mg or 50 mg Daily of REL-1017 in MDD
This a Phase 2a, multicenter, randomized, double-blind, placebo controlled 3 arm study to assess the safety and tolerability of multiple oral doses of REL-1017 25 mg and 50 mg as adjunctive therapy in the treatment of patients…
- Trial name
- NCT03051256
- Testing
- REL-1017
- Where
- 10 sites in United States
- Volunteers
- 62 people
- Sponsor
- Relmada Therapeutics, Inc.
Major Depression
Evaluation of the Deep TMS H-Coil in the Treatment of Major Depression- Augmentation of Antidepressant Medication
Evaluation of the novel deep TMS H-Coil design as an augmentation measure in the treatment of medication resistant major depression. Stimulation is administered with and without cognitive-emotional provocation.
- Trial name
- NCT00460902
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- 2 sites in Israel
- Volunteers
- 57 people
- Sponsor
- Hadassah Medical Organization
Major Depression
Selenium as Augmentation Treatment for Sertraline Resistant Major Depression
The main goals of antidepressant treatments are to achieve remission of depressive episodes and prevent recurrences. However, clinical trials designed to approve antidepressants targets a response rate of at least 50%, which is…
- Trial name
- NCT02890212
- Testing
- selenium supplementation
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo General Hospital
Major Depressive Disorder (MDD)
Switching Medication and Augmentation Strategies for SSRI-Resistant Adolescent Depression（SMART-I)
This project aims to investigate the effectiveness of existing common antidepressants in adolescents with MDD who did not respond to their first treatment.
- Trial name
- SMART-I (NCT07011693)
- Testing
- Sertraline, Agomelatine, Aripiprazole
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Xinyu Zhou
Depressive Disorder, Major
A Naturalistic Study of the Efficacy and Safety of Escitalopram in Treatment Resistant Depression
The primary objective of this multicenter study is to evaluate the efficacy of escitalopram in treatment resistant depression (TRD), assessed by 2 consecutive failed antidepressant treatments from different classes.
- Trial name
- NCT00220480
- Testing
- escitalopram
- Where
- 4 sites in Israel
- Volunteers
- 60 people
- Sponsor
- Sheba Medical Center
Major Depressive Disorder (MDD), Major Depressive Episode
Digital Interventions for Adults with Treatment-Resistant Depression: a Pilot Study
The goal of this observational study is to learn about remote mental health monitoring technology for adults with treatment-resistant depression.
- Conditions
- Major Depressive Disorder (MDD), Major Depressive Episode, Treatment-Resistant Major Depressive Disorder
- Trial name
- NCT06732089
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Unity Health Toronto
Major Depression Moderate, Major Depression Severe
EEG Microstate Parameters and Neuroinflammatory Biomarkers in Patients With Treatment-Resistant Major Depressive Disorder Receiving ECT
This study aims to investigate the neurophysiological and inflammatory changes associated with electroconvulsive therapy (ECT) in patients diagnosed with Major Depressive Disorder who are resistant to at least two antidepressant…
- Conditions
- Major Depression Moderate, Major Depression Severe, Major Depression With Comorbid Anxiety Symptoms, Major Depression With Panic Attacks
- Trial name
- NCT07748091
- Testing
- Electroconvulsive Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Major Depressive Disorder (MDD)
The Effect of Transcranial Magnetic Stimulation Treatment on Microvasculature Stracture of the Retina and the Choroid
Transcranial Magnetic Stimulation (TMS) therapy is an approved and effective treatment option in treatment-resistant depression.
- Trial name
- TMS_OCT-A (NCT06708013)
- Testing
- Transcranial Magnetic Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gulhane Training and Research Hospital
MDD, Treatment Resistant Depression
Three Dosing Regimens of Dextromethorphan (DXM) Reportedly Used in Major Depressive Disorder
This is an open-label dosing pilot study of 15 patients aged 18-50 years of age with diagnoses of Major Depressive Disorder (MDD) randomized to 1 of 3 treatment arms.
- Conditions
- MDD, Treatment Resistant Depression, Smoking Cessation, Smoking
- Trial name
- NCT04226352
- Testing
- Dextromethorphan
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Johns Hopkins University
Treatment Resistant Depression
COpenhagen Magnetic Personalized Accelerated Brain Circuit Therapy for Treatment Resistant Depression
The CoMPACT trial is a randomized double-blinded sham-controlled study aimed at testing a novel accelerated and personalized transcranial Magnetic Stimulation (TMS) treatment for patients with Treatment Resistant Depression…
- Trial name
- CoMPACT (NCT06895863)
- Testing
- MagVenture XP Orange Stimulator and active side of MagVenture COOL-B65 coil., Device: MagVenture XP Orange Stimulator and active side of MagVenture COOL-B65 coil.
- Where
- 3 sites in Denmark
- Volunteers
- 78 people
- Sponsor
- Danish Research Centre for Magnetic Resonance
Late Life Treatment Resistant Depression, Depression - Major Depressive Disorder
The BAARD Study : Evaluating a Computerized Approach to Treatment Selection in Older Adults With Treatment Resistant Depression.
The goal of this clinical trial is to test whether a personalized approach to treatment selection improves symptoms in older adults with treatment-resistant depression.
- Conditions
- Late Life Treatment Resistant Depression, Depression - Major Depressive Disorder, Treatment Resistant Depression
- Trial name
- BAARD (NCT07810738)
- Testing
- Aripiprazole Augmentation, Bupropion Augmentation
- Where
- 3 sites in United States, Canada
- Volunteers
- 300 people
- Sponsor
- Washington University School of Medicine
Depressive Disorder, Major
A Long-term Comparison of Esketamine Nasal Spray Versus Quetiapine Extended Release, Both in Combination With a Selective Serotonin Reuptake Inhibitor/Serotonin-Norepinephrine Reuptake Inhibitor, in Participants With Treatment Resistant Major Depressive Disorder
The primary purpose of this study is to evaluate the efficacy of flexibly dosed esketamine nasal spray compared with quetiapine extended-release (XR), both in combination with a continuing selective serotonin reuptake…
- Trial name
- ESCAPE-TRD (NCT04338321)
- Testing
- Esketamine 28 mg, Esketamine 56 mg, Esketamine 84 mg
- Where
- 171 sites in Argentina, Austria and 22 more
- Volunteers
- 676 people
- Sponsor
- Janssen-Cilag International NV
Treatment Resistant Depression, Major Depressive Disorder (MDD)
Behavioural Activation Therapy and Ketamine for Treatment-Resistant Depression
The goal of this clinical trial is to see if combining ketamine with behavioral activation (BA) therapy to treat moderate to severe treatment-resistant depression improves depressive symptoms and general functioning more than…
- Trial name
- NCT07801703
- Testing
- Ketamine (0.5 mg/kg), Behavioural Activation Therapy
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- The Royal's Institute of Mental Health Research
Depression, Major Depressive Disorder
Diet and Depression
This study is a pilot open label crossover trial to assess the feasibility and acceptability of reducing ultra- processed foods (UPF) in a personalized manner from the diets of patients with major depressive disorder who eat a…
- Conditions
- Depression, Major Depressive Disorder, Weight Gain, Obesity
- Trial name
- NCT06252701
- Testing
- Reduction of Ultra-processed foods
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Major Depressive Disorder, Unipolar Depression
TBS Treatment for Treatment-Resistant Depression
Depression is a highly disabling disease that is prevalent throughout the world. The treatments proposed and studied to date have shown to be partially effective in treating this condition.
- Trial name
- TTT (NCT05388539)
- Testing
- Theta Burst Stimulation
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- University of Sao Paulo
Major Depressive Disorder
5-HTP and Creatine for Depression
This is a three-armed clinical trial examining the effect of 5-hydroxytryptophan and creatine monohydrate as augmenting agents for the treatment of depression.
- Trial name
- NCT04395183
- Testing
- 5-Hydroxytryptophan 100 MG, Creatine monohydrate
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Utah
Depressive Disorder, Major
Deep Brain Stimulation for Treatment Resistant Depression
This study will investigate the safety and efficacy of deep brain stimulation (DBS) in lateral habenula (LH) for patients with treatment-resistant depression.
- Trial name
- NCT05716555
- Testing
- Deep brain stimulation
- Where
- China
- Volunteers
- 2 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Depressive Disorder, Treatment-Resistant
Biomarkers of Theta Burst Stimulation in Major Depressive Disorder
This study investigates the brain-based biomarkers of treatment response to accelerated theta burst stimulation (aTBS) in patients with Major Depressive Disorder resistant to pharmacological treatment(MDD) in an open label design.
- Trial name
- NCT03626181
- Testing
- Theta Burst Stimulation ( Transcranial Magnetic Stimulation)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Calgary
Major Depressive Disorder, Treatment-Resistant Depression
Adjuvant Accelerated piTBS for Reducing Suicidal Ideation in TRD Patients
In this double-blind, randomized, sham-controlled trial, the investigators aimed to examine the effect of accelerated piTBS on suicide risk in a group of treatment-resistant patients with MDD (i.e., TRD), using an extensive…
- Conditions
- Major Depressive Disorder, Treatment-Resistant Depression, Suicide Ideations
- Trial name
- NCT06372834
- Testing
- piTBS being delivered using the Magstim Rapid2 stimulator
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Tri-Service General Hospital (TSGH)