Clinical trials: Resistant Major Depression
Major Depression
Functional Brain Imaging Study of Response to Repetitive TMS (rTMS) Treatment of Major Depression
The investigators plan to use optical brain imaging technology to observe patients with current major depression before, during, and after repetitive Transcranial Magnetic Stimulation (rTMS) clinical treatment.
- Trial name
- NCT01768052
- Testing
- functional Near Infrared Spectroscopy
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Mclean Hospital
Major Depressive Disorder, Treatment Resistant Depression
Sustained Mood Improvement With Laughing Gas Exposure
Multi-centre, parallel group, blinded, 1:1 randomized controlled trial to determine the effect of nitrous oxide on reducing symptoms of depression in patients with treatment resistant depression.
- Trial name
- SMILE (NCT07262008)
- Testing
- Inhalation of Nitrous oxide (Laughing gas) + intravenous saline, inhalation of %100 oxygen + intravenous midazolam
- Where
- 5 sites in Canada
- Volunteers
- 120 people
- Sponsor
- Women's College Hospital
Major Depressive Disorder
Targeting IL-17A for Treatment-Resistant Depression
The proposed study aims to test ixekizumab, a monoclonal antibody (mAb) against interleukin 17A (IL-17A), in patients with treatment-resistant depression (TRD).
- Trial name
- NCT04979910
- Testing
- Ixekizumab
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Moderate Depression, Major Depressive Disorder
Neuromodulation of Different Doses to Treat TRD Guided by pBFS Technique
The aim of this study is to explore the effectiveness and safety of different doses of neural regulation under the guidance of pBFS technology in improving symptoms in patients with moderate to severe depressive disorders.
- Conditions
- Moderate Depression, Major Depressive Disorder, Severe Depression
- Trial name
- NCT06112652
- Testing
- 4 session rTMS, 6 session rTMS, 8 session rTMS
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Changping Laboratory
Treatment Resistant Depression, Major Depressive Disorder
Mechanistic Evaluation of Response in TRD (MERIT)
To evaluate the relapse prevention of AXS-05 relative to placebo in subjects with treatment resistant depression (TRD). This is a randomized, double-blind, placebo-controlled study to evaluate AXS-05 compared to placebo in…
- Trial name
- MERIT (NCT04608396)
- Testing
- AXS-05
- Where
- 20 sites in United States
- Volunteers
- 44 people
- Sponsor
- Axsome Therapeutics, Inc.
Major Depressive Disorder, Depression
Investigating Predictors of Treatment Response in Treatment-Resistant Depression (TRD) With Interleaved TMS/fMRI
The purpose of this trial is identify biomarkers of response to repetitive transcranial magnetic stimulation (rTMS) in individuals with first episode or treatment resistant depression.
- Trial name
- NCT03642522
- Testing
- repetitive transcranial magnetic stimulation
- Where
- Canada
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Treatment-resistant Depression
Cost-utility Analysis of Maintenance rTMS for Treatment-resistant Depression
Treatment resistant depression (TRD) is a frequent, debilitating condition mostly treated by antidepressants. Repeated magnetic transcranial stimulation (rTMS) has proven adjuvant efficacy in TRD in the acute phase of treatment…
- Trial name
- ACOUSTIM (NCT03701724)
- Testing
- Systematic maintenance rTMS, rTMS course in case of relapse
- Where
- 19 sites in France
- Volunteers
- 119 people
- Sponsor
- Nantes University Hospital
Major Depression
Efficacy and Safety of Task-specific, Biomarker-driven, HD-ctACS inTRD.
This is a single-center, randomized, double-blind, sham-controlled, crossover exploratory clinical trial designed to evaluate the therapeutic effects of task-specific, biomarker-driven HD-ctACS on treatment-resistant depression…
- Trial name
- NCT07184697
- Testing
- HD ctACS
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Ruijin Hospital
Major Depressive Disorder
Randomized Controlled Trial of Conventional vs Theta Burst rTMS
This trial will compare a novel form of rTMS, intermittent Theta Burst Stimulation to the standard conventional high frequency left sided stimulation protocol.
- Trial name
- HFL vs TBS (NCT01887782)
- Testing
- HFL rTMS, iTBS
- Where
- 3 sites in Canada
- Volunteers
- 414 people
- Sponsor
- Centre for Addiction and Mental Health
Depression - Major Depressive Disorder, Treatment Resistant Depression
ipRGC as a Potential Biomarker for Predicting Transcranial Magnetic Stimulation Treatment Response in Major Depressive Disorder
This research explores the potential of retinal ganglion cells (RGCs), particularly intrinsically photosensitive RGCs (ipRGCs), as biomarkers for predicting response to transcranial magnetic stimulation (TMS) in…
- Trial name
- BRIGHT (NCT07474974)
- Testing
- Repetitive transcranial magnetic stimulation (rTMS)
- Where
- Portugal
- Volunteers
- 44 people
- Sponsor
- Polytechnic Institute of Porto
Depressive Disorder, Treatment-Resistant, Treatment Resistant Depression (TRD)
Intravenous Ketamine for Treatment-Resistant Depression
The purpose of this study is to to evaluate the relationships between peak (% change from baseline) central GABA and Glu levels during a 40-min IV ketamine or normal saline infusion utilizing fMRS, and change in peripheral GABA…
- Trial name
- G2K (NCT06668571)
- Testing
- Ketamine, Normal Saline
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Major Depressive Disorder
E-field Guided iTBS for Treatment Resistant Depression
The purpose of this study is to establish how personalization of repetitive transcranial magnetic stimulation (rTMS) can change markers of brain activity and improve treatment response.
- Trial name
- NCT05583747
- Testing
- iTBS
- Where
- 2 sites in Canada
- Volunteers
- 110 people
- Sponsor
- Centre for Addiction and Mental Health
Treatment-resistant Depression
Efficacy Study of Deep Brain Stimulation in Patients With Treatment Resistant Major Depression
The primary objective of this multicenter, randomized, sham-controlled, double blind (patient and observer blinded) clinical trial is to assess the antidepressant effect of Deep Brain Stimulation (DBS) in patients with treatment…
- Trial name
- FORESEE III (NCT03653858)
- Testing
- Vercise GEVIA deep brain stimulation (DBS) system
- Where
- 2 sites in France, Germany
- Volunteers
- 46 people
- Sponsor
- University Hospital Freiburg
Major Depressive Disorder
Accelerated rTMS for Treatment-Resistant Major Depression
High frequency repetitive transcranial magnetic stimulation (HF-rTMS) has shown safety and efficacy for treatment-resistant depression, but requires daily treatment for 4-6 weeks.
- Trial name
- NCT02125799
- Testing
- Accelerated HF-rTMS (Magstim Rapid 2 stimulator)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Douglas Mental Health University Institute
Depression - Major Depressive Disorder
Measurement of Serum Inflammatory Markers in Patients Treatment-resistant Depression Given Psilocybin
About one in three people with major depression respond poorly to standard antidepressant treatments. This kind of depression is called treatment-resistant depression, and it can lead to long-term disability, financial…
- Trial name
- NCT07164755
- Where
- United Kingdom
- Volunteers
- 46 people
- Sponsor
- King's College London
Treatment Resistant Depression, Major Depressive Disorder
Sustained Mood Improvement With Laughing Gas Exposure: A Randomized Controlled Pilot Trial
The purpose of the study is to investigate a short-term treatment option for major depressive disorders by administering nitrous oxide gas.
- Trial name
- SMILE (NCT04957368)
- Testing
- Nitrous Oxide 99 %, Oxygen + Midazolam
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Unity Health Toronto
Treatment Resistant Depression, Suicidal Ideation
The Safety and Efficacy of Psilocybin in Patients With Treatment-resistant Depression and Chronic Suicidal Ideation
This study aims to explore the safety and tolerability of a single dose of psilocybin (25mg) administered under supportive conditions to adult participants with TRD and chronic suicidal ideation
- Trial name
- NCT05220410
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Sheppard Pratt Health System
Treatment Resistant Depression (TRD), Depression - Major Depressive Disorder
2-Year Study of Vagus Nerve Stimulation for Higher-Grade Treatment-Resistant Depression: Clinical Outcomes and Policy Recommendation
The goal of this observational study is to evaluate whether vagus nerve stimulation (VNS) intervention can reduce depressive symptoms and suicidality in adults with higher-grade treatment-resistant depression (HG-TRD)-individuals…
- Conditions
- Treatment Resistant Depression (TRD), Depression - Major Depressive Disorder, Bipolar Depression
- Trial name
- VNS TRD HG-TRD (NCT07097025)
- Testing
- vagus nerve stimulation
- Where
- 2 sites in Israel
- Volunteers
- 19 people
- Sponsor
- Dr.Yoav Domany
Depression, Dementia
RCT of Brain Longitudinal Biomarker Study (OPT-Neuro RCT)
The purpose of this study is to assess which antidepressants work the best in older adults who have treatment-resistant depression (TRD), and to test whether treatment-resistant late life depression is associated with declines in…
- Conditions
- Depression, Dementia, Mild Cognitive Impairment, Treatment Resistant Depression
- Trial name
- ONR (NCT05531591)
- Testing
- Aripiprazole Augmentation, Bupropion Augmentation, Switch to bupropion
- Where
- 4 sites in United States, Canada
- Volunteers
- 87 people
- Sponsor
- Centre for Addiction and Mental Health
Major Depressive Disorder
Ketamine in Adolescents With Treatment-Resistant Depression
This study will test the use of ketamine for treatment of depression in adolescents that have not responded to other treatments. We will also examine neurobiological mechanisms of treatment.
- Trial name
- NCT02078817
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Minnesota