Clinical trials: Resolution
Myopia, Astigmatism
Comparative In-Vivo Wetting Characteristics of Silicone Hydrogel Materials With Selected Lens Care Systems
The purpose of this study is to evaluate the lipid uptake, wetting characteristics, and visual performance of AIR OPTIX® AQUA and ACUVUE® OASYS® with HYDRACLEAR® contact lenses when used in conjunction with two contact lens care…
- Conditions
- Myopia, Astigmatism, Refractive Error
- Trial name
- NCT01699750
- Testing
- Lotrafilcon B contact lenses, Senofilcon A contact lenses, OPTI-FREE® PUREMOIST® MPDS
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- Alcon Research
Wounds and Injuries, Wound Healing
Negative Pressure Wound Therapy With Instillation of Saline Solution Versus Collagenase Ointment in Full-thickness Wounds
Evaluation of wound bed surface area containing clean, healthy viable tissue in full-thickness wounds.
- Conditions
- Wounds and Injuries, Wound Healing, Granulation Tissue
- Trial name
- ACCELERATE (NCT03722485)
- Testing
- Negative Pressure Therapy w/ instillation and dwell (NPWTi-d), Collagenase Ointment
- Where
- 10 sites in United States
- Volunteers
- 44 people
- Sponsor
- KCI USA, Inc
Healthy
Bioavailability, Pharmacokinetics and Safety of ESR 1150 CL in Healthy Adult Male Volunteers
To investigate the bioavailability of ESR 1150 CL by the time course determination of plasma concentration (pharmacokinetics) of no-transformed ESR 1150 after single administration to healthy adult male volunteers.
- Trial name
- NCT02183259
- Testing
- ESR 1150 CL, Capsule, oral, ESR 1150 CL, solution, intravenous
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Urinary Catheter Blockage and Encrustation
Efficacy Study of Auriclosene Irrigation Solution on Urinary Catheter Patency
Long-term indwelling urinary catheters are associated with chronic recurrent urinary tract infections and blockage caused by crystalline biofilm accumulation (encrustation) of the catheter surfaces.
- Trial name
- NCT02130518
- Testing
- Auriclosene Irrigation Solution, 0.2%, Auriclosene Vehicle Solution
- Where
- 17 sites in United States
- Volunteers
- 140 people
- Sponsor
- NovaBay Pharmaceuticals, Inc.
Verruca Plantaris
Nitric Oxide Releasing Solution (NORS) For The Treatment Of Human Papillomavirus(HPV) Verrucae Plantaris (Plantar Warts)
A phase 2a multicenter, randomized, double-blinded, placebo-controlled clinical trial to evaluate the safety and efficacy of topical nitric oxide releasing solution (NORS) for the treatment of human papillomavirus (HPV) caused…
- Trial name
- NCT05877313
- Testing
- Sterile water foot bath, Nitric Oxide
- Where
- 3 sites in Canada
- Volunteers
- 20 people
- Sponsor
- Sanotize Research and Development corp.
Healthy Volunteers
A Study of ENX-104 in Healthy Participants
The study is designed to evaluate the relative bioavailability, safety, and tolerability of a single dose of ENX-104 administered orally as a solution fasted, a tablet fasted, or a tablet with a high fat meal in healthy…
- Trial name
- NCT07472361
- Testing
- ENX-104
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Engrail Therapeutics INC
Elective Colonoscopy
Efficacy and Safety of mAnnitol in Bowel Preparation During Elective Colonoscopy and Comparison With Moviprep®
The purpose of this dose finding/comparative efficacy study is to first single out the most appropriate dose of mannitol for bowel preparation (phase II) and, subsequently, demonstrate the non-inferiority of the efficacy of…
- Trial name
- SATISFACTION (NCT04759885)
- Testing
- Phase II: NTC015 low dose, Phase II: NTC015 medium dose, Phase II: NTC015 high dose
- Where
- 35 sites in France, Germany and 2 more
- Volunteers
- 886 people
- Sponsor
- NTC srl
Onychomycosis of Toenail
Study to Evaluate the Efficacy and Safety of P-3058 Nail Solution in the Treatment of Onychomycosis
The aim of this phase III study is to establish the efficacy and safety of P-3058 (terbinafine 10% nail solution) topically administered once weekly in patients with onychomycosis in comparison to the Vehicle in a double-blind…
- Trial name
- NCT03094468
- Testing
- P-3058 (terbinafine hydrochloride 10%), Vehicle of P-3058
- Where
- 26 sites in United States, Canada
- Sponsor
- Polichem S.A.
Glaucoma
Study to Evaluate Safety and Efficacy of rhNGF Eye Drops Solution Versus Vehicle in Patients With Glaucoma
The primary objective of the study is to assess the safety and tolerability of a 180μg/ml TID dose regimen of recombinant human nerve growth factor (rhNGF) eye drop solution administered over 8 weeks versus a vehicle control in…
- Trial name
- NGF-Glaucoma (NCT02855450)
- Testing
- rhNGF, Vehicle
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Dompé Farmaceutici S.p.A
Cystic Fibrosis
Safety and Efficacy Study of Aztreonam for Inhalation Solution (AZLI) in Cystic Fibrosis Patients With P. Aeruginosa
The purpose of this study was to evaluate the safety and efficacy of aztreonam for inhalation solution (AZLI) in patients with cystic fibrosis (CF) and lung infection due to Pseudomonas aeruginosa (PA).
- Trial name
- AIR-CF2 (NCT00104520)
- Testing
- AZLI 75 mg two times a day (BID)/three times a day (TID)
- Where
- 56 sites in United States
- Volunteers
- 211 people
- Sponsor
- Gilead Sciences
Healthy
A Study of JNJ-64417184, Administered as an Oral Solution, in Healthy Participants
The purpose of this study is to assess the food effect on the single-dose pharmacokinetic (PK) of the JNJ-64417184 oral solution, administered as 2 different formulations, in healthy adult participants.
- Trial name
- NCT04258189
- Testing
- JNJ-64417184
- Where
- Belgium
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Chronic Obstructive Pulmonary Disease (COPD)
A Trial to Evaluate the Safety and Efficacy of HL231 Solution for Inhalation in Patients with COPD
To evaluate the efficacy and safety of HL231 Solution for Inhalation vs Ultibro in Chinese patients with moderate to severe COPD.
- Trial name
- NCT06619210
- Testing
- HL231 Dose 1/2/3/4
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Allergic Conjunctivitis
Evaluation of the Safety and Efficacy of Ketotifen 4.0% Patch as Compared to Placebo Patch, Olopatadine 0.2% Ophthalmic Solution, and Artificial Tears in the Conjunctival Allergen Challenge (CAC) Model of Acute Allergic Conjunctivitis
This is a phase 2 study that will consist of 4 visits over a 5 week period. Drug will be evaluated using the conjunctival allergen challenge model of allergic conjunctivitis.
- Trial name
- NCT00836485
- Testing
- Ketotifen 4.0% Patch, Olopatadine 0.2%, Artificial tears
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- Senju USA, Inc.
Epilepsy (treatment Refractory)
Bioequivalence Study of Two Brivaracetam Oral Solutions in Healthy Adults Under Fasting and High-Fat Meal Conditions
The goal of this clinical trial is to evaluate the bioequivalence of Brivaracetam oral solution under fasting and high-fat meal conditions in healthy adults.
- Trial name
- BE (NCT06762743)
- Testing
- Brivaracetam Oral Solution (Test Formulation), Brivaracetam Oral Solution (Reference Formulation)
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jiangsu Chia Tai Fenghai Pharmaceutical Co., Ltd.
Allergic Conjunctivitis
Study Evaluating the Safety of KetoNaph Ophthalmic Solution in Healthy Volunteers
This study is being conducted to evaluate the safety of KetoNaph ophthalmic solution in healthy adult subjects and in pediatric subjects with a history or family history of ocular allergy.
- Trial name
- NCT01159015
- Testing
- KetoNaph, Vehicle
- Volunteers
- 534 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Allergic Conjunctivitis
Clinical Efficacy of PRO-118 Compared With Olopatadine Hydrochloride Ophthalmic Solution in Allergic Conjunctivitis
The purpose of this study is to evaluate the clinical efficacy of the ophthalmic solution PRO-118 compared with olopatadine hydrochloride ophthalmic solution in allergic conjunctivitis.
- Trial name
- NCT01657240
- Testing
- PRO-118, Olopatadine Hydrochloride
- Sponsor
- Laboratorios Sophia S.A de C.V.
Normal Tension Glaucoma, Ocular Hypertension
Investigation of Intraocular Pressure (IOP) Reduction Efficacy of Travoprost Ophthalmic Solution in Patients With Normal Tension Glaucoma
The purpose of this study is to investigate IOP reduction efficacy of travoprost 0.004% ophthalmic solution (TRAVATAN Z®) in subjects with normal tension glaucoma.
- Trial name
- NCT01995136
- Testing
- Travoprost Ophthalmic Solution 0.004%
- Where
- Japan
- Volunteers
- 32 people
- Sponsor
- Alcon Research
Healthy
A Study of Mirikizumab in Healthy Participants
The main purpose of this study is to compare the amount of mirikizumab that gets into the blood stream and how long it takes the body to get rid of it, when given as a solution formulation via manual prefilled syringe or…
- Trial name
- NCT04607733
- Testing
- Mirikizumab Prefilled Syringe, Mirikizumab Autoinjector
- Where
- 4 sites in United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Cervical Intraepithelial Neoplasia Grade 2/3
The Study of Folate Receptor-Mediated Staining Solution (FRD™) In Cervical Lesion Detection
The FRDTM is easy to perform and does not require sophisticated laboratory technology and/or experienced pathologists for test result interpretation.
- Trial name
- NCT03366493
- Testing
- FRD, Cytology, HPV testing
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- GY Highland Biotech LLC
Hepatitis C, Chronic
Evaluation of the Antiviral Pharmacodynamic Effect, Safety, and Pharmacokinetics of Escalating Doses of BILB 1941 ZW to Patients With Chronic Hepatitis C Genotype 1 Virus Infection
To assess the antiviral effect, safety and pharmacokinetics of rising doses of 10 mg, 20 mg, 40 mg, 60 mg, 80 mg, 100 mg, 150 mg, 200 mg, 300 mg, 450 mg, 650 mg, 900 mg oral BILB 1941 ZW administered Q8H in a polyethyleneglycol…
- Trial name
- NCT02254707
- Testing
- BILB 1941 ZW
- Volunteers
- 96 people
- Sponsor
- Boehringer Ingelheim
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