Clinical trials: Resolution
HIV Infections, Proteinuria
Pilot Study of Raltegravir Switch to Resolve Tenofovir Induced Proteinuria
The study is designed to evaluate the proportion of patients with tenofovir induced proteinuria that will resolve their proteinuria when the tenofovir containing nucleoside/nucleotide backbone is switched to a raltegravir…
- Trial name
- RALPIR (NCT01044771)
- Testing
- change from tenofovir to raltegravir
- Volunteers
- 20 people
- Sponsor
- Metropolis Medical
Double Incontinence, Faecal Incontinence
Prospective Database of Factors Associated With Faecal vs. Double Incontinence in Patients Referred for High Resolution Anorectal Manometry.
This study aims to verify the results from our previous retrospective cohort analysis by establishing a database of well-characterised patients prospectively.
- Conditions
- Double Incontinence, Faecal Incontinence, Urinary Incontinence
- Trial name
- NCT05550675
- Testing
- Questionnaires
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Bile Leakage
Diagnostic Role of the "White Test" With Lipidic Solution in the Early Intraoperative Identification of Open Bile Ducts for the Prevention of Bile Leakage After Liver Resection (BiLe -Trial)
Bile leakage (BL) is the most frequent complication after liver resection. This study is to investigate the role of intraoperative administration of SMOFlipid 20% (fat emulsion which allows intraoperative identification of open…
- Trial name
- BiLe (NCT04523701)
- Testing
- "white" test" (= the administration of SMOFlipid retrograde through the cystic duct)
- Where
- 5 sites in Switzerland
- Volunteers
- 210 people
- Sponsor
- Giulia Manzini
Joint Infection
Rate of Total Joint Infection 90-day After Surgery Following Irrigation With Next Science No-Rinse Solution vs SOC Alone
A prospective, single-site, double-arm, parallel, interventional, randomized, controlled clinical trial to assess 90-day rate of joint infections in subjects undergoing primary hip replacements after administration of Next…
- Trial name
- NCT05519007
- Testing
- No-Rinse Solution (NS), Saline irrigation
- Where
- 3 sites in United States
- Volunteers
- 936 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Comparative Bioavailability
Cannabidiol Bioavailability Trial With Oral Multiple Dose Administration
Glatt Pharmaceutical Services GmbH \& Co. KG is developing a new CBD granules formulation (GLA-015 / Cannabidiol 1500 mg 29,7% w/w GRA BLD P) which is intended to be used in the treatment of the new Coronavirus disease 2019…
- Trial name
- NCT04790136
- Testing
- GLA-015, DAC C-052 "Cannabidiol" / NRF 22.10 "Oily cannabidiol solution 100 mg/ml"
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- SocraTec R&D GmbH
Pulmonary Arterial Hypertension
Safety, Tolerability, & Pharmacokinetics Study of Single & Multiple Inhaled Doses of Imatinib Inhalation Solution
This is a randomised, double-blind, placebo-controlled, dose escalation study to evaluate the safety, tolerability, and PK of single and multiple inhaled doses of imatinib inhalation solution (AER-901) in healthy adult…
- Trial name
- NCT04903730
- Testing
- AER-901 Solution for Nebulization
- Where
- Australia
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Aerami Therapeutics
Chronic Kidney Failure
Icodextrin Study to Test Short-Term Safety, Tolerability and Preliminary Efficacy of Sodium-Free Solution in PD Patients
Patients with kidney failure rely on dialysis for sodium and fluid removal. The importance of a sodium and fluid balance in patients with kidney disease is very important.
- Trial name
- NCT05185999
- Testing
- Icodextrin/Dextrose
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Healthy
Comparison of Polyethylene Glycol With Ascorbic Acid and Oral Sulfate Solution for Bowel Preparation
Colonoscopy is considered by many the preferred mode of screening for colorectal cancer (CRC). The effectiveness of any CRC screening program is critically dependent on an adequate bowel preparation.
- Trial name
- NCT02551198
- Testing
- HAPREP®, SUCLEAR®
- Where
- South Korea
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- National Cancer Center, Korea
Ocular Discomfort
A Study to Evaluate the Clinical Performance of a Novel Multipurpose Solution
The objective of this study is to evaluate the clinical performance of Bausch \& Lomb investigational Multi-Purpose Solution compared to Ciba Vision Multi-Purpose Solution when used by wearers of silicone hydrogel or Group IV…
- Trial name
- NCT01024751
- Testing
- Bausch & Lomb Multi-Purpose Solution, Ciba's Multi-Purpose Solution
- Where
- United States
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Chronic Sinusitis
Evaluating SPRC-AB01 in Post-Surgical Subjects With Chronic Sinusitis
The primary objective of the study is to evaluate the safety and efficacy of SPRC-AB01 versus placebo for treatment of chronic sinusitis in subjects who have had sinus surgery.
- Trial name
- NCT00447837
- Testing
- SPRC-AB01
- Where
- 43 sites in United States
- Volunteers
- 180 people
- Sponsor
- Naryx Pharma
Oral Cancer Screening
Non-invasive Methods for Oral Cancer Screening
Oral cancer is a common cancer worldwide, with approximately 250,000 new cases annually and a high mortality rate. Its major risk factors include smoking, alcohol consumption, and betel nut chewing.
- Trial name
- HRME (NCT07249437)
- Where
- Taiwan
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Pruritus, Uremia
Gabapentin - A Solution to Uremic Pruritus?
To investigate using the drug gabapentin to relieve the intense pruritic sensation associated with chronic renal failure patients undergoing peritoneal dialysis.
- Trial name
- NCT00577967
- Testing
- Gabapentin
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Hospital Authority, Hong Kong
Asthma COPD
Clinical and Medico-economic Validation of the HEPHAI Solution.
In a context where the use of inhalation devices for respiratory medications is associated with a high frequency of critical errors, our primary hypothesis is that the use of the HEPHAÏ solution reduces this frequency compared to…
- Trial name
- VAL-HEPHAI (NCT06099145)
- Testing
- Hephaï
- Where
- 5 sites in France
- Volunteers
- 238 people
- Sponsor
- Hephai
Open-angle Glaucoma, Ocular Hypertension
Efficacy of Changing to TRAVATAN® From Prior Therapy
The purpose of this study was to assess the efficacy and tolerability of TRAVATAN® solution without BAK (benzalkonium chloride) after changing from prior latanoprost 0.005% ophthalmic solution monotherapy in subjects with…
- Trial name
- NCT01510145
- Testing
- Travoprost 0.004% BAK-free
- Volunteers
- 191 people
- Sponsor
- Alcon Research
Living Donor Liver Transplantation
Effect of Ascites Replacement Strategy on Time to 1st Flatus After LDLT
The aim of this study is to evaluate difference in the rate of recovery of intestinal motility according to different ascites replacement strategy after living donor liver transplantation.
- Trial name
- NCT04184401
- Testing
- Ascites replacement with albumin and hartmann's solution, Ascites replacement with hartmann's solution
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Seoul National University Hospital
Partial Epilepsy
Localizing the Epileptogenic Zone With High Resolution Electroencephalography
Multicenter prospective study comparing the diagnosis value of high-resolution EEG and depth-EEG to localize the epileptogenic zone in drug resistant partial epilepsies.
- Trial name
- EEG-HR (NCT01090934)
- Testing
- High Resolution EEG, Stereo-electroencephalography
- Where
- 2 sites in France
- Volunteers
- 115 people
- Sponsor
- Central Hospital, Nancy, France
Breast Cancer
Pilot Study to Evaluate High Resolution PET Image-Guidance for Sampling of Breast Abnormalities
The purpose of this pilot clinical study is to test a methodology for using high-resolution Positron Emission Tomography (PET) imaging to guide vacuum-assisted core biopsy of breast abnormalities identified on PET.
- Trial name
- PEM-BX (NCT00606931)
- Testing
- Stereo Navigator Accessory to PEM Flex PET Scanner
- Where
- 5 sites in United States
- Volunteers
- 22 people
- Sponsor
- Naviscan PET Systems
Traumatic Brain Injury, Subdural Hematoma
Hypernatremia for the Prevention and Treatment of Cerebral Edema in Traumatic Brain Injury
Cerebral edema is seen heterogenous group of neurological disease states that mainly fall under the categories of metabolic, infectious, neoplasia, cerebrovascular, and traumatic brain injury disease states.
- Conditions
- Traumatic Brain Injury, Subdural Hematoma, Cerebral Contusion, Head Injury
- Trial name
- NCT01605357
- Testing
- Induced, sustained hypernatremia using hypertonic saline, Standard of care (hypertonic saline and mannitol; serum sodium)
- Sponsor
- Massachusetts General Hospital
Transplantation, Kidney Transplantation
Sirolimus Blood Concentrations on Conversion From Oral Solution to Tablets
The purpose of this study is to understand the pharmacokinetics of sirolimus tablets in different regimens in newly renal transplant patients, and the effect of dosage form conversion on the concentration of sirolimus in stable…
- Conditions
- Transplantation, Kidney Transplantation, Immunosuppression
- Trial name
- NCT00166842
- Testing
- sirolimus, cyclosporine, tacrolimus
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Keratoconus, Pellucid Marginal Corneal Degeneration
Safety & Effectiveness of the PXL-Platinum 330 System for CXL Using Riboflavin Solution
Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Collagen Cross-linking in Eyes With Corneal Thinning Conditions
- Conditions
- Keratoconus, Pellucid Marginal Corneal Degeneration, Corneal Degeneration, Corneal Ectasia
- Trial name
- NCT04667572
- Testing
- PXL-330 Platinum device for crosslinking with Peschke riboflavin solution
- Where
- United States
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Cornea Associates of Texas
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