Clinical trials: Resolution
Dry Eye Disease
A Clinical Trial to Assess the Safety and Efficacy of Subjects With Dry Eye Disease
A Multicenter, Phase 3, Randomized, Double-Masked, Parallel-Group, Vehicle-Controlled, Environment Exposure Clinical Trial to Assess the Efficacy and Safety of 0.25% Reproxalap
- Trial name
- NCT06424444
- Testing
- Reproxalap ophthalmic solution (0.25%), Vehicle ophthalmic solution
- Where
- United States
- Volunteers
- 421 people
- Sponsor
- Aldeyra Therapeutics, Inc.
Achalasia, Dysphagia
Correlation of High Resolution Esophageal Manometry With Symptoms
High Resolution Manometry is a new technology that utilizes 36 solid state sensors on a thin catheter spaced at 1-cm intervals. One can more effectively measure the pressure of the esophagus.
- Conditions
- Achalasia, Dysphagia, GERD, Chest Pain
- Trial name
- NCT01202929
- Testing
- High Resolution Manometry
- Where
- United States
- Sponsor
- University of Louisville
Open-Angle Glaucoma, Ocular Hypertension
Nebivolol 0.5, 1.0, or Timolol 0.5 Suspension Compared to Timolol 0.5 Solution to Treat Glaucoma/Ocular Hypertension
The purpose of this study is to evaluate the safety (in the eye and throughout the body) and effectiveness of nebivolol (0.5 and 1 percent) and timolol (0.5 percent) eye drop suspensions.
- Trial name
- NCT04910100
- Testing
- Nebivolol Ophthalmic Suspension 1 Percent, Nebivolol Ophthalmic Suspension 0.5 Percent, Timolol Ophthalmic Suspension 0.5 Percent
- Where
- United States
- Volunteers
- 226 people
- Sponsor
- Betaliq, Inc.
Dry Eye Disease (DED)
Phase 3 Study of EBI-005 in Dry Eye Disease
This is a phase III double-masked, randomized, controlled study evaluating the efficacy of EBI-005 as compared to vehicle given as a topical ophthalmic solution in each eye to subjects with moderate to severe DED three times…
- Trial name
- EBI-005 (NCT01998802)
- Testing
- Active Comparator EBI-005
- Where
- 45 sites in United States
- Volunteers
- 670 people
- Sponsor
- Eleven Biotherapeutics
Retinal Vein Occlusion, Macular Edema
Study of Squalamine Lactate for the Treatment of Macular Edema Related to Retinal Vein Occlusion
This was a prospective, single center, open label, randomized study evaluating the biological effect of squalamine lactate ophthalmic solution, 0.2% combined with intravitreous ranibizumab in patients with macular edema secondary…
- Trial name
- NCT02614937
- Testing
- ranibizumab, Squalamine Lactate Ophthalmic Solution, 0.2%
- Volunteers
- 20 people
- Sponsor
- Ohr Pharmaceutical Inc.
Cervical Cancer
Cervical Cancer Screening Study in Brazil
Objectives: Primary Objective: To perform a pilot clinical study to test multi-modal optical imaging for detection of cervical neoplasia in Brazil.
- Trial name
- NCT02335372
- Testing
- Wide-Field White Light Imaging, Acetic Acid, Proflavine Solution
- Where
- Brazil
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Bone Fracture
Fracture Healing Assessed by HR-pQCT After Administration of Calcium and Vitamin D
This study is designed as a single-blind RCT in 80 postmenopausal women to compare the effect of immediate administration of daily calcium supplementation (1000 mg calcium) or two daily dosages of calcium + vitamin D (1000 mg…
- Trial name
- NCT02889237
- Testing
- Calcium, Calcium + low dose vitamin D, Calcium + high dose vitamin D
- Where
- Netherlands
- Volunteers
- 52 people
- Sponsor
- VieCuri Medical Centre
Keratitis, Corneal Ulcer
Safety and Effectiveness of the PXL Platinum 330 System With Riboflavin Solution for Previously Untreated Corneal Ulcers
This study is being conducted to evaluate the safety and effectiveness of using the PXL Platinum 330 System with riboflavin solution for performing corneal collagen crosslinking (CXL) for the treatment of previously untreated…
- Trial name
- NCT05255107
- Testing
- Standard of Care Therapy + CXL + Riboflavin 0.23% L Solution
- Where
- 12 sites in United States
- Volunteers
- 468 people
- Sponsor
- Peschke GmbH
Chronic Back Pain, Chronic Pain (Back / Neck)
Low Intensity Focused Ultrasound for Chronic Pain: High Resolution Targeting of The Human Insula
In this study, the research team will use low-intensity focused ultrasound (LIFU) to temporarily change brain activity in a brain region that is known to be involved in chronic pain.
- Trial name
- LIFU_Pain (NCT06906211)
- Testing
- low intensity focused ultrasound (LIFU)
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Washington D.C. Veterans Affairs Medical Center
Chronic Obstructive Pulmonary Disease
Long-term Maintenance Benefits of a Pulmonary Rehabilitation Program Using a Mobile Digital Solution: a Prospective, Randomized, Controlled, Multicenter Study in a Population of COPD Patients
Chronic obstructive pulmonary disease (COPD) is a public health problem: high prevalence; increasing morbidity and mortality; impact on health costs.
- Trial name
- m-Rehab COPD (NCT04550741)
- Testing
- telerehabilitation
- Where
- 2 sites in France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Acute Kidney Injury, Osmolality Disturbance
Hyperosmolality and Acute Kidney Injury After Cardiac Surgery
The goal of this randomized controlled trial is to test if a hyperosmolar prime solution used for cardiopulmonary bypass increases the risk for acute postoperative kidney injury.
- Conditions
- Acute Kidney Injury, Osmolality Disturbance, Cardiopulmonary Bypass
- Trial name
- NCT05914896
- Testing
- HighOsmo
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Umeå University
Healthy
A Study to Evaluate the Bioequivalence of an Oral Suspension Formulation, an Oral Solution Formulation, and the Marketed Tablet Formulation of Levofloxacin in Healthy Subjects
The primary objective of the study was to assess the bioequivalence of the oral suspension formulation, the oral solution formulation, and the marketed tablet formulation of levofloxacin, with the marketed tablet as the reference.
- Trial name
- NCT00602589
- Testing
- Levofloxacin oral suspension; Levofloxacin oral solution; and Levofloxacin marketed tablet formulations
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Cystic Fibrosis
A Study of Lung Clearance After Hypertonic Saline Delivery Using the tPAD Device
The primary objective of this study is to determine whether a single overnight, eight-hour administration of a 7% NaCl solution delivered by the Parion Sciences transnasal Pulmonary Aerosol Delivery (tPAD) device has a…
- Trial name
- NCT02141191
- Testing
- inhaled hypertonic saline (7%)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Pittsburgh
Diarrhea
Antibacterial Treatment Against Diarrhea in Oral Rehydration Solution
This study hopes to demonstrate the potentials of a new form of therapy for childhood diarrhea, a major cause of morbidity and deaths in Bangladesh and other developing countries, and thus a priority for improving child health.
- Trial name
- NCT00937274
- Testing
- T4 phage cocktail test, Commercial T4 phage cocktail, standard oral rehydration solution (ORS)
- Where
- Bangladesh
- Volunteers
- 120 people
- Sponsor
- Société des Produits Nestlé (SPN)
Burnout, Professional
Better Together Physician Coaching: An Innovative Solution to Medical Trainee Burnout
Burnout refers to feelings of exhaustion, negativism, and reduced personal efficacy resulting from chronic workplace stress. In healthcare, burnout leads to increased medical errors, poorer patient care and negatively affects…
- Trial name
- NCT05222685
- Testing
- Better Together Physician Coaching
- Where
- United States
- Volunteers
- 1,017 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Healthy Volunteers
Study to Evaluate Properties of Radiprodil Given in Oral Solution to Healthy Volunteers
To evaluate the pharmacokinetics (PK) profile of Radiprodil in suspension form in healthy adult subjects.
- Trial name
- NCT02647697
- Testing
- Radiprodil oral
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- UCB Biopharma S.P.R.L.
Vitiligo, Repigmentation
Topical Bimatoprost Solution 0.03%in Stable Vitiligo
Vitiligo is an acquired depigmentation disorder of great cosmetic importance, affecting 1-4% of the world's population. Phototherapy and topical agents such as corticosteroids, calcineurin inhibitors, and vitamin-D derivatives…
- Trial name
- NCT01202513
- Testing
- Bimatoprost 0.03% topical ophthalmic solution
- Volunteers
- 20 people
- Sponsor
- Gian Sagar Medical College and Hospital
Allergic Conjunctivitis
Safety and Efficacy of Bepotastine Besilate Ophthalmic Solution in Seasonal Allergic Conjunctivitis Patients
The purpose of this study is to study the safety and efficacy of bepotastine besilate ophthalmic solution in allergic conjunctivitis patients.
- Trial name
- NCT01174823
- Testing
- bepotastine besilate ophthalmic solution
- Where
- United States
- Volunteers
- 245 people
- Sponsor
- Bausch & Lomb Incorporated
Hypogonadism
To Determine the Effects of Deodorant, Antiperspirant and Washing on the Pharmacokinetics of 2% Testosterone MD Lotion
Testosterone replacement treatment is the most effective way of treating hypogonadism in men. Acrux has a propriety testosterone replacement product, Testosterone MD-Lotion and this study will evaluate the impact of application…
- Trial name
- MTE10 (NCT00857168)
- Testing
- Testosterone MD-Lotion
- Where
- Australia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Acrux DDS Pty Ltd
Dental Plaque, Denture Stomatitis
Efficacy of a Propolis-based Denture Cleanser
The purpose of this study is to assess if a propolis solution is able to remove plaque and kill microbes from complete dentures.
- Conditions
- Dental Plaque, Denture Stomatitis, Oral Candidiasis, Oral Hygiene
- Trial name
- NCT01237782
- Testing
- Denture soaking solution, Saline solution
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Raphael Freitas de Souza
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