Clinical trials: Resolution
Ocular Itching, Ocular Allergy
Efficacy and Safety of PRO-118 Ophthalmic Solution in Allergic Conjunctivitis
The purpose of this study is to evaluate the efficacy and safety of four doses of PRO-118 ophthalmic solution ophthalmic solution compared with placebo, for the treatment of seasonal (SAC) and perennial (PAC) allergic…
- Conditions
- Ocular Itching, Ocular Allergy, Seasonal Allergic Conjunctivitis, Perennial Allergic Conjunctivitis
- Trial name
- PRO-118 (NCT01541904)
- Testing
- PRO-118 Ophthalmic Solution 0.015%, PRO-118 Ophthalmic Solution 0.015 %, PRO-118 Ophthalmic Solution 0.020 %
- Where
- 2 sites in Mexico
- Sponsor
- Laboratorios Sophia S.A de C.V.
Dry Eye Disease
A Study to Evaluate Efficacy and Safety of Lifitegrast in Subjects With Dry Eye (OPUS-3)
Evaluate the efficacy and safety of Lifitegrast in subjects with dry eye disease and a recent history of artificial tear use.
- Trial name
- OPUS-3 (NCT02284516)
- Testing
- Lifitegrast
- Where
- 41 sites in United States
- Volunteers
- 711 people
- Sponsor
- Shire
Focus of Study: Pharmacokinetics Analysis, in Vivo Dissolution Studies
Pharmacokinetics of a Standard Paracetamol Tablet and Oral Solution After Oral Administration in Chinese Healthy Volunteers
Drug dissolution in vivo play a crucial role for the bioavailability and therapeutic of an orally administered solid dosage form.
- Trial name
- NCT02095704
- Testing
- paracetamol oral solution, paracetamol tablet
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Central South University
Glioblastoma
Glioblastoma: Validation and Comparison Between Primary Tumor and Its Murine Model
Despite maximal safe surgery followed by combined chemo-radiation therapy, the outcome of patients suffering from glioblastoma (GBM) remains extremely poor with a median survival of 15 months.
- Trial name
- XENOGBM (NCT02904525)
- Testing
- 7 Tesla MRI, no contrast agent
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Andreas Hottinger
Ocular Hypertension, Open Angle-glaucoma
A 28 Day Study of ONO-9054 Ophthalmic Solution in Subjects With Ocular Hypertension (OHT) or Open-angle Glaucoma (OAG)
The primary objectives of this study are to compare the safety, tolerability, and mean change from baseline in diurnal intraocular pressure (IOP) of ONO-9054 30 µg/mL (0.003%) to latanoprost 0.005% following ocular instillation…
- Trial name
- NCT02083289
- Testing
- ONO-9054, Latanoprost
- Where
- 12 sites in United States
- Volunteers
- 123 people
- Sponsor
- Ono Pharmaceutical Co., Ltd.
Hypogonadism, Erectile Dysfunction
The Therapy of Nebido as Mono or in Combination With PDE-5 Inhibitors in Hypogonadal Patients With Erectile Dysfunction
The purpose of this study is to evaluate the response of a treatment with testosterone undecanoate and determine the levels of total and free testosterone in hypogonadal patients with erectile dysfunction.
- Trial name
- NCT00421460
- Testing
- Testosterone Undecanoate,1000mg
- Where
- 3 sites in Thailand
- Volunteers
- 30 people
- Sponsor
- Chulalongkorn University
Myocardial Injury
Comparison of the Effects of Crystalloid Cardioplegia and HTK Solution for Postoperative Troponin-I and CK-MB Levels After Pediatric Cardiac Surgery
The purpose of this study is to compare two different cardioplegia solutions effect on postoperative Troponin-I and CK-MB levels after pediatric cardiac surgery.
- Trial name
- NCT01548872
- Testing
- HTK solution, crystalloid cardioplegia solution
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Baskent University
HER2 + Breast Cancer
Paclitaxel Oral Solution in HER2-Positive Breast Cancer Neoadjuvant Therapy: A Dose-Finding Study
This is a multicenter, open-label, dose-finding trial using a backfill Bayesian optimal interval (BF-BOIN) design to determine the maximum tolerated dose (MTD) and/or recommended phase 2 dose (RP2D) for paclitaxel oral solution…
- Trial name
- GBCF002 (NCT07739511)
- Testing
- Paclitaxel oral solution plus Trastuzumab and Pertuzumab
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Liu Shu
Dry Eye Disease
Study of INS365 Ophthalmic Solution in Subjects With Dry Eye Disease
The purpose of this trial is to compare the effectiveness and safety of INS365 Ophthalmic Solution with placebo when applied topically in subjects with dry eye disease.
- Trial name
- NCT00404131
- Testing
- diquafosol tetrasodium (INS365) Ophthalmic Solution
- Volunteers
- 500 people
- Sponsor
- Merck Sharp & Dohme LLC
End-Stage Renal Disease
L-Carnitine in Peritoneal Dialysis
The development of glucose-sparing strategies able to provide an efficacious ultrafiltration profile represents one of the modern goals of peritoneal dialysis therapy.
- Trial name
- NCT00922701
- Testing
- L-carnitine
- Where
- Italy
- Volunteers
- 4 people
- Sponsor
- Iperboreal Pharma Srl
Compare Blood Age for Transfusion
Effect of Blood Storage Age on the Resolution of Lactic Acidosis in Children With Severe Malarial Anemia at Mulago Hospital
In resolving lactic acidosis among children with severe malarial anemia, there is no difference between those transfused with blood of longer storage compared to shorter storage age
- Trial name
- NCT01580111
- Testing
- Blood transfusion
- Where
- Uganda
- Volunteers
- 74 people
- Sponsor
- Makerere University
Allergic Conjunctivitis
Evaluation of Efficacy of Ophthalmic Solution in Induced Acute Allergic Conjunctivitis
The purpose of this study is to establish the efficacy of R89674 0.25% ophthalmic solution compared with placebo in alleviating the signs and symptoms of conjunctival allergen challenge-induced allergic conjunctivitis
- Trial name
- NCT00241319
- Testing
- R89674 (generic name not yet established)
- Where
- 5 sites in United States
- Volunteers
- 150 people
- Sponsor
- Vistakon Pharmaceuticals
Breast Cancer
Study To Investigate the Feasibility and Safety of A Dedicated High Resolution Nuclear Breast Imaging Camera
To evaluate the feasibility, acceptability and safety of using a molecular breast imaging (MBI) Gamma Camera in women at high risk of developing breast cancer
- Trial name
- THORN (NCT01062100)
- Testing
- nuclear breast imaging using MBI Gamma camera
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- Ontario Clinical Oncology Group (OCOG)
Obesity, Chronic Inflammation
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish)
Omega-3 fatty acids, especially EPA and DHA have long been acknowledged for their capacity to counteract inflammatory responses in the human body.
- Trial name
- EPICO (NCT05068557)
- Testing
- Dietary plan along with fish oil capsules (3 capsules daily. Containing EPA+DHA: 1.8 g)., Dietary plan along with chia/linseed oil capsules (3 capsules daily. Containing ALA 1.6 g).
- Where
- Mexico
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Guadalajara
Healthy Subjects
Assessment of Nasal Deposition and Clearance of Ketorolac Solution Administered Using the Valois Nasal Spray Device
This was a randomised three-way crossover design study. The study consisted of three study periods each separated by a minimum 44 hour washout period.
- Trial name
- NCT01356212
- Testing
- Ketorolac tromethamine
- Where
- United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Egalet Ltd
Constipation
Comparison of PEG Solutions With and Without Electrolytes in the Treatment of Constipation
The aim of the study is to show that new polyethylene glycol (PEG) solution without electrolytes is as effective in the treatment of constipation as PEG solution with electrolytes in the elderly institutionalized people.
- Trial name
- PEGorion (NCT00603681)
- Testing
- Polyethylene glycol 4000, Polyethylene glycol 4000 with electrolytes
- Where
- 10 sites in Finland
- Volunteers
- 67 people
- Sponsor
- Orion Corporation, Orion Pharma
Quality of Life, Anxiety
A Telemedicine Solution for Remote Support of Rehabilitation, for Patients Undergoing, Total Hip Arthroplasty Surgery
The RRS project is a Randomized Clinical Trial documenting the effect of Remote Rehabilitation and Support via a telemedicine solution for patients undergoing an optimized fast-track orthopedic surgery procedure with the…
- Trial name
- RRS (NCT00969020)
- Testing
- remote rehabilitation support
- Where
- Denmark
- Volunteers
- 72 people
- Sponsor
- Regionshospitalet Silkeborg
Fuchs Dystrophy, Cataract
The Evaluation of Balanced Salt Solution During Cataract Surgery
This study aims to identify if the use of BSS PLUS® Sterile Intraocular Irrigating Solution as an irrigation solution leads to improved corneal outcomes vs BSS® Sterile Irrigating Solution in more compromised corneas.
- Trial name
- NCT05853978
- Testing
- BSS Plus, BSS
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Adam Fedyk, MD, FACS
Healthy
Clinical Drug Trial in Healthy Male Subjects to Determine and Compare the Blood Concentrations of BI 144807 Following Administration as Oral Solution and Tablet Under Fasted and Fed Conditions
The purpose of this trial is to investigate the relative bioavailability of a BI 144807 tablet formulation compared to the oral solution formulation after single dose administration (intermediate and high dose) under fasted…
- Trial name
- NCT01897597
- Testing
- BI 144807 high dose, BI 144807 intermediate dose
- Where
- Germany
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Hearing Loss, Tinnitus
Establishment and Application of a New Imaging System for Otology Based on Ultra-high Resolution CT
Tinnitus, hearing loss and vertigo are the three major diseases of otology, affecting hundreds of millions of people in our country, and are major health problems.
- Conditions
- Hearing Loss, Tinnitus, Vertigo
- Trial name
- NCT05533840
- Testing
- ultra-high-resolution computed tomography exams
- Where
- China
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
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