Clinical trials: Resolution of Inflammation
Pain, Inflammation
Efficacy Study of Bromfenac Ophthalmic Solution in Patients Undergoing Cataract Surgery
Efficacy study of Bromfenac Ophthalmic Solution in cataract surgery
- Trial name
- NCT00853970
- Testing
- Bromfenac Ophthalmic Solution
- Where
- United States
- Volunteers
- 299 people
- Sponsor
- Bausch & Lomb Incorporated
Dissecting Aneurysm of Cerebral Artery
Metformin in Patients With Unruptured Vertebrobasilar Dissecting Aneurysms (METTLE)
Vertebrobasilar dissecting aneurysms (VBDAs) are one of the most important causes of stroke in young and middle-aged people, and the natural history of VBDAs is complex and varied, often leading to high rates of disability and…
- Trial name
- METTLE (NCT06405971)
- Testing
- Metformin
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Ming Lv
Pneumonia
Does Vitamin D Supplementation Enhance Resolution of Inflammation After Community-acquired Pneumonia?
Previous research has shown that people who have been hospitalised for pneumonia are more likely to die of conditions such as heart attacks, stroke and cancer in the weeks to months after their illness.
- Trial name
- ResolveD-CAP (NCT02802722)
- Testing
- Vitamin D3 supplementation, Peripheral blood and induced sputum sampling, Chest computerised tomography (CT) scans
- Where
- United Kingdom
- Volunteers
- 3 people
- Sponsor
- Queen Mary University of London
Respiratory Distress Syndrome, Adult
Evaluation of Safety & Efficacy of BIO-11006 Inhalation Solution in Patients With ARDS
This Phase IIa pilot study is a placebo controlled, multicenter study to evaluate safety and efficacy of aerosolized BIO-11006 Inhalation Solution in ARDS patients.
- Trial name
- NCT03202394
- Testing
- BIO-11006
- Where
- 5 sites in United States
- Volunteers
- 38 people
- Sponsor
- BioMarck Pharmaceuticals, Ltd.
Severe Sepsis, Septic Shock
Scandinavian Starch for Severe Sepsis/Septic Shock Trial
By tradition hydroxyethyl starch (HES) is used to obtain fast circulatory stabilisation in critically ill. High molecular weight HES may, however, cause acute kidney failure in patients with severe sepsis.
- Trial name
- 6S (NCT00962156)
- Testing
- 6% Hydroxyethyl starch 130/0.4, Ringers acetate
- Where
- 26 sites in Denmark, Finland and 2 more
- Volunteers
- 804 people
- Sponsor
- Anders Perner
Corneal Infiltrates
A Phase II Study of Moxidex Ophthalmic Solution for Treatment of Marginal Corneal Infiltrates
The purpose of the study is to determine whether Moxidex ophthalmic solution is safe and effective in treating marginal corneal infiltrates.
- Trial name
- NCT00579020
- Testing
- Moxifloxacin/dexamethasone phosphate ophthalmic solution, Moxifloxacin ophthalmic solution 0.5%, Dexamethasone phosphate solution, 0.1%
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Alcon Research
Empyema, Pleural
Trial of Antiseptic Irrigation for Pleural Infection
Pleural antiseptic irrigation (PAI) is used in conjunction with open drainage for treating adults with chronic post-thoracotomy empyema.
- Trial name
- RINSE (NCT05546762)
- Testing
- Povidone-iodine solution, Normal saline
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Alexandria University
Cataract, Anterior Chamber Inflammation
Iontophoretic Delivery of EGP-437 in Patients Who Have Undergone Cataract Surgery
Phase 2b trial evaluating the safety and efficacy of EGP-437, versus placebo using the EyeGate® II Drug Delivery System (EGDS) in patients having undergone cataract surgery with implantation of a monofocal posterior chamber…
- Conditions
- Cataract, Anterior Chamber Inflammation, Pain, Postoperative
- Trial name
- NCT03180255
- Testing
- Dexamethasone phosphate
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Eyegate Pharmaceuticals, Inc.
Obesity, Metabolic Syndrome
The Predictive Role of Preoperative Pentraxin-3 (PTX3) in Metabolic and Inflammatory Outcomes After Roux-en-Y Gastric Bypass
This study evaluated the prognostic value of preoperative pentraxin-3 (PTX3) levels in predicting weight loss, inflammatory resolution (CRP, IL-6), and metabolic improvements (HOMA-IR) following Roux-en-Y gastric bypass in…
- Conditions
- Obesity, Metabolic Syndrome, Insulin Resistance, Inflammation
- Trial name
- PTX3-BYPASS (NCT07241741)
- Testing
- Biomarker Stratification by PTX3
- Volunteers
- 23 people
- Sponsor
- Istanbul University
Gut Microbiomes
Grape Impact on Human Gut Microbiome
This is a bio-specimen analysis and dietary intervention study that will examine whether the daily consumption of California table grape powder significantly modulates the gut microbiome and systemic immune profiles in healthy…
- Trial name
- NCT07797803
- Testing
- Grape Powder
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Sepsis, Intoxication; Septic
Efficacy and Safety of Rheosorbilact® Solution for Infusion, in a Complex Therapy of Sepsis.
This study evaluates the efficacy and safety of Rheosorbilact®, solution for infusion ("Yuria-Pharm" LLC), in comparison with Ringer's Lactate, solution for infusion, in a complex therapy of sepsis.
- Trial name
- NCT03764085
- Testing
- Rheosorbilact®, Ringer lactate
- Where
- 13 sites in Georgia, Kazakhstan and 3 more
- Volunteers
- 180 people
- Sponsor
- Yuria-Pharm
Intracranial Aneurysm, Inflammation Vascular
Statin Treatment for UnruptureD Intracranial anEurysms Study
This study was designed to identify whether there is a measurable reduction in inflammation in walls of intracranial aneurysms with oral atorvastatin.
- Trial name
- STUDIES (NCT04149483)
- Testing
- Atorvastatin
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Neurosurgical Institute
Catheter Related Infection, Bacteremia
Efficacy and Safety of an Ethanol/Sodium Citrate Locking Solution: A Pilot Study
Currently in Canada, either 4% sodium citrate or heparin 1,000-10,000 U/ml solutions are "locked" into hemodialysis catheters between dialysis sessions to prevent thrombosis.
- Trial name
- NCT01394458
- Testing
- 30 % ethanol / 4% sodium citrate catheter locking solution, Heparin 1000 u / ml
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Manitoba
Asthma
Depemokimab Asthma Imaging and Bronchoscopy Sub-Study
Asthma is a chronic condition marked by narrowed and swollen airways due to inflammation leading to recurring symptoms that can vary and worsen unpredictably.\xa0The purpose of this study is to assess how depemokimab, a…
- Trial name
- NCT06979323
- Testing
- Depemokimab
- Where
- 50 sites in United States, Belgium and 10 more
- Volunteers
- 150 people
- Sponsor
- GlaxoSmithKline
Septicemic Shock
High Strong Ion Difference Fluid vs Hartmann's Solution on Acid-Base Status in Sepsis
This is a research to study primarily the effect of rapidly infused high strong ion difference (SID) fluid vs Hartmann's solution in altering the pH and bicarbonate level of the patient, who is in sepsis with metabolic acidosis.
- Trial name
- HiSIDSS (NCT03530046)
- Testing
- High SID fluid, Hartmann's solution
- Volunteers
- 162 people
- Sponsor
- Clinical Research Centre, Malaysia
Post Abdominal Surgery, Sepsis Abdominal
Clinical Effects of Ringers Lactate Versus Sterofundin/ Plasmalyte Solution in Patients With Sepsis
The goal of this clinical trial is to compare the clinical effects of using Ringer's Lactate and Sterofundin/ Plasmalyte as maintenance fluids in adult patients who have undergone abdominal surgery and are septic.
- Trial name
- NCT07239713
- Testing
- Ringer's Lactate Crystalloid Solutions, Sterofundin (Bolus of crystalloids)
- Where
- Pakistan
- Volunteers
- 82 people
- Sponsor
- CMH Lahore Medical College and Institute of Dentistry
ARDS, COVID-19
Mesenchymal Stem Cells (MSCs) in Inflammation-Resolution Programs of Coronavirus Disease 2019 (COVID-19) Induced Acute Respiratory Distress Syndrome (ARDS)
To evaluate the safety, toxicity and immunological effects of infusion of allogeneic bone marrow-derived human mesenchymal stem (stromal) cells (MSCs) and whether this therapy has an influence on the resolution processes in ARDS…
- Trial name
- NCT04377334
- Testing
- MSC
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University Hospital Tuebingen
Muscular Injury
Almond Supplementation and Exercise Recovery
The PURPOSE of this study is to see if eating almonds for four weeks will reduce muscle damage, soreness, and inflammation during several days of recovery from eccentric exercise.
- Trial name
- NCT04958018
- Testing
- Almonds, Snack bars
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Molluscum Contagiosum
Cantharidin Application in Molluscum Patients
This study is a Phase 3, randomized, double-blind, placebo-controlled, pivotal study to evaluate the safety and efficacy of VP-102 topical film-forming solution in subjects with Molluscum Contagiosum.
- Trial name
- CAMP-2 (NCT03377803)
- Testing
- VP-102 - Cantharidin, Topical Film Forming Solution
- Where
- 15 sites in United States
- Volunteers
- 262 people
- Sponsor
- Verrica Pharmaceuticals Inc.
Septic Shock
Early Metabolic Support as a Potential Solution to Multi-Organ Dysfunction Syndrome (MODS) During Severe Sepsis
The goal of this clinical research study is to learn if adding liquid nutrition therapy that is given by vein to standard-of-care treatment for sepsis can help to control sepsis symptoms better than giving standard-of-care…
- Trial name
- NCT02885688
- Testing
- Liquid Nutrition, Insulin Drip
- Sponsor
- M.D. Anderson Cancer Center