Clinical trials: Resolution of Pathologic Process
Chronic Kidney Disease, Peritoneal Dialysis
Efficacy and Safety of a 7.5% Icodextrin Peritoneal Dialysis Solution in Once-Daily Long Dwell Exchange
The purpose of this study is to evaluate the efficacy and safety of a 7.5% Icodextrin peritoneal dialysis solution for once-daily long dwell exchange in patients undergoing Continuous Ambulatory Peritoneal Dialysis (CAPD) in…
- Trial name
- NCT00725517
- Testing
- Icodextrin
- Volunteers
- 2 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Post-Lumbar Puncture Headache
Epidural Blood Patch on the Resolution of Postdural Puncture Headache (PDPH)
The purpose of this study is to address the question, "What is the volume of blood for injection at epidural blood patch that most effectively relieves post-dural puncture headache?"
- Trial name
- NCT00373074
- Testing
- Epidural Blood Patch
- Where
- United States
- Sponsor
- The University of Texas Health Science Center, Houston
Lymphangioleiomyomatosis
A Study to Determine the Safety and Effectiveness of RAD001 (Everolimus) in Patients With Lymphangioleiomyomatosis
This was an exploratory study to determine whether escalating doses of RAD001 (everolimus) were safe and effective in patients with Lymphangioleiomyomatosis
- Trial name
- NCT01059318
- Testing
- Everolimus
- Where
- 4 sites in United States, France and 1 more
- Volunteers
- 24 people
- Sponsor
- Novartis Pharmaceuticals
Dehydration in Children, Fluid Therapy
Boluses of Ringer's in Surgical Kids (BRiSK Study)
Traditional protocols for intravenous fluid administration in children who have undergone a major abdominal or thoracic operation are based on a landmark paper published in 1957 by Holliday and Segar.
- Trial name
- BRiSK (NCT05285371)
- Testing
- Urinalysis (UA), Complete Metabolic Panel (CMP), Glucose Stick Test (d-Stick)
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Cochlear Implants, Hearing Loss
CT Guided CI Programming
The current standard of care for cochlear implants (CI) does not address the significant pitch-place mismatch that is inherent in cochlear implantation (see detailed description below).
- Conditions
- Cochlear Implants, Hearing Loss, Amusia
- Trial name
- NCT04506424
- Testing
- CT Guided Cochlear Implant Programming
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of California, San Francisco
End Stage Renal Failure, Hemodialysis
Catheters Dysfunction Rate After Instillation of Ethanol 60% Lock Solution in Tunneled Silicone Catheter of Chronic Hemodialysis Patients
The primary objective of the study is to examine the risk of catheter dysfunction during the dialysis session that follows the instillation of ethanol 60% as lock solution in tunneled silicone catheters of end stage renal failure…
- Trial name
- Ethanol (NCT00563342)
- Testing
- Ethanol
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Clermont-Ferrand
Patients with Atrial Fibrillation and Healthy Volunters
Magnetic Resonance Imaging Development for High Resolution Atrial Structural and Functional Characterization
The main objective is to optimize the MRI protocol for the assessment of the LA in addition to a basic CMR protocol in order to define the best compromise between acquisition time and image quality (contrast between the different…
- Trial name
- MRI-HiRA (NCT06617624)
- Testing
- MRI, MRI Contrast
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
High Resolution Vessel Wall Imaging, Recurrent Stroke
Plaque Characteristics Predict Recurrent Stroke in MCA Stroke Patients
The epidemiology of TOAST classification in Asian patients seems to differ due to the higher rates of large-artery atherosclerosis.
- Conditions
- High Resolution Vessel Wall Imaging, Recurrent Stroke, Stroke, Mechanism, Atheroscleroses, Intracranial
- Trial name
- NCT06404242
- Where
- Vietnam
- Volunteers
- 75 people
- Sponsor
- University Medical Center Ho Chi Minh City (UMC)
Sleep Apnea
High-resolution Oximetry to Diagnose Obstructive Sleep Apnea
The aim of this study was to compare an overnight digital monitoring device (ODM) with home sleep apnea testing (HSAT) using respiratory flow and effort parameters in a large population sample, who were in a waiting list for…
- Trial name
- NCT04366193
- Testing
- Oximetry
- Where
- Brazil
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Pregnancy Tests
Resolution of Uncertainty Through Testing
Given the high rate of delayed adoption of antenatal care (ANC), and high rates of unintended pregnancy and unsafe abortion in Uganda, research on the period of time before confirmation of pregnancy is critical to understand…
- Trial name
- NCT03179059
- Testing
- Pregnancy test at Baseline, Pregnancy test at follow up survey
- Where
- Uganda
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Stroke, Hemiplegia
Impact of Hemiplegia Due to Stroke on the Microarchitecture of the Bone
In hemiplegic, there is very little data on the impact of neurological deficit on the microarchitecture independent of bone mineral density and composition of the bone marrow.
- Trial name
- NCT02544386
- Testing
- MRI and 3D CT scan
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Corneal Infiltrates
A Phase II Study of Moxidex Ophthalmic Solution for Treatment of Marginal Corneal Infiltrates
The purpose of the study is to determine whether Moxidex ophthalmic solution is safe and effective in treating marginal corneal infiltrates.
- Trial name
- NCT00579020
- Testing
- Moxifloxacin/dexamethasone phosphate ophthalmic solution, Moxifloxacin ophthalmic solution 0.5%, Dexamethasone phosphate solution, 0.1%
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Alcon Research
Prostate Cancer Surgery, Head and Neck Cancers
Investigating the Diagnostic Performance of High-resolution Specimen PET-CT in Determining Margin Status in Cancer Resection
Surgical removal is the treatment for many different cancers. Patient outcomes depend on complete cancer removal with no tumour present at the edge of the section removed (specimen).
- Trial name
- eXcision (NCT06676943)
- Testing
- XEOS AURA 10 specimen PET-CT scan of tumour specimens
- Where
- United Kingdom
- Volunteers
- 57 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Pilonidal Sinus
Metronidazole Ointment in Non-healing Pilonidal Sinus Wounds
Title of Study: Randomised, double-blind, placebo-controlled trial evaluating the effects of metronidazole ointment in facilitating resolution on non-healing pilonidal sinus wounds Medical Condition Under Investigation…
- Trial name
- NCT04273997
- Testing
- Metronidazole 10% ointment
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- S.L.A. Pharma AG
Heart Attack, Cardioplegia Solution Adverse Reaction
Combined Use of a Novel Cardioplegic Formula With MPS® Versus Cardioplexol ® in Urgent Isolated CABG Using MiECC in Patients With Recent Acute Myocardial Infarction
The goal of this study is to compare the two cardioplegia solutions (blood cardioplegia by means of MPS ® vs. Cardioplexol ®) regarding perioperative outcome and with special attention to cardiac markers in patients with a recent…
- Conditions
- Heart Attack, Cardioplegia Solution Adverse Reaction, Coronary Artery Bypass Grafting (CABG)
- Trial name
- NCT04309994
- Testing
- Myocardial protection system (MPS), Cardioplexol
- Where
- Switzerland
- Volunteers
- 307 people
- Sponsor
- University Hospital, Basel, Switzerland
Leiomyomatosis
Official Record of Patients Diagnosed With Lymphangioleiomyomatosis (LAM)
Pulmonary lymphoangioleiomyomatosis (LAM) is a rare destructive lung disease typically affecting women of childbearing age. Currently, there is no effective therapy for the disease and the prognosis is poor.
- Trial name
- NCT00001869
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Children, Anorectal Disorder
3D High Resolution Anorectal Manometry in Children After Surgery for Anorectal Disorders
3D high resolution anorectal manometry (3DHRAM) is the most precise tool to assess function and 3D topographic picture of pressures along the anal canal.
- Conditions
- Children, Anorectal Disorder, Anorectal Atresia, Hirschsprung Disease
- Trial name
- NCT02296008
- Testing
- 3D high resolution anorectal manometry
- Where
- Poland
- Volunteers
- 43 people
- Sponsor
- Medical University of Warsaw
Surgical Site Infection
Effect of a Combination of Bundles on Surgical-site Infection After Elective Colorectal Surgery
A prospective randomized clinical trial will be performed. Patients will be randomized in 2 groups. The experimental group will undergo the combined application of intraperitoneal irrigation with clindamycin and gentamicin…
- Trial name
- NCT03081962
- Testing
- Bundle, Standard care
- Where
- Spain
- Volunteers
- 102 people
- Sponsor
- Hospital General Universitario Elche
Pancreatitis
Genetic Analysis for Predicting of Relapse During Steroid Treatment for Autoimmune Pancreatitis (AIP)
To determine whether certain alleles or haplotypes of major histocompatibility complex gene are associated with AIP in Korean population, we undertook this study with high-resolution typing for HLA (sequence-based typing).
- Trial name
- NCT00444444
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Retinal Imaging, Cardiovascular Biomarker
High Resolution Imaging of Retinal Vessels as a Biomarker of Cardiovascular Disease in Patients With Renal Insufficiency - RI
The objectives are to better understand, in the dialysis patient, the relationships between microvascular morphometry and cardiovascular events, survival, arterial hypertension, the pathology responsible for renal failure, the…
- Conditions
- Retinal Imaging, Cardiovascular Biomarker, Renal Insufficiency
- Trial name
- IRIR (NCT04116814)
- Testing
- wall-to-lumen ratio measurement
- Where
- France
- Volunteers
- 83 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
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