Clinical trials: Resolution of Pathologic Process
Cervical Cancer
Use of High-Resolution Microendoscopy (HRME) in Patients With Cervical Dysplasia
The goal of this clinical research study is to compare a type of imaging called high-resolution microendoscopy (HRME) for detecting abnormal tissue in the cervix to the standard of care, which is visual inspection with acetic…
- Trial name
- NCT02420665
- Testing
- Proflavine, HRME Imaging, Phone Call
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- M.D. Anderson Cancer Center
Rheumatoid Arthritis
JAK-i on RA B-lymphocytes Tolerance and Disease Resolution Through JAK Signaling In Rheumatoid Arthritis
The study will reveal the transcriptomic signature linked to the aberrant activation of B lymphocytes in RA identifying novel molecular potential targets for inflammation resolution and immune tolerance promotion.
- Trial name
- NCT05754112
- Testing
- B lymphocyte profiling
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Operation Wound; Infection, Endometritis
Use of Antiseptic Solution for Vaginal Wash Before Cesarean Section
To evaluate the rate of infections after cesarean sections in patients with premature rupture of membranes after vaginal wash either with an antiseptic solution (clorhexidine solution) vs. saline solution (placebo).
- Trial name
- NCT03442218
- Testing
- Clorhexidine, Saline solution
- Where
- Panama
- Volunteers
- 203 people
- Sponsor
- Saint Thomas Hospital, Panama
Gastroesophageal Reflux Disease, Hiatal Hernia
Preoperative Predictors of Symptom Improvement After Laparoscopic Fundoplication
Laparoscopic fundoplication is the standard operation for gastroesophageal reflux disease (GERD) that does not respond adequately to medication, and it relieves reflux symptoms in most patients who are carefully selected for it.
- Conditions
- Gastroesophageal Reflux Disease, Hiatal Hernia, Esophagitis, Peptic, Barrett Esophagus
- Trial name
- NCT07809620
- Testing
- Laparoscopic Nissen fundoplication, Laparoscopic Toupet fundoplication
- Where
- Egypt
- Volunteers
- 470 people
- Sponsor
- Minia University
Meibomian Gland Dysfunction, Cataract
Ultrahigh-resolution Optical Coherence Tomography Imaging of the Anterior Eye Segment Structures
The development of optical coherence tomography (OCT) and its application for in vivo imaging has opened entirely new opportunities in ophthalmology.
- Conditions
- Meibomian Gland Dysfunction, Cataract, Glaucoma, Corneal Transplantation
- Trial name
- NCT03461978
- Testing
- Ultrahigh resolution Spectral Domain OCT
- Where
- Austria
- Volunteers
- 14 people
- Sponsor
- Medical University of Vienna
Cardiac Disease
Validation of Multi-contrast, High-resolution Cardiac Magnetic Resonance Imaging
Cardiovascular disease (CVD) causes at least 1.8 million European deaths annually, exceeding fatalities from cancer, chronic respiratory disease, and diabetes.
- Trial name
- CARDIO-IRM (NCT05877755)
- Testing
- Cardiac MRI acquisition
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Inflammation, Obesity
Inflammatory Resolution in Cardiometabolic Health and Disease
The specific aim of this study is to determine molecular pathways that differentiate metabolically healthy vs unhealthy human phenotypes, and to investigate the therapeutic potential of pro-resolving lipids.
- Conditions
- Inflammation, Obesity, Cardiovascular Diseases
- Trial name
- RESOLVE AU (NCT06390189)
- Where
- Denmark
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Breast Neoplasms, Nipple Discharge
Clinical Value of Breast High-Resolution MR Ductography in Patients With Pathological Nipple Discharge
Nipple discharge is one of the common symptoms of breast disease patients. Nipple discharge can be divided into physiological and pathological nipple discharge (PND).
- Trial name
- NCT05812040
- Testing
- Magnetic Resonance Ductography (MRD); and High-Resolution Magnetic Resonance Ductography (HR-MRD)
- Where
- China
- Volunteers
- 134 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Soft Tissue Neoplasm, Bone Neoplasm
Novel Imaging Techniques for the Characterization of Musculoskeletal Tumors II
This study aims at evaluating the value of various artificial intelligence based techniques to improve the characterization and image post-processing for patients with musculoskeletal tumors.
- Trial name
- TUMOSTEO II (NCT04394052)
- Testing
- MR imaging
- Where
- France
- Volunteers
- 740 people
- Sponsor
- Central Hospital, Nancy, France
ST Segment Elevation Myocardial Infarction, Non-ST Segment Elevation Myocardial Infarction
Cardiac Care Solution for Coronary Disease Follow up
This is a prospective, randomized controlled trial. The aim of the study is to evaluate the impacts of a cardiac post-discharge management solution in the secondary prevention of Coronary Artery Disease (CAD).
- Conditions
- ST Segment Elevation Myocardial Infarction, Non-ST Segment Elevation Myocardial Infarction, Unstable Angina
- Trial name
- BAMA (NCT03565978)
- Testing
- BAMA solution
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Peking University First Hospital
Chronic Obstructive Pulmonary Disease, COPD
Sunovion Brovana Versus Serevent Inspiratory Capacity High Resolution Computed Tomography
This is a PI-initiated study taking place only at UCLA, sponsored by Sunovion. The investigators plan to enroll about 20 subjects who are at least 40 years old and have Chronic Obstructive Pulmonary Disease (COPD).
- Conditions
- Chronic Obstructive Pulmonary Disease, COPD, Emphysema, Chronic Bronchitis
- Trial name
- NCT01361984
- Testing
- Nebulized arformoterol, Salmeterol
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Los Angeles
Otosclerosis
Ultra-high Resolution CT: the End of Stapes Prosthesis Measurement Misestimation
Actual CT scanners overestimate stapes piston size, and do not represent a valuable technique for their follow-up, especially in case of complication. Ultra-high resolution has not yet been evaluated in this setting.
- Trial name
- NCT06323863
- Testing
- stapedectomy, ultra high resolution CT
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Central Hospital, Nancy, France
Influenza
Efficacy of Sambucol in the Treatment of Influenza
The trial will examine the efficacy of sambucol in the treatment of influenza. The primary efficacy endpoint will be the length of time to resolution of influenza illness.The double blind trial will be conducted at the Personnel…
- Trial name
- NCT00375115
- Testing
- Sambucol
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Hadassah Medical Organization
End-Stage Kidney Disease, Renal Dialysis
The Impact of Different Citrate Concentrations as Locking Solutions on Development of Biofilm and Function of Hemodialysis Catheters
Evidence that supports using certain concentration of trisodium citrate as a locking solution for hemodialysis catheters has not yet been established.
- Conditions
- End-Stage Kidney Disease, Renal Dialysis, Central Venous Catheter, Biofilms
- Trial name
- NCT03683563
- Testing
- 4% sodium citrate, 30% sodium citrate
- Where
- Slovenia
- Volunteers
- 50 people
- Sponsor
- University Medical Centre Ljubljana
Cervical Intraepithelial Neoplasia Grade 1, Cervical Intraepithelial Neoplasia Grade 2
Colposcopy and High Resolution Anoscopy in Screening For Anal Dysplasia in Patients With Cervical, Vaginal, or Vulvar Dysplasia or Cancer
This clinical trial studies colposcopy and high resolution anoscopy in screening for anal dysplasia in patients with cervical, vaginal, or vulvar dysplasia or cancer.
- Conditions
- Cervical Intraepithelial Neoplasia Grade 1, Cervical Intraepithelial Neoplasia Grade 2, Cervical Intraepithelial Neoplasia Grade 3, Recurrent Cervical Cancer
- Trial name
- NCT01313104
- Testing
- colposcopy, cervical Papanicolaou test, screening method
- Sponsor
- Northwestern University
Healthy, Colonic Motility
High Resolution Colonic Manometry in Relation to 3D-Transit Times in Healthy Controls.
Background: Within recent years, new methods for detailed assessment of gastrointestinal (GI) motility have been developed. Hence, the electromagnetic 3D-Transit system is a safe, non-invasive method for detailed description of…
- Trial name
- NCT04231721
- Testing
- High Resolution Colonic Manometry and 3D-Transit system
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Janne Ladefoged Fassov
Cataract, Retinal Edema
Prolensa (Bromfenac) 0.07% QD vs. Ilevro (Nepafenac) 0.3% QD for Treatment of Ocular Inflammation Post Cataract Surgery
To investigate inflammation, visual acuity and macular thickness after treatment with Prolensa vs Ilevro after cataract surgery.
- Conditions
- Cataract, Retinal Edema, Inflammation
- Trial name
- QD (NCT01847638)
- Testing
- Prolensa (bromfenac 0.07%), Ilevro (nepafenac 0.3%)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Melissa Toyos
Healthy Volunteers
Transient Lower Esophageal Sphincter Relaxations and High Resolution Manometry
Transient lower esophageal sphincter relaxations (tLESr) are the main mechanism of gastro-oesophageal reflux disease. They occur without any deglutition in patients but also in healthy volunteers. They are induced by meal.
- Trial name
- NCT00931593
- Testing
- Esophageal high resolution manometry associated or not with manometry with perfused Dentsleeve probe (as determined by randomization)
- Where
- 3 sites in France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Intracerebral Hemorrhage
Safety of Pioglitazone for Hematoma Resolution In Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is a devastating disease with less than 20% of survivors being independent at 6 months. There is currently no approved treatment for ICH which has been shown to improve outcomes.
- Trial name
- SHRINC (NCT00827892)
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- The University of Texas Health Science Center, Houston
Primary Hyperparathyroidism, Bone Disease
Bone Architectural Parameters in Postmenopausal Women Affected With Primary Hyperparathyroidism
Bone lesions are frequent in primary hyperparathyroidism (PHPT). Conventional measurement by Dual-Energy X-ray Absorptiometry does not provide enough information about the bone impact of excessive parathyroid hormone (PTH)…
- Trial name
- MicrOs (NCT02539498)
- Testing
- HR-pQCT
- Where
- 3 sites in France
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.