Clinical trials: Resolution of Pathologic Process
Pulpal Necrosis
Evaluation of Chitosan as Irrigating Solution for Pulpectomy in Non-Vital Primary Teeth
45 teeth will be sub-divided at random with a computerized method, according to the type irrigant and duration of its application into 3 groups (15 teeth in each group): Group1(control group): The teeth will be irrigated by 2 ml…
- Trial name
- NCT06506526
- Testing
- Sodium hypochlorite irrigating solution, one minute NaOCL+Chitosan, Three minute NaOCL+Chitosan
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Suez Canal University
Oropharyngeal Dysphagia
Rehabilitation Manometry Study
Oropharyngeal dysphagia, or difficulty swallowing, is a devastating condition that affects physiological and psychosocial functioning in 1 in 25 adults.
- Trial name
- NCT04130867
- Testing
- pHRM, VFSS
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Band Atrophy, Chiasmal Compression
High-Resolution Optical Coherence Tomography for Detection of Retinal Nerve Fiber Layer Loss in Band Atrophy of the Optic Nerve
The purpose of this study is to compare the abilities of high-speed,high-resolution (HR) optical coherence tomography (OCT) and Stratus OCT for detection of retinal nerve fiber layer (RNFL) loss in eyes with band atrophy (BA) of…
- Conditions
- Band Atrophy, Chiasmal Compression, Neural Loss
- Trial name
- NCT00607100
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Head and Neck Cancer, Lymphoma
SUper-Resolution Ultrasound Imaging of Erythrocytes (SURE) in Normal and Malignant Lymph Nodes
The goal of this observational study is to visualize the small vessels in normal and cancerous lymph nodes on the neck with a new ultrasound technique.
- Conditions
- Head and Neck Cancer, Lymphoma, Lymph Node Metastasis
- Trial name
- NCT05754814
- Testing
- Malignant lymph nodes
- Where
- 2 sites in Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Parkinson Disease
Investigation of the Benefits of Electrical Non-invasive Stimulation on Cognitive Symptoms in Parkinson's Disease
Parkinson's disease is the second most common neurodegenerative disease after Alzheimer's disease. It is mostly characterized by the presence of motor difficulties.
- Trial name
- STIMPARK (NCT05808504)
- Testing
- Neuropsychological assessment, Neurological assessment, Cognitive task
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Critically Ill Cirrhotics
To Study the Efficacy of Intravenous Neostigmine in Resolution of Acute GI Paralysis in Critically Ill Cirrhotics
Aim: To determine the efficacy of intravenous neostigmine in the resolution of acute GI paralysis in patients with Critically Ill Cirrhosis (CIC).
- Trial name
- NCT06462872
- Testing
- observational study
- Where
- India
- Volunteers
- 48 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Chronic Obstructive Pulmonary Disease (COPD)
A Study of Arformoterol Tartrate Inhalation Solution and Tiotropium Bromide on Re-hospitalization in Chronic Obstructive Pulmonary Disease (COPD) Subjects
This is a randomized, open-label, parallel group, multicenter, outpatient study in COPD subjects who are discharged from the hospital due to a COPD exacerbation.
- Trial name
- NCT02275481
- Testing
- Arformoterol tartrate inhalation solution, Tiotropium
- Where
- 28 sites in United States
- Volunteers
- 66 people
- Sponsor
- Sumitomo Pharma America, Inc.
Infection of Intravenous Catheter, Phlebitis
Normal Saline Versus Heparinized Solution Flush for Maintaining Patency of Peripheral Venous Catheters in Children
The aim of the study is to verify if the periodic flush with normal saline 0.9% NaCl causes a longer or equal duration of patency of peripheral venous catheters, compared with heparin solution 50 U / ml flush, in children from 2…
- Conditions
- Infection of Intravenous Catheter, Phlebitis, Extravasation of Diagnostic and Therapeutic Materials
- Trial name
- NCT01794767
- Testing
- 0,9% NaCl flush, Heparin 50U/ml
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- University of Florence
Neuroendocrine Tumors, Carcinoid Tumors
Safety of 68Ga-DOTA-tyr3-Octreotide PET in Diagnosis of Solid Tumors
This protocol is designed to test the efficacy of 68Ga-DOTATOC PET/CT in diagnosis, staging, and measurement of response to treatment in patients with somatostatin receptor positive tumors.
- Conditions
- Neuroendocrine Tumors, Carcinoid Tumors, Neuroblastoma, Medulloblastoma
- Trial name
- GA-68 (NCT01619865)
- Testing
- 68Ga-DOTATOC PET/CT
- Where
- United States
- Volunteers
- 223 people
- Sponsor
- Sue O'Dorisio
Suspected or Known Squamous Cell Neoplasia, Prior History of Squamous Cell Dysplasia and /or Neoplasia
High Resolution Microendoscopy for the Detection of Esophageal Squamous Cell Neoplasia
The overall objective of this multicenter trial is to determine whether the use of a low-cost, high-resolution microendoscope during diagnostic upper endoscopy can improve the efficiency and accuracy of endoscopic screening for…
- Trial name
- NCT02029937
- Testing
- Proflavine, high resolution imaging
- Where
- 3 sites in United States, China
- Volunteers
- 1,300 people
- Sponsor
- Anandasabapathy, Sharmila, M.D.
Gastro-oesophageal Reflux
A Study to Compare the Number of Patients With Gastro-Oesophageal Reflux Disease (GORD) Achieving Heartburn and Regurgitation Symptom Resolution After Treatment With Either Rabeprazole Sodium 20mg, Esomeprazole 20mg or Esomeprazole 40mg
The primary objective of this study is to compare, the number of patients with heartburn and regurgitation symptom resolution after treatment with either rabeprazole 20 mg, esomeprazole 20 mg or esomeprazole 40 mg.
- Trial name
- NCT00464308
- Testing
- Esomeprazole, Rabeprazole
- Where
- 25 sites in Australia
- Volunteers
- 1,392 people
- Sponsor
- Janssen-Cilag Pty Ltd
Benign Neuronal Desease
High Resolution Imaging for Analysis of MVNT
MVNT (multinodular and vacuolating neuronal tumor of the cerebrum) is a benign, recently discovered, neuronal lesion, the incidence of which is unknown.
- Trial name
- HAM (NCT04285125)
- Testing
- cerebral MRI
- Where
- 7 sites in France
- Volunteers
- 33 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Dyssynergic Defecation, Puborectalis Syndrome
Puborectalis Syndrome as a Phenotype of Dyssynergic Defecation in Chronic Constipation: a Comparative Study of Defecography,High-resolution Anorectal Manometry, and Pelvic Floor Ultrasound
Patients with suspected DD who met the Rome IV criteria were divided into the DD group and other types of constipation groups. The differences between the two groups were analyzed to explore the precise diagnostic scheme for DD.
- Conditions
- Dyssynergic Defecation, Puborectalis Syndrome, Impaired Rectal Evacuation
- Trial name
- NCT07683390
- Testing
- Analysis of inter-group differences
- Where
- China
- Volunteers
- 164 people
- Sponsor
- Third Military Medical University
Microalbuminuria, Gastrectomy
Resolution of Microalbuminuria and Dysmetabolism Following Bariatric Surgery: Prospective Study
Favorable effects of bariatric surgery have been demonstrated in particular regarding increased insulin sensitivity, decreased blood pressure, improved blood lipids and decreased cardiovascular risk.
- Conditions
- Microalbuminuria, Gastrectomy, Biliopancreatic Diversion With Duodenal Switch
- Trial name
- NCT02068833
- Testing
- Gastrectomy, BPD-DS
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Laval University
Spinal Cord Stimulation, Chronic Pain
Epigenetic Mechanisms and Symptom Clusters Associated with Resolution of Pain Following Spinal Cord Stimulation
Spinal cord stimulation (SCS) is indicated for selected patients with chronic pain who have not responded to conventional medical management.
- Trial name
- NCT04960592
- Testing
- Spinal Cord Stimulation
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- University of Arkansas
Shock
Effect of Balanced Saline Solution and Albumin on Volume Expansion in Shock Patients
To compare the direct effect of sodium acetate ringer injection or albumin on volume expansion in shock patients, and to provide reference for volume resuscitation strategy in shock patients
- Trial name
- NCT05463471
- Testing
- Compound sodium acetate ringer injection, Albumin
- Volunteers
- 500 people
- Sponsor
- Peking Union Medical College Hospital
Pulmonary Disease, Chronic Obstructive
Efficacy and Safety Comparison of Tiotropium Inhalation Solution (Respimat Inhaler) and Spiriva HandiHaler in COPD
Non-inferiority of lung function response to Tiotropium inhalation solution compared to Spiriva HandiHaler
- Trial name
- NCT00239447
- Testing
- Tiotropium, HandiHaler, Respimat SMI
- Where
- 11 sites in United States, Canada
- Volunteers
- 131 people
- Sponsor
- Boehringer Ingelheim
Ischemic Stroke
Mexidol® Safety and Efficacy in Treatment of Hyperacute and Acute Ischemic Stroke
The primary objective of this study is to further define the mechanisms of action of Mexidol® (solution for intravenous and intramuscular injection, 50 mg/ml) and Mexidol® FORTE 250 (film-coated tablets, 250 mg) in the hyperacute…
- Trial name
- NCT07575984
- Testing
- Mexidol, Glycine
- Where
- 9 sites in Russia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Pharmasoft
Rheumatoid Arthritis (RA)
HRV Variation in Rheumatoid Arthritis
The goal of this observational study is to determine the association between continuous Heart Rate Variability (HRV) measured by the Oura ring and Rheumatoid Arthritis (RA) disease activity.
- Trial name
- NCT07878975
- Testing
- Oura Ring
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Central Florida
Oral Cancer, Osteosarcoma
Quantitative Margin Assessment Using High-resolution Positron Emission Tomography - Computed Tomograhy
The primary endpoint is the assessment of the clinical value of a novel high-resolution mobile PET-CT scanner for intraoperative margin assessment in oral squamous cell carcinoma, soft tissue sarcoma and osteosarcoma surgery.
- Conditions
- Oral Cancer, Osteosarcoma, Soft Tissue Sarcoma, Oral Squamous Cell Carcinoma (OSCC)
- Trial name
- qMAP (NCT06726512)
- Testing
- XEOS AURA 10
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- University Medical Center Groningen
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