Clinical trials: Resolution of Pathologic Process, open to volunteers
Autism Spectrum Disorder, Language Development
HR-EEG Contribution in Prognostic Evaluation of Language Development in Children With ASD
The goal of this prospective observational multicentric cohort study is to evaluate the clinical prognostic value of the speech tracking score of language development in children with ASD aged from 3 years to 4 years and half at…
- Conditions
- Autism Spectrum Disorder, Language Development, Neurocognitive Disorders, Child Language
- Trial name
- EE-TSA-LANG (NCT05586672)
- Testing
- EEG-HR, ADI-R, ADOS-2
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Etablissement Public de Santé Barthélemy Durand
Not Applicable - Healthy Participants, Focus is the Memory System
MEMRI: Memory Emergence Using MRI
Episodic memory is our ability to remember personal experiences, such as a birthday party or a visit to the park. This study aims to understand how this type of memory develops during the first two years of a baby's life.
- Conditions
- Not Applicable - Healthy Participants, Focus is the Memory System, Paediatric
- Trial name
- MEMRI (NCT07849075)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Paediatric Neuroimaging Research Group
Oral Cavity Neoplasm
Wide-Field and High Resolution In Vivo Imaging in Visualizing Lesions in Patients With Oral Neoplasia Undergoing Surgery
This clinical trial studies wide-field and high resolution in vivo imaging in visualizing lesions in patients with abnormal or uncontrolled oral cell growth (neoplasia) undergoing surgery.
- Trial name
- NCT01269190
- Testing
- High-Resolution Microendoscopy, Multispectral Imaging, Proflavine
- Where
- United States
- Volunteers
- 275 people
- Sponsor
- M.D. Anderson Cancer Center
Resolution of Inflammation, Reduction of Cell Proliferation
Increased Inflammation-resolving Activity by Omega-3 Monoglycerides in Peripheral Blood Mononuclear Cells (PBMC).
The purpose of this biological study is to provide Dr. Samuel Fortin's laboratory with a continuous supply of blood mononuclear cells (PBMCs) so that he can pursue research on the potential beneficial effects of monoglyceride…
- Trial name
- PBMC (NCT05161702)
- Testing
- MAG-SPM treatment on isolated PBMC cells, Isolated PBMC cells without treatment.
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- SCF Pharma
Acute Pancreatitis, Necrosis; Pancreas, Acute (Infectious)
Conventional Endoscopic Techniques Versus EndoRotor® System for Necrosectomy of Walled of Necrosis
In acute pancreatitis, approximately 20% of the cases result in severe necrotizing pancreatitis which is associated with significant morbidity and mortality.
- Trial name
- RESOlVE (NCT04814693)
- Testing
- EndoRotor® System (Interscope, Inc., Northbridge, MA USA),, Conventional endoscopic devices (according to standards of care)
- Where
- 12 sites in United States, Denmark and 4 more
- Volunteers
- 60 people
- Sponsor
- Erasmus Medical Center
Multiple Sclerosis, Fatigue Syndrome, Chronic
Chronic Fatigue in Multiple Sclerosis: MS Copilot Boost Solution Compared to Standard Care
The main objective of the MS Boost study is to demonstrate the superiority of MSCopilot Boost over standard practice in reducing the impact of fatigue on Patients with Multiple Sclerosis (MS).
- Trial name
- MSBoost (NCT06386133)
- Testing
- MS Boost, Standard of care
- Volunteers
- 208 people
- Sponsor
- Ad scientiam
Dehydration, Menstruation
Hydration & Female Life Stages
Female life stages including premenopausal, perimenopausal, postmenopausal, are characterized by changing concentrations and patterns of hormones.
- Conditions
- Dehydration, Menstruation, Pre-menopause, Peri-menopausal Women
- Trial name
- NCT07653620
- Testing
- electrolyte beverage
- Where
- 2 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Breast Cancer
High-Resolution Lower Dose Dedicated Breast Computed Tomography (CT)
This study is being performed to find out if a new kind of breast imaging (called dedicated breast CT or BCT) can help doctors to see the small structures in breast tissue more clearly.
- Trial name
- LowerDoseBCT (NCT03954431)
- Testing
- Dedicated breast CT(BCT)
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Postthrombotic Syndrome
DVT Burden and the Risk of Post-thrombotic Syndrome
Post-thrombotic syndrome (PTS) is the most common chronic complication of deep vein thrombosis (DVT), with major consequences for patient quality of life and cost of management.
- Trial name
- DVT-Burden (NCT06385353)
- Testing
- Quantification of deep vein thrombosis burden and assessment of post-thrombotic syndrome
- Where
- 27 sites in France
- Volunteers
- 400 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Coronary Artery Disease
High-Resolution CT for Heart
This prospective observational study aims to evaluate a high-resolution coronary CT platform (uCT SiriuX Pro) for non-invasive assessment of coronary plaque biomechanics and functional physiology in high-risk patients.
- Trial name
- NCT07169201
- Testing
- Angiography based RWS and OCT based plaque characteristcis
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Shanghai Zhongshan Hospital
Obsessive Compulsive Disorder (OCD)
Exploring the Efficacy of Accelerated Transcranial Direct Current Stimulation (tDCS) as Adjunct to Pharmacotherapy in the Treatment of Obsessive-compulsive Disorder
This study will evaluate the decision-making ability and therapeutic effects of accelerated Transcranial Direct Current Stimulation (tDCS) as adjunct to pharmacotherapy in obsessive-compulsive disorder (OCD) patients, and the…
- Trial name
- NCT07115615
- Testing
- high-definition transcranial direct current stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Mental Health Center
Arthritis, Rheumatoid
Progression of Bone Erosions in Rheumatoid Arthritis Assessed by HR-pQCT and Conventional X-ray
Today, regular X-ray examination is not sufficiently sensitive for detecting progression of bone destruction in rheumatoid arthritis, but a new type of high-resolution CT scanner, the High-Resolution peripheral Quantitative…
- Trial name
- RACTX (NCT03429426)
- Where
- Denmark
- Volunteers
- 625 people
- Sponsor
- Aarhus University Hospital
Skin Lesion, Skin Cancer
Applicability of a Cellular Resolution Full-field OCT Image System for Pigmented and Non-pigmented Skin Tumors
The incidence of skin cancer has been continuously increasing over the past decades und the number of non melanoma skin cancer is well as melanoma is still going to increase.
- Trial name
- NCT05068310
- Testing
- Cellular resolution full-field optical coherence tomography, Confocal microscopy, Optical coherence tomography imaging
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Apollo Medical Optics, Ltd
Reumatoid Arthritis, Interstitial Lung Disease Due to Systemic Disease (Disorder)
Radiologic Features of Rheumatoid Arthritis Interstitial Lung Disease at Chest High Resolution Computed Tomography
Lung involvement is one of the most frequent extra articular involvements of rheumatoid arthritis (RA). RA related lung involvement can affect parenchyma, airway, vascular tree and serosa.
- Conditions
- Reumatoid Arthritis, Interstitial Lung Disease Due to Systemic Disease (Disorder), Idiopathic Pulmonary Fibrosis (IPF), Connective Tissue Disease (CTD)
- Trial name
- NCT07174102
- Testing
- High resolution computed tomography
- Where
- 5 sites in Czechia, Italy
- Volunteers
- 500 people
- Sponsor
- Azienda Unita Sanitaria Locale di Piacenza
Periodontal Diseases, Periodontitis
Inflammation-resolution Therapy in MINST of Periodontal Intrabony Defect: a Pilot Randomised Controlled Trial
The aim of this study is to assess whether and how a mouthwash containing an ingredient that reduces inflammation in combination with a recently developed treatment is more effective at improving advanced gum disease.
- Trial name
- AIRTIM (NCT07203872)
- Testing
- IsoDent Paro Strong (Isodent Ltd. Valtakatu 4 D, 96100 Rovaniemi, Finland) mouthwash
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Intracranial Stenosis, Venous Sinus Stenosis
This Prospective Observational Study Aims to Evaluate the Capability of Ultra-high-resolution Photon-counting CT Angiography (UHR PCD-CTA) for Noninvasive Evaluation of Intracranial Venous Sinus Stents. The Study Will Compare Image Quality, Stent Visualization, Metal-related Artifacts, and Diagnosti
This prospective observational study aims to evaluate the effectiveness of ultra-high-resolution photon-counting CT angiography (UHR PCD-CTA) for noninvasive assessment of intracranial venous sinus stents.
- Conditions
- Intracranial Stenosis, Venous Sinus Stenosis, Stent Implantation, Intracranial Venous Pressures
- Trial name
- NCT07762677
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xin Lou
Extraesophageal Reflux, Laryngopharyngeal Reflux
Comprehensive Analysis of the Swallowing Mechanism Using High-resolution Manometry With Impedance
The aim of this project is to perform a detailed evaluation of upper esophageal sphincter function and the swallowing mechanism in patients with swallowing disorders or suspected extraesophageal reflux using high-resolution…
- Conditions
- Extraesophageal Reflux, Laryngopharyngeal Reflux, Dysphagia, Chronic Cough
- Trial name
- NCT07365046
- Testing
- High resolution oesophageal manometry with impedance, 24-hour pH metry
- Where
- Czechia
- Volunteers
- 160 people
- Sponsor
- University Hospital Ostrava
Parkinson's Disease
Evaluation of Tau-Pathology in Sporadic and LRRK2 Parkinson's Disease
The study aims to evaluate the burden of tau pathology in people with Sporadic and LRRK2 PD via in vivo imaging using the tau tracer, [18F]PI-2620, and a high resolution PET camera, NeuroEXPLORER.
- Trial name
- NCT07020026
- Testing
- [18F]PI-2620
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Michael J. Fox Foundation for Parkinson's Research
Ischemic Heart Diseases
AI-enhanced Heart MRI for Evaluating Blood Flow
This study will compare the standard MRI protocol with an advanced MRI protocol for the assessment of ischemic heart disease. The goal is to evaluate whether the advanced protocol provides comparable or improved diagnostic…
- Trial name
- NCT07833774
- Testing
- Accelerated advanced MRI sequences protocol
- Volunteers
- 300 people
- Sponsor
- IRCCS San Raffaele
High Resolution Vessel Wall Imaging, Intracranial Atherosclerotic Stenosis, ICAS
Imaging of Intracranial and Extracranial Arterial Atherosclerotic Plaques Using Different Field Strength MRIs
Atherosclerotic stenosis of the carotid and intracranial arteries is one of the leading causes of ischemic cerebrovascular events worldwide.
- Conditions
- High Resolution Vessel Wall Imaging, Intracranial Atherosclerotic Stenosis, ICAS, Arteriosclerosis
- Trial name
- NCT06754956
- Testing
- The patient will receive two intravenous injections of the same gadoterate meglumine contrast agent.
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital