Clinical trials: Resolution of Pathologic Process
Neovascular Age-related Macular Degeneration (nAMD), Diabetic Macular Edema (DME)
Observational Study to Evaluate Fluid Resolution and Effectiveness in Patients Receiving Beovu in Neovascular Age-related Macular Degeneration and Visual Impairment Due to Diabetic Macular Edema
This study is a prospective, non-interventional, multicenter, open-label study in nAMD and DME patients being treated with brolucizumab according to the EU SmPC.
- Trial name
- BLUE SKY (NCT04543331)
- Testing
- brolucizumab
- Where
- 41 sites in Germany
- Volunteers
- 572 people
- Sponsor
- Novartis Pharmaceuticals
Central Line-associated Bloodstream Infection (CLABSI), Catheter-related Bloodstream Infection
Effect of Vancomycin After Catheter Replacement
Randomized controlled trial of the effect of a single-dose intravenous Vancomycin after catheter replacement for suspected central line-associated bloodstream infection on resolution of infection in critically ill patients.
- Trial name
- VanCat (NCT04856878)
- Testing
- Vancomycin
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Colon Polyps, Colonic Dysplasia
Evaluation of a Low-Cost High Resolution Microendoscope for the Detection of Lower Gastrointestinal Neoplasia
The overall objective of this study is to obtain data to evaluate whether high-resolution imaging of the colon can assist clinicians in detecting dysplastic (precancerous) and neoplastic areas.
- Conditions
- Colon Polyps, Colonic Dysplasia, Anal Dysplasia
- Trial name
- NCT01384240
- Testing
- Proflavine Hemisulfate
- Where
- United States
- Volunteers
- 183 people
- Sponsor
- Anandasabapathy, Sharmila, M.D.
Brain Diseases
Evaluation of a New MRI Technique to Reduce Breathing-Related Artifacts in Brain Imaging
This study aims to improve the quality of brain magnetic resonance imaging (MRI) scans by testing a new imaging method that reduces distortions caused by breathing.
- Trial name
- DORK (NCT07305948)
- Testing
- Dual Free Induction Decay (FID) Navigator Off-Resonance Corrected (DORK) 3D Susceptibility Weighted (SWI) Echo Planar Imaging (EPI)
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Region Stockholm
Common Peroneal Neuropathy
Sensory Potentials and Ultrasonography in Common Peroneal Mononeuropathy
Common peroneal mononeuropathy at the fibular neck (CPN) is one of the most frequent mononeuropathies of the lower extremities. The common peroneal nerve sub serves sensation to the dorsum of the foot and toes.
- Trial name
- NCT03753178
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- rania sanad
Macular Edema, CNV
Evaluation of Retinal Structure With High Resolution Optical Coherence Tomography (OCT)
Comparison of different OCT instruments to assess retinal thickness, correlation to fluorescein angiography, and visual outcome after therapy with anti-VEGF therapy
- Trial name
- NCT00564291
- Testing
- Examination with an OCT device
- Where
- 2 sites in Switzerland
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Sebastian Wolf
Fluorodeoxyglucose F18
Peroperative Assessment of Tumour Resection Margins Using High-resolution 18F-FDG-PET/CT in Pancreatic Adenocarcinoma
One of the main risks for recurrence in patients with pancreatic cancer is incomplete surgery of the primary tumor. During the operation, the surgeon bases himself for this on imaging and peroperative vision.
- Trial name
- IMA-PANC-CA (NCT05023291)
- Testing
- Positron Emissie Tomografie - Computer Tomografie
- Where
- Belgium
- Volunteers
- 5 people
- Sponsor
- University Hospital, Ghent
Stargardts, Retinitis Pigmentosa
High Resolution Retinal Imaging
Studying the morphology and function of the normal and diseased retina in vivo is needed for advancing the detection, diagnosis, and treatment of retinal disease.
- Conditions
- Stargardts, Retinitis Pigmentosa, Age-related Macular Degeneration, Choroideremia
- Trial name
- AOSLO (NCT01866371)
- Testing
- Retinal imaging
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Prostate Cancer
Single-center Trial for the Validation of High-resolution Transrectal Ultrasound (Exact Imaging Scanner ExactVu) for the Detection of Prostate Cancer
The primary objective of this study is to evaluate the performance of HR-TRUS in detection of prostate cancer lesions relative to whole mount section after radical prostatectomy as the reference.
- Trial name
- EXACTVU (NCT03679819)
- Testing
- HR-TRUS
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Institut Paoli-Calmettes
Cricoid Pressure
Effect of Incorrectly Applied Cricoid Pressure During Rapid Sequence Induction. Evaluation With High-resolution Manometry.
During emergency anesthesia (rapid sequence induction) , a firm pressure is applied to the cricoid cartilage of the patient in order to prevent passive regurgitation of gastric content into the pharynx.
- Trial name
- NCT02161601
- Testing
- Cricoid Pressure
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Örebro University, Sweden
Scoliosis, Scoliosis Idiopathic
Paravertebral Muscles Assessment Using High-resolution MRI in Idiopathic or Neuromuscular Scoliosis Children
Scoliosis is a common three-dimensional spinal deformity defined by vertebral rotation. Apart from collapse scoliosis, clinical and radiological similarities have been observed in children with secondary scoliosis of…
- Conditions
- Scoliosis, Scoliosis Idiopathic, Scoliosis Neuromuscular
- Trial name
- MRISCOL (NCT07135765)
- Testing
- Additional 5 minutes of lying down position during MRI
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Magnetic Resonance Imaging, Pregnancy
Non-contrast 3D MR Angiography for Assessment of the Thoracic Aorta in Pregnancy
Introduction: Native magnetic resonance angiography (MRA) is recommended to assess the thoracic aorta during pregnancy, avoiding the risks of ionising radiation and contrast agent administration.
- Trial name
- NCT02793570
- Testing
- observational
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Breast Neoplasms
Light-CT in the Diagnosis of Breast Tumor and Lymph Node
Intraoperative pathological diagnosis such as frozen section and imprint cytology is not routinely recommended in clinical practice because of time and accuracy concerns.
- Trial name
- NCT03791853
- Testing
- Light-CT
- Where
- 3 sites in China
- Volunteers
- 150 people
- Sponsor
- Peking University People's Hospital
Extraesophageal Reflux, Laryngopharyngeal Reflux
Comprehensive Analysis of the Swallowing Mechanism Using High-resolution Manometry With Impedance
The aim of this project is to perform a detailed evaluation of upper esophageal sphincter function and the swallowing mechanism in patients with swallowing disorders or suspected extraesophageal reflux using high-resolution…
- Conditions
- Extraesophageal Reflux, Laryngopharyngeal Reflux, Dysphagia, Chronic Cough
- Trial name
- NCT07365046
- Testing
- High resolution oesophageal manometry with impedance, 24-hour pH metry
- Where
- Czechia
- Volunteers
- 160 people
- Sponsor
- University Hospital Ostrava
Covid19
COVID-19 Outpatient Pragmatic Platform Study (COPPS) - Camostat Sub-Protocol
The overall objective of this study is to efficiently evaluate the clinical efficacy and safety of different investigational therapeutics among adults who have COVID-19 but are not yet sick enough to require hospitalization.
- Trial name
- COPPS (NCT04662073)
- Testing
- Camostat
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- Stanford University
Inflammation
Pilot Study to Validate ex Vivo Expression of Specific Biomarkers of Human Resolutive Macrophages
Human resolutive macrophages are essential immune cells in the resolution of inflammation. This particular type of macrophages remains poorly known and currently there are no biomarkers to identify them in vivo.
- Trial name
- RESOMACRO (NCT05106075)
- Testing
- blood sample or joint fluid or gingival exudate
- Where
- 2 sites in France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Dysphagia, Achalasia
Diagnostic Utility of Amyl Nitrite in Patients With Suspected Achalasia Undergoing High Resolution Esophageal Manometry (HREM)
This research is being done to see if a study drug called amyl nitrite can be helpful with diagnosing different disorders affecting the lower esophageal sphincter in patients with dysphagia (difficulty swallowing foods)…
- Trial name
- NCT02428959
- Testing
- Amyl Nitrite
- Where
- United States
- Sponsor
- Johns Hopkins University
Dental Research, Pharmaceutical Preparations, Dental
The Effects of Dexamethasone on the Time to Pain Resolution in Dental Periapical Abscess
An individual's quality of life can be seriously affected by the severity of dental pain. The emergency department is a common place to find those seeking relief from their dental pain- often times seeking removal of the affected…
- Trial name
- NCT03005522
- Testing
- oral dexamethasone
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- University of Arizona
Tourette Syndrome
MRI Study of Tic Remission in Tourette Syndrome
Doctors provide a ray of hope to children and their parents with the knowledge that, for most patients, symptoms of Tourette syndrome improve by the time they are young adults.
- Trial name
- NCT01405859
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Utah
Obesity, Metabolic Syndrome
The Predictive Role of Preoperative Pentraxin-3 (PTX3) in Metabolic and Inflammatory Outcomes After Roux-en-Y Gastric Bypass
This study evaluated the prognostic value of preoperative pentraxin-3 (PTX3) levels in predicting weight loss, inflammatory resolution (CRP, IL-6), and metabolic improvements (HOMA-IR) following Roux-en-Y gastric bypass in…
- Conditions
- Obesity, Metabolic Syndrome, Insulin Resistance, Inflammation
- Trial name
- PTX3-BYPASS (NCT07241741)
- Testing
- Biomarker Stratification by PTX3
- Volunteers
- 23 people
- Sponsor
- Istanbul University
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