Clinical trials: Resolution of Pathologic Process
Living Donor Liver Transplantation
Effect of Ascites Replacement Strategy on Time to 1st Flatus After LDLT
The aim of this study is to evaluate difference in the rate of recovery of intestinal motility according to different ascites replacement strategy after living donor liver transplantation.
- Trial name
- NCT04184401
- Testing
- Ascites replacement with albumin and hartmann's solution, Ascites replacement with hartmann's solution
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Seoul National University Hospital
Partial Epilepsy
Localizing the Epileptogenic Zone With High Resolution Electroencephalography
Multicenter prospective study comparing the diagnosis value of high-resolution EEG and depth-EEG to localize the epileptogenic zone in drug resistant partial epilepsies.
- Trial name
- EEG-HR (NCT01090934)
- Testing
- High Resolution EEG, Stereo-electroencephalography
- Where
- 2 sites in France
- Volunteers
- 115 people
- Sponsor
- Central Hospital, Nancy, France
Breast Cancer
Pilot Study to Evaluate High Resolution PET Image-Guidance for Sampling of Breast Abnormalities
The purpose of this pilot clinical study is to test a methodology for using high-resolution Positron Emission Tomography (PET) imaging to guide vacuum-assisted core biopsy of breast abnormalities identified on PET.
- Trial name
- PEM-BX (NCT00606931)
- Testing
- Stereo Navigator Accessory to PEM Flex PET Scanner
- Where
- 5 sites in United States
- Volunteers
- 22 people
- Sponsor
- Naviscan PET Systems
Traumatic Brain Injury, Subdural Hematoma
Hypernatremia for the Prevention and Treatment of Cerebral Edema in Traumatic Brain Injury
Cerebral edema is seen heterogenous group of neurological disease states that mainly fall under the categories of metabolic, infectious, neoplasia, cerebrovascular, and traumatic brain injury disease states.
- Conditions
- Traumatic Brain Injury, Subdural Hematoma, Cerebral Contusion, Head Injury
- Trial name
- NCT01605357
- Testing
- Induced, sustained hypernatremia using hypertonic saline, Standard of care (hypertonic saline and mannitol; serum sodium)
- Sponsor
- Massachusetts General Hospital
Swallowing Contraction Strength
Investigating the Correlations Between Dysphagia Symptoms and Swallowing Muscle Groups by HRPM-I
Investigating the correlation between the dysphagia symptoms and swallowing muscle groups by high resolution pharyngeal manometry with impedance
- Trial name
- NCT06006195
- Testing
- patients with dysphagia symptoms, patients without dysphagia symptoms
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Diabetic Macular Edema, Hard Lipid Exudates
The Effect of Intravitreal Ranibizumab on Visual Acuity and Hard Exudate Resolution in the Treatment of Diabetic Macular Edema With Center Involved Edema and Lipid Exudates
This is an open-label, Phase I/II study of intravitreally administered 0.3mg ranibizumab in subjects with diabetic macular edema and lipid exudates in the central subfield.
- Trial name
- NCT02448446
- Testing
- ranibizumab 0.3mg
- Where
- 4 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- South Coast Retina Center; Carson, McBeath, Boswell, Inc.
Skin Lesion, Skin Cancer
Applicability of a Cellular Resolution Full-field OCT Image System for Pigmented and Non-pigmented Skin Tumors
The incidence of skin cancer has been continuously increasing over the past decades und the number of non melanoma skin cancer is well as melanoma is still going to increase.
- Trial name
- NCT05068310
- Testing
- Cellular resolution full-field optical coherence tomography, Confocal microscopy, Optical coherence tomography imaging
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Apollo Medical Optics, Ltd
Hydrocortisone, Depression
Exploring the Effects of Corticosteroids on the Human Hippocampus
Chronic corticosteroid (CS) exposure is associated with changes in memory and the hippocampus in both humans and in animal models.
- Conditions
- Hydrocortisone, Depression, Healthy Volunteers
- Trial name
- NCT03896659
- Testing
- Hydrocortisone Oral
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Postmenopausal Osteoporosis, Postmenopause
Frequency of Hyperparathyroidism in Postmenopausal Osteoporosis and Its Treatment
Recently, an increase in the prevalence of hyperparathyroidism and hypovitaminosis D in postmenopause women has been occurring in Mexico and the world.
- Conditions
- Postmenopausal Osteoporosis, Postmenopause, Hyperparathyroidism, Secondary, Hypovitaminosis D
- Trial name
- NCT05347082
- Testing
- Cholecalciferol
- Where
- Mexico
- Volunteers
- 47 people
- Sponsor
- Hospital Regional 1o de Octubre
Cerebral Stroke
Super-Resolution Ultrasound of the Brain in 3D
The goal of this proof of concept study is to determine if the visualization of the middle cerebral artery and its perforators, through 3D transtemporal ultrasound imaging, is possible thanks to an off-line analysis by 3D…
- Trial name
- ESRC3D (NCT06133179)
- Testing
- Transtemporal ultrasound with contrast product (Sonovue)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Myocardial Ischemia
Adenosine's Effect on STunning Resolution in Acute Myocardial Infarction
The aim of this study is to evaluate the effect of adenosine on the recovery of myocardial akinesia in ST-elevation myocardial infarction (STEMI).
- Trial name
- A-STAMI (NCT05014061)
- Testing
- Adenosine
- Sponsor
- Vastra Gotaland Region
Chronic Ankle Instability, CAI, Functional Magnetic Resonance Imaging (fMRI)
fMRI Study on Cerebral Localization and Network Mechanisms of rTMS in Chronic Ankle Instability Treatment
Chronic ankle instability (CAI) is a common sports injury that often leads to recurrent injuries and functional deficits. While conventional rehabilitation can restore ankle stability, the underlying neurophysiological mechanisms…
- Trial name
- NCT06971705
- Testing
- repetitive transcranial magnetic stimulation, rTMS, ankle stability training
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Wuhan University
Referral and Consultation
Effectiveness of a Educational Intervention to Improve the Resolution Capacity of Primary Health Care Teams.
There is a great variability in the different primary care teams referral rate. And variability means inappropriateness somewhere in the process of care.
- Trial name
- NCT00140283
- Testing
- Educational interactive intervention
- Where
- Spain
- Volunteers
- 48 people
- Sponsor
- Catalan Institute of Health
High Resolution Vessel Wall Imaging, Intracranial Atherosclerotic Stenosis, ICAS
Imaging of Intracranial and Extracranial Arterial Atherosclerotic Plaques Using Different Field Strength MRIs
Atherosclerotic stenosis of the carotid and intracranial arteries is one of the leading causes of ischemic cerebrovascular events worldwide.
- Conditions
- High Resolution Vessel Wall Imaging, Intracranial Atherosclerotic Stenosis, ICAS, Arteriosclerosis
- Trial name
- NCT06754956
- Testing
- The patient will receive two intravenous injections of the same gadoterate meglumine contrast agent.
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Healthy, Pulmonary Disease, Chronic Obstructive
Relative Bioavailability of of Olodaterol and Ketoconazole
This clinical trial is intended to investigate a possible effect of the p-gp inhibitor ketoconazole on the bioavailability of olodaterol
- Trial name
- NCT01153711
- Testing
- BI 1744, Ketoconazole
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Alzheimer's Disease
18F-AV-1451 High Resolution Autopsy Study
The study is designed to examine the relationship between imaging results detected on a 18F-AV-1451 PET scan and pathology found at autopsy within six months of imaging.
- Trial name
- NCT02350634
- Testing
- Flortaucipir F18
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- Avid Radiopharmaceuticals
Branch Retinal Artery Occlusion, Central Retinal Artery Occlusion
Retinal Oxygen Saturation, Blood Flow, Vascular Function and High Resolution Morphometric Imaging in the Living Human Eye
Canadians fear loss of vision more than any other disability. Vision loss has an enormous impact on quality-of-life and is extremely costly from a societal and economic perspective.
- Conditions
- Branch Retinal Artery Occlusion, Central Retinal Artery Occlusion, Branch Retinal Vein Occlusion, Central Retinal Vein Occlusion
- Trial name
- NCT01348633
- Where
- Canada
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Brain Tumor
High Resolution Magnetic Resonance Imaging in Patients With Brain Tumors
The study will compare two different size MRI's of a brain tumor.
- Trial name
- NCT02035852
- Testing
- MRI
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- University of Texas Southwestern Medical Center
Surgical Site Infections
PVP Iodine vs Chlorhexidine in Alcohol for Disinfection of the Surgical Site
Prospective cluster-randomized multicenter cross-over trial to prove non-inferiority of PI compared to CHX in preoperative skin antisepsis
- Trial name
- PICASSo (NCT03685604)
- Testing
- CHX disinfection, PI Disinfection
- Where
- 3 sites in Switzerland
- Volunteers
- 3,321 people
- Sponsor
- University Hospital, Basel, Switzerland
Cervix Carcinoma
Use of High-Resolution Microendoscopy (HRME) in Patients With Adenocarcinoma In-Situ (AIS) of the Cervix
The goal of this clinical research study is to learn if it is possible to get high-resolution microendoscopy (HRME) images of AIS tissue and/or tissue from microinvasive carcinoma right before a biopsy of the cervix.
- Trial name
- NCT02206048
- Testing
- Proflavine, High-Resolution Microendoscopy (HRME) Imaging
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- M.D. Anderson Cancer Center
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