Clinical trials: Resource-Limited Setting
Benign Gynecologic Conditions
Comparison of the Outcomes of Total Laparoscopic Hysterectomy Versus Total Abdominal Hysterectomy for Benign Gynecologic Conditions in a Limited-resources Setting.
Minimally invasive hysterectomy (laparoscopic) is associated with shorter hospital stay, less blood loss, faster recovery, and improved early postoperative quality of life compared with open abdominal hysterectomy.
- Trial name
- NCT07496814
- Volunteers
- 32 people
- Sponsor
- Assiut University
Neonatal Resuscitation
Outcomes of Neonatal Resuscitation
The primary objective of this study is to describe mortality of newborns who received basic, advanced or no neonatal resuscitation immediately after birth at Shoklo Malaria Research Unit.
- Trial name
- NCT02840682
- Where
- Thailand
- Volunteers
- 15,073 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Sepsis
Management of Sepsis in Resource Limited Settings Using a Delphi Method.
Rapid evolution of sepsis syndromes means that timely diagnosis and treatment are critical in improving outcomes but this may be difficult to achieve in many low- and middle- income countries (LMICs) and there is a lack of high…
- Trial name
- NCT05909384
- Testing
- Survey
- Where
- Vietnam
- Volunteers
- 36 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Healthy, Male Infertility
Expanding Fertility Care to Poor and Low Resourced Settings Study
The investigators currently lack an understanding of barriers to completing the male factor infertility evaluation. Furthermore, as the investigators continue to expand access to fertility treatment particularly within…
- Conditions
- Healthy, Male Infertility, Infertility, Male, Fertility Disorders
- Trial name
- EXPLORE (NCT05205733)
- Testing
- Mail-in semen analysis kit
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
HIV/AIDS
International HIV Antiretroviral Adherence, Resistance and Survival
Real-time Wireless Adherence Monitoring to HIV Antiretroviral Therapy in Rural Uganda.
- Trial name
- UARTO (NCT01596322)
- Where
- Uganda
- Volunteers
- 750 people
- Sponsor
- Massachusetts General Hospital
Iron Deficiency Anemia, Anemia
Iron Fish in Dominican Republic (DR) Children
The objective of the study is to assess the acceptability, feasibility, and barriers to Lucky Iron Fish™ (LIF) utilization among families with young children in a Latin American community with a high prevalence of iron deficiency…
- Conditions
- Iron Deficiency Anemia, Anemia, Iron-deficiency
- Trial name
- NCT03199235
- Testing
- Lucky Iron Fish, enhanced standard of care
- Where
- Dominican Republic
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Cirrhosis of the Liver, Ascites
Ultrasound Assessment of Diaphragmatic Structure and Function in Patients With Liver Cirrhosis: A Point-of-Care Tool for Predicting Complications and Sarcopenia in Limited Resource Settings
The goal of this observational study is to learn how liver cirrhosis affects the diaphragm, the main muscle used for breathing, in adults.
- Conditions
- Cirrhosis of the Liver, Ascites, Pleural Effusion Disorder, Hepatocellular Carcinoma (HCC)
- Trial name
- NCT07667608
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assiut University
Type 1 Diabetes
Comparative Efficacy of a Two Daily Mixed Insulin Injection Versus a Basal-bolus Scheme With Human Insulin
The goal of this clinical trial is to compare glycemic control and variability between children and adolescents with type 1 diabetes treated by a two daily injection of premixed human insulin (Humulin 30/70) and those who have a…
- Trial name
- NCT05768191
- Testing
- premix insulin human isophane suspension and insulin human, Humulin N plus Humulin R
- Where
- 3 sites in Burkina Faso
- Volunteers
- 22 people
- Sponsor
- Université NAZI BONI
Hydrocephalus, Ventriculoperitoneal Shunt Infection
Efficacy and Cost-Effectiveness of Topical Vancomycin Powder in Preventing Pediatric Ventriculoperitoneal Shunt Infections Across Different Etiologies
Objectives Primary: To measure the reduction in VP shunt infection rates using topical vancomycin powder. Secondary: To compare efficacy across different Etiological Strata (Congenital, Post-hemorrhagic, post-inflammatory).
- Conditions
- Hydrocephalus, Ventriculoperitoneal Shunt Infection, Surgical Site Infection (SSI), Cerebrospinal Fluid Shunt Infection
- Trial name
- NCT07547826
- Testing
- Topical Vancomycin Powder, Standard Perioperative Care
- Where
- Egypt
- Volunteers
- 164 people
- Sponsor
- Assiut University
Maternal Death
Critically-Ill Women Admitted to an Obstetric High Dependency Unit in a Resource-Limited Setting
Sierra Leone faces the highest maternal mortality ratio in the world. Despite this extreme burden, the potential roles of obstetric critical care and high dependency units (HDUs) in this and other resource-limited settings remain…
- Trial name
- NCT04121234
- Testing
- Exposure: " being admitted to HDU with a red code to OEWS"
- Where
- Sierra Leone
- Volunteers
- 523 people
- Sponsor
- Doctors with Africa - CUAMM
HIV-1 Infection, Kaposi's Sarcoma
Antiretroviral Therapy (ART) Alone or With Delayed Chemo Versus ART With Immediate Chemo for Limited AIDS-related Kaposi's Sarcoma
AIDS-related Kaposi's sarcoma (AIDS-KS) occurs in persons with HIV infection who are also infected with the Kaposi's sarcoma herpesvirus (KSHV).
- Trial name
- REACT-KS (NCT01352117)
- Testing
- efavirenz/emtricitabine/tenofovir disoproxil fumarate, etoposide
- Where
- 8 sites in Brazil, Kenya and 4 more
- Volunteers
- 192 people
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Male Circumcision
Randomized Trial Comparing PrePex Day 7 Foreskin Removal Procedure (FRP) to a Day 0 PrePex FRP .
A Prospective, Randomized, Open Label Trial Comparing PrePex™ Day 7 (FRP) to a PrePex Day 0 FRP of Male Circumcision in Resource Limited Settings.
- Trial name
- NCT03223532
- Testing
- PrePex Day 7 FRP, PrePex Day 0 FRP
- Where
- Kenya
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Nyanza Reproductive Health Society
HIV-infection/Aids, Coronavirus Infection
COHIVE: Coronavirus (COVID-19) Outcomes in HIV Evaluation in Resource Limited Settings
COHIVE is an observational cohort nested in four antiretroviral therapy research studies (ADVANCE - NCT03122262; D²EFT - NCT03017872; DolPHIN2 - NCT03249181 and NAMSAL-ANRS12313 - NCT02777229).
- Trial name
- NCT04371835
- Where
- 15 sites in Argentina, Brazil and 8 more
- Volunteers
- 596 people
- Sponsor
- Kirby Institute
HIV/AIDS
"Switch Either Near Suppression Or THOusand"
This trial addresses the question of the viral load (VL) threshold for switching from first-line to second-line antiretroviral therapy (ART). The WHO currently sets the threshold at 1000 copies/mL.
- Trial name
- SESOTHO (NCT03088241)
- Testing
- switch
- Where
- 8 sites in Lesotho
- Volunteers
- 80 people
- Sponsor
- Niklaus Labhardt
Mortality, Pediatric
Operative Duration as a Predictor of Mortality in Pediatric Emergency Surgery
Introduction Operative duration is an important but under-studied predictor of mortality in emergency laparotomies. Aims \& Objectives The objective of this study was to quantify the effect of duration of emergency laparotomy in…
- Conditions
- Mortality, Pediatric, Laparotomy, Emergencies
- Trial name
- NCT03270930
- Testing
- Emergency laparotomy
- Volunteers
- 213 people
- Sponsor
- Jawaharlal Nehru Medical College
Critical Illness
Cost Effectiveness Analysis of Critical Care in Resource Limited Setting
The purpose of this study was to examine the cost effectiveness of critical care in a middle income country with limited resources. The main study hypothesis was that critical care is cost effective in low resources setting.
- Trial name
- CEACCLR (NCT02556476)
- Testing
- mechanical ventilation, neuromuscular blockade, renal replacement therapy
- Volunteers
- 148 people
- Sponsor
- University of Sarajevo
Critical Illness, Febrile Illness
Family Assisted Severe Febrile Illness Therapy for Critically-ill Kenyan Children
The purpose of this pilot study is to improve inpatient monitoring of severely-ill children admitted to the hospital in low resource settings at Kenyatta National Hospital in Nairobi, Kenya.
- Trial name
- FASTER (NCT03513861)
- Testing
- FASTER Assessment tool
- Where
- Kenya
- Volunteers
- 182 people
- Sponsor
- Seattle Children's Hospital
HIV Infection, Pregnancy
Universal Use of EFV-TDF-FTC and AZT-3TC-LPV/r Combinations for HIV-1 PMTCT in Pregnant and Breastfeeding Women : a Phase 3 Trial
To assess the maternal and infant safety of a single daily fixed-dose combination of TDF/FTC/EFV (Atripla®), compared to the association of LPV/r (Kaletra® or Aluvia®) and 3TC/ZDV (Combivir®) given to African women to prevent…
- Conditions
- HIV Infection, Pregnancy, Breastfeeding, HIV Infections
- Trial name
- UMA (NCT00936195)
- Testing
- Efavirenz-Tenofovir-Emtricitabine, Zidovudine-Lamivudine-Lopinavir/Ritonavir
- Where
- 2 sites in Côte d’Ivoire, Zambia
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
Kaposi Sarcoma, HIV-1-infection
Paclitaxel and Pegylated Liposomal Doxorubicin for Treatment of HIV-related Kaposi Sarcoma
This study is being done to determine if two different anti-cancer drugs, paclitaxel (PTX) and pegylated liposomal doxorubicin (PLD) have similar effects on treating Kaposi Sarcoma (KS) in people living with HIV (human…
- Conditions
- Kaposi Sarcoma, HIV-1-infection, AIDS-related Kaposi Sarcoma
- Trial name
- NCT05411237
- Testing
- Pegylated liposomal doxorubicin, Paclitaxel
- Volunteers
- 130 people
- Sponsor
- AIDS Malignancy Consortium
Lupus Nephritis
A Pharmacoeconomic Study Comparing the Use of Mycophenolate Mofetil or Cyclophosphamide as Induction Therapy in Lupus Nephritis Patients in Egypt
The aim of this study is to conduct a pharmacoeconomic analysis to compare the use of Mycophenolate Mofetil or i.v. Cyclophosphamide as induction therapy from a third party payer perspective in LN patients in the Egyptian context
- Trial name
- NCT05195086
- Testing
- endoxan, cellcept
- Where
- Egypt
- Volunteers
- 122 people
- Sponsor
- Nada Magdy Mansour