Clinical trials: Respiration
Asthma
Efficacy and Safety Study of QAW039 in Patients With Severe Asthma Inadequately Controlled With Standard of Care Asthma Treatment.
This study aimed to determine the efficacy and safety of QAW039 150 mg and QAW039 450 mg, compared with placebo, when added to GINA (Global Initiative for Asthma) steps 4 and 5 standard-of- care (SoC) asthma therapy (GINA 2016)…
- Trial name
- NCT02555683
- Testing
- QAW039
- Where
- 234 sites in United States, Argentina and 25 more
- Volunteers
- 894 people
- Sponsor
- Novartis Pharmaceuticals
Sleep Disorders
Effect of High Rebound Mattress Toppers on Sleep and Sleep-Related Symptoms
The purpose of the study is to evaluate effects of high rebound mattress toppers (i.e., airweave®) on sleep and sleep-related symptoms.
- Trial name
- NCT03055156
- Testing
- Low rebound mattress toppers, High rebound mattress toppers
- Where
- United States
- Volunteers
- 558 people
- Sponsor
- Stanford University
Positive-Pressure Respiration, Communication
Determining the Benefits of Improving Communication in BPAP/CPAP Users
The purpose of this study is to determine the effectiveness of a non-invasive communication aid for BPAP/CPAP masks. This study also looks to determine the potential impact of the device on patients with obstructive sleep apnea…
- Trial name
- NCT03795753
- Testing
- F2S Communicator, Non-functioning Communicator
- Where
- 3 sites in United States
- Volunteers
- 36 people
- Sponsor
- Emory University
Obstructive Sleep Apnea
Treatment of OSA Associated Hypertension With Alpha 2 Agonist or Diuretic
Patients who have obstructive sleep apnea (OSA) frequently stop breathing while they sleep. They often develop high blood pressure. We are not sure what drug is best to treat the high blood pressure.
- Trial name
- guanhctz (NCT02699125)
- Testing
- Guanfacine, Hydrochlorothiazide
- Volunteers
- 41 people
- Sponsor
- University of California, San Diego
Transient Ischemic Attack, Stroke
Sleep Apnea in TIA/Stroke: Reducing Cardiovascular Risk With Positive Airway Pressure
The goal of this study is to develop a novel study design to safely and ethically conduct a long-term randomized controlled trial among patients at high risk for both sleep apnea and cardiovascular events that will examine…
- Trial name
- SleepTight (NCT01446913)
- Testing
- Standard CPAP Intervention, Enhanced CPAP Intervention
- Where
- 2 sites in United States
- Volunteers
- 255 people
- Sponsor
- Yale University
Sleep Apnea, Obstructive, Down Syndrome
A Pilot Study to Evaluate the Hypoglossal Nerve Stimulator in Adolescents With Down Syndrome and Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) affects up to 1% of the general pediatric population and is associated with adverse behavior and quality of life, as well as long term cardiopulmonary system complications.
- Trial name
- NCT02344108
- Testing
- Inspire® Upper Airway Simulation System (Model 3028 IPG )
- Where
- 5 sites in United States
- Volunteers
- 42 people
- Sponsor
- Christopher Hartnick, M.D.
Acute Respiratory Distress Syndrome
Human Mesenchymal Stem Cells For Acute Respiratory Distress Syndrome
This is a Phase 1, open label, dose escalation, multi-center clinical trial of Allogeneic Bone Marrow-Derived Human Mesenchymal Stem Cells (hMSCs) for the treatment of Acute Respiratory Distress Syndrome (ARDS).
- Trial name
- START (NCT01775774)
- Testing
- Allogeneic Bone Marrow-Derived Human Mesenchymal Stem Cells
- Where
- 4 sites in United States
- Volunteers
- 9 people
- Sponsor
- Michael A. Matthay
Ventilation Perfusion Mismatch
Effect of Alveolar Minute Ventilation on Respiratory Gas Heat Content
This is a single site, prospective, non-blinded, non-randomized, non-interventional study designed to evaluate the effect of changes in alveolar minute ventilation on the measurement of respiratory heat loss (enthalpy).
- Trial name
- NCT01943227
- Testing
- controlled positive pressure ventilation 9ml/kg tidal volume, controlled positive pressure ventilation 6ml/kg tidal volume
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Davis
Chronic Cough
Evaluation of S-600918 in Adults With Refractory Chronic Cough
The primary objective of this study is to determine the optimal dose of S-600918 in patients with refractory chronic cough by evaluating the change from baseline in 24-hour cough frequency (coughs per hour) with S-600918 compared…
- Trial name
- NCT04110054
- Testing
- S-600918
- Where
- 136 sites in United States, Czechia and 4 more
- Volunteers
- 406 people
- Sponsor
- Shionogi
Sleep Apnea, Obstructive, Hypopnea Syndrome
Treatment of Refractory Excessive Daytime Sleepiness in Patients With Obstructive Sleep Apnea/Hypopnea Syndrome (OSA/HS) Using Nasal Continuous Positive Airway Pressure (nCPAP) Therapy (0249-015)
The purpose of this study is to determine the safety and efficacy of MK0249 in treating refractory excessive daytime sleepiness (EDS) in patients with Obstructive Sleep Apnea/Hypopnea Syndrome (OSA/HS) using nasal continuous…
- Conditions
- Sleep Apnea, Obstructive, Hypopnea Syndrome, Excessive Daytime Sleepiness
- Trial name
- NCT00620659
- Testing
- Comparator: MK0249, Comparator: modafinil
- Volunteers
- 125 people
- Sponsor
- Merck Sharp & Dohme LLC
Pompe Disease
Response to Diaphragmatic Pacing in Subjects With Pompe Disease
The purpose of this study is to determine the effect of diaphragm pacing on respiratory function in subjects with Pompe disease by evaluating the duration and pattern of spontaneous respiratory function versus paced ventilation…
- Trial name
- NCT02354651
- Testing
- Diaphragm conditioning via phrenic nerve stimulation
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Florida
Invasive Mechanical Ventilation, Children With Medical Complexity
Parent-to-parent Coaching While Awaiting Hospital Discharge With a Child With a Ventilator
The objective of the study is to pilot a parent-to-parent coaching model with experienced family members of children with Invasive Mechanical Ventilation (IMV) as parent coaches.
- Conditions
- Invasive Mechanical Ventilation, Children With Medical Complexity, Home Nursing, Empowerment
- Trial name
- NCT05880953
- Testing
- Parent-to-parent coaching
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Stroke
Ventilation Strategies, Anesthetic Techniques and Cerebral Oxygenation in the Beach Chair Position
The seated or "beach chair" position during surgery and general anesthesia decreases brain oxygen levels and can result in stroke. As such, poor neurological outcome following beach chair positioning is a growing concern.
- Trial name
- NCT01535274
- Testing
- Inspired oxygen fraction / end tidal carbon dioxide
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- University of Michigan
Intensive Care Unit, Muscle Weakness
Use of Neuromuscular Electrostimulation (NMES) for Treatment or Prevention of ICU-Associated Weakness
The purpose of this study is to investigate whether neuromuscular electrostimulation (NMES) will decrease ICU-associated weakness.
- Trial name
- NMES (NCT00709124)
- Testing
- Neuromuscular Electrostimulation (NMES) CareStim Muscle Stimulation Device (Care Rehab; McLean, VA)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Johns Hopkins University
Nasal Obstruction
The Effectiveness of Nasal Corticosteroids Versus Placebo in Nasal Obstruction in Patients With Nasal Septal Deviation
The purpose of this project is to determine if intranasal corticosteroids have an effect on nasal obstruction in patients with nasal septal deviation.
- Trial name
- NCT02877485
- Testing
- Triamcinolone Acetonide, Ayr saline nasal mist
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Stanford University
Respiratory Distress Syndrome
Trial to Assess the Safety and Tolerability of Lucinactant for Inhalation in Premature Neonates
The primary objective of this study is to evaluate the safety and tolerability of aerosolized surfactant, specifically lucinactant for inhalation, administered in escalating inhaled doses to preterm neonates 29 to 34 weeks…
- Trial name
- NCT02074059
- Testing
- Lucinactant for Inhalation, nCPAP alone
- Where
- 11 sites in United States
- Volunteers
- 80 people
- Sponsor
- Windtree Therapeutics
Obstructive Sleep Apnea, OSA
Predictability of OSA With a Subjective Screening Scale (OSASSS1)
the study aims to evaluate the accuracy correlation between subjective perception of the air flow through airways from patients and survey and/or polysomnography they spent, using a brief clinical protocol they answered with a…
- Trial name
- OSASSS1 (NCT06092710)
- Testing
- neuro-sensorial subjective evaluation of the airways collapsibility
- Where
- Belgium
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Center for Sleep Medicine - Clinique André Renard
Pulmonary Ventilation
Tegarderm® Placement for Bag Mask Ventilation in the Bearded Patient
Difficult Bag Mask Ventilation is well described in the anesthesiology literature, and bearded patients are likely to experience this phenomenon.
- Trial name
- NCT04274686
- Testing
- Tegaderm placement, No Tegaderm
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of New Mexico
Asthma
Comparing the Efficacy of Bricanyl M2 and Bricanyl M3 at 0.5 and 1.5 mg Dose Levels, to Allow for a Switch From Bricanyl Turbuhaler M2 to Bricanyl Turbuhaler M3
A randomised, double-blind, double-dummy, multi-site, phase III, single dose, 4-way cross-over pharmacodynamic study evaluating the efficacy of Bricanyl Turbuhaler M3 compared to Bricanyl Turbuhaler M2 by studying the protective…
- Trial name
- NCT02322788
- Testing
- Terbutaline sulphate
- Where
- 4 sites in Canada, Netherlands and 1 more
- Volunteers
- 95 people
- Sponsor
- AstraZeneca
Bronchopulmonary Dysplasia (BPD), Respiratory Distress Syndrome
The Budesonide in Babies (BiB) Trial
This is a Phase 3, randomized, masked, active-controlled, multicenter trial designed to determine whether early intratracheal administration of a combination of budesonide with surfactant, as compared to surfactant alone, will…
- Conditions
- Bronchopulmonary Dysplasia (BPD), Respiratory Distress Syndrome, Prematurity; Extreme, Neonatal
- Trial name
- BiB (NCT04545866)
- Testing
- budesonide (Pulmicort nebulizing suspension)., surfactant (poractant alfa;Curosurf)
- Where
- 19 sites in United States
- Volunteers
- 642 people
- Sponsor
- NICHD Neonatal Research Network
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