Clinical trials: Respiration
Dyspnea
Feasibility Testing of a Hospice Family Caregiver Intervention to Improve Patient Dyspnea Care
This study is a pilot test of an intervention to train family caregivers of home hospice patients about recognizing and treating shortness of breath.
- Trial name
- NCT02441868
- Testing
- Shortness of breath recognition and treatment
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Wayne State University
Sleep Apnea, Obstructive, Respiration Disorders
Treatment of Children With Obstructive Sleep Apnea and Laryngomalacia: the Role of Laser Supraglottoplasty
This is a research study of the effect of treating laryngomalacia (floppiness of tissue on top of the voice box that can possibly block breathing) found in association with obstructive sleep apnea (blockage of breathing while…
- Trial name
- NCT00394550
- Testing
- supraglottoplasty with laser
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Indiana University
Respiratory Failure, Weaning Failure
Monitoring of Breathing Effort Through Pressure Time Product Measurement Using Airway Occlusion Pressure
Mechanical ventilation is essential in the management of patients in Intensive Care. The approach to patients with prolonged weaning is challenging.In this context, it is vital to implement "diaphragmatic protection" strategies…
- Trial name
- PTPPocc (NCT06040138)
- Testing
- End expiratory occlusion maneuver
- Where
- 4 sites in Argentina
- Volunteers
- 50 people
- Sponsor
- Hospital Italiano de Buenos Aires
Acute Respiratory Failure
Prevention of Damage Induced by Facial Mask Ventilation
In patients with acute respiratory failure (ARF) undergoing noninvasive ventilation (NIV), the main complication of the use of the mask is the development of decubitus, sometimes so severe and painful as to force a suspension of…
- Trial name
- 3PROSNIV (NCT01351155)
- Testing
- Skin protective dressing device
- Where
- Italy
- Volunteers
- 252 people
- Sponsor
- Ospedale San Donato
Ventilator-Induced Lung Injury, Respiratory Distress Syndrome
Mid and Standard Frequency Ventilation in Infants With Respiratory Distress Syndrome
The purpose of this study is to determine, in preterm infants less than 37 weeks gestation with respiratory distress who are ventilated in the first 48 hours after birth, if mid frequency ventilation strategy using ventilator…
- Conditions
- Ventilator-Induced Lung Injury, Respiratory Distress Syndrome, Bronchopulmonary Dysplasia, Preterm Infant
- Trial name
- MIDAS (NCT03231735)
- Testing
- Mid frequency ventilation, Standard frequency ventilation
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Alabama at Birmingham
Sore-throat, Dysphonia
No Post Intubation Laryngeal Symptoms
The purpose of the study is to test a novel endotracheal tube support device that reduces pressure of the tube on the voice box for prevention of post intubation laryngeal symptoms including sore throat, change in voice and…
- Conditions
- Sore-throat, Dysphonia, Dysphagia, Intubation Complication
- Trial name
- No-PILS (NCT05383417)
- Testing
- EndoClip
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Pulmonary Sarcoidosis
The Effect of Inspiratory Muscle Training and Breathing Exercises Combined With Upper Extremity and Trunk in Patients With Sarcoidosis
This is an educational work. Thirty patients with pulmonary sarcoidosis will be included in the study and randomly selected into two training groups.One group will receive home inspiratory muscle training (IMT) for 15 minutes…
- Trial name
- physio (NCT04173689)
- Testing
- Threshold IMT, breathing exercises combined with upper extremity and trunk
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Istanbul University - Cerrahpasa
Mechanical Ventilation Complication
Reduce Pediatric Sedation to Reduce Mechanical Ventilation Complication in ICU
Mechanical ventilation is a common procedure used in pediatric intensive care units (ICU). Its use requires almost always the establishment of a sedation.
- Trial name
- PEDIASED (NCT02040168)
- Where
- France
- Volunteers
- 106 people
- Sponsor
- Nantes University Hospital
Acute Respiratory Failure
Dexmedetomidine Versus Standard Clinical Practice During Non Invasive Mechanical Ventilation
This study compare the effectiveness of dexmedetomidine as a sedative drug during NIV and the different strategies routinely used in patients with ARF of different aetiologies.
- Trial name
- DEX-PCH-VMNI (NCT02958150)
- Testing
- Dexmedetomidine, Standard Clinical Practice
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Basque Health Service
Obstructive Sleep Apnea
The Evaluation of a Mask for the Treatment of Obstructive Sleep Apnea
This investigation is a prospective, non randomized, non blinded study. This investigation is designed to evaluate the performance, comfort and ease of use with the F\&P trial full face and nasal mask amongst Obstructive Sleep…
- Trial name
- NCT03142438
- Testing
- F&P Seal Improvement Project
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Fisher and Paykel Healthcare
Respiratory Distress Syndrome In Premature Infants, Bronchopulmonary Dysplasia
Seattle-PAP Bubble Nasal CPAP and Work of Breathing
The investigators propose to test the hypothesis that Seattle bubble nasal continuous positive airway pressure (Seattle-PAP) supports respiratory physiology in very low birth weight (VLBW) infants more effectively than standard…
- Conditions
- Respiratory Distress Syndrome In Premature Infants, Bronchopulmonary Dysplasia, Newborn Primary Sleep Apnea
- Trial name
- Seattle-PAP (NCT02210026)
- Testing
- Seattle-PAP
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Seattle Children's Hospital
Dyspnea, Chest Pain
Contactless Ultrasound Data Acquisition in Emergency Departments to Discriminate the Origin of Dyspnea and Chest Pain
PAnDA-One is a prospective, multicenter, interventional study (10 centers, France) aimed at developing and validating a diagnostic support algorithm based on the ADx-One medical device, which non-invasively acquires thoracic…
- Trial name
- PAnDA-One (NCT07653204)
- Testing
- All patients from both groups will be imaged with airborne ultrasound device
- Where
- France
- Volunteers
- 2,500 people
- Sponsor
- Austral Diagnostics
Anesthesia
Electrical Acupoint Stimulation on Gastric Reflux During I-gel Ventilation
This study will compare the effects of transcutaneous acupoint electrical stimulation versus no stimulation on intraoperative gastric reflux in patients undergoing general anesthesia with i-gel airway device ventilation.
- Trial name
- ASGARD-igel (NCT07338448)
- Testing
- transcutaneous electrical acupoint stimulation, electrodes attachment
- Volunteers
- 116 people
- Sponsor
- Air Force Military Medical University, China
Mechanical Ventilation
Study of Muscle Effects of BYM338 in Mechanically Ventilated Patients
The purpose of this study is to evaluate the effect of BYM338 on muscle mass and function in Group III failure to wean patients, as compared to placebo controls.
- Trial name
- NCT01868685
- Testing
- BYM338
- Sponsor
- Novartis Pharmaceuticals
Diaphragmatic Plication, Diaphragmatic Paralysis
Short- and Long-term Effects of Robot-assisted Plication in Diaphragmatic Paralysis
Diaphragmatic paralysis may lead to severe symptoms such as breathlessness and reduced physical capacity. Diaphragmatic plication using Robotic-Assisted Thoracic Surgery (RATS) is a minimally invasive surgical technique developed…
- Conditions
- Diaphragmatic Plication, Diaphragmatic Paralysis, Diaphragmatic Eventration
- Trial name
- RAPIDLY (NCT06919185)
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Uppsala County Council, Sweden
Obstructive Sleep Apnea
Surgical Treatment for Patients With Obstructive Sleep Apnea by Using Da Vinci SP Surgical System
This prospective, interventional, non-randomized, single arm, clinical trial will investigate feasibility and safety of trans-oral robotic surgery using da Vinci SP Surgical System in Taiwan for the surgical treatment of OSA.
- Trial name
- NCT06766760
- Testing
- Da Vinci SP Surgical System, Model SP1098
- Where
- Taiwan
- Volunteers
- 25 people
- Sponsor
- Chang Gung Memorial Hospital
Septic Shock, Acute Respiratory Distress Syndrome
Use of PiCCO System in Critically Ill Patients With Septic Shock and Acute Respiratory Distress Syndrome
PiCCO has been widely used in critical care settings for several decades. Together with pulmonary artery catheter, it is regarded as the important tool for guiding fluid management in patients with shock or acute respiratory…
- Trial name
- PiCCO (NCT01526382)
- Testing
- PiCCO monitoring (PULSION), central venous catheter
- Where
- 2 sites in China
- Volunteers
- 350 people
- Sponsor
- Jinhua Central Hospital
COVID-19
Study of Niclosamide in Moderate and Severe Hospitalized Coronavirus-19 (COVID-19) Patients
Study of ANA001 in Moderate and Severe COVID-19 Patients
- Trial name
- NCT04603924
- Testing
- Niclosamide
- Where
- 8 sites in United States
- Volunteers
- 49 people
- Sponsor
- NeuroBo Pharmaceuticals Inc.
Sleep Apnea, Obstructive
Adherence and Quality of Life of CPAP for Obstructive Sleep Apnea
A multicentre, randomized controlled trial (RCT) design.The control group followed the usual treatment, while the intervention group (PIMA) followed the treatment with an adapted and flexible care plan depending on…
- Trial name
- PIMA1-JO-PR (NCT04691479)
- Testing
- Motivational Interview (MI) & Adherence Follow-Up, Adherence Follow-Up
- Where
- Spain
- Volunteers
- 129 people
- Sponsor
- Air Liquide Healthcare Spain
Brain Injury
Effects of Viral Reactivation on Outcomes of Brain-injured Patients ( IBIS-VIRUS)
Morbidity and mortality of ICU patients is increased by the development of a "immunosuppression" systemic (IS). This IS develops in the early hours of hospitalization and is responsible for severe infections, including viral…
- Trial name
- IBIS-VIRUS (NCT02003196)
- Where
- France
- Volunteers
- 375 people
- Sponsor
- Nantes University Hospital