Clinical trials: Respiration
Respiratory Insufficiency, Acute Respiratory Insufficiency
NIV-NAVA vs NIV-PS/PC in Respiratory Insufficiency
This study evaluates the difference between Non Invasive Ventilation with Neurally Adjusted Ventilatory Assist (NIV-NAVA) and Conventional Non Invasive Ventilation with Pressure Support (PS) or Pressure Control (PC).
- Trial name
- NCT02592512
- Testing
- NIV-NAVA, NIV-PS/PC
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Vejle Hospital
Respiratory Distress Syndrome, Adult, Hypoxemic Respiratory Failure
Utility of Defining ARDS and Past and Current Definitions of ARDS
Acute Respiratory Distress Syndrome (ARDS), marked by acute hypoxemia and bilateral pulmonary infiltrates, has undergone multiple definitions over the years.
- Conditions
- Respiratory Distress Syndrome, Adult, Hypoxemic Respiratory Failure, Respiratory Failure, Phenotypic Abnormality
- Trial name
- Delphi_ARDS (NCT06159465)
- Where
- United Arab Emirates
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- NMC Specialty Hospital
Obstructive Sleep Apnea
SIESTA: Home Sleep Study With ApneaDx™ for the Diagnosis of Obstructive Sleep Apnea
The SIESTA Home Sleep Study is a pragmatic, multi-centre randomized single-blinded two arm trial, assisted by a Decision Analytic Model, primarily designed to assess the accuracy, effectiveness and cost-effectiveness of…
- Trial name
- NCT02003729
- Testing
- Portable Sleep Monitor
- Where
- Canada
- Volunteers
- 250 people
- Sponsor
- University of Toronto
Ventilation Therapy; Complications, Trachea
Comparison Between VCV and FCV Through Ultra-thin Tube in Upper Airway Surgery
Ventilation through the small endotracheal tube is not an uncommon situation. The indications for it differ from elective upper airway surgery to emergency ventilation through needle cricothyrotomy.
- Trial name
- NCT05033730
- Testing
- Flow Controlled Ventilation
- Where
- Qatar
- Volunteers
- 30 people
- Sponsor
- Hamad Medical Corporation
Lung Cancer
Reducing Lung Cancer-Related Anxiety (RELAX)
The purpose of this research study is to compare the effects of music and different levels of device-guided breathing on anxiety and shortness of breath in lung cancer survivors.
- Trial name
- RELAX (NCT02063828)
- Testing
- Group A - Device guided breathing low dose, Group B - Device guided breathing high dose, Group C - Usual Breathing Control Group
- Where
- 11 sites in United States
- Volunteers
- 46 people
- Sponsor
- Wake Forest University Health Sciences
Respiratory Control in Premature Infants
Prematurity-Related Ventilatory Control
The purpose of this research study is to improve our understanding of unstable breathing and heart blood flow patterns seen in premature infants.
- Trial name
- PreVent (NCT03464396)
- Testing
- Bedside Physiology study, Carotid Body Function Test, Room Air Challenge
- Where
- United States
- Volunteers
- 177 people
- Sponsor
- Washington University School of Medicine
Dysphagia
Post Critical Illness Dysphagia in the Intensive Care Unit
The aims of the study are to determine: 1) the prevalence of ICU acquired dysphagia, 2) identify risk factors for ICU Acquired dysphagia, and 3) consequences of ICU acquired dysphagia including: ICU mortality, hospital mortality…
- Trial name
- DysphagiaICU (NCT04349462)
- Testing
- VideoFlurosocopy Swallow Study, Water Sip Test
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Mechanical Ventilation, Sedation
Implementation of an Analgesia-sedation Algorithm in the Pediatric ICU to Reduce Benzodiazepine Use
The purpose of the study is to develop and implement an evidence-based analgesia-sedation algorithm in the pediatric intensive care unit (PICU) using quality improvement and implementation science methodology.
- Trial name
- NCT04263662
- Testing
- Analgesia-Sedation algorithm
- Where
- United States
- Volunteers
- 680 people
- Sponsor
- Boston Children's Hospital
Diabetes, Gastric Content Aspiration
Effects of GLP-1 Agonists on Gastric Volume
This study will enroll patients ages 18 and over who have a diagnosis of diabetes, are undergoing an elective surgery under general anesthesia and 1) are taking a GLP-1 receptor agonist medication, or 2) not taking a GLP-1…
- Conditions
- Diabetes, Gastric Content Aspiration, Glucagon-like Peptide 1, GLP-1
- Trial name
- NCT05854979
- Testing
- Gastric Ultrasound
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- Medical University of South Carolina
Dyspnea, Respiratory Rate
Evaluating the Effectiveness of Incentive Spirometry
Post-operative pulmonary complications (PPCs) have a major impact on patients and healthcare expenses. The goal of perioperative respiratory therapy is to improve airway clearance, increase lung volume, and mitigate atelectasis.
- Conditions
- Dyspnea, Respiratory Rate, Oxygen Saturation, Oxygen Requirements
- Trial name
- NCT02952027
- Testing
- Use-recording, patient-reminder alarm for incentive spirometry
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Lifespan
Cough, Respiratory Tract Infections
Effect of Honey and Dextromethorphan on Nocturnal Cough and Sleep
Cough is the most common reason for an acute care doctor's visit in the United States. Cough can affect sleep for both coughing children and their parents.
- Trial name
- NCT00127686
- Testing
- Dextromethorphan, Buckwheat Honey
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Penn State University
Cardiopulmonary Arrest, Pediatric ALL
Impact of 2 Resuscitation Sequences on Management of Simulated Pediatric Cardiac Arrest
The International Liaison Committee on Resuscitation regularly publishes a Consensus on Science with Treatment Recommendations but guidelines can nevertheless differ when knowledge gaps persist.
- Conditions
- Cardiopulmonary Arrest, Pediatric ALL, Resuscitation
- Trial name
- NCT05474170
- Testing
- AHA resuscitation sequence, ERC resuscitation sequence
- Where
- Switzerland
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Geneve TEAM Ambulances
Delirium
Safety and Efficacy of Combined Sedation With Midazolam and Dexmedetomidine in ICU Patients
It is well known that ICU patients need sedation. Now no ideal sedation drug existed and every sedation drug has its advantage and disadvantage,so combined sedation may use the advantage and avoid the disadvantage of the sedation…
- Trial name
- NCT02080169
- Testing
- midazolam, Dexmedetomidine, Fentanyl
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Qilu Hospital of Shandong University
Gas Exchange
High-Flow Nasal Cannula Versus Conventional Oxygen Therapy After Extubation in Liver Transplantation
Humidified oxygen therapy via high-flow nasal cannula (HFNC) is a recently available technique delivering heated and humidified high flow oxygen through simple nasal prongs.
- Trial name
- NCT03441854
- Testing
- HFNC group
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Dental Pain, Muscle Sensitivity to Pressure
Analgetic Effect of Nitrousoxide-oxygen Inhalation for Dental Treatment of Children
To assess the analgetic effect of nitrousoxide-oxygen inhalation on pain perception in 12-15 years old children from 1) the dental pulp; 2) the masseter muscle; 3) the skin on the upper lip
- Conditions
- Dental Pain, Muscle Sensitivity to Pressure, Skin Sensitivity to Electric Stimulation
- Trial name
- NCT01022294
- Testing
- Nitrousoxide-oxygen and atmospheric air, Atmospheric air; nitrousoxide-oxygen
- Where
- Denmark
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Periodic Breathing, Heart Failure
The Cyclocapnic Method for Measurement of Chemosensitivity
We aim to test our method for measuring chemosensitivity (the ventilatory response to a change in carbon dioxide), which uses sinusoidal carbon dioxide stimuli.
- Trial name
- NCT01049256
- Testing
- carbon dioxide
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Magnetic Resonance Imaging
Feasibility of Regional Lung Ventilation Imaging Using 3T MR Imaging With Ultrashort Echo Time (UTE) Pulse Sequences
Structural lung and airway alterations in CF lead to focal or heterogeneous abnormalities in regional lung ventilation. The quantitative assessment of structural and functional alterations in the lung is of great importance for…
- Trial name
- PULMOREM (NCT02786056)
- Testing
- Lung MRI examination
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Cough
Development of a Cough Control Questionnaire (CCQ)
Chronic cough (>8 weeks in duration) affects 5-12% of the global population, and is associated with considerable health status impairment and comorbidities.
- Trial name
- CCQ (NCT06918756)
- Testing
- Questionnaires, Focus group interviews, Objective cough measures
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- King's College Hospital NHS Trust
Healthy Volunteers
Airway Occlusion Measured During Non-invasive Ventilation to Assess Respiratory Effort
Non-invasive ventilation (NIV) is extensively used in critical care settings and emergency departments for a variety of aetiologies but specially for acute respiratory failure (ARF).
- Trial name
- NCT05576246
- Testing
- airway pressure occlusion measurement
- Where
- Argentina
- Volunteers
- 12 people
- Sponsor
- Clinica Olivos SMG
Congestive Heart Failure
Breathing Relaxation Exercise Heart Failure
The aim of the study is to determine the effect of breathing and relaxation exercises on dyspnea, fatigue and self-care level in heart failure patients.
- Trial name
- NCT05905627
- Testing
- exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- University of Yalova