Clinical trials: Respiration Failure, open to volunteers
Acute Respiratory Failure
Evaluation of Perfusion and Ventilation Distribution in Children: a Pilot Study.
Electrical impedance tomography (EIT) is a recent monitoring technique that provides information on regional ventilation distribution.
- Trial name
- PELUCHE 2 (NCT07532811)
- Testing
- Evaluation of perfusion with Electrical impedance tomography using sodium chloride or sodium bicarbonate
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Critically Ill, Acute Respiratory Failure
The EXCEL Registry of Patients Requiring ECMO
ECMO is associated with significant costs, risks and requires specialist training and expertise. EXCEL is a novel, high-quality, detailed prospective registry of patients requiring ECMO in Australia and New Zealand.
- Conditions
- Critically Ill, Acute Respiratory Failure, Acute Heart Failure, Cardiac Arrest
- Trial name
- NCT03793257
- Where
- 29 sites in Australia, New Zealand
- Volunteers
- 3,000 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Acute Respiratory Insufficiency
Respiratory Variability in Patients With Acute Hypoxemic Respiratory Failure and Placed on High Flow Oxygen Therapy
Recommendations from the European Respiratory Society are to use high-flow oxygen therapy rather than conventional oxygen therapy and non-invasive ventilation (NIV) in cases of acute hypoxaemic respiratory failure.
- Trial name
- HYPOXEVARIA (NCT06675045)
- Testing
- Respiratory variability monitoring
- Where
- France
- Volunteers
- 60 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Acute Respiratory Distress Syndrome (ARDS), Extracorporeal Membrane Oxygenation
Personalized Ventilator Settings for Patients on ECMO
While mechanical ventilation can be used to sustain life in those with lung injury, it, can further worsen lung injury or prevent lung healing resulting in high morbidity and mortality as seen in Acute Respiratory Distress…
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Extracorporeal Membrane Oxygenation, Respiratory Failure Patients Treated With ECMO, Respiratory Failure, ICU
- Trial name
- PEEPECMO (NCT07673250)
- Testing
- Personalized Positive End-Expiratory Pressure (PEEP)
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of California, San Diego
Respiration Disorders
Respiratory Monitoring System That Detects & Predicts OIRD
This study is being conducted to evaluate the ability of the Respiratory Monitoring System (RMS) to detect and predict opioid induced respiratory depression (OIRD) in post-operative surgical patients managed with opioid…
- Trial name
- RTM-NIH-SBIR-2 (NCT07217197)
- Testing
- Study to evaluate a Respiratory Monitoring System (RMS) with a Tracheal Sound Sensor (TSS) for detecting and predicting opioid induced respiratory Depression (OIRD).
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Thomas Jefferson University
Respiratory Failure, Critical Illness
Comparison of the Efficacy and Safety of Ciprofol Versus Propofol for Sedation in ICU Patients Undergoing Non-Invasive Ventilation
Sedation is frequently required in critically ill patients admitted to the intensive care unit (ICU), including those receiving non-invasive respiratory support such as high-flow nasal cannula (HFNC), non-invasive ventilation…
- Trial name
- CALM-ICU (NCT07536750)
- Where
- China
- Volunteers
- 1,680 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Nasal Deformity, Rhinoplasty
Patient-Reported Outcomes and Complications After Structural Rhinoplasty Using Septal Extension Grafts
Structural rhinoplasty with septal extension graft (SEG) is commonly used to achieve stable nasal tip support and predictable long-term outcomes.
- Conditions
- Nasal Deformity, Rhinoplasty, Nasal Obstruction
- Trial name
- SEG-PROM (NCT07531810)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Cumhuriyet University Hospital
Airway Obstruction
The Efficacy of Distal Pharyngeal Airway for Oxygenation During TEE
The purpose of this study is to investigate the effect of using the McMurray Enhanced Airway (MEA) which is a flexible extended-length distal pharyngeal airway on improving oxygen delivery compared to standard nasal cannula.
- Trial name
- NCT05974488
- Testing
- McMurray Enhanced Airway, Nasal Cannula
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Miami
Extubation Failure
Validation of an Effort-Based Cough Peak Flow Algorithm to Predict Extubation Outcomes
This study aims to prospectively validate the diagnostic accuracy of an effort-stratified Cough Peak Flow (CPF) decision algorithm for predicting extubation failure, maintaining strict blinding of the clinical team.
- Trial name
- NCT07737483
- Testing
- Observational measurement of Cough Peak Flow and Tidal Volume
- Volunteers
- 150 people
- Sponsor
- Hospital H+ Queretaro
Weaning Failure, Pulmonary Edema - Acute
Quantification of Systemic Congestion by Ultrasound As a Predictor of Weaning Failure From Mechanical Ventilation
Mechanical ventilation is an essential, life-saving therapy in the ICU, allowing critically ill patients to rest and recover. Transitioning patients back to spontaneous breathing-known as weaning-is clinically challenging.
- Conditions
- Weaning Failure, Pulmonary Edema - Acute, Mechanical Ventilation, POCUS
- Trial name
- SCOUT (NCT07343882)
- Testing
- point of care ultrasound
- Volunteers
- 350 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Acute Respiratory Failure, Pneumonia
Practice of Oxygenation and Respiratory Support During Fiberoptic Bronchoscopy
The current practice of oxygenation and/or ventilation supports in patients undergoing Fiberoptic Bronchoscopy is very heterogeneous among studies published in the literature; in addition, clear outcomes advantages of one…
- Conditions
- Acute Respiratory Failure, Pneumonia, Lung Cancer, Fibrosis Lung
- Trial name
- NCT05681962
- Testing
- Bronchoscopy
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- University Magna Graecia
Weaning From Mechanical Ventilation, Weaning Failure
Characterization of Weaning Practices in ICUs of Global South Countries
This is a prospective observational study to be conducted in intensive care units of Global South countries. Patients on mechanical ventilation for more than 12 hours who have initiated the weaning process and for whom the…
- Conditions
- Weaning From Mechanical Ventilation, Weaning Failure, Weaning From Mechanical Ventilation, Extubation
- Trial name
- NCT07337408
- Where
- Brazil
- Volunteers
- 900 people
- Sponsor
- Hospital do Coracao
Airway Extubation, Extubation Failure
One-Hour Positive Pressure Ventilation After a T-Piece Spontaneous Breathing Trial
This is a randomized, open, multicenter, pragmatic, adaptive clinical trial with intention-to-treat analysis. The study will compare two weaning strategies from mechanical ventilation in critically ill patients admitted to…
- Conditions
- Airway Extubation, Extubation Failure, Weaning Mechanical Ventilation
- Trial name
- GS-Wean Tpiece (NCT07324382)
- Testing
- One-hour positive pressure ventilation, Immediate extubation
- Volunteers
- 4,000 people
- Sponsor
- Hospital do Coracao
Sepsis, Acute Lung Injury(ALI)
Recovery of Physical Function After Critical Illness In Older Adults
The proposed study is a prospective, observational study assessing the recovery of muscle and physical function in patients surviving critical illness (n =150) at hospital discharge (baseline) and repeated serially.
- Trial name
- RETURN (NCT07225257)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Spinal Cord Injury Cervical, Respiratory Failure
Epidural Spinal Cord Stimulation for Respiratory Recovery in Cervical SCI
This multicenter, single-arm exploratory IIT evaluates epidural spinal cord electrical stimulation (ESCES) in 20 adults with C1-C5 SCI and respiratory failure.
- Trial name
- NCT07722130
- Testing
- Epidural spinal cord stimulation
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- Zhongda Hospital
Extracorporeal Membrane Oxygenation Complication
Anticoagulation-free VV ECMO for Acute Respiratory Failure
Currently international experts recommend therapeutic anticoagulation for veno-venous extracorporeal membrane oxygenation (VV-ECMO).
- Trial name
- A-FREE ECMO (NCT04273607)
- Testing
- Subcutaneous Heparin
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Damian Ratano
Respiratory Failure, Extubation Failure
Impact of Biphasic Cuirass Ventilation Compared to Non Invasive Ventilation in High Risk Extubations
subjects on mechanical ventilator who are about to be extubated to Non invasive ventilation because the physician thinks they are high risk for failure will be approached and consented for our study.
- Trial name
- NCT07067502
- Testing
- Biphasic cuirass ventilator which is a type of negative pressure ventilator will be applied to patients on the intervention arm
- Volunteers
- 50 people
- Sponsor
- University of Missouri-Columbia
Nasal Obstruction
Nasal Obstruction and Olfactory Losses
About 13% of US adults, some 30 million people, suffer from nasal sinus disease. Although nasal obstruction and smell loss are two of the major symptoms of the disease that are crucial to disease management, currently there is a…
- Trial name
- NCT05920330
- Testing
- Nasal Plug
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Prolonged Mechanical Ventilation, Respiratory Failure
EIT-Guided Respiratory Physiotherapy for Prolonged Mechanical Ventilation (PMV)
Patients with prolonged mechanical ventilation (PMV) frequently experience impaired ventilation distribution, respiratory muscle dysfunction, secretion retention, and delayed liberation from mechanical ventilation.
- Conditions
- Prolonged Mechanical Ventilation, Respiratory Failure, Critical Illness
- Trial name
- PMV (NCT07372794)
- Testing
- EIT-Guided Respiratory Physiotherapy, Conventional Respiratory Physiotherapy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Capital Medical University
Respiratory Viral Infection
A Clinical Trial Evaluating the Safety and Efficacy of AP1189 Versus Placebo as an add-on to Standard of Care in Participants With Respiratory Insufficiency Expected to be Caused by Infection With Respiratory Viruses
A clinical study to evaluate the efficacy and safety of once daily oral dosing of 100 mg AP1189 or placebo administered for 14 days, as an add-on to standard of care (SOC) in participants with respiratory insufficiency expected…
- Trial name
- RESPIRE (NCT07633288)
- Testing
- AP1189, 100 mg
- Where
- 11 sites in Bosnia and Herzegovina, Montenegro and 2 more
- Volunteers
- 96 people
- Sponsor
- SynAct Pharma Aps