Clinical trials: Respiratory Allergy
Asthma
A 6 Month Safety Study Comparing Symbicort With Inhaled Corticosteroid Only in Asthmatic Adults and Adolescents
The purpose of the study is to evaluate the safety of Symbicort compared to inhaled corticosteroid alone during 6 months in adult and adolescent patients with asthma
- Trial name
- NCT01444430
- Testing
- Symbicort pMDI, budesonide pMDI
- Where
- 340 sites in United States, Argentina and 24 more
- Volunteers
- 12,460 people
- Sponsor
- AstraZeneca
Asthma, Pulmonary Disease, Chronic Obstructive
Inspiratory Flow Parameters and Handling of Easyhaler and Turbuhaler Inhalers
The aim of the study is to measure the inspiratory flow that the different patient groups (asthmatic children, adults and elderly, as well as chronic obstructive pulmonary disease (COPD) patients) generate through empty Easyhaler…
- Trial name
- PIFECO (NCT00984906)
- Testing
- Empty inhalers
- Where
- 4 sites in Finland, United Kingdom
- Volunteers
- 200 people
- Sponsor
- Orion Corporation, Orion Pharma
Allergic Rhinitis
Single Dose Pharmacokinetics of Intranasal Azelastine Delivered by a Fixed Combination With Fluticasone in Comparison to Azelastine Nasal Sprays
The primary objective is to assess the effect of fluticasone propionate (FLU) on the relative bioavailability (AUC0-∞) of azelastine hydrochloride (AZE) when administered as fixed AZE-FLU combination product (TEST) compared to a…
- Trial name
- NCT01190852
- Testing
- Azelastine, Fluticasone, Azelastine mono, Azelastine
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- MEDA Pharma GmbH & Co. KG
Rhinitis, Allergic, Perennial, Allergic Rhinitis
A Randomised, Double Blind, Placebo Controlled, 4 Period, Incomplete Block, Crossover Study Assessing the Dose-response Curve of Fluticasone Propionate in an Antigen Challenge Chamber
This is a single-centre, randomised, double-blind, four-period, incomplete block, crossover study, with 8 days repeat dosing of intranasal Fluticasone Propionate (25, 50, 100, 200ug) and/or placebo in the Vienna Challenge Chamber…
- Trial name
- NCT00848965
- Testing
- Fluticasone propionate
- Where
- Austria
- Volunteers
- 59 people
- Sponsor
- GlaxoSmithKline
Asthma
The Effect Of AVANDIA On The Late Asthmatic Response
This study is to investigate the effects of AVANDIA on the asthmatic response.
- Trial name
- NCT00318630
- Testing
- Rosiglitazone
- Where
- New Zealand
- Volunteers
- 26 people
- Sponsor
- GlaxoSmithKline
Asthma
Evaluation of Pharmacokinetics and Safety of A006 in Healthy Volunteers
The objective of this study is to evaluate the pharmacokinetics (PK) and safety profiles of A006, an Albuterol dry powder inhaler (DPI), following a single dose of 110 mcg (T1) or 220 mcg (T2), in healthy male and female adult…
- Trial name
- A006-D (NCT02271334)
- Testing
- A006 DPI, Proventil® MDI
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Amphastar Pharmaceuticals, Inc.
Asthma
A Long-term Safety Study of Fluticasone Furoate (FF)/GW642444 and FF in Japanese Subjects With Asthma
The primary purpose of the study is to assess the safety and tolerability of 52-week teatment with fluticasone furoate/GW642444 inhalation powder once-daily and FF inhalation powder once-daily in Japanese adult subjects with…
- Trial name
- NCT01244984
- Testing
- Fluticasone Furoate/GW642444 Inhalation Powder, Fluticasone Furoate Inhalation Powder
- Where
- 30 sites in Japan
- Volunteers
- 243 people
- Sponsor
- GlaxoSmithKline
Healthy Participants
A Phase 1 Trial of AMG 691 in Healthy Chinese and Japanese Volunteers
The trial is designed to evaluate the pharmacokinetics, safety, tolerability, and immunogenicity of AMG 691 in healthy Chinese and Japanese participants
- Trial name
- NCT07745907
- Testing
- AMG 691
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Amgen
Asthma
A Twelve Month Long Term Safety Study to Evaluate the Safety of Albuterol in a Dry Powder Inhaler With Both Repeated and as Needed Dosing
This is a one-year study to look at the safety of a dry powder inhaler with albuterol. After a one-week run in, for the first 3 months subjects will use an inhaler with either albuterol or a dummy drug at regular times four times…
- Trial name
- NCT01218009
- Testing
- Albuterol Spiromax
- Where
- 30 sites in United States
- Volunteers
- 331 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Asthma
Efficacy/Safety Study of Nebulized IVX-0142, a Novel Antiallergic Drug, in Mild Allergic Asthma
This study is designed to evaluate the effectiveness of nebulized IVX-0142, a novel anti-allergic drug, to inhibit allergen-induced airway narrowing in patients with allergic asthma and the related increased sensitivity of the…
- Trial name
- NCT00232999
- Testing
- Nebulized IVX-0142
- Where
- 3 sites in Canada
- Volunteers
- 15 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Asthma, Asthma Patients
Fixed Triple Inhaled Combination in Asthmatic Patients in a Real-life Setting (STRENGTH)
The mainstay of asthma treatment are ICSs, mostly combined with LABA. In the past decade LAMA had been accepted as an add-on treatment for patients at GINA steps 4 and 5.
- Conditions
- Asthma, Asthma Patients, Asthma Bronchiale
- Trial name
- STRENGTH (NCT07489911)
- Testing
- BDP/FF/G (beclometasone dipropionate/formoterol fumarate dihydrate/glycopyrronium) 172/5/9 μg
- Where
- 18 sites in Slovenia
- Volunteers
- 200 people
- Sponsor
- Chiesi Slovenija, d.o.o.
Asthma
Pilot Study of a Mobile Asthma Adherence Intervention
The purpose of this study is to assess the use of a mobile health intervention to improve adherence to asthma medication among adolescents.
- Trial name
- NCT02413528
- Testing
- Inhaler sensor, Mobile application for asthma adherence
- Volunteers
- 12 people
- Sponsor
- CoheroHealth
Asthma
A Phase 1 Study of Single and Multiple Intravenous Doses of SM17 in Healthy Subjects
This trial is a phase 1, first-in-human, randomized, double-blind, placebo-controlled dose escalation trial following single and multiple doses intravenous administration of SM17.
- Trial name
- NCT05332834
- Testing
- SM17
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- SinoMab BioScience Ltd
Allergic Rhinitis
Study of CM310 in Subjects With Allergic Rhinitis
This is a multicenter, randomized, double-blind, placebo-controlled phase III clinical study aimed at evaluating the efficacy and safety of CM310 in patients with seasonal allergic rhinitis, and observing the quality of life, PK…
- Trial name
- PHECDA (NCT05908032)
- Testing
- CM310
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Keymed Biosciences Co.Ltd
Asthma, Bioequivalence
A Bioequivalence Study Between Fluticasone Propionate 100 mcg/Blister Oral Inhalation Powder/Respirent Pharmaceuticals vs. FLOVENT DISKUS® 100 mcg/Blister Oral Inhalation Powder /GSK in Healthy Volunteers Under Fasting Conditions
Bioequivalence study between two inhaler products of ffluticasone propionate inhalation powder
- Trial name
- NCT05021887
- Testing
- Fluticasone Propionate 100 mcg/Blister Oral Inhalation Powder/Respirent Pharmaceuticals, FLOVENT DISKUS
- Where
- Greece
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Respirent Pharmaceuticals Co Ltd.
Asthma
A Study of ARRY-502 in Patients With Persistent Asthma
This is a Phase 2 study, involving a 6-week treatment period, designed to evaluate the effectiveness of investigational study drug ARRY-502 in treating mild to moderate persistent asthma, and to further evaluate the safety of the…
- Trial name
- NCT01561690
- Testing
- ARRY-502, CRTh2 antagonist; oral
- Where
- 43 sites in United States
- Volunteers
- 184 people
- Sponsor
- Pfizer
Seasonal Allergic Rhinitis
Study of Mometasone Furoate Nasal Spray and Oxymetazoline Nasal Spray Given Together Once A Day To Treat Seasonal Allergic Rhinitis (P04500)
The primary objective of this study is to evaluate the efficacy of the combination of mometasone furoate nasal spray (MFNS) and oxymetazoline nasal spray (OXY) given together once a day in treating subjects with seasonal allergic…
- Trial name
- NCT00552110
- Testing
- OXY combination: mometasone furoate nasal spray (MFNS) and oxymetazoline nasal spray (OXY), mometasone furoate nasal spray (MFNS) once daily, oxymetazoline nasal spray (OXY) twice daily
- Volunteers
- 707 people
- Sponsor
- Organon and Co
Severe Asthma
A Study to Investigate the Efficacy and Safety of Verekitug (UPB-101) in Adult Participants With Severe Asthma (VALIANT)
The purpose of this study is to evaluate the efficacy and safety of verekitug (UPB-101) in participants with severe asthma. The study will evaluate the incidence of asthma exacerbations, other pharmacodynamic (PD) parameters such…
- Trial name
- NCT06196879
- Testing
- Verekitug (UPB-101)
- Where
- 155 sites in United States, Argentina and 13 more
- Volunteers
- 479 people
- Sponsor
- Upstream Bio Inc.
Asthma
A Clinical Trial of TQC2938 Injection in Healthy Adult Subjects
The study is designed in two phases: single-dose administration and multiple-dose administration. A randomized, double-blind, placebo-controlled trial design was used to evaluate the safety, tolerability, pharmacokinetic…
- Trial name
- NCT06449859
- Testing
- TQC2938 Injection
- Where
- China
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd.
Asthma
A Non- Inferiority Comparative Study Between Seretide® and Salmeterol/Fluticasone Eurofarma in Patients with Asthma
The primary objective will be to compare the formulations regarding their impact on the pulmonary function of persistent asthma patients and the secondary objective will be the clinical control of the disease's symptoms.
- Trial name
- CAINAS SF (NCT01202097)
- Testing
- Salmeterol/Fluticasone, Seretide
- Where
- 6 sites in Brazil
- Volunteers
- 334 people
- Sponsor
- Eurofarma Laboratorios S.A.
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