Clinical trials: Respiratory Allergy
Asthma
Inhaled TPI-1020 Versus Inhaled Budesonide in Smokers With Mild Reversible Asthma
The investigators will look at TPI-1020 safety and tolerability in mild to moderate asthmatic smoker subjects.
- Trial name
- NCT00327808
- Testing
- TPI-1020, budesonide
- Where
- 7 sites in Canada
- Volunteers
- 27 people
- Sponsor
- Syntara
Asthma
Behavioral Intervention to Increase Physical Activity in Patients with Asthma: Identifying Responders
To identify clinical, personal and anthropometric characteristics among patients with asthma who respond and non-responders to a behavioral intervention to increase the level of physical activity.
- Trial name
- NCT05159076
- Testing
- Behavioral Intervention to Increase Physical Activity
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- University of Sao Paulo General Hospital
Asthma
Nebulized Magnesium Sulfate in Children With Moderate to Severe Asthma
The purpose of this study is to investigate the use of magnesium sulfate nebulization in patient with moderate to severe asthma exacerbation in pediatric emergency.
- Trial name
- NCT01584726
- Testing
- Magnesium Sulfate
- Where
- 2 sites in Qatar
- Volunteers
- 400 people
- Sponsor
- Hamad Medical Corporation
Asthma
Selective β2-AR Antagonism in Asthma
The objectives are to assess the safety, tolerability and effect on the airways of TR4 in patients with mild-to-moderate asthma. The Phase 1 trial is randomised, double-blind, placebo-controlled, and ascending-dose in design.
- Trial name
- NCT07272135
- Testing
- TR4
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Trio Medicines Ltd.
Fibromyalgia, Fibromyalgia Syndrome
Slow Breathing and Resistance Exercise in Fibromyalgia
This randomized controlled trial investigates whether slow breathing techniques influence heart rate variability, exercise self-efficacy, and resistance exercise performance in women with fibromyalgia.
- Trial name
- Breath-fibro (NCT07404384)
- Testing
- Slow Breathing with Visual Pacer, Slow Breathing without Visual Pacer, Spontaneous Breathing (Active Control)
- Where
- 2 sites in Spain
- Volunteers
- 159 people
- Sponsor
- University of Malaga
Allergic Rhinitis
Is Levocetirizine Less Sedating Than Cetirizine?
The purpose of this study is to determine whether cetirizine (zyrtec), levocetirizine (xyzal), and placebo differ in the degree of sedation they produce and their relief of allergy symptoms.
- Trial name
- NCT00826943
- Testing
- Cetirizine, Levocetirizine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Vanderbilt University
IPF, Sarcoidosis
Nasal, Tracheal and Bronchial Mucosal Lining Fluid(MLF) Sampling From Patients With Respiratory Diseases
Nasal, tracheal and bronchial sampling of MLF in patients with idiopathic pulmonary fibrosis(IPF), sarcoidosis, tuberculosis(TB), asthma and COPD. Similar sampling from healthy controls for comparative data.
- Conditions
- IPF, Sarcoidosis, Tuberculosis, Asthma
- Trial name
- RESPI-SAM (NCT02807025)
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Imperial College Healthcare NHS Trust
Asthma
Real-world Effectiveness of Combination Therapies in Primary Care Asthma Management
The purpose of this study is to evaluate whether beclomethasone dipropionate / formoterol (BDP/FOR; Fostair® 100/6) is at least equivalent in terms of exacerbation prevention to fluticasone dipropionate / salmeterol (FP/SAL…
- Trial name
- Fos/Ser_switch (NCT01242098)
- Testing
- Fixed dose combination salmeterol / fluticasone, Fixed-dose combination beclometasone dipropionate / formoterol
- Where
- United Kingdom
- Volunteers
- 137 people
- Sponsor
- Research in Real-Life Ltd
Asthma,, Chronic Obstructive Pulmonary Disease
Observational Study to Evaluate the Correctness of the Use of Inhaler Device in Patients With Asthma or Chronic Obstruct
The correct use of inhalation devices is an inclusion criterion for all studies comparing inhaled treatments. In real life, however, patients may make many errors with their usual inhalation device, which may negate the benefits…
- Trial name
- NCT01426893
- Where
- 5 sites in Serbia
- Volunteers
- 310 people
- Sponsor
- AstraZeneca
Asthma
New Breath Actuated MDI Symbicort Compared to Symbicort pMDI and Budesonide pMDI for 12 Weeks Twice a Day
This is a comparison of the efficacy of the Symbicort breath actuated dose inhaler to the Symbicort pressured meter dose inhaler after 12 weeks of a twice a day dose.
- Trial name
- BAI (NCT01360021)
- Testing
- Symbicort, Budesonide
- Where
- 41 sites in United States, Bulgaria and 2 more
- Volunteers
- 214 people
- Sponsor
- AstraZeneca
Severe Asthma
The Inflammatory Profile of Exacerbations in Patients With Severe Asthma Receiving Tezepelumab: The TezEx Study
Tezepelumab is a treatment that is approved by NICE (National Institute for Health and Care Excellence, https://www.nice.org.uk/) for patients with severe asthma, that remains poorly controlled despite high dose inhaled…
- Trial name
- TezEx (NCT06666504)
- Testing
- Prospective Data Analysis
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Asthma
Intervention Study to Improve Adherence in Asthma
We wanted to investigate if it was possible to improve adherence to prescriptions and advice in pre-school children with newly diagnosed asthma.
- Trial name
- NCT00516633
- Testing
- Extra information and support
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Värmland County Council, Sweden
Asthma
ENV-294 for Moderate-to-Severe Asthma: A 12-Week Study in Adults
This study will evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and potential efficacy of ENV-294 in adults with moderate to severe asthma who are receiving background treatment with inhaled…
- Trial name
- NCT07301255
- Testing
- ENV-294
- Where
- 20 sites in United States
- Volunteers
- 50 people
- Sponsor
- Enveda Therapeutics
Rhinitis,Allergic
Effects of Broccoli Sprout Extract on Allergy Rhinitis
Allergic rhinitis is a common illness suffered among US Veterans. There are medications that help relieve allergy symptoms, including nasal steroid sprays and antihistamines.
- Trial name
- NCT02885025
- Testing
- Broccoli Sprout Extract, fluticasone nasal, normal saline nasal spray
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Seasonal Allergic Rhinitis
Comparison of the Effect of Montelukast and Cetirizine on Allergic Inflammation in Children With Allergic Rhinitis
The aim of this study is to compare the effect of montelukast and cetirizine on allergic inflammation measured by exhaled nitric oxide concentration in children with seasonal allergic rhinitis.
- Trial name
- NCT00488176
- Testing
- montelukast, cetirizine, montelukast and cetirizine
- Where
- Poland
- Volunteers
- 116 people
- Sponsor
- Medical University of Lodz
Asthma, Depression
R34 Asthma Depression
Depressive disorders are highly prevalent among older adults with asthma and are associated with poor asthma outcomes. The overall objective of this study is to integrate an asthma self-management support program that the…
- Trial name
- NCT07895576
- Testing
- SAMBA, Cognitive Behavioral Therapy-Asthma Depression (CBT-AD), Original SAMBA
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Moderate/Severe Asthma
NIS-observe Treatment Efficacy in Maintaining Symptoms Control in Moderate/Severe Asthma With Symbicort SMART
The primary objective of this non-interventional study is to evaluate efficacy of Symbicort® SMART treatment in adult patients with moderate to severe asthma using ACQ scores during 6 months period
- Trial name
- NCT00785733
- Where
- 44 sites in Romania
- Volunteers
- 1,182 people
- Sponsor
- AstraZeneca
Asthma
Adequacy of Management of Patients With Asthma Exacerbation in Martinique
Asthma is a chronic respiratory disease whose goal of therapeutic, educational and preventive care is to prevent the onset of acute crisis, the most serious of which are life threatening.
- Trial name
- APEXA (NCT05253391)
- Testing
- Routine care
- Where
- 7 sites in Martinique
- Volunteers
- 339 people
- Sponsor
- University Hospital Center of Martinique
Asthma in Children, Asthma Chronic
Evaluation of Pharmacist-guided Digital-based Asthma Education for Indonesian Children With Asthma
Poor adherence and self-management in children with asthma results in poorly controlled asthma and increased morbidity. Pharmacists could take important roles in delivering asthma education to ensure that children can manage…
- Conditions
- Asthma in Children, Asthma Chronic, Asthma
- Trial name
- MIRACLE (NCT05432440)
- Testing
- The digital asthma education program
- Where
- 4 sites in Indonesia
- Volunteers
- 50 people
- Sponsor
- Udayana University
Asthma
A Study of the Safety and Efficacy of Tofimilast in Adult Asthmatics
This is an initial proof of concept, phase to study to assess the safety and efficacy tofimilast for the chronic maintenance treatment of adults with persistent asthma
- Trial name
- NCT00150397
- Testing
- Tofimilast
- Where
- 22 sites in United States, Costa Rica and 1 more
- Volunteers
- 112 people
- Sponsor
- Pfizer
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