Clinical trials: Respiratory Allergy
Cystic Fibrosis
Anti-IL5 and Other Biotherapies in Cystic Fibrosis
Our project is to describe retrospectively and prospectively CF patients treated with biotherapy in French CF centers. Main objective: To describe the clinical and paraclinical course of CF patients before and after treatment…
- Trial name
- MAB-CF (NCT04256772)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Atopic Dermatitis, Asthma
Vitamin D and Its Receptor Gene Polymorphisms in Lithuanian, Latvian and Taiwanese Patients With Atopic Dermatitis and Asthma
The role of vitamin D is well known in calcium and phosphate homeostasis; however, in addition to traditional functions, vitamin D has an important role in pathogenesis of different allergic diseases, such as asthma, atopic…
- Trial name
- NCT04354207
- Testing
- Peripheral vein punction, Stool collection
- Where
- Lithuania
- Volunteers
- 500 people
- Sponsor
- Lithuanian University of Health Sciences
Asthma
RSPR-007 Mannitol Challenge Trial
This is a double-blind, randomised, placebo-controlled, cross-over, Phase 2 trial evaluating two doses (a low and a high) of CRD007 for the treatment of asthmatic trial subjects with a positive asthma test (mannitol challenge)…
- Trial name
- NCT02609334
- Testing
- CRD007
- Where
- 2 sites in Denmark
- Volunteers
- 24 people
- Sponsor
- RSPR Pharma AB
Corticosteroid Resistant (CR) Asthmatics
Effects of p38 Inhibitor AZD7624 in Corticosteroid Resistant Asthma
This is a double-blind, placebo controlled 4 week crossover study to investigate the efficacy and safety of AZD7624 (an inhaled p38 inhibitor) in corticosteroid resistant (CR) asthmatics.
- Trial name
- NCT02753764
- Testing
- AZD7624, prednisone
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- National Jewish Health
Asthma
Dose Ranging Study of Amlitelimab in Adult Participants With Moderate-to-severe Asthma
This was a parallel, Phase 2, global, multicenter, randomized, double-blind, placebo-controlled, dose-ranging, four-arms study for treatment.
- Trial name
- TIDE-asthma (NCT05421598)
- Testing
- Amlitelimab
- Where
- 113 sites in United States, Argentina and 12 more
- Volunteers
- 437 people
- Sponsor
- Sanofi
Seasonal Allergic Rhinitis
Effect of Intranasal Corticosteroids on Systemic Allergen Specific IgE
Evaluation of the effect of fluticasone propionate vs placebo applied as nasal spray on the increase of allergen-specific serum IgE levels following nasal exposure to recombinant allergens.
- Trial name
- NCT00755066
- Testing
- Fluticasone propionate
- Where
- Austria
- Volunteers
- 48 people
- Sponsor
- Medical University of Vienna
Asthma
Crossover Study Comparing Fluticasone Furoate (FF)/Vilanterol (VI) Once Daily Versus Fluticasone Propionate (FP) Twice Daily in Subjects With Asthma and Exercise-Induced Bronchoconstriction (EIB)
This is a multicenter, randomized, double-blind, double-dummy, crossover study with two 2-week treatment periods separated by a 2-week wash-out period.
- Trial name
- NCT02730351
- Testing
- Fluticasone furoate/ Vilanterol 100 mcg/25 mcg, Fluticasone propionate 250 mcg
- Where
- 16 sites in United States, Canada
- Volunteers
- 75 people
- Sponsor
- GlaxoSmithKline
Seasonal Allergic Rhinitis
Efficacy, Safety and Underlying Mechanisms of Sphenopalatine Ganglion Acupuncture for Seasonal Allergic Rhinitis
In recent years, a number of randomized controlled trials have confirmed the efficacy and safety of acupuncture in the treatment of allergic rhinitis (AR).
- Trial name
- NCT04052945
- Testing
- SPA acupuncture
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Beijing Tongren Hospital
Heart Failure, Coronary Disease
Effect of a Community-based Nursing Intervention on Mortality in Chronically Ill Older Adults
Care coordination, disease management, geriatric care management, and preventive programs for chronically ill older adults vary in design and their impact on long-term health outcomes is not well established.
- Conditions
- Heart Failure, Coronary Disease, Diabetes Mellitus, Asthma
- Trial name
- NCT01071967
- Testing
- Community-based nurse care management
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Health Quality Partners
Asthma
DETACT sEvere asThmAtiC paTients - a Pilot Study
The objective of this study is to investigate the effect of dupilumab treatment on mucus plugging in severe asthma patients with severe eosinophilic asthma.
- Trial name
- DETACT (NCT07025200)
- Testing
- Dupilumab
- Where
- Austria
- Volunteers
- 10 people
- Sponsor
- Medical University of Vienna
Allergic Rhinitis
Study on the Effect and Mechanism of Lupatadine Fumarate in the Treatment of Allergic Rhinitis
In China, the prevalence of allergic rhinitis reaches 17.6% and is increasing year by year, seriously affecting the quality of life of patients. Some patients still cannot be effectively treated.
- Trial name
- NCT06709092
- Testing
- lupatadine fumarate (Luso®, Yangzijiang Pharmaceuticals)
- Where
- 2 sites in China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cheng Lei
Asthma
Pediatric ASTHMA-Educator
This project seeks to develop and pilot test the pediatric ASTHMA-Educator mobile application.
- Trial name
- NCT03520881
- Testing
- Pediatric ASTHMA-Educator mobile application
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Montefiore Medical Center
Asthma in Children, Vaccine Adverse Reaction
Safety of LAIV4 in Children With Asthma
This is a prospective randomized, open label clinical trial in approximately 300 children aged 5-11 years with a physician diagnosis of persistent asthma.
- Conditions
- Asthma in Children, Vaccine Adverse Reaction, Vaccine Reaction, Asthma
- Trial name
- NCT03600428
- Testing
- Live Attenuated Influenza Vaccine (LAIV), Inactivated Influenza Vaccine (IIV)
- Where
- 3 sites in United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Asthma
Efficacy and Safety of Tiotropium and Salmeterol in Moderate Persistent Asthma Patients Homozygous for B16-Arg/Arg
This is a 16 week multicentre, multinational, randomised, double-blind, double-dummy, placebo-controlled, parallel group study to evaluate the long-term efficacy and safety of tiotropium compared to salmeterol in moderate…
- Trial name
- NCT00350207
- Testing
- Tiotropium bromide, Salmeterol xinafoate
- Where
- 109 sites in Austria, Belgium and 12 more
- Volunteers
- 388 people
- Sponsor
- Boehringer Ingelheim
Asthma
A Study to Evaluate the Pharmacokinetics of Tezepelumab After Being Delivered by an Accessorized Pre Filled Syringe or Autoinjector Compared With Vial and Syringe in Healthy Adult Subjects
This is a study to compare PK of tezepelumab exposure in healthy subjects by using vial and syringe, APFS, and AI.
- Trial name
- PATH-BRIDGE (NCT03989544)
- Testing
- Tezepelumab
- Where
- Germany
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Asthma
Tiotropium for Smoking Asthmatics Study
The study's research questions concern the appropriateness of use of tiotropium for patients with asthma who are current smokers.
- Trial name
- NCT00546234
- Testing
- tiotropium, long acting beta agonist
- Where
- 2 sites in Canada
- Sponsor
- University of Alberta
Asthma
Inflammatory, Functional and Image Composite Measure to Define Asthma Control
The goals of control status of asthma have been changed with the improvement of its management as a chronic disease; many steps should be taken to achieve asthma control as defined by the GINA/NIH guidelines.
- Trial name
- APITA (NCT00597064)
- Testing
- prednisone
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- Federal University of São Paulo
Influenza Vaccine Allergy
Influenza Vaccine Effectiveness in Among Young Children in Taiwan
This project uses questionnaires to statistically analyze whether influenza vaccination is protective for young children.
- Trial name
- NCT06446232
- Where
- Taiwan
- Volunteers
- 1 people
- Sponsor
- National Taiwan University Hospital
Asthma
The Severe Asthma Research Program III-Boston Clinical Site
Asthma is a disease characterized by inflammation in the airways. The body naturally makes compounds that reduce inflammation. Unfortunately, for patients with severe asthma, the pathway these compounds use to reduce inflammation…
- Trial name
- SARPIII-AMSA (NCT01761630)
- Where
- 2 sites in United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Elliot Israel, MD
Healthy, Asthma
The Safety and Utility of Skin Testing With XOLAIR® (Omalizumab) and Placebo Omalizumab (Formulation Excipients)
This study enrolled 30 healthy volunteers and 30 patients with atopic asthma, for a total of 60 subjects. The study examined the tolerability of omalizumab and omalizumab excipients in two successive cohorts of subjects, healthy…
- Trial name
- NCT00777764
- Testing
- Cohort I, Cohort 2
- Volunteers
- 60 people
- Sponsor
- Genentech, Inc.
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