Clinical trials: Respiratory Aspiration
Asthma
Alternate Nostril Breathing With Incentive Spirometry on Lung Function Among Asthma Patients
To compare effects of Alternate Nostril Breathing exercise with incentive spirometer on lung functions (forced vital capacity, forced expiratory volume, and peak expiratory flow rate) in Asthma patients.
- Trial name
- NCT07110116
- Testing
- Alternate nostril breathing with Incentive Spirometery, Incentive spirometery
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Riphah International University
Dysphagia
Improving Diagnostic Standards in Dysphagia
The purpose of this research is to understand the normal function of swallowing and respiratory muscles in order to establish normal parameters.
- Trial name
- NCT04773184
- Testing
- Fiberoptic Endoscopic Evaluation of Swallowing, Videofluoroscopic Swallowing Study, Voluntary Peak Cough Flow Testing
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Florida
Pseudomonas Aeruginosa Infection
Study to Evaluate Arikayce™ in CF Patients With Chronic Pseudomonas Aeruginosa Infections
A major factor in the respiratory health of Cystic Fibrosis (CF) participants is the prevalence of chronic Pseudomonas aeruginosa (Pa) infections.
- Trial name
- NCT01315678
- Testing
- Liposomal amikacin for inhalation (Arikayce™) using the PARI Investigational eFlow® Nebulizer., Tobramycin inhalation solution using a PARI LC® Plus nebulizer.
- Where
- 62 sites in Austria, Belgium and 16 more
- Volunteers
- 302 people
- Sponsor
- Insmed Incorporated
Cystic Fibrosis
Efficacy and Safety of Inhaled Nitric Oxide (NO) in Cystic Fibrosis (CF) Patients
Prospective, randomized, placebo controlled, phase II clinical study of subjects crossing over from an approved inhaled antibiotic to inhaled nitric oxide as compared to a placebo control arm.
- Trial name
- NCT02498535
- Testing
- Nitric Oxide 160 ppm
- Where
- 7 sites in United States, Canada
- Volunteers
- 49 people
- Sponsor
- Novoteris, LLC
Anesthesia, General, Electroencephalography
Anesthesia and EEG Discontinuity in Infants
This study is a randomized controlled trial to evaluate whether EEG-guided calibration of inhalation agents can reduce occurrence of EEG discontinuity in infants during general anesthesia.
- Conditions
- Anesthesia, General, Electroencephalography, Infant, Anesthesia, Inhalation
- Trial name
- NCT05906225
- Testing
- EEG guided anesthesia, Conventional anesthesia
- Where
- South Korea
- Volunteers
- 78 people
- Sponsor
- Seoul National University Hospital
Asthma
A Study to Investigate the Safety, Tolerability and Effects of AZD8630 in Healthy Subjects and Subjects With Asthma on Inhaled Corticosteroids and Long-acting Beta-agonists
This is a first in human (FIH) clinical study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of AZD8630 in healthy adults (Part A) and adult asthma patients on medium to high dose inhaled…
- Trial name
- NCT05110976
- Testing
- AZD8630
- Where
- 29 sites in United States, Germany and 1 more
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Sleep Apnea Syndromes, Oxidative Stress
Efficacy of Continuous Positive Airway Pressure in Reducing Oxidative Stress in Individuals With Sleep Apnea
Sleep-disordered breathing (SDB) is a condition in which a person experiences frequent breathing pauses during sleep, also known as sleep apnea.
- Conditions
- Sleep Apnea Syndromes, Oxidative Stress, Cardiovascular Diseases
- Trial name
- SASS (NCT00607893)
- Testing
- Continuous Positive Airway Pressure (CPAP)
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Healthy
A Pharmacokinetic Evaluation Study in Healthy Volunteers
The purpose of this trial is to characterize the pharmacokinetics of INS37217 following intravenous, intranasal, and inhalation administration and to calculate the relative bioavailability of INS37217 when administered via oral…
- Trial name
- NCT00210093
- Testing
- denufosol tetrasodium (INS37217)
- Volunteers
- 12 people
- Sponsor
- Merck Sharp & Dohme LLC
Asthma
SOLO-Symbicort® in the Treatment of Persistent Asthma in Adolescents & Adults
The purpose of this study is to compare Symbicort Single Inhaler treatment with the Best Conventional Practice in patients with persistent asthma
- Trial name
- NCT00238784
- Testing
- Budesonide/formoterol Turbuhaler
- Where
- 3 sites in Canada
- Volunteers
- 1,300 people
- Sponsor
- AstraZeneca
Respiratory Failure, Weaning Failure
Monitoring of Breathing Effort Through Pressure Time Product Measurement Using Airway Occlusion Pressure
Mechanical ventilation is essential in the management of patients in Intensive Care. The approach to patients with prolonged weaning is challenging.In this context, it is vital to implement "diaphragmatic protection" strategies…
- Trial name
- PTPPocc (NCT06040138)
- Testing
- End expiratory occlusion maneuver
- Where
- 4 sites in Argentina
- Volunteers
- 50 people
- Sponsor
- Hospital Italiano de Buenos Aires
Healthy Volunteers
A Novel Method of Preoxygenation Using a Bain Circuit
The purpose of this study is to determine whether rebreathing for a short time (a bit like breathing into a paper bag) will stimulate faster breathing and thus make the giving of Oxygen more effective.
- Trial name
- NCT00958178
- Testing
- Oxygen
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Health Service, United Kingdom
Asthma
Electronic Monitoring Combined With Weekly Feedback and Reminders
A total of 96 recruited children (aged 6 months to 3 years) with mild or moderate persistent asthma who were on regular inhaled corticosteroids (ICS) were randomly allocated to receive electronic monitoring combined with instant…
- Trial name
- NCT03277664
- Testing
- intervention group
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Shanghai Children's Medical Center
Asthma
Combivent® CFC Metered Dose Inhaler (MDI) in Moderate to Severe Asthma
The purpose of this study is to demonstrate the superior bronchodilator efficacy of inhaled Combivent® CFC MDI vs. Albuterol HFA MDI in moderate to severe asthma patients.
- Trial name
- NCT00096616
- Testing
- Combivent® CFC MDI, Albuterol HFA MDI
- Where
- 27 sites in United States
- Volunteers
- 113 people
- Sponsor
- Boehringer Ingelheim
Healthy
Safety Study of Inhaling Carbon Monoxide in Healthy Volunteers
Post operative ileus (POI), a temporary paralysis of the intestines, is a serious health care problem. It normally occurs in all patients after surgery to the abdomen but in some cases can result in serious complications.
- Trial name
- NCT01050933
- Testing
- 250 ppm carbon monoxide
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Queen's University
Chronic Kidney Disease Stage 5 on Dialysis
Inspiratory Muscle Training for Chronic Kidney Disease Patients on Hemodialysis
Chronic Kidney Disease (CKD) is a global public health problem with an increasing prevalence and incidence, poor prognosis, and high costs.
- Trial name
- NCT05241652
- Testing
- Inspiratory Muscle Training with an intensity of 50% MIP, Inspiratory Muscle Training with an intensity of 10% MIP
- Where
- Indonesia
- Volunteers
- 32 people
- Sponsor
- Universitas Padjadjaran
Panic Disorder
Xenon Inhalation for Treatment of Panic Disorder
This study is a double-blind, randomized, placebo-controlled, clinical trial in parallel groups in patients with panic disorder.
- Trial name
- NCT04432155
- Testing
- Xenon
- Volunteers
- 200 people
- Sponsor
- Nobilis Therapeutics Inc.
Shortness of Breath, Respiratory Symptoms
Work of Breathing Assessment in Triage Scale
The proposed research study will be a prospective observational study designed to validate the Canadian Triage Assessment Scale (CTAS) in regard to work of breathing in patients in the emergency department.
- Conditions
- Shortness of Breath, Respiratory Symptoms, Cough, Difficulty Breathing
- Trial name
- NCT05479929
- Testing
- Canadian Triage Assessment Scale (CTAS)
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- CHRISTUS Health
Hyperoxia
Electronic Optimization of Inspired Oxygen During Mechanical Ventilation, a Pragmatic Randomized Trial (OPTI-Oxygen)
OPTI-Oxygen is a single center, stepped wedged, cluster-randomized, un-blinded, pragmatic, comparing the use of a combined inspired oxygen (FiO2) and peripheral oxygen saturation (SpO2) titration strategy utilizing electronic…
- Trial name
- NCT05923853
- Testing
- FiO2 titration using electronic alert system
- Where
- United States
- Volunteers
- 936 people
- Sponsor
- Ohio State University
Disabling Disease
Trunk Inclination on Respiratory-swallowing Coordination
Most caregivers do not know the influence of improper positioning therefore subjects suffer from possible choking risks. The aims of this study were to investigate the timing and coordination of swallowing and respiration in 4…
- Trial name
- NCT05221801
- Testing
- angle of inclination, food type
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Chronic Obstructive Pulmonary Disease (COPD)
Effects of Different Modes of Respiratory MuscleTraining on Respiratory Mechanics and NRD in Patient With Stable COPD.
Chronic Obstructive Pulmonary Disease (COPD) is a chronic respiratory disease characterized by persistent airflow limitation. The patients are suffering dyspnea year by year, resulting in the decreased exercise tolerance and…
- Trial name
- NCT03500042
- Testing
- inspiratory pressure threshold device
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Zhujiang Hospital