Clinical trials: Respiratory Changes
Acute Respiratory Failure
SmartCare Driven Pressure Support-Non Invasive Ventilation Feasibility Study
Knowledge-based systems were initially developped to automatically adapt pressure support settings during invasive ventilation, and proved to be at least as efficient as experienced clinicians.
- Trial name
- NCT01870089
- Testing
- SmartCare/PS-NIV Drägerwerk Lübeck Germany
- Where
- Switzerland
- Volunteers
- 11 people
- Sponsor
- University of Lausanne Hospitals
Small Cell Lung Cancer
Memory and MRI Changes With Hippocampus Avoidance Prophylactic Cranial Irradiation(HA-PCI) for Small Cell Lung Cancer(SCLC)
This is a prospective, randomized phase-II study observing the memory preservation and functional brain MRI changes with conformal avoidance of the hippocampal neural stem-cell compartment during prophylactic cranial irradiation…
- Trial name
- NCT02906384
- Testing
- hippocampus avoidance
- Where
- China
- Volunteers
- 154 people
- Sponsor
- Zhejiang Cancer Hospital
Head and Neck Squamous Cell Carcinoma, Radiotherapy
DAHANCA 30: A Randomized Non-inferiority Trial of Hypoxia-profile Guided Hypoxic Modification of Radiotherapy of HNSCC.
Hypoxic modification of radiotherapy with nimorazole has previously been shown to increase radiosensitivity in hypoxic head and neck squamous cell carcinomas (HNSCC).
- Conditions
- Head and Neck Squamous Cell Carcinoma, Radiotherapy, Hypoxic Modification, Hypoxia
- Trial name
- DAHANCA30 (NCT02661152)
- Testing
- Nimorazole
- Where
- Denmark
- Volunteers
- 1,252 people
- Sponsor
- Danish Head and Neck Cancer Group
Spinal Muscular Atrophy
Pulmonary Function Test Changes and Respiratory Muscle Strength Trends in Spinal Muscular Atrophy Patients Receiving Nusinersen Treatments
It is well known that patients with spinal muscular atrophy (SMA) have progressive decline of respiratory muscle function. Therapy traditionally involved supportive means to ensure optimal nutrition and airway clearance.
- Trial name
- NCT04050852
- Testing
- Nusinersen Treatments
- Where
- United States
- Sponsor
- NYU Langone Health
Respiratory Tract Diseases, Lung Diseases
What is an Important Change in the Short Physical Performance Battery (SPPB)?
The purpose of this study is to determine the important change in the Short Physical Performance Battery (SPPB) when used in patients with lung disease.
- Trial name
- NCT01649193
- Testing
- Pulmonary rehabilitation
- Where
- United Kingdom
- Volunteers
- 400 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Asthma Exacerbation
Reduction in Clinical Variance Using Targeted Design Changes in Computerized Provider Order Entry Order (CPOE) Sets
Selective redesign of order sets using different ways to frame the order and physician decision-making in a computerized provider order entry system could increase adherence to evidence-based care and reduce population-specific…
- Trial name
- NCT00952471
- Testing
- Evidence Based Intervention to order set
- Where
- United States
- Volunteers
- 458 people
- Sponsor
- Brian Jacobs
Home Air Radon Testing, Lung Cancer
Healthy Homes Study
This study is about home air radon testing and has two phases. The goal of the first phase is to learn about renters' and homeowners' views and plans related to radon testing. The main question this phase aims to answer is: 1.
- Trial name
- HHS (NCT05833334)
- Testing
- Public health infographic (AIM 3), Online health promotion intervention tailored by smoking status (AIM 3), Online health promotion intervention tailored by smoking status, plus reminder messages (AIM 3)
- Where
- United States
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Pneumonia, Fever
VRI in Children With Acute Respiratory Symptoms.
The VRI technology provides a radiation free dynamic image of the lung, by using a combination of well-known technologies, i.e. acoustic sensors, and a proprietary algorithm.
- Trial name
- VRI (NCT01279863)
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Rabin Medical Center
Eosinophilic Asthma
Changes in Gene Transcription and Immunophenotypes Following Mepolizumab Treatment for Asthma
The purpose of this study is to identify differentially expressed gene transcripts after initiation of mepolizumab in individuals with severe eosinophilic asthma (SEA).
- Trial name
- NCT05002621
- Testing
- Observational
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Acute Respiratory Distress Syndrome
Serial Changes of Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1) Levels in Patients With Acute Respiratory Distress Syndrome
The purpose of this study is to determine the impact of the serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) on etiology and prognosis of acute respiratory distress syndrome (ARDS)
- Trial name
- NCT00557414
- Where
- Taiwan
- Volunteers
- 63 people
- Sponsor
- National Taiwan University Hospital
Weaning Failure, Central Respiratory Depression
Exploration of Mechanisms for Weaning Failure
This study is a prospective physiologic study. The primary study population will be adult invasive tracheal intubated patients with COPD, and investigators will collect relevant demographic data, vital signs, and baseline…
- Conditions
- Weaning Failure, Central Respiratory Depression, Diaphragm Injury, Phrenic Nerve Disorder
- Trial name
- NCT06424314
- Testing
- Monitoring of respiratory mechanics parameters
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Obstructive Sleep Apnea
Change in C-reactive Protein (CRP) in Men and Women With Sleep Apnea After Continuous Positive Airway Pressure (CPAP)
C-reactive protein (CRP) is directly implicated in atherogenesis and associated cardiovascular morbidity in patients with obstructive sleep apnea (OSA).
- Trial name
- NCT01365832
- Testing
- Continuous Positive Airway Pressure (CPAP)
- Where
- Greece
- Volunteers
- 436 people
- Sponsor
- University of Crete
Obesity, Obesity, Morbid
Biological Sample Repository for Gastrointestinal Disorders
The goal of this observational study has the purpose of collecting biological samples from obese patients undergoing evaluation for weight loss by means of medical or endoscopic therapies; and of post bariatric surgery patients…
- Conditions
- Obesity, Obesity, Morbid, Obesity, Primary, Gastro-Intestinal Disorder
- Trial name
- NCT05874726
- Testing
- Blood Collection, Urine Collection, Tissue Sample Collection
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Pichamol Jirapinyo, MD, MPH
Post-Acute COVID-19 Syndrome, Lung Disease With Polymyositis
Efficacy and Safety of Longidaza® for the Treatment of Patients With Residual Changes in the Lungs After COVID-19
The goal of this clinical study is to evaluate the efficacy and safety of Longidaza®, lyophilisate for preparation of solution for injection, at a dose of 3000 IU compared to placebo in the treatment of adult patients with…
- Conditions
- Post-Acute COVID-19 Syndrome, Lung Disease With Polymyositis, Fibrosis, Lung Diseases, Interstitial
- Trial name
- NCT06383819
- Testing
- Longidaza®
- Where
- 30 sites in Russia
- Volunteers
- 392 people
- Sponsor
- NPO Petrovax
Pertussis
First Adult Safety Trial on Nasal Live Attenuated B. Pertussis Vaccine
The purpose of this study is to evaluate the safety and immunogenicity of a new live attenuated vaccine against whooping-cough. It is a phase1, single centre, dose-escalating, placebo-controlled study on a genetically modified B.
- Trial name
- NCT01188512
- Testing
- BPZE1
- Where
- Sweden
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Chronic Rhinosinusitis With Nasal Polyps
Early-onset Dupilumab Effects in CRSwNP
While it is known that Dupilumab has profound effects in patients with CRSwNP, these are often seen months later after treatment initiation; however, in practice, patients often endorse feeling significantly better within days of…
- Trial name
- NCT06188871
- Testing
- Dupilumab
- Where
- United States
- Sponsor
- University of Rochester
Obstructive Sleep Apnea
Promoting the Use of CPAP Therapy Among OSA Patients
Obstructive sleep apnea (OSA) is the most common sleep breathing disorder in the U.S. Continuous Positive Airway Pressure (CPAP) therapy is the most effective treatment for OSA.
- Trial name
- NCT04372329
- Testing
- CPAP4HealthySleep system
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Sarah Alismail
ARDS, Human, Extracorporeal Membrane Oxygenation Complication
Effects of Induced Moderate Hypothermia on ARDS Patients Under Venovenous ExtraCorporeal Membrane Oxygenation
Acute respiratory distress syndrome (ARDS) is a lesional pulmonary edema that occurs as a result of direct or indirect lung injury.
- Conditions
- ARDS, Human, Extracorporeal Membrane Oxygenation Complication, Hypothermia
- Trial name
- HypoLungECMO (NCT05306392)
- Testing
- Moderate Hypothermia, Normothermia
- Volunteers
- 30 people
- Sponsor
- Central Hospital, Nancy, France
Ebola Virus Disease, Marburg Virus Disease
Evaluation of Safety, Tolerability and Immune Responses of Ebola-S and Marburg Vaccines in Healthy Adults
Primary Objective: To evaluate the safety and tolerability of cAd3-EBO-S and cAd3 Marburg vaccines when administered Intramuscular (IM) at a dose of 1 x 10^11 particle units (PU) to healthy adults.
- Trial name
- NCT04723602
- Testing
- cAd3-Marburg, cAd3-EBO-S
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Albert B. Sabin Vaccine Institute
Transgender Women, Voice Alteration
Gender-affirming Voice Training With Visual Feedback
The goal of this clinical trial is to learn if prototype software can be used to train vocal pitch and resonance in trans women.
- Trial name
- NCT07017595
- Testing
- Visual-acoustic biofeedback: experimental
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Cincinnati