Clinical trials: Respiratory Complications
Infant, Premature, Intubation, Intratracheal
Fentanyl and Rocuronium for Tracheal Intubation in Newborns
Tracheal intubation is a common and critical procedure in neonatal intensive care units (NICU). Despite its clinical importance, first-attempt success rates remain low (approximately 50%), and adverse events - including oxygen…
- Conditions
- Infant, Premature, Intubation, Intratracheal, Respiratory Distress Syndrome, Newborn, Apnea of Prematurity
- Trial name
- NEORIN (NCT07650552)
- Testing
- Rocuronium Bromide 10 MG/ML, Fentanyl 1 mcg/kg IV, single dose, administered before non-emergent tracheal intubation.
- Where
- Brazil
- Volunteers
- 102 people
- Sponsor
- UEA - Universidade Do Estado Do Amazonas
Cardiovascular, Comorbidity
Improving Patient-Centered Care for Underserved Older African American Patients With Cardiovascular Comorbidities
This is formative evaluation trial guided by the Values Clarification Theory25 and the Cultural Values Theory26, with specific aims to: Aim 1.
- Conditions
- Cardiovascular, Comorbidity, Diabetes, Inflammatory Joint Diseases
- Trial name
- PPC Heart (NCT07748858)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Alabama at Birmingham
Pulmonary Hypertension, End-Stage Renal Disease
Impact of Hemo-dialysis Therapy on Blood Levels of Treprostenil in End Stage Renal Disease Patients With Pulmonary Hypertension
Remodulin (Treprostenil sodium) is synthetic prostacyclin analog available as a solution for administration in the intravenous route.
- Conditions
- Pulmonary Hypertension, End-Stage Renal Disease, Hemo-dialysis Therapy
- Trial name
- NCT01234571
- Volunteers
- 5 people
- Sponsor
- Rambam Health Care Campus
Infection, Enterocolitis, Necrotizing
Oropharyngeal Administration of Mother's Colostrum for Premature Infants (NS-72393-360)
Extremely premature (BW<1250g) infants are at high risk for morbidity and mortality. Own mother's colostrum (OMC) and milk (OMM) protect against neonatal morbidity and are rich in immune factors which may provide…
- Conditions
- Infection, Enterocolitis, Necrotizing, Ventilator-associated Pneumonia
- Trial name
- NCT02116699
- Testing
- oropharyngeal mother's milk, oropharyngeal sterile water
- Where
- 5 sites in United States
- Volunteers
- 260 people
- Sponsor
- Endeavor Health
Extrahepatic Bile Duct Cancer, Gallbladder Cancer
Anonymous Testing of Pathology Specimens for BRCA Mutations in Ashkenazi Jewish Individuals Who Have Cancer
The intent of the proposed study is to describe the prevalence of the most common recurring mutations in BRCA1 and BRCA2, blmAsh , and the A636P MSH2 mutation among Ashkenazi Jewish individuals with a variety of cancer diagnoses.
- Conditions
- Extrahepatic Bile Duct Cancer, Gallbladder Cancer, Gastric Cancer, Lung Cancer
- Trial name
- NCT00588263
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Small Cell Lung Carcinoma, Carcinoma, Squamous Cell of Head and Neck
Durvalumab and Tremelimumab in Combination With First-Line Chemotherapy in Advanced Solid Tumors
Durvalumab and Tremelimumab in combination with first-line chemotherapy in the following indications: Ovarian/peritoneal/fallopian tube cancer, SCCHN, TNBC, SCLC and gastric/GEJ cancer, PDAC, ESCC.
- Conditions
- Small Cell Lung Carcinoma, Carcinoma, Squamous Cell of Head and Neck, Stomach Neoplasms, Triple Negative Breast Neoplasms
- Trial name
- NCT02658214
- Testing
- paclitaxel + carboplatin, carboplatin + etoposide, gemcitabine + carboplatin
- Where
- 6 sites in Japan, South Korea
- Volunteers
- 32 people
- Sponsor
- AstraZeneca
Advanced Solid Tumors, Ovarian Cancer
Alisertib (MLN8237) in Combination With Weekly Paclitaxel in East Asian Patients With Advanced Solid Tumors
The purpose of this study is to evaluate the safety and tolerability and determine the MTD to subsequently define an RP2D of alisertib in combination with weekly paclitaxel in East Asian participants with advanced solid tumors.
- Conditions
- Advanced Solid Tumors, Ovarian Cancer, Small Cell Lung Cancer
- Trial name
- NCT02367352
- Testing
- Alisertib, Paclitaxel
- Where
- 3 sites in Japan, South Korea
- Volunteers
- 9 people
- Sponsor
- Millennium Pharmaceuticals, Inc.
Bone Cancer, Brain Cancer
Enhanced Assistance During Radiotherapy for Unmet Essential Needs
This is a prospective single-arm study of an enhanced assistance intervention for patients with unmet essential needs undergoing >10 fractions of radiotherapy comparing delay-free completion of radiotherapy in study participants…
- Conditions
- Bone Cancer, Brain Cancer, Colorectal Cancer, Esophagus Cancer
- Trial name
- EARN (NCT06582849)
- Testing
- Standard assistance, Enhanced assistance
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Washington University School of Medicine
Infant, Newborn, Infant, Low Birth Weight
Physiologic Definition of Bronchopulmonary Dysplasia
This observational study was conducted to design and test a physiologic definition for bronchopulmonary dysplasia at 36 weeks of life.
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- PhysiologicDef (NCT01223287)
- Where
- 21 sites in United States
- Volunteers
- 410 people
- Sponsor
- NICHD Neonatal Research Network
Patient-Ventilator Asynchrony, Mechanical Ventilation Complication
Nurse Education to Reduce Patient-Ventilator Asynchrony in the PICU
A prospective cluster-randomized quality improvement trial was conducted to evaluate whether a structured nurse education program on ventilator waveform interpretation and alarm management reduces patient-ventilator asynchrony in…
- Conditions
- Patient-Ventilator Asynchrony, Mechanical Ventilation Complication, Nurse Education
- Trial name
- NCT07273487
- Testing
- Nurse Education on Ventilator Waveform and Alarm Management
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
Melanoma, Breast Cancer
Survival Monitoring in Russian Cancer Registries
This study aims to establish a holistic framework for continuous cancer survival surveillance in Russian regions with high-quality population-based cancer registry data.
- Conditions
- Melanoma, Breast Cancer, Oncology, Colon Cancer
- Trial name
- SURVIMON (NCT06043947)
- Where
- Russia
- Volunteers
- 100,000 people
- Sponsor
- N.N. Petrov National Medical Research Center of Oncology
Lung Cancer, Pulmonary Complications
Study of CPAP as Intervention After Lung Resection
The aim of this study was to compare the oxygenation index (OI), dyspnea, and pain scale and evaluate the duration of thoracic drainage and pleural air leaks after lung resection in two groups of patients: chest physiotherapy…
- Trial name
- CPAP (NCT01285648)
- Testing
- Cpap
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Campinas, Brazil
Respiratory Complication, Morbid Obesity
Does Residual Muscular Weakness Lead to an Increase in Respiratory Complications in Bariatric Patients?
The purpose of this study is to determine if residual weakness after weight loss surgery leads to an increased risk of respiratory complications in the postoperative period.
- Trial name
- NCT02037516
- Testing
- Accelomyography, Neostigmine, Qualitative Monitor
- Where
- United States
- Volunteers
- 330 people
- Sponsor
- Coastal Anesthesiology Consultants
Hypoxia, Gastric Cancer
Efficacy and Safety of Remimazolam Tosylate for Sedation in Gastroscopy
Propofol is the most commonly used intravenous anesthetic for painless gastroscopy, but propofol significantly inhibits the respiratory and circulatory systems.
- Conditions
- Hypoxia, Gastric Cancer, Sedation Complication, Propofol Adverse Reaction
- Trial name
- NCT04727034
- Testing
- Remimazolam tosylate, Propofol
- Where
- 5 sites in China
- Volunteers
- 1,800 people
- Sponsor
- RenJi Hospital
Esophageal Cancer, Gastric Cancer
Prospective Analysis of Robot-Assisted Surgery
The robot-assisted surgery allows three-dimensional view, detailed access of small structures, depth perception and articulated movements with wide latitude.
- Conditions
- Esophageal Cancer, Gastric Cancer, Pancreatic Cancer, Rectal Cancer
- Trial name
- NCT02292914
- Testing
- Robot-assisted surgery, Conventional Surgery
- Where
- Brazil
- Volunteers
- 1,120 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Lung Cancer, Brain Tumor
The Effects of Using Different Anesthetics on the Prognosis of Primary Tumors and Its Mechanism of Action
1. Eligible participants were assessed prior to anesthesia. After the patient is admitted to the hospital, the subject's consent form is explained, and the consent form must be signed before the operation. 2.
- Conditions
- Lung Cancer, Brain Tumor, Liver Cancer, Ovarian Cancer
- Trial name
- NCT05926336
- Testing
- Propofol, Sevoflurane
- Where
- Taiwan
- Volunteers
- 1,316 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Corona Virus Disease 19 (Covid19), Corona Virus Infection
Effect of N-acetylcysteine on Oxidative Stress in COVID-19 Patients
The purpose of the study is to assess the potential therapeutic effect of N-acetylcysteine "NAC" in COVID 19 patients.
- Conditions
- Corona Virus Disease 19 (Covid19), Corona Virus Infection, Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV2)
- Trial name
- NCT04792021
- Testing
- N-acetylcysteine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
C.Surgical Procedure; Cardiac, Right-Sided Heart Failure
Evaluation of Monitoring TECHNOlogies in the PERI-OPerative Care of Cardiac Surgical Patients
The purpose of this prospective observational cohort study is to evaluate multimodal monitoring technologies in the perioperative care of cardiac surgical patients.
- Conditions
- C.Surgical Procedure; Cardiac, Right-Sided Heart Failure, Acute Kidney Injury, Respiratory Insufficiency
- Trial name
- TechnoPeriOp (NCT02658006)
- Testing
- Cardiac surgery
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Montreal Heart Institute
Isotretinoin Adverse Reaction, Covid19
Oral Isotretinoin and Covid-19 Infection
There is a theoretical risk that the nasal mucosal dryness caused by oral retinoid medications may increase risk of infection with Covid-19.
- Trial name
- NCT04663906
- Where
- United Kingdom
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma, Recurrent Adenoid Cystic Carcinoma of the Oral Cavity
Erlotinib and Cetuximab With or Without Bevacizumab in Treating Patients With Metastatic or Unresectable Kidney, Colorectal, Head and Neck, Pancreatic, or Non-Small Cell Lung Cancer
This randomized phase I/II trial studies the side effects, best way to give, and best dose of erlotinib and bevacizumab when given with cetuximab and how well giving erlotinib and cetuximab together with or without bevacizumab…
- Conditions
- Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma, Recurrent Adenoid Cystic Carcinoma of the Oral Cavity, Recurrent Basal Cell Carcinoma of the Lip, Recurrent Colon Cancer
- Trial name
- NCT00101348
- Testing
- erlotinib hydrochloride, cetuximab, bevacizumab
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- National Cancer Institute (NCI)