Clinical trials: Respiratory Disorder
Fungal Diseases, Lung Cancer (NSCLC)
Study on the Microbial Environment of Non-small Cell Lung Cancer Based on Mycogenomics and Its Clinical Relevance
This study aims to uncover the characteristics of the fungal flora in non-small cell lung cancer, and to investigate the relationship between pulmonary fungi and the various pathological subtypes, stages, clinical features of…
- Conditions
- Fungal Diseases, Lung Cancer (NSCLC), Microbioata
- Trial name
- NCT07783971
- Where
- China
- Volunteers
- 10 people
- Sponsor
- 958th Army Hospital of the Chinese People's Liberation Army
Postural Orthostatic Tachycardia Syndrome, COVID-19
Effects of Individual Tailored Physical Exercise in Patients With POTS After COVID-19 - a Randomized Controlled Study
Covid-19 has the potential to affect physical, cognitive and psychological functions in multiple ways. It has been clear that a significant proportion of patients with Covid-19 develop long-term symptoms.
- Conditions
- Postural Orthostatic Tachycardia Syndrome, COVID-19, Post COVID-19 Condition, Post-Acute COVID-19 Syndrome
- Trial name
- NCT05877534
- Testing
- Individual tailored exercise
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Karolinska Institutet
NSCLC, Stage I
Osimertinib Therapy After Resection in High-risk Stage I EGFRm NSCLC (OSTAR)
This is a prospective, open, single-center, single-arm phase II clinical study with common EGFR-sensitive mutations (Ex19del and L858R) identified in the central laboratory.To evaluate the efficacy and safety of adjuvant…
- Trial name
- NCT05686434
- Testing
- Osimertinib
- Where
- China
- Volunteers
- 65 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Age Associated Immune Deficiency, Elderly Infection
Immunophenotype of Risk in Older Patients Admitted for Pneumonia
The objective is to evaluate if the immune risk phenotype (IRP) in patients who have been admitted for pneumonia predisposes to worse long-term outcomes.
- Conditions
- Age Associated Immune Deficiency, Elderly Infection, Pneumonia, Nutrition Disorders in Old Age
- Trial name
- NCT04062799
- Testing
- no intervention
- Where
- Spain
- Volunteers
- 174 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Epithelial Mesothelioma, Recurrent Malignant Mesothelioma
Sorafenib Tosylate in Treating Patients With Malignant Mesothelioma.
This phase II trial is studying how well sorafenib works in treating patients with malignant mesothelioma. Sorafenib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood…
- Conditions
- Epithelial Mesothelioma, Recurrent Malignant Mesothelioma, Sarcomatous Mesothelioma, Stage IA Malignant Mesothelioma
- Trial name
- NCT00107432
- Testing
- sorafenib tosylate, laboratory biomarker analysis
- Where
- 2 sites in United States
- Volunteers
- 44 people
- Sponsor
- National Cancer Institute (NCI)
General Anesthetics
Effectiveness of Facial Mask NIV in Adults Under General Anesthesia: Two-Hand C-E vs V-E Techniques
This study aims to compare two different ways doctors hold a face mask to help the participant breathe during general anesthesia. The investigators are evaluating which method, the "C-E" or the "V-E" technique, works best.
- Trial name
- VENTMASK (NCT07179432)
- Testing
- V-E facial mask ventilation maneuver, C-E facial mask ventilation maneuver
- Where
- 2 sites in Colombia
- Volunteers
- 206 people
- Sponsor
- Universidad de Antioquia
Solid Cancers, NSCLC (Advanced Non-small Cell Lung Cancer)
An Phase Ib/II Clinical Trial of TCC1727 Combination Therapy in Advanced Solid Tumors
This is a Phase Ib/II clinical study. The Phase Ib dose-escalation study aims to evaluate and determine the recommended Phase II dose (RP2D) of TCC1727 in combination with benmelstobart /olaparib /topotecanfor patients with…
- Conditions
- Solid Cancers, NSCLC (Advanced Non-small Cell Lung Cancer), Gastric (Stomach) Cancer, Endometrial Cancer
- Trial name
- NCT07371663
- Testing
- TCC1727 tablet 90mg, TCC1727 tablet 120mg, TCC1727 tablet 160mg
- Where
- 3 sites in China
- Volunteers
- 266 people
- Sponsor
- Beijing Tide Pharmaceutical Co., Ltd
Stage IIIA Non-small Cell Lung Cancer
Pathological Response After Neoadjuvant Treatment on NSCLC
This is a non-interventional, observational, multicenter and retrospective study. Being limited to the collection of patient data already filled in the Tumor Thoracic Registry data base and the data from stage IIIA clinical…
- Trial name
- PLANET (NCT05167487)
- Testing
- Cisplatin, Carboplatin
- Where
- 17 sites in Spain
- Volunteers
- 150 people
- Sponsor
- Fundación GECP
Asthma, Chronic Obstructive Pulmonary Disease (COPD)
A Study to Evaluate the Integrated Dose Counter on an Albuterol Hydrofluoroalkane (HFA) Metered Dose Inhaler (MDI)
This study is evaluating the effectiveness of a dose counter for an inhaler device used to deliver medication to people diagnosed with asthma or COPD.
- Conditions
- Asthma, Chronic Obstructive Pulmonary Disease (COPD), Emphysema, Chronic Bronchitis
- Trial name
- NCT01302587
- Testing
- Albuterol
- Where
- 25 sites in United States
- Volunteers
- 306 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Bronchial Asthma
Two Doses of the Intravenous Magnesium Sulfate Versus the Standard Single Dose ,With/ Without the Nebulized Budesonide For the Management of the Severe Asthma Exacerbation in the Emergency Room; A Randomized Controlled Trial.
Many studies have investigated the efficacy and safety of Intravenous magnesium sulfate and inhaled steroids in addition to the standard treatment for patients with severe asthma attacks.
- Trial name
- NCT02455687
- Testing
- Hi-dose iv MgSO4, Nebulized budesonide, Std-dose iv MgSO4
- Where
- Qatar
- Volunteers
- 240 people
- Sponsor
- Hamad Medical Corporation
Psychological Distress, Anxiety
Psychological Symptoms in Cardiac and Pulmonary Diseases
The European guidelines emphasize the importance of conducting psychological screenings to investigate the presence of stress and symptoms of anxiety and depression in patients with cardiovascular disease: depression, common…
- Conditions
- Psychological Distress, Anxiety, Depression, Cardiovascular Diseases
- Trial name
- NCT06396793
- Testing
- no intervention because it is an observational study
- Where
- Italy
- Volunteers
- 421 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Chronic Obstructive Pulmonary Disease, Multiple Comorbidity
Program of Integrated Care for Patients With Chronic Obstructive Pulmonary Disease and Multiple Comorbidities
Many patients with chronic obstructive pulmonary disease (COPD) also have other diseases referred to as comorbidities. Often these patients require health care by a variety of health care professionals from services linked to…
- Trial name
- PICCOPD+ (NCT01648621)
- Testing
- 40 minute standardized education session, Individualized action plan, Individualized care plan
- Where
- 2 sites in Canada
- Volunteers
- 470 people
- Sponsor
- Michael Garron Hospital
Gastro-intestinal Cancer, Lung Cancer
The Impact of a Patient Education Intervention for Ambulatory Oncology Patients
This study will test the impact of newly created and available symptom management patient education brochures on symptom burden [measured via the Edmonton Symptom Assessment System (ESAS)], health-related quality of life…
- Conditions
- Gastro-intestinal Cancer, Lung Cancer, Head and Neck Cancer, Breast Cancer
- Trial name
- NCT02038114
- Testing
- Instructed to read patient education pamphlets
- Where
- Canada
- Volunteers
- 96 people
- Sponsor
- Sunnybrook Health Sciences Centre
Asthma
PackHealth: Asthma Engagement Tool
The purpose of this study is to test the impact of an innovative patient engagement solution on patient's quality of life and asthma-related outcomes, and evaluate the correlation between a patient reported outcome measure and…
- Trial name
- NCT02413684
- Testing
- Patient engagement toolkit
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Duke University
Acute Respiratory Distress Syndrome
Assessment of Cardiac Output in Patients With ARDS Implanted With Venous-venous ECMO.
In patients with severe acute respiratory distress syndrome, extracorporeal membrane oxygenation (ECMO), which also as known as extracorporeal life support, may be used.
- Trial name
- PiCCMO (NCT05164484)
- Testing
- Transpulmonary thermodilution
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pulmonary Hypertension, Nursing Care
Dynamic Mixed Learning Module in Pulmonary Hypertension Patients
This study was conducted to evaluate the effect of the Dynamic Blended Learning Module developed for patients diagnosed with pulmonary hypertension (PH) on symptom management.
- Conditions
- Pulmonary Hypertension, Nursing Care, Learning
- Trial name
- Learning (NCT07429552)
- Testing
- Symptom Management
- Where
- Turkey (Türkiye)
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Non-small-cell Lung Cancer
Neoadjuvant Therapy of Icotinib in Epidermal Growth Factor Receptor Mutated NSCLC Patients
The purpose of this study is to evaluate the overall response rate and disease free survival for IIIAN2 non-small-cell lung cancer patients with EGFR 19 or 21 exon mutation.
- Trial name
- NCT01843647
- Testing
- Icotinib, Chemotherapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Betta Pharmaceuticals Co., Ltd.
Asthma, Severe Eosinophilic Asthma
A Study to Assess the Reduction of Daily Maintenance ICS/LABA Treatment Towards Anti-Inflammatory Reliever Treatment in Patients With Severe Eosinophilic Asthma Treated With Benralizumab
This is a multicentre, randomised, open-label, parallel-group, active-controlled, phase IV study to assess the reduction of daily Symbicort® maintenance to anti-inflammatory reliever treatment only in participants with severe…
- Trial name
- NCT04159519
- Testing
- Symbicort®, Fasenra®, Ventolin®
- Where
- 23 sites in France, Germany and 2 more
- Volunteers
- 170 people
- Sponsor
- AstraZeneca
Non Invasive Ventilation, Spinal Muscular Atrophy
Exploratory Study of Respiratory Bacterial Infections or Superinfections and Colonizations in Patients With Spinal Muscular Atrophy Under NIV
SMA (Spinal Muscular Atrophy) is a rare neuromuscular disease characterized by motoneuron damage. Symptoms consist of respiratory involvement with numerous respiratory infections and eventually respiratory failure, for which NIV…
- Conditions
- Non Invasive Ventilation, Spinal Muscular Atrophy, Respiratory Bacterial Infection
- Trial name
- AVNIR (NCT05712330)
- Testing
- non invasive ventilation samples, patient samples, parent questionnaire
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Pneumonia, Bacterial, Pneumopathy
Application of the Recommendations of the SPLIF (French Society of Infectious Pathology) in a Geriatric Population on the Duration of Treatment for Bacterial Pneumonia
Pneumopathy is the leading cause of death from infectious disease in the elderly. Prior to 2021, the recommended duration of antibiotic therapy for pneumonia, in adults, was 7 days.
- Trial name
- NCT06307730
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Centre Hospitalier de Saint-Denis
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