Clinical trials: Respiratory Disorder
Stridor
Comparison Between Budesonide and Dexamethasone Treatments for Respiratory Discomfort After Extubation on Children
The study aims to analyze and compare the clinical effects of using inhaled budesonide or intravenous dexamethasone in the treatment of postextubation stridor on children admitted to the pediatric intensive care units at Hospital…
- Trial name
- BUDEXA (NCT02056379)
- Testing
- Budesonide, Dexamethasone
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- Hospital Israelita Albert Einstein
Benign Multinodular Goiter, Thyroidectomy
Intraoperative Methylene Blue Spray for the Identification and Preservation of Vital Structures in Thyroidectomy
This randomized controlled trial aims to evaluate the efficacy of intraoperative methylene blue (MB) spray in improving the identification and preservation of the recurrent laryngeal nerve (RLN) and parathyroid glands (PGs)…
- Conditions
- Benign Multinodular Goiter, Thyroidectomy, Recurrent Laryngeal Nerve Injury, Hypoparathyroidism
- Trial name
- NCT07395388
- Testing
- Intraoperative topical methylene blue spray, Conventional Dissection
- Where
- Pakistan
- Volunteers
- 136 people
- Sponsor
- Services Hospital, Lahore
Ventilator Acquired Pneumonia, Mechanical Ventilation Complication
ClusterVAP: Multicentre Proteomic Endotyping of Ventilator-associated Pneumonia
Ventilator-associated pneumonia (VAP) is a common and serious infection in patients receiving mechanical ventilation in intensive care units.
- Trial name
- ClusterVAP (NCT07245888)
- Where
- 4 sites in France, Portugal and 1 more
- Volunteers
- 400 people
- Sponsor
- Region Skane
Pulmonary Hypertension
FREEDOM - M: Oral Treprostinil as Monotherapy for the Treatment of Pulmonary Arterial Hypertension (PAH)
This study was an international, multicenter, randomized (2:1 active:placebo), double-blind, placebo-controlled study in subjects with PAH who were NOT currently receiving approved therapy for their PAH.
- Trial name
- NCT00325403
- Testing
- Oral treprostinil (UT-15C) Sustained Release Tablets
- Where
- 77 sites in United States, Austria and 11 more
- Volunteers
- 349 people
- Sponsor
- United Therapeutics
Solid Organ Transplant Rejection, COVID-19
AlloSure Guided Immuno-Optimization for COVID-19: An Early Experience
The utilization of AlloSure to help guide immunosuppression management in solid organ transplant recipients diagnosed with COVID-19
- Trial name
- Al-COVE (NCT04341103)
- Volunteers
- 500 people
- Sponsor
- CareDx
Influenza
A Study in Healthy Adults to Assess Priming With Antigenically Mismatched Live Attenuated A/H7N3 Influenza Virus Vaccine Followed by Inactivated A/H7N9 Influenza Virus Vaccine
The purpose of this study is to assess priming with antigenically mismatched live attenuated A/H7N3 influenza virus vaccine followed by inactivated A/H7N9 influenza virus vaccine in healthy adults.
- Trial name
- NCT03581903
- Testing
- H7N3 pLAIV, H7N9 pIIV
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Healthy
Phase 1 Study to Assess the Safety of Inactivated Split Influenza Vaccine and Control Vaccine in Korean Volunteer
The purpose of this study to evaluate the safety of IL-YANG Inactivated Split Influenza Vaccine (IL-YANG FLU Vaccine Prefilled Syringe INJ.) in comparison with Fluarix Prefilled Syringe (inactivated split influenza vaccine) after…
- Trial name
- NCT02330003
- Testing
- IL-YANG FLU Vaccine Prefilled Syringe INJ., Fluarix Prefilled Syringe
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Il-Yang Pharm. Co., Ltd.
Non-small Cell Lung Cancer
MK-3475A±Calderasib (MK-1084) in Completely Resected Stage IIA-IIIB (N2) KRAS G12Cm NSCLC (MK-1084-013)
This is a phase 3, randomized, double-blind study of adjuvant calderasib plus subcutaneous pembrolizumab and berahyaluronidase alfa (MK-3475A) versus adjuvant placebo plus MK-3475a in participants with completely resected stage…
- Trial name
- KANDLELIT-013 (NCT07431827)
- Testing
- Calderasib, MK-3475A
- Where
- 120 sites in Argentina, Australia and 17 more
- Volunteers
- 400 people
- Sponsor
- Merck Sharp & Dohme LLC
Cheyne-Stokes Respiration, Sleep Apnea, Central
Bipap Automatic Servo Ventilation (autoSV) Advanced in Central Apnea Patients
Pilot study testing the Bipap autoSV Advanced Algorithm during full night, in-lab polysomnography (PSG) and 3 months at home on patients with Central Sleep Apnea, Hunter Cheyne Stokes Respiration, or Complex Sleep Apnea.
- Trial name
- NCT01199042
- Testing
- BiPAP autoSV Advanced
- Where
- 3 sites in United States
- Volunteers
- 29 people
- Sponsor
- Philips Respironics
Asthma
Chronic Bronchiolitis or Resistant Asthma?
Chronic Bronchiolitis or Resistant Asthma? Testing a way to diagnosis and treatment
- Trial name
- NCT00368342
- Testing
- Erythromycin, Azithromycin , Clarithromycin
- Sponsor
- Baqiyatallah Medical Sciences University
Postoperative Care, Deterioration, Clinical
Optimized Novel Wireless Assessment of Respiratory and Circulatory Dirstress - Alarm Validation
The ONWARD study evaluates user experiences from continuous vital sign monitoring alarms sent to the clinical staff in case of deviating vital signs at the general hospital ward.
- Trial name
- ONWARD - AV (NCT07649642)
- Testing
- Continuous vital sign monitoring
- Where
- 2 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Eske Kvanner Aasvang
Legionnaires' Disease
Legionnaires' Effect on Smell
The goal of this study is to determine whether survivors of Legionnaires' disease suffer smell loss. A quantitative olfactory test will be performed by the participants.
- Trial name
- NCT03321786
- Testing
- The University of Pennsylvania Smell Identification Test (UPSIT)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Pennsylvania
Asthma
XKH001 Injection in Healthy Subjects
This study is a randomized, double-blind, placebo-controlled, multiple ascending dose (MAD) clinical study. The primary objective is to evaluate the safety, tolerability, and PK of multiple SC doses of XKH001 in healthy subjects.
- Trial name
- NCT05991661
- Testing
- XKH001 Injection
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Beijing Kanova Biopharmaceutical Co., LTD
Sleep Apnea, Obstructive
Portable Monitoring for Diagnosis and Management of Sleep Apnea
This multi-site project compares compares the efficiency of a home-based portable monitoring strategy to a standard of care sleep laboratory-based strategy for the diagnosis and positive airway pressure treatment of obstructive…
- Trial name
- HomePAP (NCT00642486)
- Testing
- Portable (Embla Embletta X30 system and Respironic REMStar Auto M series with CFlex), Standard polysomnography (PSG)
- Where
- United States
- Volunteers
- 373 people
- Sponsor
- Case Western Reserve University
Blood Clots, Vascular Disease
Single Center Post-Market Study of Thrombolytic Therapy Using the Versus™ Catheter
Assess the functionality of the Versus Catheter for catheter-directed thrombolysis of pulmonary blood clots, including advanced imaging assessment.
- Conditions
- Blood Clots, Vascular Disease, Embolism Thrombosis, Cardiovascular Diseases
- Trial name
- NCT06975969
- Testing
- Versus™ Endovascular Pulmonary Artery Drug Delivery Catheter
- Where
- United States
- Sponsor
- Liquet Medical Inc.
Obstructive Chronic Pulmonary Disease, Emphysema
Effectiveness of Different Exercise Training Programs to the Profile of COPD Patients
Aims: To prove the benefits of an specific strength training program in COPD patients compared to those achieved with the traditional endurance training.
- Trial name
- NCT01336283
- Testing
- Endurance training, Strength training, Combined training
- Where
- Spain
- Volunteers
- 66 people
- Sponsor
- Hospitales Universitarios Virgen del Rocío
Chronic Obstructive Pulmonary Disease
Study to Assess the Efficacy, Safety, and Tolerability of SAR440340/REGN3500/Itepekimab in Chronic Obstructive Pulmonary Disease (COPD)
Primary Objective: Evaluate the efficacy of itepekimab compared with placebo on the annualized rate of acute moderate-or-severe COPD exacerbations in former smokers with moderate-to-severe COPD Secondary Objectives: Evaluate the…
- Trial name
- AERIFY-1 (NCT04701983)
- Testing
- Itepekimab SAR440340
- Where
- 232 sites in United States, Argentina and 19 more
- Volunteers
- 1,127 people
- Sponsor
- Sanofi
Airway Obstruction
Comparison of High Dose and Low Dose Dexamethasone in Preventing Post-Extubation Airway Obstruction in Adults
The specific objectives were to determine whether high dose dexamethasone are more effective than low dose dexamethasone in the reduction or prevention of post-extubation airway obstruction among patients with a cuff leak volume…
- Trial name
- NCT00548483
- Testing
- dexamethasone (Oradexon, Nederland)
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Mackay Memorial Hospital
Laryngospasm
Laryngeal Reflex Study Under Propofol Anesthesia: Effect of Intravenous Lidocaine
To describe respiratory and laryngeal responses to laryngeal stimulation during propofol anesthesia in children. To determine whether the co-administration of lidocaine blunts these reflex responses.
- Trial name
- LR6 (NCT01222169)
- Testing
- NaCl 0,9%
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- Thomas Erb
Chronic Obstructive Pulmonary Disease
Evidence-based Analysis of Low-dose CT in Management of COPD
Background: Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of chronic morbidity and mortality worldwide.
- Trial name
- NCT02599883
- Testing
- Low-Dose Computed Tomography
- Volunteers
- 195 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
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