Clinical trials: Respiratory Disorder
Pneumonia
Evaluation of Innovative Tools in Development of Antibiotics
The investigators will determine the difference of pharmacokinetics of ciprofloxacin and imipenem between healthy volunteers and intensive care patients suffering from pneumonia in plasma and at the target site - lung - using…
- Trial name
- NCT03177720
- Testing
- Ciprofloxacin, Imipenem
- Where
- Austria
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Pulmonary Disease, Chronic Obstructive
Post-marketing Surveillance of Ventilat® Metered Dose Inhaler in Chronic Obstructive Bronchitis
Study to obtain further information on the tolerability and efficacy of Ventilat® metered-dose inhaler in the treatment of Chronic Obstructive bronchitis under conditions of daily practice
- Trial name
- NCT02233920
- Testing
- Ventilat® - metered dose inhaler
- Volunteers
- 716 people
- Sponsor
- Boehringer Ingelheim
Obstructive Airway Disease
In Patients With Obstructive Airway Disease, Investigate the Effects of Different Breathing Strategies and Pedaling Rates on the Physiological Response to Bicycle Exercise
The definition of obstructive airway disease is a ratio of the forced expiratory volume in one second (FEV1) to the forced vital capacity (FVC) of less than 0.7, which includes conditions such as chronic obstructive pulmonary…
- Trial name
- NCT06332820
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Non-small Cell Lung Cancer, NSCLC
A Study of Ociperlimab With Tislelizumab Compared to Pembrolizumab in Participants With Untreated Lung Cancer
The purpose of this study is to evaluate the efficacy and safety of ociperlimab + tislelizumab compared with that of pembrolizumab in adults with high levels of programmed cell death ligand-1 (PD-L1), locally advanced/recurrent…
- Trial name
- NCT04746924
- Testing
- Tislelizumab, Ociperlimab, Pembrolizumab
- Where
- 218 sites in United States, Argentina and 17 more
- Volunteers
- 669 people
- Sponsor
- BeiGene
Pneumonia, Pleural Effusion
Procoagulant Activity in Patients With Community Acquired Pneumonia, Pleural Effusion and Empyema
Community acquired pneumonia (CAP) is still one of the most important causes of morbidity in adults. (1) In severe cases, parapneumonic effusions or empyema may develop.
- Conditions
- Pneumonia, Pleural Effusion, Empyema
- Trial name
- NCT01178580
- Where
- Israel
- Volunteers
- 75 people
- Sponsor
- Meir Medical Center
Hydrostatic Pulmonary Edema, Acute Respiratory Failure
Acute DYSPnea in the Emergency Department: Diagnostic Value of Point-of-care UltraSound
Acute dyspnea is a common reason for emergency department (ED) admission and is frequently caused by acute heart failure with pulmonary edema.
- Conditions
- Hydrostatic Pulmonary Edema, Acute Respiratory Failure, Dyspnea
- Trial name
- DYSP-ED-US (NCT07324980)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Università degli Studi del Piemonte Orientale Amedeo Avogadro
COPD, Hyperglycemia
Tight Glycemic Control in Acute Exacerbations of COPD
Glucose control has been shown as an important and independent prognostic factor in several acute conditions in hospitalized patients, including Acute MI, stroke, cardiac surgery and in critical care units.
- Trial name
- NCT00452296
- Testing
- tight insulin treatment in patients hospitalized with COPD exacerbation, tight glycemic control
- Volunteers
- 84 people
- Sponsor
- Soroka University Medical Center
Lung Cancer
Gefitinib and Sirolimus in Treating Patients With Recurrent or Refractory Stage IIIB or Stage IV Non-Small Cell Lung Cancer
RATIONALE: Gefitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as sirolimus, work in different ways to stop the growth of tumor cells, either by…
- Trial name
- NCT00098462
- Testing
- gefitinib, sirolimus
- Sponsor
- Jonsson Comprehensive Cancer Center
Nonsmall Cell Lung Cancer
CT-based Radiomic Signature Can Identify Adenocarcinoma Lung Tumor Histology
Lung cancer remains the leading cause of cancer related mortality worldwide, with more than 1.5 million related deaths annually.
- Trial name
- NCT03940846
- Testing
- Virtual biopsy
- Where
- Netherlands
- Volunteers
- 650 people
- Sponsor
- Maastricht University
Asthma
Efficacy and Safety of Ciclesonide (CIC) Administered Twice Daily in Pediatric Patients With Asthma.
Primary objective: To demonstrate the efficacy of ciclesonide, compared to placebo, at 80 μg twice daily (BID) or 40 μg BID for 12 weeks in patients with persistent asthma.
- Trial name
- NCT00392288
- Testing
- Ciclesonide
- Where
- 6 sites in United States, Hungary and 4 more
- Volunteers
- 528 people
- Sponsor
- AstraZeneca
Lung Cancer
Neo-adjuvant Treatment in Non-Small Cell Lung Cancer (NSCLC)
RATIONALE: Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Trial name
- NCT01059188
- Testing
- cetuximab, cisplatin, docetaxel
- Where
- 15 sites in Switzerland
- Volunteers
- 69 people
- Sponsor
- Swiss Cancer Institute
Airway Obstruction
The Efficacy of Distal Pharyngeal Airway for Oxygenation During TEE
The purpose of this study is to investigate the effect of using the McMurray Enhanced Airway (MEA) which is a flexible extended-length distal pharyngeal airway on improving oxygen delivery compared to standard nasal cannula.
- Trial name
- NCT05974488
- Testing
- McMurray Enhanced Airway, Nasal Cannula
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Miami
Chronic Obstructive Pulmonary Disease
Effect of Staphylococcus and Neisseria Tablets on Clinical Outcome Among Patients With Chronic Obstructive Pulmonary Disease
This is a multi-center, prospective study. This study aims to investigate the incidence of acute exacerbation within 12 months, as well as the safety of Staphylococcus and Neisseria Tablets on patients with chronic obstructive…
- Trial name
- NCT05975788
- Testing
- Staphylococcus and Neisseria Tablets
- Where
- China
- Volunteers
- 750 people
- Sponsor
- Peking University Third Hospital
Airway Obstruction, Dyspnea
Heliox in Experimental Upper Airway Obstruction
Currently it is common medical wisdom that HELIOX (mixture of Helium in Oxygen) with a fraction of Helium below 60% is not effective in reducing airway obstruction.
- Trial name
- NCT00788788
- Testing
- HELIOX
- Where
- Germany
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Witten/Herdecke
Pneumonia, Bacterial
Prevalence and Serotype of Streptococcus Pneumoniae Hospitalized Adult With Community-Acquired Pneumonia
Streptococcus Pneumoniae is one of the etiology in severe CAP and accounts for about 60-75% of cases and is likely to be the leading cause of unknown etiologic pneumonia.
- Trial name
- HACAP (NCT05173727)
- Where
- Indonesia
- Volunteers
- 355 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Pulmonary Atelectasis, Patient Comfort
HFNC During Awake Craniotomy - Impact on Patient Comfort
Background: Patients undergoing awake brain surgery are exposed to non-humidified, non-warmed oxygen/air mix flow through a face mask for a prolonged duration.
- Trial name
- NCT03763461
- Testing
- HFNC, Oxygen Mask
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Western University, Canada
Lung Cancer
Amino Acid Tracer (FACBC) Positron Emission Tomography for Lung Nodule
This study will look at how the [18]FACBC goes into the lung nodules. This will hopefully lead to the development of better imaging techniques to look at lung nodules.
- Trial name
- SPN (NCT01502670)
- Testing
- 18F-FACBC Radiotracer
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Emory University
Lung Cancer
Paclitaxel, Bevacizumab and Pemetrexed in Patients With Untreated, Advanced Non-Small Cell Lung Cancer Using Web-Based Data Collection, Patient Self-Reporting of Adverse Effects and Automated Response Assessment
The purpose of this study is to determine the percentage of patients with non-small cell lung cancer that will experience a shrinkage of their tumors following treatment with three medications given together: paclitaxel…
- Trial name
- NCT00807573
- Testing
- Paclitaxel, Pemetrexed, Bevacizumab
- Where
- 5 sites in United States
- Volunteers
- 44 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Bronchiectasis Adult, Bronchiectasis With Acute Exacerbation
Airway Clearance by Fiberoptic Bronchoscopy in Bronchiectasis Followed by Gentamicin and Dexamethason Injection
Fiberoptic Bronchoscopic Removal of Secretions and Antibiotic Injection
- Trial name
- NCT06906354
- Testing
- Airway Clearance by Fiberoptic Bronchoscopy in Bronchiectasis Followed by Gentamicin and Dexamethason Injection
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Dental Pain, Muscle Sensitivity to Pressure
Analgetic Effect of Nitrousoxide-oxygen Inhalation for Dental Treatment of Children
To assess the analgetic effect of nitrousoxide-oxygen inhalation on pain perception in 12-15 years old children from 1) the dental pulp; 2) the masseter muscle; 3) the skin on the upper lip
- Conditions
- Dental Pain, Muscle Sensitivity to Pressure, Skin Sensitivity to Electric Stimulation
- Trial name
- NCT01022294
- Testing
- Nitrousoxide-oxygen and atmospheric air, Atmospheric air; nitrousoxide-oxygen
- Where
- Denmark
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
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