Clinical trials: Respiratory Distress
COVID-19 Acute Respiratory Distress Syndrome
Is Prolonged Period of Prone Position Effective and Safe in Mechanically Ventilated Patients With SARS-COV-2?
the aim of the study is to assess safety and efficacy of prone position ventilation beyond the usual 16 hrs in patients with SARS-COV-2
- Trial name
- NCT05109624
- Testing
- prolonged prone position ventilation
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Ain Shams University
Sepsis, Acute Respiratory Distress Syndrome
Electroacupuncture Modulates SPMs Metabolism and Respiratory Symptoms in Patients With Sepsis Complicating ARDS
In this interventional clinical trial, researchers will administer electroacupuncture versus sham electroacupuncture to sepsis patients with ARDS and collect objective outcome measures. The study will be divided into 2 groups.
- Trial name
- NCT06006325
- Testing
- electroacupuncture treatment
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Tianjin Nankai Hospital
Sleep Disturbance
Sleep Quality During COVID-19 Containment in Children Whether or Not Usually Followed in Child Psychiatry
The purpose of this study is to determine whether sleep disturbances in children aged 7 to 12 during COVID-19 containment are more prevalent in children who received routine psychiatric care before containment compared to…
- Trial name
- CONFIDODO (NCT04370210)
- Testing
- Questionnaires
- Where
- France
- Volunteers
- 247 people, healthy volunteers welcome
- Sponsor
- Hôpital NOVO
Sepsis, Acute Respiratory Distress Syndrome
A Validation Study on a Prognostic Prediction Model for Respiratory Tract Infections
This study adopted a prospective, single-center, open-label design, aiming to evaluate the efficacy of the RTI clinical outcome prediction model in predicting clinical outcomes in subjects with acute respiratory tract infections.
- Conditions
- Sepsis, Acute Respiratory Distress Syndrome, Community Acquired Pneumonia, Transcriptome
- Trial name
- NCT07109310
- Testing
- RTImodel001
- Volunteers
- 150 people
- Sponsor
- Peking Union Medical College Hospital
ARDS (Moderate or Severe), Adult Patients
Role of Elastic Power in Acute Respiratory Distress Syndrome
Mechanical ventilation is essential for managing acute respiratory distress syndrome (ARDS), but it can also cause ventilator-induced lung injury (VILI) due to mechanical forces.
- Trial name
- NCT06878313
- Volunteers
- 20 people
- Sponsor
- Hospital El Cruce
Ankylosing Spondylitis, Respiratory Distress
Effectiveness of Mobile Respiratory Training in Ankylosing Spondylitis
Introduction and aim; Low functionality of respiratory muscles is frequently observed in various diseases such as chronic obstructive pulmonary disease, cystic fibrosis, idiopathic pulmonary fibrosis, and rheumatological diseases…
- Conditions
- Ankylosing Spondylitis, Respiratory Distress, Exercise Therapy, Breath Tests
- Trial name
- NCT06652984
- Testing
- Exercise 1, Exercise 2
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Uşak University
Coronavirus, SARS-CoV-2
Hemodynamic Characteristics of Patients With SARS-CoV-2
The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been declared a public health emergency of international concern.
- Conditions
- Coronavirus, SARS-CoV-2, COVID-19, Acute Respiratory Distress Syndrome
- Trial name
- PiCCOVID (NCT04337983)
- Testing
- Transpulmonary thermodilution, Echocardiography
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Bicetre Hospital
Respiratory Distress Syndrome, Adult
Establishment of a Biomarkers-based Early Warning System of Acute Respiratory Distress Syndrome (ARDS)
The aim of the investigators 'study is to investigate the relationship between the biomarkers (e.g. protein markers, genetic polymorphisms and epigenetic markers) and the onset of ARDS.
- Trial name
- NCT03236272
- Where
- China
- Volunteers
- 376 people
- Sponsor
- Mingdong Hu
Premature Birth, Respiratory Distress Syndrome
Non-invasive Ventilation in Preterm Infants
This is a prospective, observational cohort study. For the study part on noninvasive neurally adjusted ventilatory assist (NIV-NAVA) the design is interventional.
- Conditions
- Premature Birth, Respiratory Distress Syndrome, Ventilator Lung; Newborn
- Trial name
- NCT05987800
- Testing
- Titration procedure, Electrical impedance tomography, Lung and diaphragm ultrasound
- Where
- Belgium
- Volunteers
- 136 people
- Sponsor
- Universitair Ziekenhuis Brussel
Acute Respiratory Distress
The Epidemiology of Acute Respiratory Distress Among Children, A Retrospective Cross-Sectional Study
l Respiratory distress is still a major concern in pediatric medicine. l In this study we evaluated the symptoms and causes of respiratory distress among children in a tertiary hospital.
- Trial name
- NCT06578377
- Testing
- descriptive study
- Where
- Iran
- Volunteers
- 154 people
- Sponsor
- Mofid Children Hospital
Systemic Inflammatory Response Syndrome
INFLACOR - Clinical and Genetic Predictors of Inflammation Related Complications After Heart Surgery
The aim of the study is to evaluate a clinically and economically most effective diagnostic algorithm for prediction of inflammatory response related complications in patients undergoing heart surgery with use of cardiopulmonary…
- Trial name
- INFLACOR (NCT01020409)
- Testing
- cardiac surgery with CPB use
- Where
- Poland
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
Acute Respiratory Distress Syndrome, Neuromyopathies
Effect of Randomization to Neuromuscular Blockade on Physical Functional Impairment and Recovery in ARDS
The proposed work will determine the effect of neuromuscular blockade on physical function and recovery in patients with ARDS. The investigators will conduct a prospective ancillary study at five PETAL clinical centers that will…
- Trial name
- PRIMROSE (NCT03038906)
- Where
- United States
- Volunteers
- 290 people
- Sponsor
- University of Washington
Neonatal Respiratory Distress Syndrome, Gestational Age Conditions
The Use of Sedation Drugs in the Procedure of Administering Surfactant Without Intubation (LISA/MIST)
The purpose of this study is to evaluate the efficacy and impact of intravenous ketamine or sublingual 30% glucose as sedation drugs used in preterm premature babies during the LISA procedure.
- Trial name
- LISA KGS (NCT04409665)
- Testing
- Ketamine, Glucose
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Medical University of Warsaw
Acute Respiratory Distress Syndrome, Influenza
STIP: Statin Trial for Influenza Patients
To assess the efficacy and safety of oral rosuvastatin in patients with suspected or confirmed influenza who require intensive care unit (ICU) admission due to respiratory distress.
- Conditions
- Acute Respiratory Distress Syndrome, Influenza, H1N1 Influenza
- Trial name
- STIP (NCT00970606)
- Testing
- Rosuvastatin (crestor)
- Where
- 21 sites in United States
- Volunteers
- 7 people
- Sponsor
- Gordon Bernard
SARS-CoV 2, COVID
Inhaled ZYESAMI (Aviptadil Acetate) for Treatment of Severe COVID-19
Brief Summary: SARS-CoV-2 virus infection is known to cause Lung Injury that begins as dyspnea and exercise intolerance, but may rapidly progress to Critical COVID-19 with Respiratory Failure and the need for noninvasive or…
- Conditions
- SARS-CoV 2, COVID, ARDS, ALI
- Trial name
- AVICOVID-3 (NCT05137795)
- Testing
- ZYESAMI™ (aviptadil acetate)
- Sponsor
- APR Applied Pharma Research s.a.
Hypoxemic Respiratory Failure
Optimisation of High Flow Oxygen Therapy Settings During Hypoxaemic Respiratory Distress Based on Non-contact Measurement of Lung Volumes by Depth Camera
The goal of this clinical trial is to validate the interest of a strategy adjusting the flow rate delivered under high-flow oxygen (HFO) therapy according to the lung volumes measured by a new technique, in intensive care…
- Trial name
- DiStok (NCT06819644)
- Testing
- high flow oxygen therapy rate adjusted of lung volumes measured
- Where
- 8 sites in France
- Volunteers
- 406 people
- Sponsor
- University Hospital, Brest
Acute Respiratory Distress Syndrome (ARDS), Multiple Organ Failure
Intrapleural Methylprednisolone Injection for Multiple Organ Failure With Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) in combination with multi-organ dysfunction syndrome (MODS) is a life-threatening condition, particularly when treatment modalities such as extracorporeal membrane oxygenation (ECMO) and…
- Trial name
- IP steroid (NCT01423864)
- Testing
- conventional ECMO with intravenous steroid, solumedrol
- Where
- Taiwan
- Volunteers
- 29 people
- Sponsor
- National Taiwan University Hospital
Acute Severe Respiratory Failure, Acute Respiratory Distress Syndrome
WorldwidE AssessmeNt of Separation of pAtients From Ventilatory assistancE
WEAN SAFE (WorldwidE AssessmeNt of Separation of pAtients From ventilatory assistancE) is a multi-centre, prospective, observational, 4-week inception cohort study being carried out by the Acute Respiratory Failure section of…
- Trial name
- WEAN SAFE (NCT03255109)
- Where
- Belgium
- Volunteers
- 11,000 people
- Sponsor
- European Society of Intensive Care Medicine
ARDS, Pediatric Respiratory Distress Syndrome
REcruitment MAneuvers and Mechanical Ventilation Guided by EIT in pARDS
There is evidence from randomized controlled trials in adult patients with Acute Respiratory Distress Syndrome (ARDS) suggesting that delivering small tidal volumes with adequate levels of Positive End-Expiratory Pressure (PEEP)…
- Conditions
- ARDS, Pediatric Respiratory Distress Syndrome, Respiratory Disease
- Trial name
- REMAV-EIT (NCT06067152)
- Testing
- EIT measurement, Staircase Recruitment Maneuvers with EIT guided and decremental PEEP trial, Setting of EIT-guided mechanical ventilation
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Infant, Newborn, Infant, Low Birth Weight
Exosurf Neonatal and Survanta for Treatment of Respiratory Distress Syndrome
The purpose of this study is to compare the efficacy of two surfactants, Exosurf Neonatal (Burroughs Wellcome Co.) and Survanta (Ross Laboratories), for the treatment of neonatal respiratory distress syndrome.
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- Surfactant 1 (NCT01203358)
- Testing
- Exosurf, Survanta
- Where
- 13 sites in United States
- Volunteers
- 617 people
- Sponsor
- NICHD Neonatal Research Network