Clinical trials: Respiratory Distress
Acute Respiratory Distress Syndrome (ARDS), Acute Lung Injury (ALI)
Trial of Steroids in Pediatric Acute Lung Injury/ARDS
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are devastating disorders associated with lung inflammation, low oxygen levels and respiratory failure in children.
- Trial name
- SPALIT (NCT01274260)
- Testing
- methylprednisolone, Normal Saline (0.9%)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Tennessee
Acute Respiratory Distress Syndrome
Efficacy and Safety of Sivelestat Sodium and Dexamethasone in the Treatment of ARDS
The goal of this clinical trial is to evaluate the efficacy and safety of Sivelestat sodium and dexamethasone in the treatment of patients with moderate to severe ARDS.
- Trial name
- STAR (NCT06387823)
- Testing
- Sivelestat sodium, Dexamethasone
- Where
- 4 sites in China
- Volunteers
- 300 people
- Sponsor
- Peking Union Medical College Hospital
Preterm Birth, Low Birth Weight
Perinatal Conditions Influencing Morbidity, Mortality, and Medical Care in Newborns
This study focuses on understanding the conditions that affect newborn health and survival from pregnancy to the first weeks of life at the Isidro Ayora Hospital.
- Conditions
- Preterm Birth, Low Birth Weight, Intrauterine Growth Restriction (IUGR), Perinatal Asphyxia
- Trial name
- UCE (NCT06653374)
- Testing
- Infant, Premature
- Where
- Ecuador
- Volunteers
- 26,000 people
- Sponsor
- HOSPITAL GINECO OBSTETRICO ISIDRO AYORA
Acute Respiratory Distress Syndrome
Association Between Driving Transpulmonary Pressure and Extravascular Lung Water in Patients with ARDS
Intubated patients with the acute respiratory distress syndrome (ARDS) are usually treated with protective ventilation limiting plateau pressure below 30 centimeter of water (cmH2O) and, if possible, a driving pressure under 15…
- Trial name
- NCT05474196
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Bicetre Hospital
Bronchiolitis
Atrial and Brain Natriuretic Peptides in Bronchiolitis
The purpose of this study is to collect information about what happens to certain chemicals produced in the body called hormones during respiratory infections such as bronchiolitis.
- Trial name
- NCT00347880
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Florida
Patent Ductus Arteriosus
Closure of Patent Ductus Arteriosus With Indomethacin or Ibuprofen in Extreme Low Birth Weight Infants
Pharmacological closure of ductus arteriosus with prostaglandin (PG) inhibitors has been used for years. Previous studies indicated that ibuprofen has similar effect on ductal closure as indomethacin but has less adverse effects…
- Trial name
- NCT01758913
- Testing
- Ibuprofen
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Taipei Medical University Hospital
ARDS
Establishment of a Early Risk Model of ECMO in Children With ARDS
The key problem in the treatment of ARDS is refractory hypoxemia. Extracorporeal Membrane Oxygenation (ECMO) is an extracorporeal oxygenation of venous blood to eliminate carbon dioxide and return to the body.
- Trial name
- NCT04710173
- Testing
- ECMO
- Where
- 3 sites in China
- Volunteers
- 95 people
- Sponsor
- Children's Hospital of Fudan University
Transient Tachypnea of the Newborn
Role of Salbutamol and Furosemide in TTN
to see the effects of slabutamol and IV furosemide in the treatment of transient tachypnea of newborn
- Trial name
- NCT03208894
- Testing
- Furosemide Injection
- Where
- 2 sites in Pakistan
- Volunteers
- 100 people
- Sponsor
- Armed Forces Hospital, Pakistan
Respiratory Distress Syndrome RDS, Preterm Birth
Early Prediction of Lung Injury in Preterm Infants Score
The main hypothesis is that even preterm infants considered "stable" receiving non-invasive ventilation may be at risk of developing BPD due to an inhomogeneous distribution of ventilation.
- Trial name
- EPLIPS (NCT07265583)
- Where
- Italy
- Volunteers
- 104 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Respiratory Distress Syndrome, Adult, Ventilator-Induced Lung Injury
Asynchrony During Mechanical Ventilation in Patients With Acute Respiratory Distress Syndrome
Asynchrony during mechanical ventilation has been poorly described in patients suffering from acute respiratory distress syndrome.
- Trial name
- NCT02732041
- Where
- 5 sites in Argentina
- Volunteers
- 103 people
- Sponsor
- Centro de Educación Medica e Investigaciones Clínicas Norberto Quirno
Sepsis, Respiratory Distress Syndrome
Phase I Study of Vasoactive Intestinal Peptide in Patients With Acute Respiratory Distress Syndrome and Sepsis
OBJECTIVES: I. Determine the maximum tolerated dose of vasoactive intestinal peptide in patients with acute respiratory distress syndrome. II. Evaluate the safety and pharmacodynamic activity of this peptide in these patients.
- Conditions
- Sepsis, Respiratory Distress Syndrome, Respiratory Distress Syndrome, Adult
- Trial name
- NCT00004494
- Testing
- vasoactive intestinal peptide
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- Stony Brook University
ARDS (Moderate or Severe)
Effect of Inhaled Nitric Oxide Therapy in Adults With Moderate-to-Severe Acute Respiratory Distress Syndrome
The goal of this clinical trial is to evaluate whether inhaled nitric oxide (iNO), added to standard care, can reduce mortality in adults with moderate-to-severe Acute Respiratory Distress Syndrome (ARDS).
- Trial name
- ENARCT-ARDS (NCT07334873)
- Testing
- Inhaled Nitric Oxide Therapy
- Where
- China
- Volunteers
- 536 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Deglutition Disorders, Respiratory Distress Syndrome In Premature Infants
Effect of Nasal Continuous Positive Airway Pressure on The Pharyngeal Swallow in Neonates
Oral feeding of neonates while on nasal continuous positive airway pressure (NCPAP) is a common practice in many neonatal intensive care units (NICU) all over the country.
- Conditions
- Deglutition Disorders, Respiratory Distress Syndrome In Premature Infants, Respiratory Aspiration, Newborn, Premature
- Trial name
- NCT02661256
- Testing
- NCPAP, Varibar® Thin Liquid Barium Sulfate for Suspension
- Volunteers
- 7 people
- Sponsor
- NYU Langone Health
Severe Acute Respiratory Syndrome Coronavirus 2
Ruxolitinib for the Treatment of Acute Respiratory Distress Syndrome in Patients With COVID-19 Infection
It is an observational, cohort, retrospective, monocentric, non-profit study. The primary objective is to evaluate the efficacy and safety of ruxolitinib in acute respiratory distress syndrome in patients with SARS-CoV-2 COVID-19…
- Trial name
- RESPIRE (NCT04361903)
- Testing
- Ruxolitinib Oral Tablet
- Volunteers
- 13 people
- Sponsor
- Azienda USL Toscana Nord Ovest
Covid19
Study of Intravenous COVI-MSC for Treatment of COVID-19-Induced Acute Respiratory Distress
This is a Phase 2 randomized controlled study to assess the safety and efficacy of COVI-MSC in the setting of current standard of care treatments for COVID-19 infection in hospitalized subjects with acute respiratory distress…
- Trial name
- NCT04903327
- Testing
- COVI-MSC
- Where
- 6 sites in Brazil
- Volunteers
- 43 people
- Sponsor
- Sorrento Therapeutics, Inc.
Severe Acute Respiratory Syndrome (SARS), Acute Respiratory Distress Syndrome (ARDS)
Extracellular Vesicles From Mesenchymal Cells in the Treatment of Acute Respiratory Failure
This is a phase I/II, randomized, double-blind, placebo-controlled clinical trial that will evaluate the safety and potential efficacy of therapy with extracellular vesicles (EVs) obtained from mesenchymal stromal cells (MSCs)…
- Conditions
- Severe Acute Respiratory Syndrome (SARS), Acute Respiratory Distress Syndrome (ARDS), Pneumonia
- Trial name
- NCT06002841
- Testing
- intravenous treatment with EVs
- Where
- Brazil
- Volunteers
- 15 people
- Sponsor
- D'Or Institute for Research and Education
Acute Respiratory Distress Syndrome (ARDS)
Application of Electrical Impedance Tomography in Evaluating Pulmonary Function Improvement After High Lateral Recumbent Position Therapy in ARDS Patients
This randomized controlled trial investigates the effects of prone positioning versus lateral positioning at different angles (30°, 90°, 120°) on pulmonary function improvement in patients with acute respiratory distress syndrome…
- Trial name
- NCT07375849
- Testing
- Place the patient in the 90-degree high lateral position., Place the patient in the 30-degree low lateral position., Place the patient in the 120-degree high lateral position.
- Volunteers
- 140 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Acute Lung Injury, Adult Respiratory Distress Syndrome
Assessing Respiratory Variability During Mechanical Ventilation in Acute Lung Injury (ALI)
Healthy biological systems are characterized by a normal range of "variability" in organ function. For example, many studies of heart rate clearly document that loss of the normal level of intrinsic, beat-to-beat variability in…
- Trial name
- NCT01083355
- Where
- United States
- Sponsor
- Boston Medical Center
Respiratory Distress Syndrome In Premature Infants, Bronchopulmonary Dysplasia
Seattle-PAP Bubble Nasal CPAP and Work of Breathing
The investigators propose to test the hypothesis that Seattle bubble nasal continuous positive airway pressure (Seattle-PAP) supports respiratory physiology in very low birth weight (VLBW) infants more effectively than standard…
- Conditions
- Respiratory Distress Syndrome In Premature Infants, Bronchopulmonary Dysplasia, Newborn Primary Sleep Apnea
- Trial name
- Seattle-PAP (NCT02210026)
- Testing
- Seattle-PAP
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Seattle Children's Hospital
Bronchopulmonary Dysplasia, Pulmonary Hypertension Due to Lung Diseases and Hypoxia
Ventilator Pressure and Optimization of Compliance and Hemodynamics
In preterm infants < 34 weeks' gestation at birth receiving respiratory support with invasive positive pressure ventilation, the positive end-expiratory pressure (PEEP) of best compliance will increase the cardiac output and…
- Conditions
- Bronchopulmonary Dysplasia, Pulmonary Hypertension Due to Lung Diseases and Hypoxia, Extreme Prematurity, Ventilator Lung; Newborn
- Trial name
- VPOCH (NCT06512935)
- Testing
- Increase in the PEEP followed by decrease in the PEEP, Decrease in the PEEP followed by increase in the PEEP
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Alabama at Birmingham