Clinical trials: Respiratory Distress Syndrome, Adult
Acute Respiratory Distress Syndrome, Acute Lung Injury
Iloprost Effects on Gas Exchange and Pulmonary Mechanics
This study will examine the hypothesis that iloprost maintains and improves ventilation perfusion matching in patients with pulmonary hypertension and ARDS/ALI as reflected by 1) an improved PaO2/FIO2 ratio as calculated from the…
- Conditions
- Acute Respiratory Distress Syndrome, Acute Lung Injury, Pulmonary Hypertension
- Trial name
- NCT01274481
- Testing
- Iloprost
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Oklahoma
Respiratory Distress Syndrome, Premature Birth
nCPAP Versus High-Flow Nasal Cannula in Preterm Infants With RDS
This randomized controlled trial aims to compare the efficacy and safety of nasal continuous positive airway pressure versus high-flow nasal cannula as initial non-invasive respiratory support in preterm infants with respiratory…
- Trial name
- NCT07869719
- Testing
- Non-invasive respiratory support
- Volunteers
- 94 people
- Sponsor
- Assiut University
Respiratory Distress Syndrome, Newborn
NIPPV vs.nCPAP During LISA Procedure
The goal of this randomized controlled study is to compare the efficacy of using NIPPV versus NCPAP during the LISA procedure in very preterm infants.
- Trial name
- NIPAL (NCT05796128)
- Testing
- Nasal Intermittent Positive Pressure Ventilation (NIPPV), Nasal continuous positive airway pressure (NCPAP)
- Where
- Italy
- Volunteers
- 202 people
- Sponsor
- University of Florence
Neonatal, Premature Birth
Extending CPAP Therapy in Stable Preterm Infants to Increase Lung Growth and Function
This is a study to see if an extra 2 weeks of continuous positive airway pressure (CPAP) in stable preterm infants in the neonatal intensive care unit (NICU) can cause increased lung growth and lung function in the infants as…
- Conditions
- Neonatal, Premature Birth, Respiratory Distress Syndrome
- Trial name
- NCT04295564
- Testing
- Additional 2 weeks of CPAP
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Cynthia McEvoy
Sepsis
Biomarkers to Predict Acute Respiratory Distress Syndrome(ARDS) in Patients With Sepsis
Sepsis-induced acute respiratory distress syndrome (ARDS) is a life-threatening acute inflammatory lung injury, associated with increased pulmonary microvascular permeability, increased lung weight, and loss of aerated lung…
- Trial name
- NCT05914428
- Testing
- ALDH2 rs671 mutation
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Qilu Hospital of Shandong University
COVID-19, ARDS, Human
Cardiac Dysfunction in Critically Ill Covid-19 Patients
We conducted an observation sub-study of the prospective randomized controlled trial "High Dose Inhaled Nitric Oxide in Acute Hypoxemic Respiratory Failure", in which we analysed the echocardiographic data collected both at…
- Conditions
- COVID-19, ARDS, Human, Cardiac Failure, Right Ventricular Dysfunction
- Trial name
- NCT06197256
- Where
- Sweden
- Volunteers
- 39 people
- Sponsor
- Region Stockholm
Acute Respiratory Distress Syndrome
Effects of SEvoflurane on Gas Exchange and Inflammation in Patients With ARDS (SEGA Study)
Numerous trials support the efficacy and safety of volatile anesthetic agents, namely inhalation of sevoflurane through dedicated devices, for the sedation of ICU patients.
- Trial name
- SEGA (NCT02166853)
- Testing
- sevoflurane, midazolam
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand
Acute Respiratory Distress Syndrome (ARDS)
Safety and Preliminary Efficacy of TISA-818 Injection in Patients With Acute Respiratory Distress Syndrome
This is a randomized, double-blind, placebo-controlled Phase II clinical study of TISA-818-Inj in patients with ARDS to evaluate the safety, preliminary efficacy, and population PK (Pop PK) profile of TISA-818-Inj in adult ARDS…
- Trial name
- NCT07319351
- Testing
- TISA-818-Inj
- Where
- China
- Volunteers
- 57 people
- Sponsor
- EnliTISA (Shanghai) Pharmaceutical Co., Ltd.
Hypoxic Pulmonary Vasoconstriction, Hypoxemia
Effects in Oxygenation and Hypoxic Pulmonary Vasoconstriction in ARDS Secondary to SARS-CoV2
Summary Currently, the COVID-19 pandemic has overtaken health systems worldwide, exceeding the capacity of intensive care units.
- Conditions
- Hypoxic Pulmonary Vasoconstriction, Hypoxemia, Acute Respiratory Distress Syndrome, SARS-CoV-2 Acute Respiratory Disease
- Trial name
- COVID-19 (NCT04998253)
- Testing
- Effects in oxygenation and hypoxic pulmonary vasoconstriction
- Where
- Mexico
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Unidad Temporal COVID-19 en Centro Citibanamex
Chronic Thromboembolic Pulmonary Hypertension, Acute Lung Injury
Lung Protective Ventilation in Pulmonary Thromboendarterectomy (PTE) Patients
Chronic thromboembolic pulmonary hypertension (CTEPH) is caused by unresolved thromboemboli in the pulmonary arteries, which lead to pulmonary hypertension and, left untreated, right heart failure.
- Trial name
- NCT00747045
- Testing
- Ventilation Strategy
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- University of California, San Diego
Acute Respiratory Distress Syndrome, Barotrauma
Laboratory Biomarkers and Pulmonary Interstitial Emphysema in ARDS (PIE-ARDS)
Barotrauma (pneumothorax, pneumomediastinum) is a well-described complication of Acute Respiratory Distress Syndrome (ARDS), especially in patients with coronavirus disease 2019 (COVID-19) (16.1% in COVID-19, and about 6% in…
- Trial name
- PIE-ARDS (NCT06001645)
- Testing
- Blood and bronchoalveolar fluid collection and analysis, Chest CT scan
- Where
- 4 sites in Italy
- Volunteers
- 110 people
- Sponsor
- Università Vita-Salute San Raffaele
Acute Respiratory Distress Syndrome
Corticosteroid Treatment for Acute Respiratory Distress Syndrome
It is acknowledged that IL-18, as a product of the inflammasome, is involved in host defence against viral and bacterial stimuli by modulating the immune response.
- Trial name
- NCT02819453
- Where
- China
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Acute Lung Injury
Anesthetic Methods and Liver Transplantation
Postoperative pulmonary complications are not uncommon after liver transplantation. They can not only prolong the stay in intensive care unit and in hospital but also increase the morbidity and mortality rate.
- Trial name
- NCT01936545
- Testing
- propofol during liver transplantation., Desflurane during liver transplantation.
- Where
- Taiwan
- Volunteers
- 144 people
- Sponsor
- National Taiwan University Hospital
Prematurity, Respiratory Distress Syndrome, Infant
Weaning of Nasal Continuous Positive Airway Pressure (CPAP) in Premature Infants
The aim of this study is to investigate two different strategies for the withdrawal of CPAP in preterm infants born before 32 weeks of gestation.
- Trial name
- NCT01721629
- Testing
- Sudden wean of nasal CPAP, Gradual wean of nasal CPAP
- Where
- 6 sites in Denmark
- Volunteers
- 380 people
- Sponsor
- Aarhus University Hospital
Neonatal Respiratory Distress Syndrome
To Investigate the Effect of Pulmonary Surfactant With Different Inspired Oxygen Concentrations on the Clinical Outcomes of Very Preterm Infants Under Non-invasive Assisted Ventilation
A prospective multicenter randomized controlled study was conducted. Eligible very preterm infants with a gestational age of <32 weeks were enrolled.
- Trial name
- NCT07235345
- Testing
- According to the FiO2 threshold of PS application corresponding to randomization, PS treatment was given when FiO2 reached the threshold
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xu Falin
Acute Respiratory Distress Syndrome
Association Between Driving Transpulmonary Pressure and Extravascular Lung Water in Patients with ARDS
Intubated patients with the acute respiratory distress syndrome (ARDS) are usually treated with protective ventilation limiting plateau pressure below 30 centimeter of water (cmH2O) and, if possible, a driving pressure under 15…
- Trial name
- NCT05474196
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Bicetre Hospital
COVID-19 Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation Complication
Correlation Between PaCO2 and Respiratory Effort in Patients With COVID-19 With Extracorporeal Membrane Oxygenation
Excessive respiratory effort may cause self-inflicted lung injury (SILI) and inspiratory muscle injuries , stimulate desynchronization between the patient and ventilator , and worsen the perfusion of extrapulmonary organs .
- Conditions
- COVID-19 Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation Complication, Respiratory Effort-Related Arousal
- Trial name
- NCT05882474
- Testing
- PaCO2
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Peking Union Medical College Hospital
Covid-19, Acute Respiratory Failure
Mavrilimumab in Severe COVID-19 Pneumonia and Hyper-inflammation (COMBAT-19)
This study is a prospective, phase II, multi-center, randomized, double-blind, placebo-controlled trial to evaluate the efficacy and safety of mavrilimumab in hospitalized patients with acute respiratory failure requiring oxygen…
- Conditions
- Covid-19, Acute Respiratory Failure, ARDS, Human, Sars-CoV2
- Trial name
- COMBAT-19 (NCT04397497)
- Testing
- Mavrilimumab
- Where
- 3 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Ospedale San Raffaele
COVID-19, ARDS, Human
Inhaled Iloprost for Suspected COVID-19 Respiratory Failure
Acute respiratory distress syndrome (ARDS) is a type of respiratory failure characterized by the rapid onset of widespread inflammation in the lungs.
- Conditions
- COVID-19, ARDS, Human, Hypoxemic Respiratory Failure
- Trial name
- ILOCOVID (NCT04445246)
- Testing
- Inhaled ILOPROST
- Where
- Qatar
- Volunteers
- 40 people
- Sponsor
- Hamad Medical Corporation
Respiratory Distress Syndrome, Adult, Acute Lung Injury
A Phase II Study to Determine the Efficacy and Safety of Sivelestat in Subjects With Acute Lung Injury
The purpose of this study is to determine whether sivelestat will reduce the amount of time a patient must spend on a ventilator and/or increase the chance of survival of patients with acute lung injury.
- Trial name
- NCT00036062
- Testing
- Sivelestat
- Where
- 110 sites in United States, Australia and 4 more
- Volunteers
- 600 people
- Sponsor
- Eli Lilly and Company
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