Clinical trials: Respiratory Distress Syndrome, Adult
Acute Lung Injury, Adult Respiratory Distress Syndrome
Airway Pressure Release Ventilation (APRV) Compared to ARDSnet Ventilation
Traditional modes of ventilation have failed to improve patient survival. Subsequent observations that elevated airway pressures observed in traditional forms of ventilation resulted in barotrauma and extension of ALI lead to the…
- Conditions
- Acute Lung Injury, Adult Respiratory Distress Syndrome, Kidney Injury
- Trial name
- PRESSURE (NCT00793013)
- Testing
- Volume-Cycled Assist-Control (AC) mode, Airway Pressure Release Ventilation (APRV) mode
- Where
- United States
- Sponsor
- University of Tennessee, Chattanooga
ARDS
Lung Sonography in Patients With Acute Respiratory Distress Syndrome in Intensive Care Unit
The purpose of this study is to evaluate the role of lung sonography during different PEEP settings in ICU patients with ARDS.
- Trial name
- NCT01881061
- Where
- Greece
- Volunteers
- 10 people
- Sponsor
- University of Athens
Mechanical Ventilation Complication
BIPAP in the Management of Acute Respiratory Distress Syndrome
Evaluation of biphasic positive airway pressure as a new mode of ventilation in management of acute respiratory failure constituted in ARDS as a category of hypoxaemic respiratory failure in comparison to conventional ventilation.
- Trial name
- NCT05483959
- Testing
- BIPAP mode/SIMV PC mode
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- South Valley University
ARDS (Moderate or Severe)
Effect of Inhaled Nitric Oxide Therapy in Adults With Moderate-to-Severe Acute Respiratory Distress Syndrome
The goal of this clinical trial is to evaluate whether inhaled nitric oxide (iNO), added to standard care, can reduce mortality in adults with moderate-to-severe Acute Respiratory Distress Syndrome (ARDS).
- Trial name
- ENARCT-ARDS (NCT07334873)
- Testing
- Inhaled Nitric Oxide Therapy
- Where
- China
- Volunteers
- 536 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Acute Lung Injury, Acute Respiratory Distress Syndrome
Safety Study of Nebulized Sodium Nitroprusside in Adult Acute Lung Injury
Acute lung injury (ALI) is caused by a wide variety of conditions, but always characterized by hypoxia and non-cardiogenic pulmonary edema. Current treatment of ALI is supportive and treatment of the underlying cause.
- Conditions
- Acute Lung Injury, Acute Respiratory Distress Syndrome, Sodium Nitroprusside, Hypoxia
- Trial name
- NCT01619280
- Testing
- Sodium Nitroprusside
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Mount Sinai Hospital, Canada
Respiratory Distress Syndrome, Adult, Multi-antibiotic Resistance
Multi-drug Resistant Gram-negative Bacteria and Veno-venous Extracorporeal Membrane Oxygenation (ECMO)
Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is a life-support technique used in patients with most severe acute respiratory distress syndrome (ARDS).
- Trial name
- MDR-ECMO (NCT06199141)
- Where
- Italy
- Volunteers
- 279 people
- Sponsor
- University of Padova
ARDS, Human
Decrease of Lesions Induced by Mechanical Ventilation During ARDS
Modification of mechanically ventilated lesions by an ultra-protective multimodal strategy compared to a protective strategy in patients with veno-venous ECMO for severe ARDS.
- Trial name
- ECMO-VILI (NCT03918603)
- Testing
- ventral décubitus
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Acute Respiratory Distress Syndrome (ARDS), s100b
A Study of the Determinants of Neurological Outcomes in Patients With Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is characterized by pathological pulmonary edema caused by direct or indirect damage to the alveolar-capillary membrane.
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), s100b, Mechanical Power, Ventilator Induced Lung Injury
- Trial name
- NEURDS (NCT07629973)
- Testing
- Blood test scores calculations
- Volunteers
- 150 people
- Sponsor
- University Hospital, Angers
Acute Respiratory Distress Syndrome, COVID-19 Pneumonia
Double-blind, Randomized, Controlled Clinical Trial to Assess Efficacy of MSC in Patients With COVID-19 ARDS
A double-blind, randomized, controlled, clinical trial to evaluate the efficacy and safety of MSC (mesenchymal stromal cells) intravenous administration in patients with COVID-induced ARDS compared to a control arm.
- Trial name
- NCT04615429
- Testing
- Mesenchymal stromal cells
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Cristina Avendaño Solá
COVID-19
Study of Niclosamide in Moderate and Severe Hospitalized Coronavirus-19 (COVID-19) Patients
Study of ANA001 in Moderate and Severe COVID-19 Patients
- Trial name
- NCT04603924
- Testing
- Niclosamide
- Where
- 8 sites in United States
- Volunteers
- 49 people
- Sponsor
- NeuroBo Pharmaceuticals Inc.
Covid19, Corona Virus Infection
Expanded Access to Zofin for Patients With COVID-19
This expanded access protocol will provide access to the investigational product Zofin for patients in outpatient facilities infected with SARS-CoV-2 who have mild to moderate COVID-19, or who are judged by a healthcare provider…
- Conditions
- Covid19, Corona Virus Infection, SARS (Severe Acute Respiratory Syndrome), Acute Respiratory Distress Syndrome
- Trial name
- NCT04657406
- Testing
- Zofin
- Sponsor
- ZEO ScientifiX, Inc.
Acute Respiratory Distress Syndrome, Ventilator-Induced Lung Injury
Height Measurement Procedures Influence the Risk of Ventilator-induced Lung Injury in ARDS
Acute respiratory distress syndrome is characterized by heterogeneous lung injury, with dependent regions often collapsed and non-dependent regions relatively well-aerated, forming the so called "baby lung." Mechanical…
- Conditions
- Acute Respiratory Distress Syndrome, Ventilator-Induced Lung Injury, Tidal Volume, Predicted Body Weight
- Trial name
- SIZE-ARDS (NCT07595926)
- Testing
- height measured
- Where
- France
- Volunteers
- 39 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
COVID-19 Acute Respiratory Distress Syndrome, Respiration, Artificial
Flow-controlled Ventilation (FCV) in Moderate Acute Respiratory Distress Syndrome (ARDS) Due to COVID-19
Flow controlled ventilation (FCV) is a fairly new mode of mechanical ventilation, consisting of a constant inspiratory and expiratory flow. Inspiration is thus comparable to volume controlled ventilation (VCV).
- Trial name
- VICAR (NCT04894214)
- Testing
- Arterial blood gas (ABG), Recording of hemodynamic monitoring, Recording of respiratory monitoring
- Where
- Belgium
- Volunteers
- 11 people
- Sponsor
- University Hospital, Antwerp
Respiratory Distress Syndrome
Diaphragm Dysfunction in ARDS Patients With V-V ECMO
Use of veno-venous extracorporeal oxygenation membrane is a therapeutic option for the management of the most severe patients with acute respiratory distress syndrome (ARDS).
- Trial name
- DD-ECMO (NCT04613752)
- Testing
- diaphragmatic function measurements and diaphragmatic ultrasound
- Where
- France
- Volunteers
- 63 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Lung Injury, Acute
Lung Atelectasis Improvement Through Positive End Expiratory Pressure During Anesthetic Induction
Anesthetic induction could lead to lung atelectasis, increase intrapulmonary shunt, and potentially impair oxygenation. The study aimed to validate that a positive end-expiratory pressure (PEEP) of 10 cmH2O could reduce lung…
- Trial name
- NCT06900426
- Testing
- 10 PEEP, ZEEP, 5PEEP
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fudan University
Acute Respiratory Distress Syndrome, Mechanical Ventilation
The Physiological Effect of RCexp on Ventilation/Perfusion Distribution
With the exception of setting the positive end-expiratory pressure (PEEP), the expiratory phase is commonly overlooked during MV.
- Trial name
- NCT06919484
- Testing
- RCexp
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Southeast University, China
Acute Lung Injury
The Study of ELEctronic Cigarette Toxicity in a Human Model in Vivo Model of Inflammation and Vascular Dysfunction
To carry out a prospective cohort study of healthy volunteers, assessing differences between baseline pulmonary inflammation, response to LPS inhalation and endothelial function, as measured by flow mediated dilation between…
- Trial name
- SELECT (NCT02739438)
- Testing
- Electronic cigarette use, Cigarette use, Control group
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Acute Respiratory Distress Syndrome
Acute Respiratory Distress Syndrome in Taiwan
The study enrolls ARDS patients in medical ICUs in 11 Hospitals in Taiwan. The epidemiology and long-term outcomes of the patients will be recorded.
- Trial name
- NCT03260348
- Volunteers
- 2,000 people
- Sponsor
- Chang Gung Memorial Hospital
Premature, Respiratory Distress Syndrome in Premature Infant
Novel Low Cost Bubble CPAP as an Alternative Respiratory Support in Low Resource Setting
This is a single-blind randomized controlled trial done in a Level III neonatal intensive care unit. Preterm newborns with RDS were randomized to receive oxygen therapy through bubble CPAP vs ventilator-derived CPAP.
- Trial name
- NCT06082674
- Testing
- Vayu bCPAP, Mechanical Ventilator Driven CPAP
- Where
- Philippines
- Volunteers
- 70 people
- Sponsor
- Ilocos Training and Regional Medical Center
ARDS (Acute Respiratory Distress Syndrome), Real World Study
A Real World Study of Respiratory Critical Disease.
Acute Respiratory Distress Syndrome (ARDS) is a form of acute diffuse lung injury caused by various etiologies, which rapidly progresses to acute respiratory failure.
- Trial name
- NCT07165717
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Ming Zhong
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